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  • PMID
  • Vesicles have specific coat proteins (such as clathrin or coatomer) that are important for cargo selection and direction of transfer [ PMID: 15261670 ]. (ebi.ac.uk)
  • While clathrin mediates endocytic protein transport, and transport from ER to Golgi, coatomers primarily mediate intra-Golgi transport, as well as the reverse Golgi to ER transport of dilysine-tagged proteins [ PMID: 14690497 ]. (ebi.ac.uk)
  • For example, the coatomer COP1 (coat protein complex 1) is responsible for reverse transport of recycled proteins from Golgi and pre-Golgi compartments back to the ER, while COPII buds vesicles from the ER to the Golgi [ PMID: 11208122 ]. (ebi.ac.uk)
  • Coatomers reversibly associate with Golgi (non-clathrin-coated) vesicles to mediate protein transport and for budding from Golgi membranes [ PMID: 17041781 ]. (ebi.ac.uk)
  • Coatomer protein complex I (COPI)-coated vesicles are involved in transport between the endoplasmic reticulum and the Golgi but also participate in transport from early to late endosomes within the endocytic pathway [ PMID: 12893528 ]. (ebi.ac.uk)
  • encodes
  • The human genome encodes roughly 800 G protein-coupled receptors, which detect photons of light, hormones, growth factors, drugs, and other endogenous ligands. (wikipedia.org)
  • phosphorylation
  • Cell signaling mechanisms often transmit information via posttranslational protein modifications, most importantly reversible protein phosphorylation. (genes2cognition.org)
  • We have detected 6,600 phosphorylation sites on 2,244 proteins and have determined their temporal dynamics after stimulating HeLa cells with epidermal growth factor (EGF) and recorded them in the Phosida database. (genes2cognition.org)
  • Surprisingly, a majority of proteins contain multiple phosphorylation sites showing different kinetics, suggesting that they serve as platforms for integrating signals. (genes2cognition.org)
  • p110
  • In contrast, a truncated p85(1-333), which lacks the SH2 and iSH2 domains and does not bind p110, had no effect on EGF-stimulated mitogenesis but still blocked EGF-stimulated lamellipod extension. (embl-heidelberg.de)
  • Gbetagamma
  • Here, we show that co-expression of the Gbetagamma dimer decreased phorbol 12-myristate 13-acetate (PMA)-stimulated AP-1 gene reporter activity in HEK293 cells as well as the AP-1 dependent gonadotropin-releasing hormone-stimulated human follicle-stimulating hormone beta reporter activity in LbetaT2 gonadotrope cells. (biomedsearch.com)
  • Gbetagamma did not interfere with the dimerization of Fos and Jun or their ability to bind DNA. (biomedsearch.com)
  • polypeptide
  • Folding of the β-subunit is thought to be aided by the chaperone CCT (chaperonin containing tailless-complex polypeptide 1), which also prevents aggregation of folded subunits. (wikipedia.org)