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Vitro and in vivoMurineRodentsTracheaBronchodilatorSpeciesMiceInfectionTissueRatsInhalationHistopathologicalCochleaEnzymeConcentrationsRelaxantEfficacyStudyDoseMeasurementsPotentLiverRespiratoryContinuouslyObservationsModelsAnimalsEffectsHumanReceptorCageModelControlResponseDietResultsMouseSmooth muscleCultureHealthPhaseVitalDevelopArticle

Vitro and in vivo3

• In vitro and in vivo studies. (aspetjournals.org)
• 1961). Effects on enzymes Vamidothion inhibits cholinesterase in vitro and in vivo . (inchem.org)
• Part I: In vitro and in vivo bronchodilator studies. (aspetjournals.org)

Murine3

• The aim of the study was to identify the receptor involved in prostaglandin E 2 (PGE 2 )-induced relaxation in guinea pig, murine, monkey, rat and human airways in vitro . (bmj.com)
• Methods Using an extensive range of pharmacological tools, the relaxant potential of PGE 2 and selective agonists for the EP 1-4 receptors in the presence and absence of selective antagonists in guinea pig, murine, monkey, rat and human isolated airways was investigated. (bmj.com)
• Results In agreement with previous studies, it was found that the EP 2 receptor mediates PGE 2 -induced relaxation of guinea pig, murine and monkey trachea and that the EP 4 receptor mediates PGE 2 -induced relaxation of the rat trachea. (bmj.com)

Rodents1

• VIVO Pets » Rodents » Guinea Pigs » What do Guinea Pigs Eat? (vivopets.com)

Trachea5

• We evaluated the effect of Brazilian propolis (P1) in guinea pig isolated trachea in vitro contracted with hista-mine, in paw oedema induced by histamine in mice and anti-ulcerogenic effect of propolis formulation in mice. (scirp.org)
• In the guinea pig trachea Brazilian propolis extract (10 μg/mL) produced a non-significant inhibition in the cumulative response curve for histamine. (scirp.org)
• Brazilian propolis has recently been tested in the guinea pig isolated trachea, in vitro, and shows a potent relaxant effect. (scirp.org)
• The objectives of the present study were to evaluate the effect of standardized Brazilian propolis extract (P1) on response to histamine cumulative-concentration contraction on guinea pig isolated trachea in vitro, on the oedema induced by histamine in mice, and to evaluate the effect of P1 on ulceration in mice's stomach treated with sodium diclofenac. (scirp.org)
• Depending on the contractile stimulus, Ro 25-1553 is 24 to 89 times more potent than VIP as a relaxant of guinea pig trachea. (aspetjournals.org)

Bronchodilator1

• Aims: To evaluate the in vivo bronchodilator activity of the ethanolic extract of the stems of J. macrantha. (edu.pe)

Species2

• The results showed that two phase-I cultures from pigs colonised the nasal cavity and respiratory tract of gnotobiotic piglets better than did four phase-I cultures from other species. (microbiologyresearch.org)
• This chapter compares the arterial spinal cord blood supply of the frequently used species (pig, dog, cat, rabbit and rat) in experimental spinal cord injury and in human. (intechopen.com)

Mice11

• Do Guinea Pigs Attract Mice and Rats? (vivopets.com)
• To novice pet owners, it comes as a surprise that guinea pigs do not directly attract rats and mice. (vivopets.com)
• Are Mice and Rats Dangerous to Guinea Pigs? (vivopets.com)
• Are Mice Scared of Guinea Pigs? (vivopets.com)
• Guinea pigs are slightly bigger than the mice. (vivopets.com)
• Naturally, the smell of leftovers or guinea pigs dropping lures mice in the backyard or home. (vivopets.com)
• Currently, limited information dictates mice activity around guinea pigs. (vivopets.com)
• Despite all, there is a common misconception that pigs keep mice away. (vivopets.com)
• Although they come from the same genus, it is still not very clear whether pigs certainly frighten mice. (vivopets.com)
• This has been done on mice, guinea pigs, and rats using a variety of growth-promoting molecules. (hearingreview.com)
• It describes the successful isolation and identification of the aetiological agents, their physicochemical and antigenic characteristics and describes in vivo studies using mice, guinea pigs and Rhesus monkeys. (bl.uk)

Infection4

• In rare cases, some guinea pigs and other little animals contact the infection but fail to display warning signals. (vivopets.com)
• Overall, this study provides evidence that NB-DNJ and MON-DNJ do not protect guinea pigs from a lethal EBOV-infection at the dose levels and regimens tested. (ox.ac.uk)
• Utilizing clinically related in vivo mouse fashions of sepsis and a novel septic arthritis mannequin, we discovered that the quantity and exercise of SLO was important in figuring out the course of an infection. (holliseden.com)
• The virulence of Bordetella bronchiseptica in gnotobiotic piglets was studied by intranasal infection with 11 cultures derived from eight strains isolated from pigs (4), dogs (2), a human subject and a monkey. (microbiologyresearch.org)

Tissue3

• Relating in vitro to in vivo exposures with physiologically based tissue dosimetry and tissue response models. (cdc.gov)
• In an ex-vivo setup, the team tested the permeability of the released drug through dissected tympanic membrane tissue in guinea pig models with the use of their device. (pitt.edu)
• Relaxant activity of AH13205 (EP 2 agonist) was also demonstrated in guinea pig but not human airway tissue, which may explain its failure in clinical studies. (bmj.com)

Rats2

• There are few cases where rats physically attack or kill pups and elderly guinea pigs. (vivopets.com)
• Compared to pigs, rats are extremely territorial and aggressive. (vivopets.com)

Inhalation3

• The current study examined in vivo effects on guinea pig cholinesterases resulting from inhalation of HDI. (cdc.gov)
• In conclusion, although in vitro experiments had demonstrated potent anticholinesterase activity by HDI, in vivo inhalation exposure of guinea pigs to HDI at concentrations 25-200 times above the recommended (ACGIH) ceiling value did not produce measurable inhibition of cholinesterase activity. (cdc.gov)
• TMA-related respiratory hyperresponsiveness can be elicited readily in guinea pigs upon inhalation challenge with the free chemical. (cdc.gov)

Histopathological1

• The results showed that co-treatment of vitE and vitC protected guinea pigs from DM-induced biochemical and histopathological changes. (scialert.net)

Cochlea1

• In fact, a team of researchers has recently used new findings from research on development of the inner ear to induce a few new cells in the guinea pig cochlea to become hair cells again proving that hair cell regeneration will be possible. (hearingreview.com)

Enzyme1

• Four hours after guinea-pigs had received 40 mg vamidothion/kg orally, 81% inhibition of plasma and 20% inhibition of cellular enzyme occurred. (inchem.org)

Concentrations1

• Using wild type guinea pig and rat, we demonstrate a PK/PD relationship between free drug concentrations in the brain and CSF Aβ lowering. (rcsb.org)

Relaxant1

• The potent smooth muscle relaxant activity exhibited in vitro by Ro 25-1553 is also evident after in vivo intratracheal administration or aerosolization of the compound. (aspetjournals.org)

Efficacy3

• Minimal In Vivo Efficacy of Iminosugars in a Lethal Ebola Virus Guinea Pig Model. (ox.ac.uk)
• We tested the iminosugars N-butyl-deoxynojirimycin (NB-DNJ) and N-(9-methoxynonyl)-1deoxynojirimycin (MON-DNJ) for safety in uninfected animals, and for antiviral efficacy in animals infected with a lethal dose of guinea pig adapted EBOV. (ox.ac.uk)
• The guinea pig model was also used to perform pilot in-vivo efficacy as well as safety testing. (pitt.edu)

Study6

• We created an in vivo air sampling model to study airborne transmission of tuberculosis from patients coinfected with human immunodeficiency virus (HIV) and to evaluate environmental control measures. (nih.gov)
• Therefore, the present study investigated the ameliorative properties of vitamin C (vitC) and E (vitE) on DM toxicity of guinea pigs. (scialert.net)
• Data from an in vivo sensitsation study in guinea pigs are available. (europa.eu)
• Due to the limitation with metals (e.g. false negative findings in the LLNA with certain metals) as per OECD 429 §5, the recommended in vivo test (LLNA study) is also not applicable for this test item. (europa.eu)
• Therefore, the guinea pig study (using the Magnusson and Kligman method) was selected to provide information about the skin sensitization potential of the test item. (europa.eu)
• The Rhesus monkey and guinea pig proved suitable experimental models in which to study and compare the pathogenic responses and also to evaluate various aspects of protection. (bl.uk)

Dose1

• Lamotrigine 2-N-glucuronide accounted for 60% of an i.v. bolus dose of lamotrigine in guinea pig urine. (aspetjournals.org)

Measurements2

• An optical coherence tomography (OCT) system was built to acquire in vivo, both images and vibration measurements of the organ of Corti of the guinea pig. (elsevierpure.com)
• Subsequently, hearts were cannulated via Langendorff perfusion for ex vivo optical mapping measurements of action potential duration (APD90) and arrhythmia inducibility. (bvsalud.org)

Potent1

• It remains puz- zling that the physiological effects (change in breathing patterns upon challenge with the hapten) of the potent respiratory-tract sensitizer TMA could be satisfactorily modeled in the guinea pig, while those of the free or conjugated MDI could not, in spite of the presence of MDI-induced allergic bronchial inflammation and anti-MDI antibodies, important fea- tures in occupational asthma. (cdc.gov)

Liver1

• The glucuronide was also formed in Triton-X-100-activated liver microsomes and isolated guinea pig hepatocytes. (aspetjournals.org)

Respiratory1

• In several laboratories, these chem- icals have been evaluated in the guinea pig respiratory hypersensitivity model using either the free chemicals or their homologous protein conju- gates for elicitation of respiratory response. (cdc.gov)

Continuously1

• A mean of 92 guinea pigs were continuously exposed to all ward exhaust air for 16 months. (nih.gov)

Observations1

• Clinical, bacteriological and epidemiological observations on infectious atrophic rhinitis of pigs in Southern England. (microbiologyresearch.org)

Models4

• We observed hydrocortisone and benzoic acid absorption in relation to experimentally induced in vivo damaged skin models in the hairless guinea pig. (karger.com)
• however, their effects have not been tested in larger animal models such as guinea pigs. (ox.ac.uk)
• In Vitro or In Vivo Models, the Next Frontier for Unraveling Interactions between Malassezia spp. (uu.nl)
• The guinea pig displays an extreme sensitivity in systemic as well as passive cutaneous anaphylaxis models (Verdier et al. (cdc.gov)

Animals5

• In reality, guinea pigs are relatively hygienic animals and do not produce a foul smell. (vivopets.com)
• Altogether, pigs are non-aggressive and passive animals. (vivopets.com)
• To facilitate scoring, all animals were shaved immediately prior to scoring during the induction phase, while all of the guinea pigs were depilated with hair remover approximately 2 hours prior to the 24-hour scoring during the challenge phase. (europa.eu)
• Chymotrypsinogen synthesis in the exocrine cell of the guinea pig pancreas was studied under the following conditions: Animals fed after a fast of ∼48 hours received ∼1 hour after feeding an intravenous injection of DL -leucine-1-C 14 . (rupress.org)
• With imposed blurring of the animals vision early in life, guinea pigs experience excessive eye elongation and develop high myopia within a week, which leads to pathologic myopia within 6 weeks. (acoustics.org)

Effects4

• MON-DNJ showed no protective effects when EBOV-infected guinea pigs were treated. (ox.ac.uk)
• In order to investigate acute effects of loud noise exposure on cochlear microcirculation and hearing function, we have established a new standardized animal model by using in vivo-fluorescence microscopy and auditory brainstem response. (uni-muenchen.de)
• Effects of inhaled hexamethylene diisocyanate (HDI) on guinea pig cholinesterases. (cdc.gov)
• Sex differences and the effects of intrauterine hypoxia on growth and in vivo heart function of fetal guinea pigs. (umaryland.edu)

Human1

• For instance, rat bite fever is a popular bacterial sickness that affects both guinea pigs and human beings. (vivopets.com)

Receptor1

• METHODS: Guinea pigs were injected intraperitoneally with IL-6/soluble IL-6 receptor and QT changes were measured in vivo. (bvsalud.org)

Cage1

• Even when a tiny mouse finds its way inside the cage, rarely would a guinea pig retaliate. (vivopets.com)

Model1

• The guinea pig is a well-established animal model of myopia. (acoustics.org)

Control1

• The first approach termed quantitative-ultrasound (QUS) was applied to intact ex-vivo eyeballs of myopic and control guinea-pig eyes using an 80-MHz ultrasound transducer (Figure 1). (acoustics.org)

Response2

• However, the in vivo chronic inflammatory response of these conductive hydrogels remains unknown. (frontiersin.org)
• The present experiments examined the contractile response to a series of benzamides in the guinea-pig non-stimulated ileum. (nih.gov)

Diet1

• Guinea pigs require a herbivorous diet, which means that their food should include fruits, hay, vegetables, and pellets. (vivopets.com)

Results1

• RESULTS: IL-6 prolonged QTc in vivo guinea pigs from 306.74 ± 7.19 ms to 332.60 ± 8.75 ms (n = 8, p = .0021). (bvsalud.org)

Mouse2

• Can Guinea Pig Kill and Eat a Mouse? (vivopets.com)
• Even if a devious little mouse comes into contact with a guinea pig, mostly probably, it would not lead to a struggle or death. (vivopets.com)

Smooth muscle1

• On isolated guinea pig tracheal smooth muscle, Ro 25-1553 produces concentration-dependent relaxation of contractile responses to a number of different spasmogens. (aspetjournals.org)

Culture2

• The work on mammals now is at a point where we can induce a small amount of cell division in the inner ear in a dish (that is, in a culture), as well as in vivo (occurring within a living organism). (hearingreview.com)
• Phase variation from I to III occurred in culture and in vivo , but variation from III to I occurred in vivo only and was accompanied by enhanced colonisation. (microbiologyresearch.org)

Health1

• Look out for pellets with Vitamin C since it is essential for the health of guinea pigs. (vivopets.com)

Phase1

• Phase-I organisms invariably produced capsules, fimbriae and mannose-resistant haemagglutination of guinea-pig erythrocytes. (microbiologyresearch.org)

Vital2

• The teeth of the pigs are continually growing, which is why it is vital to wear them out to limit the growth. (vivopets.com)
• Our findings show that SLO is vital to in vivo phenotype and illness final result. (holliseden.com)

Develop1

• Another thing to remember when rearing guinea pigs is that they develop dietary preferences at a tender age. (vivopets.com)

Article1

• In this article, we will clarify if indeed guinea pigs play any role in rodent's infestation. (vivopets.com)