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  • PMID
  • Vesicles have specific coat proteins (such as clathrin or coatomer) that are important for cargo selection and direction of transfer [ PMID: 15261670 ]. (ebi.ac.uk)
  • While clathrin mediates endocytic protein transport, and transport from ER to Golgi, coatomers primarily mediate intra-Golgi transport, as well as the reverse Golgi to ER transport of dilysine-tagged proteins [ PMID: 14690497 ]. (ebi.ac.uk)
  • For example, the coatomer COP1 (coat protein complex 1) is responsible for reverse transport of recycled proteins from Golgi and pre-Golgi compartments back to the ER, while COPII buds vesicles from the ER to the Golgi [ PMID: 11208122 ]. (ebi.ac.uk)
  • Coatomers reversibly associate with Golgi (non-clathrin-coated) vesicles to mediate protein transport and for budding from Golgi membranes [ PMID: 17041781 ]. (ebi.ac.uk)
  • Coatomer protein complex I (COPI)-coated vesicles are involved in transport between the endoplasmic reticulum and the Golgi but also participate in transport from early to late endosomes within the endocytic pathway [ PMID: 12893528 ]. (ebi.ac.uk)
  • individual subunits
  • The individual subunits of the G protein complex were first identified in 1980 when the regulatory component of adenylate cyclase was successfully purified, yielding three polypeptides of different molecular weights. (wikipedia.org)
  • The Gβγ subunit is a dimer composed of two polypeptides, however it acts functionally as a monomer, as the individual subunits do not separate, and have not been found to function independently. (wikipedia.org)
  • They present a unique opportunity to address the physiological roles of individual subunits of heterotrimeric G-proteins because their phototransduction cascade is mediated by a single G-protein transducin (Gt) that consists of Gtα 1 (Gtα), Gtβ 1 (Gtβ), and Gtγ 1 (Gtγ) isoforms. (jneurosci.org)
  • vitro
  • Further, we identify Fos transcription factors as novel interactors of the Gbeta1 subunit, using protein fragment complementation assays, as well as co-immunoprecipitation in vivo and in vitro. (biomedsearch.com)
  • novel
  • Our data indicate a novel role for Gbetagamma subunits as transcriptional regulators. (biomedsearch.com)
  • Structural similarities between Ruk, CIN85 and CD2AP/CMS suggest that these proteins form a novel family of adaptor molecules that are involved in various intracellular signalling pathways. (embl-heidelberg.de)
  • p110
  • In contrast, a truncated p85(1-333), which lacks the SH2 and iSH2 domains and does not bind p110, had no effect on EGF-stimulated mitogenesis but still blocked EGF-stimulated lamellipod extension. (embl-heidelberg.de)
  • Mice
  • Increasing the expression of the RGS14 protein in the V2 secondary visual cortex of mice promotes the conversion of short-term to long-term object-recognition memory. (wikipedia.org)
  • phosphorylation sites
  • We have detected 6,600 phosphorylation sites on 2,244 proteins and have determined their temporal dynamics after stimulating HeLa cells with epidermal growth factor (EGF) and recorded them in the Phosida database. (genes2cognition.org)
  • Surprisingly, a majority of proteins contain multiple phosphorylation sites showing different kinetics, suggesting that they serve as platforms for integrating signals. (genes2cognition.org)