Loading...
  • Chronic
  • Chronic rejection occurred in 9 percent of the bone marrow patients and in 42 percent of those who did not receive bone marrow. (bio-medicine.org)
  • However, the higher T cell content of PBSC may also lead to increased incidence and severity of acute and chronic graft-versus-host disease (GVHD). (knowcancer.com)
  • Secondary analyses will consider neutrophil and platelet recovery, acute and chronic GVHD, time off all immunosuppressive therapy, relapse, infections, adverse events and immune reconstitution. (knowcancer.com)
  • Tr1 cells possess huge clinical potential in means to prevent, block and even cure several T cells mediated diseases, including GvHD, allograft rejection, autoimmunity and chronic inflammatory diseases. (wikipedia.org)
  • Additionally, chronic GVHD can affect the joints and lungs, among other organs. (emory.edu)
  • Causes of death were related to relapse of the underlying cancer, development of a second cancer, chronic GVHD, or transfusion-acquired viral infection. (medscape.com)
  • [ 2 , 8 ] Survivors of bone marrow transplantation were more likely to have a severe or life threatening condition (relative risk [RR] = 3.9), more than one chronic condition (RR = 2.6), functional impairment (RR=3.5), and activity limitations (RR = 5.8) than conventionally treated patients. (medscape.com)
  • In fact, early attempts to decrease treatment related mortality in chronic myelogenous leukemia (CML) patients undergoing allogeneic BMT by T-cell depletion of the graft resulted in an unacceptably high rate of relapse suggesting that alloreactivity in the donor graft accounted for a significant portion of the cure rate in this disease. (knowcancer.com)
  • The end points of this study are engraftment, degree of donor-host chimerism, incidence of acute and chronic GVHD, transplant related morbidity and mortality, disease free survival, as well as overall survival, and overall level and persistence of progeny of gene modified cells. (knowcancer.com)
  • citation needed] Mucosal damage to the vagina can result in severe pain and scarring, and appears in both acute and chronic GvHD. (wikipedia.org)
  • 2010 Application of HLA-A*0201/WT1 pentamer combined with intracellular IFNgamma+ staining in detecting circulating WT1 specific T cells in leukemia 2010 "Comparison of Wilms' tumor antigen 1-specific T lymphocyte generation soon after nonmyeloablative allergenic stem-cell transplantation in acute and chronic leukemia patients", published in Int J Hematol. (wikipedia.org)
  • patient's
  • The personalized cells are derived from the patient's own bone marrow rather than using another person's, making the product more likely to be effective. (emory.edu)
  • lymphocytes
  • Studies using antithymocyte globulin (ATG), and more recently the use of monoclonal antibodies to deplete T lymphocytes, revealed that contaminating mature T cells from the donor recognize the recipient's histocompatibility antigens. (hindawi.com)
  • Donor lymphocytes are usually identified as foreign and destroyed by the recipient's immune system. (wikipedia.org)
  • TA-GvHD can be suspected from a biopsy of the affected skin, and established by HLA analysis of the circulating lymphocytes. (wikipedia.org)
  • Dendritic cells (DCs), which are the primary antigen-presenting cells (APCs), of the donor tissue migrate to the recipient's peripheral lymphoid tissue (lymphoid follicles and lymph nodes), and present the donor's self peptides to the recipient's lymphocytes (immune cells residing in lymphoid tissues). (wikipedia.org)
  • vivo
  • This study aimed to determine the ability of ex vivo generated 1,25D 3 -DCs to trigger the expansion of Tregs that are able to control lethal xenogeneic GVHD in humanized NOD/LtSz-Prkdc scid IL2rγ tm1Wjl (NSG) mice. (nih.gov)
  • lymphocyte
  • Current approaches to prevent GVHD rely on donor lymphocyte/T cell depletion or general immunosuppression, leading to opportunistic infections and cancer relapse. (nih.gov)
  • This complex specifically elicits donor-cytotoxic T lymphocyte (CTL) reactivity in B-cell acute lymphoblastic leukemia (B-ALL) after treatment by HLA-identical allogenic bone marrow transplantation (BMT). (uniprot.org)
  • donor's
  • Most donors in the registry are partially matched at HLA A and B. The HapLogic algorithm in the NMDP utilizes extended HLA typing for haplotype analysis to predict the donor's DRB1 type and narrow the list of potential unrelated donors. (psychiatryadvisor.com)