OrganismsChemicals and DrugsPhenomena and Processes
Guanosine TetraphosphateGuanine NucleotidesGuanosine PentaphosphateDinucleoside PhosphatesRNA, BacterialEscherichia coliMyxococcalesGuanosineRNA, RibosomalAdenine NucleotidesAcid Anhydride HydrolasesRNA, TransferDNA-Directed RNA PolymerasesChloramphenicolLigasesKineticsGene Expression Regulation, BacterialBacterial ProteinsGenes, BacterialGuanosine TriphosphateGuanosine 5'-O-(3-Thiotriphosphate)Transcription, GeneticMutationLysine-tRNA LigasePyrophosphatasesGuanosine MonophosphateNucleotidyltransferasesTryptophan-tRNA LigaseSuraminPurinergic P2X Receptor AntagonistsGuanosine DiphosphateReceptors, Purinergic P2Receptors, Purinergic P2XPurinergic P2Y Receptor AgonistsUracil NucleotidesRNA Cap AnalogsPurinergic P2 Receptor AgonistsAdenosine TriphosphatePolyphosphatesPhenylalanine-tRNA LigasePhosphoric Diester HydrolasesHydrolysis
PpGppPentaphosphateNucleotidesTriphosphateMonophosphateAdenosineInosineMonophosphate
PpGpp7
  • p)ppGpp, guanosine pentaphosphate and tetraphosphate, also known as the "magic spot" nucleotides, are alarmones involved in the stringent response in bacteria that cause the inhibition of RNA synthesis when there is a shortage of amino acids. (wikipedia.org)
  • however, upon binding to guanosine tetraphosphate (ppGpp), the global regulator of stringent response, ObgE exhibits an enhanced interaction with the 50S subunit, resulting in increased equilibrium dissociation of the 70S ribosome into subunits. (rcsb.org)
  • Studies have shown that the accumulation of unusual guanosine nucleotides, collectively called (p)ppGpp, is the hallmark of the stringent response of E. coli [ 15 - 18 ] (Figure 1 ). (biomedcentral.com)
  • One major mechanism for dealing with stress is the stringent stress response intermediated by the second messenger guanosine tetraphosphate (ppGpp). (pletzerlab.com)
  • We hypothesise that the hyperphosphorylated nucleotide alarmone ppGpp (guanosine tetraphosphate), acts as a pivotal regulator of these processes, given its established roles in nutrient management, degreening, and ROS regulation in leaves. (bvsalud.org)
  • Two alarmone (magic spot) second messengers, guanosine pentaphosphate (pppGpp) and guanosine tetraphosphate (ppGpp), which are synthesized by RelA/SpoT homologue (RSH) proteins, play central roles in the stringent response. (bvsalud.org)
  • Methods Preparation of guanosine tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp) from Escherichia coli displays high catalase activity: an additional cleanup using the Procreate app. (theoldrailwayshop.com)
Pentaphosphate1
Nucleotides2
  • Tde-SAS also synthesizes "alarmone-like" nucleotides such as adenosine tetraphosphate (ppApp), albeit at considerably lower rates. (bvsalud.org)
  • There's no additional purification step in the process and all the impurities (such as pyrophosphates and modified nucleotides) and PCR inhibitors (for example, deoxynucleoside tetraphosphate) are eliminated. (excedr.com)
Triphosphate1
  • In this article, we will cover the functions of dGTP, how it performs those functions, its structural characteristics, and how it is different from GTP (guanosine triphosphate). (excedr.com)
Monophosphate3
  • Guanosine Monophosphate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
  • This graph shows the total number of publications written about "Guanosine Monophosphate" by people in this website by year, and whether "Guanosine Monophosphate" was a major or minor topic of these publications. (uchicago.edu)
  • Below are the most recent publications written about "Guanosine Monophosphate" by people in Profiles. (uchicago.edu)
Adenosine1
  • The 210-aa Tde-SAH protein efficiently hydrolyzes all guanosine and adenosine-based alarmones in a Mn(II) ion-dependent manner. (bvsalud.org)
Inosine1
  • Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity). (nih.gov)
Monophosphate3
  • Guanosine Monophosphate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
  • This graph shows the total number of publications written about "Guanosine Monophosphate" by people in this website by year, and whether "Guanosine Monophosphate" was a major or minor topic of these publications. (uchicago.edu)
  • Below are the most recent publications written about "Guanosine Monophosphate" by people in Profiles. (uchicago.edu)