• However, very little is known with regard to potential regulation by G-protein regulatory factors (e.g., the guanosine diphosphate-dissociation inhibitor [GDI]) of insulin secretion from the islet β-cell. (diabetesjournals.org)
  • In a manner akin to the heterotrimeric G-proteins, small G-proteins cycle between their guanosine diphosphate (GDP)-bound (inactive) and GTP-bound (active) conformations, which appear to be tightly regulated by various G-protein regulatory factors (RGFs). (diabetesjournals.org)
  • Guanosine diphosphate is a moderately basic compound (based on its pKa). (ymdb.ca)
  • Conversely, expression of a guanosine diphosphate-bound Rag mutant prevented stimulation of mTORC1 by amino acids. (sciencemag.org)
  • The strain BSK814G2, in which purA was knocked out, and prs , purF and guaB were co-overexpressed, produced 115.2 mg/L of guanosine, which was 4.4-fold higher compared to the control strain constructed by introducing the same gene modifications into the parental strain. (biomedcentral.com)
  • By introducing specific gene modifications related to guanosine and thymidine accumulation, respectively, we demonstrated that genome-reduced strains had greatly improved properties compared to the wild-type strain as chassis cells for the production of these two products. (biomedcentral.com)