• Effects of yew alkaloids and related compounds on guinea-pig isolated perfused heart and papillary muscle. (unito.it)
  • Minimum lethal dose, oral LDmin for many different animals were tested: Chicken 82.5 mg/kg Cow 10.0 mg/kg Dog 11.5 mg/kg Goat 60.0 mg/kg Horse 1.0-2.0 mg/kg Pig 3.5 mg/kg Sheep 12.5 mg/kg Several studies have found taxine LD50 values under 20 mg/kg in mice and rats. (wikipedia.org)
  • Immunohistochemical analysis of paraffin-embedded human serous papillary carcinoma of the ovary using α-Actinin 4 (D7U5A) Rabbit mAb (left) compared to concentration matched Rabbit (DA1E) mAb IgG XP ® Isotype Control #3900 (right). (cellsignal.com)
  • On December 16, 2022, the Food and Drug Administration approved nadofaragene firadenovec-vncg (Adstiladrin, Ferring Pharmaceuticals) for adult patients with high-risk Bacillus Calmette-Guérin (BCG) unresponsive non-muscle invasive bladder cancer (NMIBC) with carcinoma in situ (CIS) with or without papillary tumors. (privacytools.io)
  • Weak acid and neutral fractions separated from the extracts of male and female human urine showed an inhibitory action against contraction of smooth muscle preparations. (go.jp)
  • Their inhibitory action was tested on contraction of isolated guinea-pig ileum induced by histamine and isolated rat uterus by oxytocin. (go.jp)
  • Stimulation of either 5 HT receptor purchase Bicalutamide elicited a contraction that was mediated by acetylcholine and to a lesser extent by a tachykinin acting on smooth muscle tachykinin NK, receptors. (others-signal.com)
  • Immunohistochemical analysis of paraffin-embedded human skin (left) or skeletal muscle (right) using using α-Actinin 4 (D7U5A) Rabbit mAb. (cellsignal.com)
  • Smith IJ, Aversa Z, Hasselgren PO, Pacelp F, Rosa F, Dogpetto GB, Bossola M. Calpain activity is increased in skeletal muscle from gastric patients with no or only minimal weight loss . (per-olofhasselgren.com)
  • Currently, steroid therapy and assisted ventilation help combat skeletal muscle-related respiratory dysfunction and significantly prolong the lives of DMD patients. (jci.org)
  • Transmission electron micrograph of section of cardiac muscle from guinea pig right atrium. (ucsd.edu)
  • The mechanical and electrical effects of selected yew alkaloids were studied on two different cardiac preparations: the isolated coronary perfused heart and the isolated papillary muscle of the guinea-pig. (unito.it)
  • Propulsid (cisapride) is a "prokinetic" agent that increases muscle contractions of the lower esophagus and the lower esophagus sphincter used to treat gastric reflux (the regurgitation of stomach acid into the esophagus), which is usually experienced as heartburn . (rxlist.com)
  • For example, through needle aspiration of gastric secretions at the onset of the pectinate muscles relative to the fetal liver, two apposed venous systems develop: Afferent and efferent. (lowerbricktown.com)
  • Model prediction was verified in experiments on papillary muscles from the right ventricle of guinea pigs overloaded with calcium [2]. (icgbio.ru)
  • Effects of sarcoplasmic reticulum calcium pump inhibitors on vascular smooth muscle. (mcmaster.ca)
  • We utilized the cellular model to study effects of the electromechanical coupling between cardiomyocytes in a 1D heterogeneous muscle strand formed of 90% of normal (N) cardiomyocytes and 10% of sub-critical (SC) cardiomyocytes with decreased Na + -K + pump activity. (icgbio.ru)
  • Figure 427 from Chapter 16 (Cytoplasmic matrix and cytoskeleton) of 'The Cell, 2nd Ed.' by Don W. Fawcett M.D. Papillary muscle of cat heart shows the cross-banded organization of striated muscle. (ucsd.edu)
  • Transmission electron micrograph of a section of the right atrium of a guinea pig heart. (ucsd.edu)
  • Cardiovascular disease (CVD) is a world-leading health problem and encompasses a broad spectrum of disorders, including diseases of the blood vessels, the heart muscle, the electrical conduction system, and congenital heart disease. (springer.com)
  • Does naloxone induce relaxation of guinea-pig airway smooth muscle? (mcmaster.ca)
  • Dual effect of cobra cardiotoxin on vascular smooth muscle and endothelium. (mcmaster.ca)
  • Resveratrol prevents dexamethasone-induced expression of the muscle atrophy-related ubiquitin pgases atrogin-1 and MuRF1 in cultured myotubes through a SIRT1-dependent mechanism. (per-olofhasselgren.com)
  • No alterations in electrical and contractile activities were in fact recorded after perfusion of the isolated papillary muscle with 4. (unito.it)
  • Two large studies in monkeys, lambs, and guinea pigs have characterized the relationship between prenatal development of trust. (lowerbricktown.com)
  • Multiple muscle wasting-related transcription factors are acetylated in dexamethasone-treated muscle cells. (per-olofhasselgren.com)
  • Superfused canine papillary muscles were mapped to locate a Purkinje-ventricular muscle junction (PVJ), and bipolar electrodes were placed to measure Purkinje and endocardial conduction velocity and PVJ conduction time during stimulation of the Purkinje layer. (silverchair.com)
  • OBJECTIVES: To characterize the steady state frequency-dependent properties and restitution kinetics of action potential duration (APD) in isolated human atrial and ventricular cardiac muscle preparations. (unideb.hu)
  • MATERIALS AND METHODS: Conventional microelectrode techniques were used to record action potentials in preparations of human left ventricular muscle and right atrial appendages under steady state conditions or after abrupt changes in cycle length, ie, following increasingly longer diastolic intervals (DI). (unideb.hu)
  • In atrial preparations, restitution kinetics were characterized by three exponentials with time constants of 154 ms, 1.52 s and 25.5 s (BCL of 750 ms). The very fast component of restitution, observed in ventricular muscle, was apparently missing in atrial fibres. (unideb.hu)
  • however, the amplitudes of the second and third atrial components decreased significantly compared with preparations paced at a BCL of 750 ms. CONCLUSIONS: Comparing the time constant values estimated for restitution with the reported kinetic parameters of cardiac ion channels, it may be speculated that the first component of restitution in ventricular muscle is attributed to the recovery of L-type calcium current from inactivation. (unideb.hu)
  • We tested and confirmed these in silico predictions with in vitro experiments on isolated guinea-pig ventricular cells and papillary muscles stimulated at various rates (2-6.67 Hz) and exposed to various concentrations (5 × 10(-6) to 500 × 10(-6) mol/l) of lidocaine. (ox.ac.uk)
  • Effect of intracellular and extracellular pH on contraction in isolated, mammalian cardiac muscle. (ox.ac.uk)
  • The lack of this very rapid component in atrial muscle can be explained by the parallel recovery of the calcium current and the transient outward potassium current, prominent in atrial myocardium. (unideb.hu)
  • Demonstration in Tupaia papillary muscle preparations of alpha-adrenoceptors mediating positive inotropic effects: comparison with guinea-pigs. (nih.gov)
  • Flexible tissue bath system suitable for many standard pharmacological experiments to measure smooth and skeletal muscle contractions, from small isolated vascular rings to larger tissue vessels and other muscle preparations. (harvardapparatus.com)
  • Larger tissue baths of 5, 10 or 20 ml are available for larger vessels and other muscle preparations. (harvardapparatus.com)
  • The flexible Graz Tissue Bath System can be used for many standard pharmacological experiments to measure smooth and skeletal muscle contractions. (harvardapparatus.com)
  • These baths can also be used for experiments on papillary muscle or isolated atria (e.g. guinea-pig), with provision for electrical stimulation. (harvardapparatus.com)
  • Minimum lethal dose, oral LDmin for many different animals were tested: Chicken 82.5 mg/kg Cow 10.0 mg/kg Dog 11.5 mg/kg Goat 60.0 mg/kg Horse 1.0-2.0 mg/kg Pig 3.5 mg/kg Sheep 12.5 mg/kg Several studies have found taxine LD50 values under 20 mg/kg in mice and rats. (wikipedia.org)
  • 1. Intracellular pH (pHi) and Na+ activity were recorded (ion-selective microelectrodes) in guinea-pig papillary muscle and the sheep cardiac Purkinje fibre while simultaneously recording twitch tension. (ox.ac.uk)
  • The most salient result was that whereas large doses (5 × 10(-4) mol/l or higher) of lidocaine were required to inhibit action potentials temporarily in single cells, much lower doses (5 × 10(-6) mol/l), i.e., therapeutic levels, were sufficient to have the same effect in papillary muscles: a hundredfold difference. (ox.ac.uk)
  • tension of 20 mN was applied to each muscle strip. (pdfdrugs.com)
  • In guinea pigs mesenteric arteries, CP-060S exhib- isometric tension was recorded through a force-displace- ited the profile of the L-type Ca2q channel antagonists, similar to that of diltiazem and gallopamil, whereas higher concentrations of CP-060S inhibited the delayed Kq chan-nel currents ŽOhya et al. (pdfdrugs.com)
  • Removal of NH4Cl or addition of sodium acetate (pHo 7.4) reduced pHi but this gave either an increase of tension (papillary muscle) or an initial fall followed by a subsequent recovery of tension (Purkinje fibre). (ox.ac.uk)
  • PMID- 5428658 TI - Accessory extraocular muscle. (nih.gov)
  • PMID- 5428672 TI - Results of the dynamic muscle sphincter operation in cleft palates. (nih.gov)
  • The epidermis, epidermal-dermal junction, and papillary dermis appear homogenized immediately after tattoo injection. (medscape.com)
  • Results: Similar to other species, lymphocyte numbers significantly decreased in pigs both in vivo and in vitro in a dose-dependent selleck kinase inhibitor manner. (pdgfrinhibitors.com)
  • 16. α-Lipoic acid protects against arsenic trioxide-induced acute QT prolongation in anesthetized guinea pigs. (nih.gov)
  • 18. Arrhythmogenic effects of arsenic trioxide in patients with acute promyelocytic leukemia and an electrophysiological study in isolated guinea pig papillary muscles. (nih.gov)
  • The most common manifestations of acute selenium toxicity are vomiting, muscle cramps, fatigue and diarrhoea. (canada.ca)
  • Beta actin is a non-muscle cytoskeletal protein in all human cell types and is involved in cell motility, structure, and integrity. (thermofisher.com)