• Guanylate cyclase (GC) catalyzes the biosynthesis of cyclic guanosine 3',5'- monophosphate (cGMP) from GTP. (nih.gov)
  • Guanylate cyclase (GC) catalyzes cGMP synthesis. (wikipedia.org)
  • This enzyme converts GTP to cGMP. (wikipedia.org)
  • cGMP in the olfactory is synthesized by both membrane guanylyl cyclase (mGC) as well as soluble guanylyl cyclase (sGC). (wikipedia.org)
  • These enzymes catalyzed the synthesis of cAMP or cGMP from ATP or GTP, respectively. (tcdb.org)
  • The guanylate cyclase converts a chemical called GTP into another chemical called cGMP. (howstuffworks.com)
  • There is a cycle -- guanylate cyclase turns GTP into cGMP, and PDE turns cGMP into GTP. (howstuffworks.com)
  • 3) cGMP also causes dephosphorylation of myosin light chain by activating other enzyme systems. (pharmacology2000.com)
  • In men with ED, the enzyme PDE5 breaks down cGMP too quickly, preventing the blood vessels in the penis from relaxing and widening. (villagecountryinn.com)
  • cGMP is typically present at levels 10 to 100 fold lower than cAMP in most tissues and is formed by the action of the enzyme guanylate cyclase on GTP. (enzolifesciences.com)
  • Free nitric oxide activates the enzyme guanylate cyclase, stimulating increased levels of cGMP, which causes relaxation of smooth muscle fibers of the cavernous bodies and increased blood flow. (pharmadm.com)
  • Nitric oxide then activates the enzyme guanylate cyclase, which results in increased levels of cGMP. (empowerpharmacy.com)
  • CGMP is required to activate this enzyme. (enzyme-database.org)
  • The enzyme also has two allosteric cGMP-binding sites (sites A and B). Binding of cGMP causes a conformational change that is associated with activation of the kinase [4]. (enzyme-database.org)
  • Richie-Jannetta, R., Francis, S.H. and Corbin, J.D. Dimerization of cGMP-dependent protein kinase Iβ is mediated by an extensive amino-terminal leucine zipper motif, and dimerization modulates enzyme function. (enzyme-database.org)
  • This enzyme enables the conversion of GTP into cGMP, which causes smooth muscle relaxation, especially in the walls of the blood vessels. (trc-p.nl)
  • Sildenafil helps to save cGMP molecules from the cGMP-specific Phosphodiesterase 5 Enzyme (PDE-5) enzyme which destroys cGMP. (hisblue.com)
  • Vardenafil works by preventing another enzyme known as phosphodiesterase-5 from destroying the cGMP. (infomedly.com)
  • Through the inhibition of this enzyme, Tadalafil aids in boosting the body's cGMP levels. (edweeksnet.com)
  • Nitric oxide turns on a special enzyme called guanylate cyclase, which makes cGMP. (edweeksnet.com)
  • However, in a portion of individuals suffering from erectile dysfunction, there exists an enzyme known as PDE5 that excessively degrades the chemical cGMP. (edweeksnet.com)
  • When the cGMP is destroyed by another enzyme, phosphodiesterase-5, the blood vessels return to their normal size, blood leaves the penis, and the erection ends. (roidsseek.com)
  • It works by inhibiting the enzyme PDE5 and allowing the compound cGMP to accumulate, leading to improved erectile function. (topdollsites.com)
  • Nitric oxide helps to activate an enzyme called guanylate cyclase, which increases cGMP levels further. (topdollsites.com)
  • Contraindicated) Coadministration of vericiguat with other soluble guanylate cyclase (sGC) stimulators, such as riociguat, is contraindicated. (pdr.net)
  • Coadministration of nonspecific PDE-5 inhibitors (eg, dipyridamole, theophylline) and guanylate cyclase stimulators (eg, riociguat) is contraindicated due to risk of additive hypotension. (medscape.com)
  • A class of cellular membrane receptors that either have an intrinsic guanylate cyclase activity or are closely coupled to specific guanylate cyclases within the cell. (bvsalud.org)
  • 35. Synthesis and guanyl cyclase activity current concepts of femininity and smooth muscle, vasodilate pulmonary at the sigmoid colon. (ben.edu)
  • SACURE pipeline annotates genes based on a logistic function that converts evidence from multiple resources into a KEGG orthology decision, which is then associated with enzymes and reactions . (umassmed.edu)
  • Metabolism: Vardenafil is metabolized predominantly by the hepatic enzyme CYP3A4, with contribution from the CYP3A5 and CYP2C isoforms. (itopmeds.com)
  • theophylline will increase the level or effect of fezolinetant by affecting hepatic enzyme CYP1A2 metabolism. (medscape.com)
  • When you take tadalafil 20mg, it works by inhibiting the enzyme phosphodiesterase type 5 (PDE5). (topdollsites.com)
  • Cenforce 50 mg is used to treat sexual dysfunction problems in men like impotence or erectile dysfunction (ED). It is one of the lower doses usually prescribed for people in the initial stages of ED. Sildenafil citrate is its active ingredient which is a commonly known Phosphodiesterase 5 Enzyme (PDE-5) inhibitor. (hisblue.com)
  • When a man is sexually stimulated, the penis releases nitric oxide (NO), which activates an enzyme called guanylate cyclase. (villagecountryinn.com)
  • Nitric oxide is released into the animal tissue of the penis during sexual stimulation, activating the enzyme guanylate cyclase. (festivaleurocine.com)
  • Or even after taking the amount of medicine prescribed to you 52, the enzyme aids in the relaxation of Vardenafil 20mg Price the muscles of the member and raises the blood flow to the penis thereby buy viagra in usa.The two secondary endpoints were investigator assessment and ratings of photographs. (imlauren.com)
  • In order to find new modulators for this important enzyme, an innovative cell-based assay has been developed and optimized for the use in high-throughput screening. (nih.gov)
  • Enzymes that are part of the current metabolic network model . (umassmed.edu)
  • Enzymes that are associated with this gene in the WormFlux database, but not included in the current network model . (umassmed.edu)