Gtpase activating protein 1. Medical search. Frequent questions

Quercetin suppresses the proliferation of multiple myeloma cells by down-regulating IQ motif-containing GTPase activating protein 1 expression and extracellular signal-regulated kinase activation. (curehunter.com)
Ras-GTPases act as molecular switches that bind to downstream effectors, such as the protein kinase c-Raf , and localizes them to the membrane resulting in their activation. (bionity.com)
Activating mutations in the Leucine Rich Repeat Kinase 2 (LRRK2) cause Parkinson's disease and previously we showed that activated LRRK2 phosphorylates a subset of Rab GTPases (Steger et al. (stanford.edu)
Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold. (eu.org)
They also activate other kinase cascades. (embl-heidelberg.de)
Gupta DD, Saha S, Chakrabarti MK (2005) Involvement of protein kinase C in the mechanism of action of Escherichia coli heat-stable enterotoxin (STa) in a human colonic carcinoma cell line, COLO-205. (springer.com)
We have previously shown that second-messenger-dependent kinases (cAMP-dependent kinase, protein kinase C) in the olfactory system are essential in terminating second-messenger signaling in response to odorants. (duke.edu)
Bbeta-adrenergic receptor kinase-1 levels in catecholamine-induced myocardial hypertrophy: regulation by beta- but not alpha1-adrenergic stimulation. (duke.edu)
beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein. (duke.edu)
Chronic human heart failure is characterized by abnormalities in beta-adrenergic receptor (betaAR) signaling, including increased levels of betaAR kinase 1 (betaARK1), which seems critical to the pathogenesis of the disease. (duke.edu)
Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras. (duke.edu)
Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function. (duke.edu)
The beta-adrenergic receptor kinase 1 (beta ARK1) is a member of the G protein-coupled receptor kinase (GRK) family that mediates the agonist-dependent phosphorylation and desensitization of G protein-coupled receptors. (duke.edu)
Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice. (duke.edu)
Functional desensitization of the isolated beta-adrenergic receptor by the beta-adrenergic receptor kinase: potential role of an analog of the retinal protein arrestin (48-kDa protein). (duke.edu)
Patrick A. Lewis ABSTRACT Leucine-rich repeat kinase 2 (LRRK2) is a multidomain scaffolding protein with dual guanosine triphosphatase ( GTPase ) and kinase enzymatic activities, providing this protein with the capacity to regulate a multitude of signalling pathways. (biologists.com)
This study reveals a noncanonical role of AMP-activated kinase in which the α subunit C-terminal regulatory domain serves as a guanine-nucleotide-exchange factor for Arf6 during glucose deprivation. (biologists.com)
We show that phosphorylation of synGAP by Ca^(2+)/calmodulin-dependent protein kinase II (CaMKII) decreases its affinity for the PDZ domains as much as 10-fold, measured by surface plasmon resonance. (caltech.edu)
In addition, they play important roles in gene transcription (via activation of mitogen activated protein (MAP) kinase pathways and, in higher eukaryotes, the transcription factor NFκB), generation of reactive oxygen species, apoptosis, and cell-cycle progression. (biomedcentral.com)
The guanine nucleotide exchange factor Sos (Son-of-sevenless) is a complex multidomain protein that activates the small GTPase Ras (H-Ras, K-Ras, N-Ras, but not functionally distinct R-Ras) in response to receptor tyrosine kinase stimulation. (novusbio.com)
The integrin dependent COX-2 expression was shown to be mediated through the activation of CD47 and its associated G?i3 protein, which in turn lead to protein kinase C? (lu.se)

They cycle between inactive GDP-bound and activated GTP-bound states, which is controlled by GTP hydrolysis-activating proteins (GAPs). (nih.gov)
The inactive GDP bound form is promoted by GTPase-activating proteins (GAPs). (embl.de)
In addition to the intrinsic GTPase activity of the α subunit, G protein deactivation is accelerated by GTPase activating proteins (GAPs). (sigmaaldrich.com)
GAPs for heterotrimeric G proteins include G protein effectors, such as the Gα q -dependent phospholipase Cβ and the Gα 13 -dependent p115RhoGEF, as well as the family of regulators of G protein signaling (RGS proteins). (sigmaaldrich.com)
Palmitate turns over and may affect regulation of GTPase activity by GAPs of Gα subunits as well their subcellular localization. (sigmaaldrich.com)
The active conformation is promoted by guanine-nucleotide exchange factors, and the inactive state by GTPase-activating proteins (GAPs) which stimulate the intrinsic GTPase activity of small G proteins. (embl-heidelberg.de)
Putative zinc fingers with GTPase activating proteins (GAPs) towards the small GTPase, Arf. (embl.de)
Both guanine nucleotide-exchange proteins and GTPase-activating proteins (GAPs) for ARFs have been cloned recently. (embl.de)
It is regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase. (novusbio.com)

CTX irreversibly activates Gα s by inhibiting its intrinsic GTPase activity. (sigmaaldrich.com)
Neurofibromin, the protein product of the NF1 gene, functions at least in part as a GTPase activating protein that regulates Ras proteins by stimulating their intrinsic GTPase activity. (iu.edu)

Probable ADP-ribosylation factor GTPase-activating protein AGD5 OS=Arabidopsis thaliana GN=AGD5 PE=1. (yeastrc.org)
Probable ADP-ribosylation factor GTPase-activating protein AGD6 OS=Arabidopsis thaliana GN=AGD6 PE=1. (yeastrc.org)

ARHGAP21 functions preferentially as a GTPase-activating protein (GAP) for CDC42 (MIM 116952) and regulates the ARP2/3 complex (MIM 604221) and F-actin dynamics at the Golgi through control of CDC42 activity (Dubois et al. (wikipedia.org)
Manzerra, Pasquale, Synaptic Ras GTPase activating protein (SynGAP) regulates N-methyl-D-aspartate receptor (NMDAR)-mediated excitotoxicity via P38 MAPK activation. (usd.edu)

Homo sapiens G protein subunit alpha o1 (GNAO1), transcript variant 1, mRNA. (genecopoeia.com)

This motif is involved in protein-protein interaction mediated by SH3 domains. (eu.org)
These proteins contain a characteristic zinc finger motif (Cys-x2-Cys-x(16,17)-x2-Cys) which displays some similarity to the C4-type GATA zinc finger. (embl.de)
Many, but not all, of these effectors contain a conserved 18 amino-acid binding motif that has been termed CRIB (Cdc42-Rac interactive binding), PBD (p21-binding domain) or GBD (GTPase-binding domain) [ 4 ]. (biomedcentral.com)
This motif is found in Cdc42/Rac-associated proteins such as the protein kinases Pak, MRCK and Ack, the adaptor proteins Spec and WASP, and, in degenerate form, in the kinases MLK, Mekk4, adaptor Par6, scaffold protein IRSp53, and the Borg proteins. (biomedcentral.com)

In this way these mutations are thought to create SOS1 alleles encoding hyper-activated and dysregulated variants of the protein. (bionity.com)
Activating mutations in Ras genes are found in 33% of human cancers, with Ras well recognized as the most commonly mutated oncogene in human cancer. (aacrjournals.org)
Mutations in Ras associated with cancer promote cellular activation by populating the active state of Ras, most frequently by impairing the action of proteins that downregulate its activity. (aacrjournals.org)
In previous work, we found that gain-of-function mutations that hyperactivate GEM-1 (an SLC16A transporter protein) can bypass the requirement for GON-2 (a TRPM channel protein) during the initiation of gonadogenesis in C. elegans. (cipsm.de)
Mutations on DLC-1 perturb the interaction with cten and disrupt the focal adhesion localization of DLC-1. (rupress.org)
Mutations in NF1 cause the common genetic disorder neurofibromatosis type 1 (NF1) which is associated with a predisposition to neural crest derived tumors and juvenile myelomonocytic leukemia (JMML). (iu.edu)
Mutations in ciliary protein genes can lead to dysfunctional or absent cilia and are the cause of a large group of heterogeneous diseases known as ciliopathies. (bvsalud.org)
KRAS is one of the most highly mutated proteins in cancer accounting for nearly 30% of cancer related mutations, and 86% of all RAS related mutations (reviewed in (1, 2)) . (cytoskeleton.com)
Mutations to codon 12 in KRAS maintains kRAS in an active, GTP-bound state through preventing GTPase-activating proteins (GAP) association. (cytoskeleton.com)

Ras signaling can be thought of in simple terms as occuring downstream of receptor tyrosine kinases, triggered by association of adaptor proteins with the phosphorylated cytoplasmic tails of these receptors. (sdbonline.org)
We have previously reported the identification and characterization of an LKB1-specific adaptor protein, STRAD, which activates LKB1 and translocates it from nucleus to cytoplasm. (nih.gov)

Once released from SOS, the Ras-GTPase quickly binds fresh guanine nucleotide from the cytosol. (bionity.com)
ADP-ribosylation factors (ARFs) are approximately 20-kDa guanine nucleotide-binding proteins recognized as critical components in intracellular vesicular transport and phospholipase D activation. (embl.de)

Identification of a protein that binds to the SH3 region of Abl and is similar to Bcr and GAP-rho. (eu.org)
We had reported that the ARF domain of ARD1 binds specifically GDP and GTP and that the amino-terminal extension acts as a GAP for the ARF domain of ARD1 but not for ARF proteins. (embl.de)
In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. (novusbio.com)
We report that cten binds to another tumor suppressor, deleted in liver cancer 1 (DLC-1), and the SH2 domain of cten is responsible for the interaction. (rupress.org)
SynGAP is a Ras/Rap GTPase-activating protein (GAP) present in high concentration in postsynaptic densities (PSDs) from mammalian forebrain where it binds to all three PDZ (PSD-95, Discs-large, ZO-1) domains of PSD-95. (caltech.edu)
When mutated, p120 Ras GTPase-activating protein binds to Krev-1/rap1a, an integrin β1-mediated cell adhesion and angiogenesis protein. (medscape.com)

Heterotrimeric G proteins, comprising α, β and γ subunits, respond to extracellular signals generated by activated seven-transmembrane (7TM) receptors by modulating intracellular effector proteins such as enzymes and ion channels. (sigmaaldrich.com)
Although dozens of proteins act downstream of these GTPases, a comparison of effector proteins from evolutionarily diverse organisms suggests that six groups of proteins serve as the core machinery for signaling from Cdc42 and Rac. (biomedcentral.com)

Association of p62, a multifunctional SH2- and SH3-domain-binding protein, with src family tyrosine kinases, Grb2, and phospholipase C gamma-1. (eu.org)
G protein-coupled receptor activation leads to the membrane recruitment and activation of G protein-coupled receptor kinases, which phosphorylate receptors and lead to their inactivation. (duke.edu)
Stimulation of Gi-coupled receptors leads to the activation of mitogen-activated protein kinases (MAP kinases). (duke.edu)

GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. (embl-heidelberg.de)
Like all other GTPases, Rho proteins act as molecular switches, with an active GTP-bound form and an inactive GDP-bound form. (embl-heidelberg.de)
Rho GTPases are small (20-30 kDa) GTP-binding proteins of the Ras superfamily. (biomedcentral.com)
In all systems, these GTPases are best known for their effects on the polymerization and distribution of actin in the cell cortex [ 1 ]. (biomedcentral.com)

The normal rate of Ras catalytic GTPase (GTP hydrolysis) activity can be increased by proteins of the RasGAP family, which bind to Ras and increase its catalytic rate by a factor of one thousand - in effect, increasing the rate at which Ras is inactivated. (bionity.com)
The GAP of ARD1 stimulates GTPase hydrolysis for ARD1 but not ARFs. (embl.de)

The junctional proteins ZO-1 and p120 redistribute in a dotted circle peripheral to the brush border, in the absence of cell-cell contacts. (nih.gov)
The RASA1 gene encodes p120 Ras GTPase-activating protein. (medscape.com)

Here, the Ras-GTPase-activating protein SH3 domain-binding protein 1 (G3BP1) was identified as a potential target of resveratrol, and in vitro binding assay results using resveratrol-conjugated Sepharose 4B beads confirmed their direct binding. (umn.edu)

This gene encodes a small GTP-binding protein that belongs to the largest family within the Ras superfamily. (nih.gov)
Oligophrenin-1 encodes a rhoGAP protein involved in X-linked mental retardation. (embl-heidelberg.de)
This gene is highly expressed in fetal brain and encodes a protein of relative molecular mass 91K, named oligophrenin-1, which contains a domain typical of a Rho-GTPase-activating protein (rhoGAP). (embl-heidelberg.de)

These proteins function as regulators of membrane trafficking. (nih.gov)
Ras proteins are critical regulators of multiple pathways involved in cellular growth control. (aacrjournals.org)

Molecular characterization of the GTPase-activating domain of ADP-ribosylation factor domain protein 1 (ARD1). (embl.de)
ADP-ribosylation factor GTPase Glucose deprivation Cell invasion Ministry of Education http. (biologists.com)

A single ligand occupied receptor is able to activate several G protein molecules during the lifetime of a single αGTP complex. (sigmaaldrich.com)
MybiosourceProduct Short Name: [G-Protein Coupled Receptor 126 (GPR126)]Product Name Synonyme: [G-Protein Coupled Receptor. (biocheminfo.org)

Molecular mechanisms of Streptococcus pneumoniae-targeted autophagy via pneumolysin, Golgi-resident Rab41, and Nedd4-1-mediated K63-linked ubiquitination. (nih.gov)
The long term goal of our research is to elucidate the molecular mechanisms by which proteins are targeted to specific and distinct compartments. (stanford.edu)
The ECM proteins bind to the extracellular domains of integrin heterodimers, whereas the actin stress fibers link to integrin cytoplasmic tails via large molecular complexes. (rupress.org)
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. (novusbio.com)

We recently discovered that the stress granule protein G3BP1 (Ras GTPase-activating protein-binding protein 1) anchors the TSC complex to lysosomes needed for the suppression of mTORC1 by nutritional signals (PMID: 33497611). (tugraz.at)

Members of the Rho family of small G proteins transduce signals from plasma-membrane receptors and control cell adhesion, motility and shape by actin cytoskeleton formation. (embl-heidelberg.de)
an enzyme involved in the production of various eicosanoids) expression, by activating integrin collagen receptors. (lu.se)

Mammalian tuberin protein, the product of a familial tuberous sclerosis gene which, when deleted, causes begnin tumours. (embl.de)
Mammalian tuberin-like protein TULIP. (embl.de)
In mammalian cells, as many as twenty types of protein have been reported to bind to activated Cdc42 [ 2 ]. (biomedcentral.com)

The analysis of Cdc42 and Rac function in evolutionarily distant organisms is useful as a tool to uncover the basic activities of these proteins. (biomedcentral.com)
By regulating filamentous actin, Cdc42 and Rac exert a profound effect on cell shape, polarity, migration, cell:cell and cell:matrix adhesion, protein traffic, and cytokinesis. (biomedcentral.com)

Drosophila Gigas protein, an homologue of tuberin involved in regulation of cell cycle. (embl.de)
These findings represent a paradigm shift in our understanding of the role monoubiquitination may play in protein regulation as well as new mechanisms for regulation of Ras activity. (aacrjournals.org)

GAP proteins specific for Rap contain a conserved region of around 200 amino-acid residues, the RapGAP domain. (embl.de)

J Cell Biol (2007) 176 (1): 43-49. (rupress.org)

Furthermore, a strong positive genetic interaction occurs between Gap1 and phospholipase Cgamma (PLCgamma), an enzyme that generates inositol-1,4,5-trisphosphate, a precursor for IP4 and a second messenger for intracellular Ca2+ release. (sdbonline.org)
The SOS-01 reacts with human Sos, an ubiquitously expressed 150 kDa intracellular protein. (novusbio.com)
An intracellular signaling and tumor suppressor protein that forms a complex with TUBEROUS SCLEROSIS COMPLEX 1 PROTEIN (TSC1) and other signaling factors to negatively regulate MTORC1 and affect cell growth and proliferation. (bvsalud.org)

It has recently been shown that K-Ras monoubiquitination, upregulates its activity by populating the active GTP-bound state, enhances interactions with certain downstream effectors and promotes Ras-mediated tumorigenesis [1]. (aacrjournals.org)
Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. (novusbio.com)

Homo sapiens Rho GTPase activating protein 45 (ARHGAP45), transcript variant 3, mRNA. (genecopoeia.com)
Homo sapiens cyclin L2 (CCNL2), transcript variant 1, mRNA. (genecopoeia.com)
Homo sapiens hypothetical protein SB138 isoform YLJ001 mRNA. (genecopoeia.com)

Therefore, we hypothesize that phosphorylation by CaMKII reduces synGAP′s ability to restrict binding of other proteins to the PDZ domains of PSD-95. (caltech.edu)
We support this hypothesis by showing that three critical postsynaptic signaling proteins that bind to the PDZ domains of PSD-95 are present at a higher ratio to PSD-95 in PSDs isolated from synGAP heterozygous mice. (caltech.edu)

The present invention relates generally to improved methods and pharmaceutical compositions for mobilizing hematopoietic stem and progenitor cell from bone marrow into peripheral blood by administration of at least one inhibitor of a GTPase, such as Rac1 and/or Rac2 GTPase. (justia.com)

engagement triggers rapid GTP-loading of the small GTPase Rac as a master regulator of cytoskeletal rearrangements and lamellipodia-driven internalization. (biologists.com)

Macropinocytosis GTPase Rab Phosphatase Phosphoinositide EGF Ruffling Macropinocytosis is an actin-driven process that involves the formation and extension of plasma membrane ruffles and the eventual closure of large (≥0.2 to 5.0. (biologists.com)
and proteins that interact with members of the Arp2/3 complex and hence the actin cytoskeleton (Table 1 ). (biomedcentral.com)

Rap small G proteins have been implicated in various cellular processes such as exocytosis, cAMP signalling, cell adhesion and cell proliferation. (embl.de)
Dr. Clapp's group is also interested in the cellular and biochemical functions of an orphan group of proteins that are involved in the heterogenetic disorder Fanconi Anemia. (iu.edu)

Tensin is a gene family with four members (tensin1, tensin2, tensin3, and cten), and their encoding proteins are localized to the cytoplasmic side of focal adhesions. (rupress.org)

There are 47093 RhoGAP domains in 46979 proteins in SMART's nrdb database. (embl-heidelberg.de)
Taxonomic distribution of proteins containing RhoGAP domain. (embl-heidelberg.de)
The complete taxonomic breakdown of all proteins with RhoGAP domain is also avaliable . (embl-heidelberg.de)
Click on the protein counts, or double click on taxonomic names to display all proteins containing RhoGAP domain in the selected taxonomic class. (embl-heidelberg.de)
By enhancing their GTPase activity, GAP proteins inactivate small Rho and Ras proteins, so inactivation of rhoGAP proteins might cause constitutive activation of their GTPase targets. (embl-heidelberg.de)
Residues conserved across the rhoGAP family are largely confined to one face of this bundle, which may be an interaction site for target G proteins. (embl-heidelberg.de)

Our results demonstrate an association between cognitive impairment and a defect in a signalling pathway that depends on a Ras-like GTPase. (embl-heidelberg.de)

Rapid GTPase activating protein (GAP)-mediated inactivation (RhoA flux) is proposed to limit RhoA zone dimensions. (cipsm.de)

A GTPase-activating protein controls Rab5 function in endocytic trafficking. (nih.gov)
Pharmacological agonists and antagonists are used to define Gα protein function. (sigmaaldrich.com)
2. Site-Specific Monoubiquitination Activates Ras by Impeding GTPase Activating Protein Function. (aacrjournals.org)
Bacterial toxins can be single proteins or oligomeric protein complexes that are organized with distinct AB structure-function properties. (springer.com)
Bacterial toxins also catalyze the non-covalent modification of host protein function or can modify host cell properties through direct protein-protein interactions. (springer.com)
This activity is strongly conserved and probably represents a primordial function of these proteins. (biomedcentral.com)
It can also function as GTPASE-ACTIVATING PROTEIN (GAP) for RHEB GTPASE to activate mTORC1 independent of its role in the complex. (bvsalud.org)

Here we define the precise Rab29 binding region of the LRRK2 Armadillo domain between residues 360-450 and show that this domain, termed 'Site #1', can also bind additional LRRK2 substrates, Rab8A and Rab10. (stanford.edu)

Indirect stimulation, by activating COX-2 expression in a ?2?1 integrin dependent manner was able to elicit a migratory response. (lu.se)

1. Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors. (aacrjournals.org)

1 Austin, TX: Cell Adhesion and Migration, 2014. (usd.edu)

This may be explained because the SOS1 protein adopts an auto-inhibited conformation dependent on multiple domain-to-domain interactions that cooperate to block access of the SOS1 catalytic core to its Ras-GTPase targets [7] . (bionity.com)
Alternative drugs have been developed to target Farnesyl transferase and downstream MEK targets, but these have failed for various reasons (reviewed in (1, 2)) . (cytoskeleton.com)

These functions are mediated via the inhibition of the metabolic master regulator mTORC1 (mechanistic target of rapamycin complex 1) at its central signaling platform - the lysosomes. (tugraz.at)
Proteína de señalización intracelular y supresora tumoral que forma un complejo con la PROTEÍNA 1 DEL COMPLEJO DE ESCLEROSIS TUBEROSA (TSC1) y con otros factores de señalización para regular negativamente MTORC1 e influir en el crecimiento y la proliferación celulares. (bvsalud.org)
También puede actuar como proteína activadora de GTPASA (GAP) para la RHEB GTPASA para activar mTORC1 independientemente de su papel en el complejo. (bvsalud.org)

North et al highlighted the presence of human glucose transporter 1 (GLUT-1) isoform as a useful differentiating factor between infantile hemangiomas and other vascular anomalies. (medscape.com)

Immunohistochemistry: Rac1 Antibody [NB100-91266] - Rat spinal cord using Rabbit antibody to RAC1, RAC2 (100-150) at 1:1000 dilution. (novusbio.com)
This Rac1 antibody was developed against a synthetic peptide from amino acid region 100-150 as a part of human Rac1 conjugated to blue carrier protein. (novusbio.com)

The GTP-bound form of ARF is essential for the maintenance of normal Golgi morphology, it participates in recruitment of coat proteins which are required for budding and fission of membranes. (embl.de)

When these DLC-1 mutants were fused to a focal adhesion targeting sequence, their tumor suppression activities were significantly restored. (rupress.org)

We find that this activating mutation introduces a redox active cysteine that renders Ras G12C sensitive to thiol oxidation. (aacrjournals.org)

Pasteurella multocida toxin (PMT, produced by Pasteurella multocida ) offers the possibility to discriminate between Gα q and Gα 11 proteins, since it stimulates inositol phosphate formation in a strictly Gα q -dependent manner. (sigmaaldrich.com)

2017). Moreover, Golgi-associated Rab29 can recruit LRRK2 to the surface of the Golgi and activate it there for both auto- and Rab substrate phosphorylation. (stanford.edu)
Unexpectedly, the interaction between DLC-1 and the cten SH2 domain is independent of tyrosine phosphorylation of DLC-1. (rupress.org)

During animal cell cytokinesis, the spindle directs contractile ring assembly by activating RhoA in a narrow equatorial zone. (cipsm.de)

2023 Jul 1;108(7):1768-1781. (helsinki.fi)

An inositol-1,3,4,5-tetrakisphosphate (IP4)-sensitive extended PH domain is essential for Gap1 activity, while Ca2+-sensitive C2 domains and a glutamine-rich region contribute equally to full activity in vivo. (sdbonline.org)
Thus, upon binding to GTP, the duration of Ras-GTPase activity is limited by the rate at which it hydrolyzes its bound GTP to GDP. (bionity.com)
RGS proteins display GAP activity towards either Gα i/o or Gα q/11 type G proteins, thereby shortening the duration that Gα is GTP bound and βγ is free. (sigmaaldrich.com)
In particular, we propose that Arg 85 and Asn 194 are involved in binding G proteins and enhancing GTPase activity. (embl-heidelberg.de)
Classical GAP proteins accelerate GTPase activity by supplying an arginine finger to the active site. (embl.de)
These results provide a novel mechanism whereby the SH2 domain of cten-mediated focal adhesion localization of DLC-1 plays an essential role in its tumor suppression activity. (rupress.org)

Evolution of the Rab family of small GTP-binding proteins. (nih.gov)
SH3 (Src Homolgy 3) domains are small protein modules of about 50-60 residues. (eu.org)

Glioblastoma multiforme (GBM) is the most prevalent primary malignant brain tumor and, remains one of the most lethal cancers, with a median survival of only 15 months upon diagnosis 1 . (nature.com)
Meanwhile, the DOC-2/DAB2 interacting protein DAB2IP was previously identified as a member of the Ras-GTPase activating protein family, and functions as a tumor suppressor in cancer progression 7 , 8 . (nature.com)
Furthermore, these DLC-1 mutants have lost their tumor suppression activities. (rupress.org)
The tuberous sclerosis protein (TSC) complex acts as a relay for anabolic signaling and as a tumor suppressor. (tugraz.at)

Anatomy40

Organisms13

Chemicals and Drugs130

Analytical, Diagnostic and Therapeutic Techniques and Equipment17

Phenomena and Processes52

Information Science3

Health Care1

Kinase21

GAPs9

Intrinsic GTPase activity2

Factor GTPase-activat2

Regulates2

Subunit1

Motif4

Mutations9

Adaptor2

Guanine2

Binds6

Effector proteins2

Kinases3

GTPases4

Hydrolysis2

P1202

Domain-binding1

Encodes3

Regulators2

Ribosylation2

Receptor2

Molecular4

PMID1

Receptors2

Mammalian3

Cdc422

Regulation2

Contain a conserved1

Biol1

Intracellular3

Active GTP-bound2

MRNA3

SynGAP2

Inhibitor1

Cytoskeletal1

Actin2

Cellular2

Cytoplasmic1

RhoGAP6

Pathway1

Inactivation1

Function7

Bind1

Integrin1

Effectors1

Cell adhesion1

Targets2

MTORC13

Glucose1

Rac12

Coat proteins1

Sequence1

Mutation1

Stimulates1

Phosphorylation2

RhoA1

20231

Activity6

Small2

Tumor4