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  • bone marrow
  • The purpose of this study is to find out if giving the study drug Ruxolitinib (INC424) prior to a combination of other chemotherapeutic drugs (Fludarabine and Busulfan) before infusing another person's hematopoietic stem cells (bone marrow transplantation) will be successful in people who have advanced primary myelofibrosis (PMF), post-polycythemia vera myelofibrosis (PPV-MF) or post-essential thrombocythemia myelofibrosis (PET-MF), collectively known as myelofibrosis (MF). (clinicaltrials.gov)
  • The majority of experimental murine bone marrow (BM) transplantation (BMT) studies have focused on the role of nTregs, whereas the contribution of iTregs to the prevention of GVHD lethality is still largely unclear. (jimmunol.org)
  • RATIONALE: Bone marrow transplantation may be able to replace immune cells that were destroyed by chemotherapy used to kill tumor cells. (bioportfolio.com)
  • After myeloablative conditioning, patients received transplantation of blood stem cells (n=164) or bone marrow grafts (n=37). (perssupport.nl)
  • Comparison of the Direct Effects of Human Adipose- and Bone-Marrow-Derived Stem Cells on Postischemic Cardiomyoblasts in an In Vitro Simulated Ischemia-Reperfusion Model. (stembook.org)
  • Murine Bone Marrow Lin(-)Sca-1(+)CD45(-) Very Small Embryonic-Like (VSEL) Cells Are Heterogeneous Population Lacking Oct-4A Expression. (stembook.org)
  • Bone marrow mesenchymal stromal cells (BM-MSCs) are referred as a promising immunotherapeutic cell product. (springer.com)
  • Fayyad-Kazan H, Faour WH, Badran B, Lagneaux L, Najar M. The immunomodulatory properties of human bone marrow-derived mesenchymal stromal cells are defined according to multiple immunobiological criteria. (springer.com)
  • Bone marrow mesenchymal stromal cells induce proliferative, cytokinic and molecular changes during the T cell response: the importance of the IL-10/CD210 axis. (springer.com)
  • Haspot F, Li HW, Lucas CL, Fehr T, Beyaz S, Sykes M. Allospecific rejection of MHC class I-deficient bone marrow by CD8 T cells . (columbia.edu)
  • pathogenesis
  • In conclusion, these findings reinforce a concept where GVHD and IBD share a subset of genetic susceptibility factors, and may lead to a better understanding of GVHD pathogenesis after SCT for haematological malignancy. (ecco-ibd.eu)
  • cytokine
  • Vascular endothelial cells are primary targets of cytokine-induced cell death leading to tissue injury. (semanticscholar.org)
  • This decline in Treg numbers unleashes cytotoxic T cells and proinflammatory cytokine pathways that subsequently mediate pathological damage. (jimmunol.org)
  • Altered cytokine environment in post-HSCT lymphopenia with a relative functional deficiency of IL-2 could hamper the reconstitution of Treg, leading to refractory GVHD. (springer.com)
  • Cytokine profiles during delivery affect cord blood hematopoietic stem and progenitors cells. (stembook.org)
  • To run this study, we have used BM-MSC cell cultures, a pro-inflammatory cytokine cocktail priming, flow cytometry analysis, qPCR and ELISA techniques. (springer.com)
  • Application of the principles of cytokine signaling to the clinical setting may necessitate new trial design structures that take into consideration donor and host characteristics as well as the kinetics of GVHD development. (springer.com)
  • Stromal Cells
  • Mesenchymal stromal cells (MSC) exhibit immunomodulatory properties and a recent pilot study suggests a response rate of 70% in steroid- refractory patients. (clinicaltrials.gov)
  • Interactions between acute myeloid leukemia (AML) blasts and neighboring stromal cells are important for disease development and chemosensitivity. (uib.no)
  • The immunomodulatory potential of mesenchymal stromal cells: a story of a regulatory network. (springer.com)
  • Najar M, Raicevic G, Fayyad-Kazan H, Bron D, Toungouz M, Lagneaux L. Mesenchymal stromal cells and immunomodulation: a gathering of regulatory immune cells. (springer.com)
  • Immune-related antigens, surface molecules and regulatory factors in human-derived mesenchymal stromal cells: the expression and impact of inflammatory priming. (springer.com)
  • recipients
  • A growing understanding of the role of DAMPs in directing the immune response to transplantation has suggested novel avenues for the treatment or prevention of allograft rejection that complement contemporary immunosuppression and could lead to improved outcomes for solid organ recipients. (jci.org)
  • cGVHD
  • 1 A breakdown in peripheral B cell homeostasis in cGVHD is in part due to high levels of B cell activating factor (BAFF), a member of the tumor necrosis factor (TNF) superfamily. (haematologica.org)
  • 2 BAFF levels are increased in cGVHD and high BAFF/B-cell ratios are associated with cGVHD activity. (haematologica.org)
  • cGVHD is mediated by naive T cells differentiating within IL-17-secreting T cell and follicular Th cell paradigms to generate IL-21 and IL-17A, which drive pathogenic germinal center (GC) B cell reactions and monocyte-macrophage differentiation, respectively. (jci.org)
  • Biology
  • Here, we discuss new insights into the biology of lower GI tract GVHD and focus on intrinsic pathways and regulatory mechanisms crucial to normal intestinal function. (jci.org)
  • Here, we review SCI cell biology, which varies considerably across three different lesion-related tissue compartments: (a) non-neural lesion core, (b) astrocyte scar border, and (c) surrounding spared but reactive neural tissue. (jci.org)
  • The emerging understanding of how SCI cell biology differs across lesion compartments is fundamental to developing rationally targeted repair strategies. (jci.org)
  • The most well-characterized population of Tregs in GVHD biology has been CD4 + T cells, which express the Foxp3 transcription factor ( 11 ). (jimmunol.org)
  • patients
  • In each stratum, we will enroll additional patients (up to 20%) of stratum total to take into account exclusions due to donor failure (such as donor deemed unsuitable for stem cell donation due to medical or other reasons) only. (clinicaltrials.gov)
  • The cells are then irradiated, which prevents them from being able to grow, before being administered to patients in a series of vaccinations. (clinicaltrials.gov)
  • Information from studies in psoriasis and in other patients with GVHD suggests that this drug may help to treat chronic GVHD. (clinicaltrials.gov)
  • Safety of Alefacept Infusions in Patients With Chronic GVHD. (clinicaltrials.gov)
  • Immunomagnetic selection of HLA-mismatched CD34+ progenitor cells has demonstrated high levels of T cell depletion and successful engraftment in adult and pediatric patients with the malignant and nonmalignant disease. (centerwatch.com)
  • This is supported by the fact that the vast majority of patients alive after ATLG-containing GvHD prophylaxis are free of immunosuppressive therapy," said Professor Juergen Finke, the principal investigator of the study and Deputy Head of the Department of Hematology and Oncology at the Faculty of Medicine and Medical Center at the University of Freiburg, Germany. (perssupport.nl)
  • Approved by Food and Drug Administration for prophylaxis of organ rejection in patients receiving allogeneic renal allografts. (medscape.com)
  • murine
  • A preponderance of evidence in experimental murine models and humans indicates that there is a progressive loss of regulatory T cells (Tregs) during GVHD ( 2 - 5 ). (jimmunol.org)
  • Murine models have demonstrated the roles of interleukin (IL)-12 and IL-18 in chronic GVHD. (springer.com)
  • exacerbation
  • We then describe multiple instances in which these homeostatic mechanisms are altered by donor T cells or conditioning therapy, resulting in exacerbation of GVHD. (jci.org)
  • renal
  • The prospects for combination therapy with capecitabine in the rapidly evolving treatment landscape of renal cell carcinoma. (emory.edu)
  • Multiple cell death pathways are independently activated by lethal hypertonicity in renal epithelial cells. (semanticscholar.org)
  • donor T cells
  • The absence of both iTreg populations was associated with significantly greater expansion of activated donor T cells and increased numbers of CD4 + and CD8 + T cells that secreted IFN-γ and IL-17. (jimmunol.org)
  • toxicity
  • Comparison of the toxicity profile of PD-1 versus PD-L1 inhibitors in non-small cell lung cancer: A systematic analysis of the literature. (emory.edu)
  • Tregs
  • Commensal bacteria also produce metabolites such as butyrate, which promote the health of Tregs, as well as enterocytes and ILC2s, which maintain antiinflammatory myeloid-derived suppressor cells (MDSCs) and enhance GI barrier function. (jci.org)
  • Regulatory T cells (Tregs), in particular CD4 + Foxp3 + T cells, have been shown to play an important role in the maintenance of tolerance after allogeneic stem cell transplantation. (jimmunol.org)
  • These cells expressed many of the same cell surface molecules as found on CD4 + Tregs and potently suppressed in vitro alloreactive T cell responses. (jimmunol.org)
  • Induction of these cells correlated positively with the degree of MHC disparity between donor and recipient and was significantly greater than that observed for CD4 + -induced Tregs (iTregs) in nearly all tissue sites. (jimmunol.org)
  • This population is comprised of two major subsets that have been termed natural Tregs (nTregs) and induced Tregs (iTregs), based on the unique ontological and developmental characteristics that are specific for each cell population ( 12 ). (jimmunol.org)
  • Studies in other inflammatory disease models, however, have provided strong evidence that these two populations have nonredundant, complementary roles in maintaining immunological tolerance ( 15 , 16 ), indicating that Tregs are not a monolithic population, but constitute a heterogeneous population of cells with differing specificities and functions. (jimmunol.org)
  • CD4 + CD25 + Foxp3 + regulatory T cells (Tregs) are a functionally distinct subset of mature T cells with broad suppressive activity [ 1 , 2 ] and play a critical role in the maintenance of peripheral tolerance. (springer.com)
  • organs
  • GVHD is a condition that results from a reaction of transplanted donor T-lymphocytes (a kind of white blood cell) against the recipient's body and organs. (centerwatch.com)
  • immune response
  • In recent years, researchers at the Dana-Farber Cancer Institute have discovered that GVAX, a vaccine made from the patient's own cancer cells engineered to produce a protein called GM-CSF, can be effective in stimulating a powerful immune response specific to that cancer. (clinicaltrials.gov)
  • Sometimes the transplanted cells can make an immune response against the body's normal tissues. (bioportfolio.com)
  • In contrast, IL-18 prevents chronic GVHD by decreasing numbers of CD4+ (Th2) cells and host-reactive B-cell activation and reducing alloantigen-specific immune response. (springer.com)
  • Thymic
  • Conditioning regimens and acute GVHD may disrupt thymic function and dysregulate the negative selection process of potentially autoreactive T-lymphocytes. (springer.com)