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  • enzyme
  • Thus, the two substrates of this enzyme are GTP and H 2 O , whereas its 3 products are formate , 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine , and diphosphate . (wikipedia.org)
  • The systematic name of this enzyme class is GTP 7,8-8,9-dihydrolase (diphosphate-forming) . (wikipedia.org)
  • transgenic
  • GTP cyclohydrolase-1 transgenic (Tg) mice demonstrated a significant increase in baseline urine NO-to-creatinine ratio and a more significant increase in renal iNOS expression and serum NO levels with LPS treatment compared with the wild-type (WT) mice. (ox.ac.uk)
  • Mice
  • GTP cyclohydrolase I responds to hormonal treatment and is found altered in a variety of mice with genetically based neurological and immunological disorders. (unt.edu)
  • Genetic
  • Genetic loci can greatly modify the activity of GTP cyclohydrolase: Punch mutant in Drosophila hph-1 in mouse and atypical phenylketonuria in human. (unt.edu)
  • mutant
  • Enzymatic activity was determined by the measurement of fluorescent converted neopterin with assay validation by using mutant and GTP analogue. (beds.ac.uk)
  • known
  • The potential to use the assay for inhibitor screening was validated by 8-oxo-GTP, a known GTP analogue inhibitor. (beds.ac.uk)
  • site
  • The structure contains, in the active site, five GTP molecules and Ca(2+) ions probably from crystallization in place of Zn(2+) determined by atomic distances and fluorescence spectrum. (csgid.org)
  • effect
  • The inhibitor test against P. falciparum GCH1 is now possible as indicated by the inhibitory effect by 8-oxo-GTP. (beds.ac.uk)