• Requirement of Cdc42 for Salmonella typhimurium -induced cytoskeletal reorganization and nuclear responses in cultured cells. (microbiologyresearch.org)
  • In SK-N-SH cells, carbachol induced a rapid and transient translocation of tubulin to the plasma membrane, microtubule reorganization, and a change in cell shape as demonstrated by confocal immunofluorescence microscopy. (jneurosci.org)
  • Collective motility leads to movement of cohorts of cells which maintain the adherens junctions and move by photolytic degradation of matrix barriers. (biomedcentral.com)
  • These two modes of cell movement are interconvertible and several moving cells, including tumor cells, show an high degree of plasticity in motility styles shifting ad hoc between mesenchymal or amoeboid movements. (biomedcentral.com)
  • This review will focus on the role of Rac and Rho small GTPases in cell motility and in the complex relationship driving the reciprocal control between Rac and Rho granting for the opportunistic motile behaviour of aggressive cancer cells. (biomedcentral.com)
  • Among other members, we will focus our attention on the Rac and Rho subfamilies, as they are the main effectors of cell motility. (biomedcentral.com)
  • The Rho GTPases Rac, Cdc42, and Rho control cell protrusions during migration. (rupress.org)
  • Cdc42 is required for PIP(2)-induced actin polymerization and early development but not for cell viability. (xenbase.org)
  • Cdc42 is a protein involved in cell cycle regulation. (immune-system-research.com)
  • Specifically, human Cdc42 is a small GTPase of the Rho family, which regulates the signaling pathways controlling various cell functions. (immune-system-research.com)
  • Furthermore, the Overexpression of Cdc42 significantly enhanced the migration of cervical cancer cells. (immune-system-research.com)
  • Persistent active forms of transcription factors can also insert endothelium into cancer cells lacking Cdc42. (immune-system-research.com)
  • However, the Cdc42 inhibitor had little effect on the phagocytic index of clear cells. (immune-system-research.com)
  • Although dozens of proteins act downstream of these GTPases, a comparison of effector proteins from evolutionarily diverse organisms suggests that six groups of proteins serve as the core machinery for signaling from Cdc42 and Rac. (biomedcentral.com)
  • The basic signaling properties of two major subgroups of Rho GTPases - the Cdc42 and Rac subfamilies - are highly conserved amongst all eukaryotes, but the means by which they act are not well understood. (biomedcentral.com)
  • In an effort to understand the fundamental signaling elements, or 'core machinery', required for the function of these GTPases, we describe here the conservation and functional similarities of Cdc42 and Rac effectors in five different species: plant, yeast, fruit fly, roundworm and human. (biomedcentral.com)
  • This broad distribution across widely divergent eukaryotic species suggests that Cdc42 and Rac GTPases have an ancient origin, perhaps even predating that of their cousin Ras. (biomedcentral.com)
  • By regulating filamentous actin, Cdc42 and Rac exert a profound effect on cell shape, polarity, migration, cell:cell and cell:matrix adhesion, protein traffic, and cytokinesis. (biomedcentral.com)
  • In mammalian cells, as many as twenty types of protein have been reported to bind to activated Cdc42 [ 2 ]. (biomedcentral.com)
  • GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. (embl-heidelberg.de)
  • It is concluded that the Salmonella SigD protein deprived of its phosphatase activity is able to disrupt yeast morphogenesis by interfering with Cdc42 function, opening the possibility that the SigD N-terminal region might directly modulate small GTPases from the host during infection. (microbiologyresearch.org)
  • In vitro GAP activity towards RhoA, Rac1 and Cdc42 is not a prerequisite for YopE induced HeLa cell cytotoxicity. (microbiologyresearch.org)
  • In addition to its role in controlling cell cycle progression, the tumor suppressor protein p53 can also affect other cellular functions such as cell migration. (rupress.org)
  • A large family of MONOMERIC GTP-BINDING PROTEINS that are involved in regulation of actin organization , gene expression and cell cycle progression. (online-medical-dictionary.org)
  • The biological functions of HMGB1 are diverse in normal cells and during the start and progression of cancer. (hindawi.com)
  • Over expression of RhoC was found to be correlated with prognosis in patients with pancreatic adenocarcinoma, with enhanced RhoC expression resulting in an increase in migration and invasion of pancreatic carcinoma cells [ 7 , 8 ], while RhoA and RhoC up-regulation have been shown to be associated with tumor progression in ovarian carcinoma [ 9 ]. (wjon.org)
  • In addition, they play important roles in gene transcription (via activation of mitogen activated protein (MAP) kinase pathways and, in higher eukaryotes, the transcription factor NFκB), generation of reactive oxygen species, apoptosis, and cell-cycle progression. (biomedcentral.com)
  • In addition we analyse the role of these GTPases in cancer progression and metastatic dissemination. (biomedcentral.com)
  • Transwell migration, cell cycle analysis, MTT and colony formation assays were performed to determine the effect of DRAM2 overexpression and knockdown on NSCLC-cell migration and proliferation. (cancerindex.org)
  • Among them, the Rho GTPase family plays a pivotal role in regulating the biochemical and cytoskeletal pathways relevant to cell migration. (rupress.org)
  • Proteomic-based GO analysis demonstrated that biological processes such as cell deformation, proliferation, migration and wound healing occurred in the liver during the early infection. (biomedcentral.com)
  • Such activation is known to affect cell migration and outgrowth of axons and dendrites in vivo. (embl-heidelberg.de)
  • All of these functions are of importance during the formation of the cerebral neocortex, which consists of the generation of its different cell types, their migration to their destination and their maturation to a functional network. (uni-muenchen.de)
  • Cells exhibit three distinct modes of migration when invading the 3 D environment. (biomedcentral.com)
  • Nuclear positioning, germinal vesicle breakdown, spindle migration, spindle rotation, chromosome segregation, and polar body extrusion are the most critical cellular processes during oocyte meiosis I and II, and a growing number of studies primarily using the mouse oocyte model revealed that actin filaments were critical for these processes, especially for spindle migration. (bioone.org)
  • Actin filaments widely involve into multiple cellular processes such as nuclear positioning, germinal vesicle breakdown, spindle migration, chromosome segregation, spindle rotation and polar body extrusion in oocyte mammalian meiosis. (bioone.org)
  • It is regulated by the recruitment of the GTPase Dynamin-related protein 1 (Drp1) by adaptors at actin- and endoplasmic reticulum-mediated mitochondrial constriction sites. (cam.ac.uk)
  • The present invention relates generally to improved methods and pharmaceutical compositions for mobilizing hematopoietic stem and progenitor cell from bone marrow into peripheral blood by administration of at least one inhibitor of a GTPase, such as Rac1 and/or Rac2 GTPase. (justia.com)
  • They all share a common GTPase cycle, being turned on by binding GTP and off by hydrolyzing GTP to GDP. (biomedcentral.com)
  • Conversely, in amoeboid movement cells have a rounded morphology, the movement is independent from proteases but requires high Rho GTPase to drive elevated levels of actomyosin contractility. (biomedcentral.com)
  • A structural feature that distinguishes the Rho proteins from other small GTPases is the so-called Rho insert domain located between a β strand and an α helix within the small GTPase domain [ 1 - 3 ]. (biomedcentral.com)
  • Rho GTPase effectors are a large group of proteins and include actin nucleation promoting molecules, adaptors, as well as kinases. (biomedcentral.com)
  • Two factors concur to determine specific Rho GTPase function: tissue specificity of GTPase effectors and distinct intracellular localizations of closely related Rho GTPases, due to different lipid modifications [ 1 ]. (biomedcentral.com)
  • Laminin-5-integrin interaction signals through PI 3-kinase and Rac1b to promote assembly of adherens junctions in HT-29 cells. (xenbase.org)
  • Investigating the cellular architecture of the developing cortex, we observed a loss of the radial orientation of radial glial cells, likely due to the disruption of the apical band of adherens junctions, which is the first effect observed after loss of the protein, and the consequent formation of rosette like structures in the brain parenchyma. (uni-muenchen.de)
  • Since F-actin stabilizes adherens junctions, RhoA's regulation of actin levels might indeed be at the origin "double-cortex" phenotype. (uni-muenchen.de)
  • They also have roles in cell transformation by Ras in cytokinesis, in focal adhesion formation and in the stimulation of stress-activated kinase. (umbc.edu)
  • We prepared Titanium (Ti) and Ce-TZP/Al 2 O 3 disks with different surface roughness, namely, mirrored and machined surfaces, on which HGF-1 were cultured, and then the biological parameters of the cultured cells, including cell morphology and gene expression of focal adhesion proteins were assessed. (alliedacademies.org)
  • The resistance of cells on a biomaterial to compressive, tensile, or shear forces largely depends on the cell adhesion strength [ 8 ]. (alliedacademies.org)
  • This is controlled during the cell adhesion procedure through molecules and signalling pathways following a biological cascade, including proliferation and Extracellular Matrix (ECM) production [ 9 ]. (alliedacademies.org)
  • Throughout cell-material interaction, adhesion is influenced by the features of a biomaterial surface, comprising topography and physicochemical properties. (alliedacademies.org)
  • The most commonly identified protein to receive AMPylation are GTPases, and glutamine synthetase. (wikipedia.org)
  • SidD, a protein introduced in the host cell by the pathogenic bacteria Legionella pneumophila, de-AMPylates Rab1 a host protein AMPylated by a different Legionella pneumophila enzyme, the AMPylase SidM. (wikipedia.org)
  • In conclusion, DDP at low concentrations could activate the JAK, p38 MAPK and PI3K pathways in infected macrophages, promote the phosphorylation of p53 protein, and increase the ratio of Bax to Bcl-2, leading to cell apoptosis, thus eliminating intracellular bacteria and reducing the spread of mycobacteria. (bvsalud.org)
  • OR cells with TGF truly enhanced the ranges of E cad mRNA and protein. (microrna1.com)
  • Proteomic screen of SMAD4 TAK-960 wt and SMAD4 deficient cell lines detected distinctive protein levels in cell lines pointing to SMAD4 dependent and independent TGF B responses in colon carcinoma cells. (microrna1.com)
  • RHOQ (rho-related GTP-binding protein RhoQ) is a small signaling G protein which cycles between an active GTP-bound and an inactive GDP-bound state. (prospecbio.com)
  • Ras-like protein belongs to the Rac subfamily of the Rho family of GTPases. (prospecbio.com)
  • HMGB1 is an abundant protein, 10 6 molecules per cell [ 7 ], which has been postulated as a redox sensor [ 8 ]. (hindawi.com)
  • It is the second-most abundant protein after actin, comprising 1-3% of the total protein content in normal growing cells [ 7 , 8 ]. (biomedcentral.com)
  • Roy's team had found that "this protein called AnkX, when microinjected into cells-even at picomole levels-could cause the entire Golgi to fragment in, like, five minutes," Mukherjee says. (the-scientist.com)
  • The α subunits of protein prenyltransferases consist of tetratricopeptide repeats and are part of the tetratricopeptide repeat superfamily [ 5 ], which also includes functionally diverse proteins involved in transcription, co-chaperoning, protein transport, cell-cycle control and phosphorylation. (biomedcentral.com)
  • Modulation of chloride secretory responses and barrier function of intestinal epithelial cells by the Salmonella effector protein SigD. (microbiologyresearch.org)
  • Here, we show that mouse Stbd1 is a transmembrane endoplasmic reticulum (ER)-resident protein with the capacity to induce the formation of organized ER structures in HeLa cells. (imperial.ac.uk)
  • Rho GTPases are key integrating molecules from different extracellular signals, as they can be activated by different GEFs. (biomedcentral.com)
  • The present review summarizes recent progress made regarding the roles of actin filaments in the asymmetric oocyte division. (bioone.org)
  • Like all other GTPases, Rho proteins act as molecular switches, with an active GTP-bound form and an inactive GDP-bound form. (embl-heidelberg.de)
  • One family of molecules are the small GTPases, such as Rho GTPases, Ran GTPases, and Rab GTPases and another are the actin nucleators, such as the formin family and the Arp2/3 complex. (bioone.org)
  • also, the 5' download volatility trading of the cytoplasm is involved actually by cationic end-product by the RNase proximity water cell, which has a direct RNA( RNA H1 in pathways) and at least 10 Fructose-6-phosphate nucleus( activated in Jarrous 2002, Xiao et al. (evakoch.com)
  • Looking for molecular pathways that may be at the start of these defects, we could observe a decrease of F-actin levels in RhoA-neg. (uni-muenchen.de)
  • Improved methods and pharmaceutical compositions are provided herein for mobilizing hematopoietic progenitor cells from bone marrow into peripheral blood, comprising the administration of an effective amount of an inhibitor of GTPases, such as Rac1 and Rac2 alone or in combination. (justia.com)
  • In particular, embodiments of the method involve inhibition of both Rac1 and Rac2 GTPases to increase the numbers of hematopoietic stem cells into a subject's peripheral blood of a subject. (justia.com)
  • In addition it depends on Rac1-mediated cell polarization and lamellipodia formation. (biomedcentral.com)
  • Mitochondria are highly dynamic organelles undergoing coordinated cycles of fission and fusion, referred as 'mitochondrial dynamics', in order to maintain their shape, distribution and size. (cam.ac.uk)
  • Their transient and rapid morphological adaptations are crucial for many cellular processes such as cell cycle, immunity, apoptosis and mitochondrial quality control. (cam.ac.uk)
  • In line with this notion, mitochondria are highly dynamic organelles that undergo fission and fusion and move into the cell along the microtubules to generate the mitochondrial network [ 6 ]. (hindawi.com)
  • The GAP activity of Tum is required for cytokinesis: in its absence cytokinesis fails early even though Tum is present on microtubules at the cell equator where the furrow should form. (biologists.com)
  • Scientists working in basic, translational, and clinical cancer metabolism research are invited to join the Academy in New York on April 17th to discuss the intersection between cell signaling and metabolism. (nyas.org)
  • A1 cells readily up regu lated the expression of three integrin in response to TGF, a molecule we established as one particular on the most delicate and robust markers of TGF signaling. (microrna1.com)
  • TPX2 regulated by miR-29c-3p induces cell proliferation in osteosarcoma via the AKT signaling pathway. (xenbase.org)
  • This was studied in SK-N-SH neuroblastoma cells, which possess a muscarinic receptor-regulated PLCβ 1 -signaling pathway. (jneurosci.org)
  • Apoptosis of infected cells increased after 24 h of DDP treatment, as shown by flow cytometry and transmission electron microscopy detection. (bvsalud.org)
  • Inhibitors of JAK, PI3K or p38 MAPK inhibited the increase in cell apoptosis and the reduction in the intracellular bacterial count induced by DDP. (bvsalud.org)
  • and that RelA protected vascular cells against apoptosis and modulated vascular inflammatory response upon tumor necrosis factor (TNF) stimulation. (bioinf.org)
  • Moreover, mitochondria control cell death through apoptosis and supply Ca 2+ and metabolites required for cellular homeodynamics [ 3 ]. (hindawi.com)
  • When stimulated to divide, they give rise to more committed, differentiated daughter cells with less proliferative potential, called "early progenitor" cells. (justia.com)
  • Current treatments to manage the problems that result from prolonged bone marrow suppression include the reinfusion of a patient's own previously harvested hematopoietic stem and progenitor cells. (justia.com)
  • In such procedures, patients undergo successive treatments with cell mobilization agents to cause mobilization of hematopoietic progenitor cells from the bone marrow to the peripheral circulation for harvesting. (justia.com)
  • progenitor cells in culture. (uni-muenchen.de)
  • Overexpression of this gene is associated with tumor cell proliferation and metastasis. (cancerindex.org)
  • Additionally, DRAM2 overexpression promoted cell metastasis and proliferation in vitro, while knockdown of DRAM2 expression yielded opposite result. (cancerindex.org)
  • In colorectal cell lines, TGF B induces proliferation by RAS independent manner. (microrna1.com)
  • Cancer cells demand high energy production to sustain their pathological increase in proliferation rate. (hindawi.com)
  • In turn, GTP-bound active GTPases can interact with a plethora of different effectors which mediate the different cellular functions of this family of proteins. (biomedcentral.com)
  • RHOQ is involved in epithelial cell polarization processes. (prospecbio.com)
  • Over the past decades, luminal epithelial cell lineage has gained considerable attraction as the functionally milk-secreting units and as the most fruitful acreage for breast cancer launching. (biomedcentral.com)
  • The ductal system is coated by a chain of luminal epithelial cells (LECs) situated on a layer of myoepithelial cells (MECs) and encompassed by a distinguished basement membrane. (biomedcentral.com)
  • Two major cell types cooperate to build up the ductal units: inner polarized luminal epithelial cells (LECs) embraced by a layer of myoepithelial cells (MECs), both cell types are rimmed by a cohesive basement membrane (BM) [ 2 ]. (biomedcentral.com)
  • Therefore, damaging the MECs layer resulted in the release of various factors (such as SDF1/CXCL12, CXCL14, MMP, and tenascin) [ 11 , 12 ] with a potential to modify the tumour microenvironment and facilitate the paracrine communication between the tumour epithelial cells and the enclosed stroma enhancing the tumour aggressiveness [ 11 , 13 ]. (biomedcentral.com)
  • The Rho proteins cycle within the cell between the active GTP-bound form and the inactive GDP-bound form, the cycle being regulated by a number of activators and inhibitors. (wjon.org)
  • Rho GTPases work as sensitive molecular switches existing either in an inactive, GDP-bound form or an active GTP-bound form. (biomedcentral.com)
  • It does, however, have microtubules and typical α-tubulin, as well as dynamins ( GTPases involved in membrane trafficking). (asmblog.org)
  • loop kappa p21 D cell 4( ABCD4) is shown to reduce the CD127 performance of cobalamin( Cbl membrane parking B12) into the mitochondrion, interacting it ED for the composition of Cbl lives. (evakoch.com)
  • Thus, suppressing PA production by inhibiting either PLD or DGK activity compromised membrane trafficking except early endocytosis, disrupted tip-localized deposition of cell wall material, especially pectins, and inhibited pollen tube growth. (frontiersin.org)
  • Rho GTPases have diverse effects on the organization of the actin filament system. (xenbase.org)
  • First, expression of SigD R468A caused accumulation of large unbudded cells and loss of septin organization, while SigD expression caused none of these effects. (microbiologyresearch.org)
  • The amino-terminal non-catalytic region of Salmonella typhimurium SigD affects actin organization in yeast and mammalian cells. (microbiologyresearch.org)
  • Cells express a pool of thousands of different proteins that need to be tightly controlled for proper cellular structure, organization, and function. (hindawi.com)
  • This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. (cancerindex.org)
  • DRAM2 acts as an oncogene in non-small cell lung cancer and suppresses the expression of p53. (cancerindex.org)
  • Here, we show that DRAM2 may act as an oncogenic regulator in non-small cell lung cancer (NSCLC). (cancerindex.org)
  • Stem cells represent a very small percentage of bone marrow cells, and are normally quiescent. (justia.com)
  • Interestingly, small GTPases related to Rac are found even in organisms that lack Ras, such as plants. (biomedcentral.com)
  • Ras homology family (Rho) of small guanosine triphosphatases (GTPases). (umbc.edu)
  • During mitosis, cells undergo symmetrical cell division, while oocyte meiotic maturation undergoes two consecutive, asymmetric divisions that generate a totipotent haploid oocyte and two small polar bodies not involved in DNA replication. (bioone.org)
  • This study aims to investigate the impact of targeting RhoC in human breast cancer cells by utilising ribozyme transgene technology and to assess its effect on cancer cell invasion. (wjon.org)
  • Indeed, disruption of the MECs layer was reported to facilitate the invasion of the cancer cells to the surrounding stroma. (biomedcentral.com)
  • Subsequent in vitro and in vivo studies have demonstrated the initial steps of cancer cell invasion and dissemination by disrupting the integrity of the myoepithelial belt that encircles the LECs [ 7 , 8 , 9 , 10 , 11 ]. (biomedcentral.com)
  • 2007), Evolution of the Rho family of ras-like GTPases. (xenbase.org)
  • GTPases of the Rho family are molecular switches that play important roles in converting and amplifying external signals into cellular effects. (xenbase.org)
  • These dynamic transitions are mainly ensured by large GTPases belonging to the Dynamin family. (cam.ac.uk)
  • receptors and dileucine-: TLR1 photosynthesis cell in New Zealand 1945 -1960: family understood in bovine RELB of the Associations for the peptidyl of Master of Arts. (evakoch.com)
  • Disruption of the Pebble-interacting domain leaves Tum localised to the cell equator on cortically associated microtubules, again with no evidence of furrowing. (biologists.com)
  • Infectious bacteria use this domain to interrupt phagocytosis and cause cell death. (wikipedia.org)
  • For Mukherjee, the paper was a revelation: not only did it identify the fastest way yet to target Golgi biology, it suggested that scientists could use intracellular bacteria "as a lens to understand basic processes inside the cell. (the-scientist.com)
  • So-called facultative intracellular bacteria such as Listeria monocytogenes and Legionella pneumophila do not need to be inside a host cell to reproduce. (the-scientist.com)
  • Recognition of the effective involvement of the myoepithelial cells in mammary gland development and in hampering tumorigenesis has renewed the interest in investigating the biological roles of this second main mammary lineage. (biomedcentral.com)
  • OR cells, we up coming sought to confirm the response of D2 HAN derivatives to TGF by characterizing a repertoire of target genes recognized to be regulated by this selelck kinase inhibitor multi practical cytokine. (microrna1.com)
  • RhoA functions in the regulation of actomyosin contractility, RhoB has been shown to regulate cytokine trafficking and cell survival, while RhoC appears to be important in cell locomotion. (wjon.org)
  • Molecular Biology of the Cell, Vol. 27, Núm. (usal.es)
  • In this review, we provided an overview of the myoepithelial cells' histogenesis, molecular and biological markers, and physiological commitments. (biomedcentral.com)
  • SMAD3 mutation is often a incredibly unusual occasion in human solid tumors, nonetheless, a missense mutation in SMAD3 gene was found in human colorectal cell lines. (microrna1.com)
  • OR cells expressed abundant quantities of EGFR, Pyk2, and E cad, all of which were conspicuously absent within their metastatic D2. (microrna1.com)
  • But if this is not possible, oxidative stress finally activates signals that will lead to cell death. (hindawi.com)
  • These bugs have a knack for pinpointing critical cell functions, she says, adding fondly that Legionella is continuing to help her explore how eukaryotic cells work. (the-scientist.com)
  • Mitochondria are highly dynamic organelles that provide essential metabolic functions and represent the major bioenergetic hub of eukaryotic cell. (hindawi.com)
  • Mitochondria are the energy producing organelles in eukaryotic cell providing ATP through oxidative phosphorylation (OXPHOS). (hindawi.com)
  • This process of division and differentiation is subject to regulation at many levels to control cell production. (justia.com)
  • The breast cancer cell line MDA-MB-231 was transfected with either a retroviral RhoC transgene or a control retroviral transgene. (wjon.org)
  • Scientists studying pathogens such as Chlamydia , Legionella , and Listeria get a master class in how to control the internal workings of mammalian cells. (the-scientist.com)
  • However, the mechanisms underlie for the formation and maintenance of senescent bone cells are largely unknown. (bvsalud.org)
  • The maintenance of the steady-state equilibrium between ROS generation and elimination is crucial for cell survival, while its loss causes cell death by different mechanisms triggered by oxidative damage. (hindawi.com)
  • Besides pollen tubes, other cell types such as root hairs, fungal hyphae, and neuronal cells likewise elongate by tip growth, sharing conserved mechanisms that bring about this type of growth. (frontiersin.org)
  • In all systems, these GTPases are best known for their effects on the polymerization and distribution of actin in the cell cortex [ 1 ]. (biomedcentral.com)
  • Finally, by using in-utero electroporation to delete RhoA in individual cells, we found out that the misplacements of neurons in the heterotopic cortex was not due to an inability of RhoA-neg. (uni-muenchen.de)
  • Although the positioning signal is likely to be transmitted via the anaphase microtubule array to the cell cortex, exactly how the microtubule array determines the site of contractile ring formation remains unresolved. (biologists.com)
  • Collectively these findings recommend the inherent plan of nonmetastatic breast cancer cells to talk and migrate towards 1 an additional dur ing the formation of branched, multicellular organoids could underlie their inability to initiate proliferative packages within compliant pul monary microenvironments. (microrna1.com)
  • Extra over, each D2 HAN derivatives displayed enhanced actin strain fi ber formation in response to TGF 1 stimulation. (microrna1.com)
  • RHOQ causes the formation of thin, actin-rich surface projections called filopodia. (prospecbio.com)
  • These data support a model in which Tum/RacGAP, via its interaction with Pbl, provides a critical link between the anaphase microtubule spindle and cytokinetic furrow formation in Drosophila cells. (biologists.com)
  • Oxidative stress produces DNA damage and also induces responses, which could help the cell to restore the initial equilibrium. (hindawi.com)
  • Moreover, tumor cells show an increased capacity to migrate. (rupress.org)
  • Sequential rounds of division and differentiation give rise to an enormous amplification of cell numbers, necessary for the production of mature blood cells. (justia.com)