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  • inositol
  • 1 increased from 600 to 700 nmol/L.In additon, the accumulation of in inositol (1, 4, 5) trisphosphate (IP^3) was observed. (nii.ac.jp)
  • inhibit
  • Also, isoproterenol (ISO) did not stimulate and CCh, alone or in the presence of ISO, did not inhibit I Ca(L) . Block of CCh effect by ATPγS, although consistent with cGMP action in muscarinic inhibition, could be explained by guanosine 5′- O -(3-thiotriphosphate) (GTPγS) formation from ATPγS via nucleoside diphosphate kinase. (aspetjournals.org)
  • Activity
  • Site-directed mutagenesis revealed that a single point mutation in transmembrane V (N735D), previously shown to be an important residue for potentiation activity of the mGluR2 allosteric potentiator LY487379 [ N -(4-(2-methoxyphenoxy)phenyl)- N -(2,2,2-trifluoroethylsulfonyl)pyrid-3-ylmethylamine], is not critical for the inhibitory activity of negative allosteric modulators of group II mGluRs. (aspetjournals.org)
  • Following reconstitution, aliquot and freeze (-20°C). Stock solutions lose about 5% of their activity after 6 months at -20°C. (emdmillipore.com)
  • potent
  • Thus, escitalopram is potent, rapid and efficacious in translocating Gα s from lipid rafts, and this effect seems to occur independently of 5-hydroxytryptamine transporters. (aspetjournals.org)
  • treatment
  • Dimebon (latrepirdine, dimebolin) is an investigational drug in Phase 3 clinical trials for the treatment of Alzheimer's disease (AD) and Huntington's disease (HD). (aspetjournals.org)