The aim of the study was to identify the receptor involved in prostaglandin E 2 (PGE 2 )-induced relaxation in guinea pig, murine, monkey, rat and human airways in vitro . (bmj.com)
STUDY OBJECTIVES: To study the effects of extracts of brewery dust on isolated guinea pig tracheal smooth muscle in vitro. (cdc.gov)
A bioactive extract from parched and ground garden slugs has H1-antihistamine properties which inhibited contraction of guinea pig in vitro tracheal muscle preparation and cutaneous allergic responses. (uwi.edu)
Oxidative damage, apoptosis and lung injury were assessed in vitro , ex vivo in A549 cells as well as in vivo in guinea pigs. (biomedcentral.com)
Using various in vitro , ex vivo and in vivo approaches, here we show that p-BSQ largely mimics AECS in causing oxidative protein damage, proteolysis, apoptosis and lung injury in guinea pigs. (biomedcentral.com)
Severe tracheal collapse2
Stenting in the tracheobronchial tree is usually used as a last resort for severe conditions such as recurrent carcinoma and severe tracheal collapse that results in periods of prolonged apnea. (medscape.com)
Primarily for severe tracheal collapse causing respiratory distress in toy breeds of dogs. (superiorveterinarysurgery.com)
Epithelial2
Binding of serum autoantibodies to sialidase-treated tracheal epithelial cells. (hal.science)
Cultured epithelial cells isolated from guinea pig trachea were treated with Vibrio cholerae sialidase. (hal.science)
Epithelium7
In influenza-infected guinea-pigs, as assessed by reactivity with peanut agglutinin, the tracheal and lung epithelium, as well as alveolar cells were hyposialylated. (hal.science)
In epithelium-intact tracheal ring preparations isolated from LPS-untreated guinea-pigs, sivelestat (100 µmol/l) significantly inhibited substance Pinduced contractions. (archive.org)
On the other hand, in bronchial ring preparations isolated from LPS-untreated guinea-pigs, sivelestat had only a very slight effect on substance P-induced contraction of the epithelium-intact preparation, whereas sivelestat greatly inhibited contraction in epithelium-removed bronchial ring preparations. (archive.org)
In LPS-treated guinea-pigs, whether the epithelium was intact or not, sivelestat significantly inhibited the substance Pinduced contraction of bronchial ring preparations. (archive.org)
In conclusion, epithelium removal or LPS treatment induced hyperreactivity to substance P in the guinea-pig airway. (archive.org)
Sivelestat caused epithelium-, nitric oxide-and prostaglandin-dependent inhibition of the substance P-induced contraction of isolated guinea-pig tracheal ring preparations. (archive.org)
In contrast, the inhibitory effect of sivelestat on substance P-induced contraction of guinea-pig bronchial ring preparations is mediated by epithelium-, nitric oxide-and prostaglandin-independent mechanisms. (archive.org)
Stents3
Laryngeal and tracheal stents are solid or hollow absorbable or nonabsorbable tubes of various shapes, sizes, and materials. (medscape.com)
An image depicting laryngeal and tracheal stents can be seen below. (medscape.com)
I have been placing intraluminal trachea stents for nearly 10 years, and I have never had a pet suffer long-term from tracheal stent complications. (superiorveterinarysurgery.com)
Stenosis2
Post-intubation iatrogenic tracheal stenosis is well established in humans, cats and horses. (vin.com)
In a study of 30 children who underwent tracheal disease surgery, either for congenital tracheal stenosis (25 patients) or acquired lesions (5 patients), Arcieri et al found that 19 patients (63%) required endoscopic reinterventions, including 13 (43.3%) in whom stent positioning was performed. (medscape.com)
Contractions3
Dose-related contractions of nonsensitized guinea pig tracheas were demonstrated using these extracts. (cdc.gov)
Results:Our results showed that aqueous fractions of R. damascena dose-dependently increased basal guinea pigsileum contractions (pConclusion: It is concluded that aqueous fraction of R. damascena has mild excitatory effect on ileum contraction and this fraction may be beneficial as a mild laxative agent. (ac.ir)
The effects of verapamil and nifedipine on K+-induced contractions were studied in the isolated ileum of newborn, 30-day-old and adult guinea pigs. (karger.com)
Airway4
Relaxant activity of AH13205 (EP 2 agonist) was also demonstrated in guinea pig but not human airway tissue, which may explain its failure in clinical studies. (bmj.com)
No study has investigated the relationship between cough reflex sensitivity and NO. In this study, we hypothesized that NO produced by iNOS might be a promoter in cough reflex sensitivity, and therefore performed the iNOS inhibition experiment using NOS inhibitors, in non-sensitized guinea pigs with normal cough reflex sensitivity and in OVA-sensitized guinea pigs which were of increased cough reflex sensitivity associated with allergic eosinophilic airway inflammation. (biomedcentral.com)
Neurokinin-containing nerve fibers were localized to guinea pig airway parasympathetic ganglia in control tissues but not in tissues pretreated with capsaicin. (johnshopkins.edu)
It is possible that upper respiratory disease happens frequently because guinea pigs have a mandible that is flared caudally and so allows for a broader access to the upper airway structures. (a1meds.live)
Trachea1
Results In agreement with previous studies, it was found that the EP 2 receptor mediates PGE 2 -induced relaxation of guinea pig, murine and monkey trachea and that the EP 4 receptor mediates PGE 2 -induced relaxation of the rat trachea. (bmj.com)
Lung6
Binding of radiolabeled high affinity antagonist to leukotriene D4 receptor in guinea pig lung membranes: interconversion of agonist-receptor binding affinity states. (aspetjournals.org)
The kinetic parameters and the pharmacological specificity of a high affinity leukotriene D4 (LTD4) receptor antagonist, ICI-198615, binding to guinea pig lung membranes were characterized. (aspetjournals.org)
Monovalent cations (Na+, Li+, and Cs+), divalent cations (Mg2+, Ca2+, and Mn2+), and guanine nucleotides did not significantly affect the specific binding of [3H]ICI-198615 to guinea pig lung LTD4 receptors. (aspetjournals.org)
The specific binding of [3H]ICI-198615 to guinea pig lung membranes was saturable and the equilibrium saturation binding was best approximated by a single-site model. (aspetjournals.org)
Exposure of guinea pigs to cigarette smoke resulted in progressive protein damage, inflammation, apoptosis and lung injury up to 21 days of the experimental period. (biomedcentral.com)
MATERIAL: The isolated guinea pig tracheal tissue of 18 guinea pigs. (cdc.gov)
Lateral thoracic radiographs demonstrated narrowing of the tracheal lumen with soft tissue opacity approximately 2-3 cm caudal to the hyoid apparatus. (vin.com)
Cholinergic2
Cholinergic, somatostatin-immunoreactive interneurons in the guinea pig intestine: morphology, ultrastructure, connections and projections. (ac.ir)
In situ, senktide analog markedly increased baseline tracheal cholinergic tone, an effect that was reversed by atropine and prevented by vagotomy or SB-223412. (johnshopkins.edu)
Ileum2
In this study, the effect of aqueous fraction of R. damascena on the contractionsofisolated guinea pig ileum was investigated. (ac.ir)
To evaluate effect of this fraction on ileum contraction, guinea pig ileum was removed and mounted on organ bath and its contraction was recorded. (ac.ir)
Smooth10
MEASUREMENTS AND RESULTS: The effect of brewery dust extracts on isolated guinea pig tracheal smooth muscle was studied using water-soluble extracts of dust obtained from brewery materials, including hops, barley, and brewery yeast. (cdc.gov)
Several LTD4 receptor antagonists (ICI-198615, WY-48252, WY-49511, FPL-55712, and LY-171883) displaced [3H]ICI-198615 specific binding, with a rank order of potency equivalent to that described in the guinea pig tracheal smooth muscle contraction system. (aspetjournals.org)
The Differences in the Relaxant Effects of Different Fractions of Rosa damascena on Guinea Pig Tracheal Smooth Muscle. (ac.ir)
Homologous β2-adrenoceptor desensitisation models were established in guinea-pigs and in human bronchial smooth muscle cells (BSMC) by chronic salbutamol administration. (unipi.it)
Characterisation tools included measurement of the response of tracheal smooth muscle tissues to salbutamol, analysis of gene expression and receptor trafficking, evaluation of intracellular cAMP levels and phosphodiesterase (PDE) activity in human bronchial smooth muscle cells. (unipi.it)
0.001) in desensitised tracheal smooth muscle, as compared to controls. (unipi.it)
larvae typically have a smooth external aspect, with dorsal tracheal trunks and are pigmented. (uab.edu)
Respiratory5
The tracheal cannula is used in a tracheotomy for general ventilation or respiratory mechanics studies. (harvardapparatus.com)
Primarily a respiratory disease in growing pigs: Clinical signs include coughing and fever. (a1meds.live)
Two types of bacteria Bordetella bronchiseptica and Streptococcus pneumoniae are the primary causes of respiratory infections in guinea pigs. (a1meds.live)
Loss of [8] Your vet will use diagnostic test results to select which antibiotic will effectively treat your guinea pigs respiratory problem. (a1meds.live)
Upper Respiratory Infections (URIs) are one of the most common illnesses in guinea pigs. (a1meds.live)
Chains3
11. Boskabady MH, Kiani S, Rakhshandeh H. Relaxant effects of Rosa damascena on guinea pig tracheal chains. (ac.ir)
13. Boskabady MH, Ramazani M, Tabei T. Relaxant effects of different fractions of essential oil from carum copticum on guinea pig tracheal chains. (ac.ir)
Possible mechanism (s) for relaxant effect of aqueous and macerated extracts from Nigella sativa on tracheal chains of guinea pig. (ac.ir)
Inhibition2
however, iNOS inhibition caused by ONO1714 partially suppressed the OVA-induced increase in cough reflex sensitivity, but not the normal cough response in non-sensitized guinea pigs. (biomedcentral.com)
Blockade of eosinophil migration by 5-lipoxygenase and cyclooxygenase inhibition in explanted guinea pig trachealis. (uchicago.edu)
BALF1
The bronchoalveolar lavage fluid (BALF) was analyzed in an NO depletion setting using the inducible NOS (iNOS) inhibitor ONO1714 in OVA-sensitized guinea pigs. (biomedcentral.com)
Aqueous1
17. Boskabady MH, Shafei MN, Parsaee H. Effects of aqueous and macerated extracts from Nigella sativa on guinea pig isolated heart. (ac.ir)
Receptors1
Methods Using an extensive range of pharmacological tools, the relaxant potential of PGE 2 and selective agonists for the EP 1-4 receptors in the presence and absence of selective antagonists in guinea pig, murine, monkey, rat and human isolated airways was investigated. (bmj.com)
Rosa2
In conclusion this study showed a relatively potent inotropic and chornotropic effect for Rosa damascena on isolated guinea-pig heart. (ac.ir)
Pressure or contact tracheal necrosis were presumed. (vin.com)
Extracts1
INTERVENTIONS: Pretreatment of guinea pig rings by mediator-modifying agents before challenge with the brewery dust extracts. (cdc.gov)
Evaluate1
Please schedule an appointment with our board-certified surgeon, Dr. Jeff Christiansen at the clinic of your choice , to evaluate your pet and to discuss tracheal stenting to improve your pet's or patient's length and quality of life. (superiorveterinarysurgery.com)
Normal1
After incubation in serum from normal guinea pigs, membrane-bound immunoglobulins were detected using peroxidase-labelled antibodies. (hal.science)
Dogs1
He is a farmer and has regular contact with cattle, goats, guinea pigs and dogs. (uab.edu)
Mouse1
It was found that AELL inhibited the high K + or acetylcholine chloride (ACh)-induced precontraction of mouse tracheal rings by 64.8 ± 2.9%, or 48.8 ± 4.7%, respectively. (biomedcentral.com)
Rings1
DESIGN: Parallel pharmacologic intervention on guinea pig tracheal rings that were obtained from the same animal. (cdc.gov)
Male2
Male albino Hartley-strain guinea pigs (body weight, 450-500 g and 150-200 g), obtained from Sankyo Laboratory Service (Toyama, Japan), were used in the non-sensitized model experiment and in actively ovalbumin (OVA)-sensitized and -challenged model experiments, respectively. (biomedcentral.com)
This report describes a case of tracheal necrosis and reduction of the intraluminal tracheal diameter caused by an inflammatory process and accompanied by accumulation of necrotic material and fibrinous exudate in a 10-year-old, male, neutered, Labrador Retriever. (vin.com)
Tone1
EP1 receptor blockade attenuates both spontaneous tone and PGE2-elicited contraction in guinea pig trachealis. (uchicago.edu)