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  • lipid
  • Increased Gsα within blood cell membrane lipid microdomains in some depressive disorders: an exploratory study. (nih.gov)
  • residues
  • An activated PKA has the ability to phosphorylate serine and threonine residues on substrate proteins which then initiate a variety of responses within the cell. (statpearls.com)
  • Thus prediction of GTP interacting residues in a protein is one of the major challenges in the field of the computational biology. (biomedcentral.com)
  • In this study, an attempt has been made to develop a computational method for predicting GTP interacting residues in a protein with high accuracy (Acc), precision (Prec) and recall (Rc). (biomedcentral.com)
  • In this work, we have introduced a new concept of predicting GTP interacting dipeptide (two consecutive GTP interacting residues) and tripeptide (three consecutive GTP interacting residues) for the first time. (biomedcentral.com)
  • A web server "GTPBinder" http://www.imtech.res.in/raghava/gtpbinder/ based on above models has been developed for predicting GTP interacting residues in a protein. (biomedcentral.com)
  • Finding and predicting nucleotide-binding residues in a protein structures are important for understanding the function of these proteins. (biomedcentral.com)
  • But this motif is not sufficient for identification of all GTP interacting residues. (biomedcentral.com)
  • In this study, we have used the second approach for predicting GTP interacting residues in a protein from its amino acid sequence. (biomedcentral.com)
  • affinity
  • They are often N-terminally acylated, usually with myristate and/or palmitoylate, and these fatty acid modifications are probably important for membrane association and high-affinity interactions with other proteins. (embl.de)
  • consist
  • These 343 (176 different) mutations are scattered throughout the 13 exons that encode Gs-alpha and consist of 44.9% frameshift, 28.0% missense, 14.0% nonsense, and 9.0% splice-site mutations, 3.2% in-frame deletions or insertions, and 0.9% whole or partial gene deletions. (ox.ac.uk)
  • enzymes
  • This enzyme converts adenosine triphosphate (ATP) to cAMP, which activates specific phosphorylating enzymes or protein kinases to produce the physiologic response. (brainstrom.org)
  • mutations
  • PHP1a is caused by maternally inherited inactivating mutations of Gs-alpha, which is encoded by a complex imprinted locus termed GNAS. (ox.ac.uk)
  • The clinical aspects and molecular genetics of PHP1a and its related disorders are reviewed together with the 343 kindreds with Gs-alpha germline mutations reported so far in the literature. (ox.ac.uk)
  • Heterozygous G(s)alpha mutations lead to obesity in Albright hereditary osteodystrophy (AHO) patients and in mice. (duke.edu)
  • cell and mol
  • Because the B subunit appears to be relatively non-toxic, researchers have found a number of applications for it in cell and molecular biology. (wikipedia.org)
  • Gnas
  • The GNAS locus is imprinted in a complex manner, giving rise to distinct paternally, maternally and biallelically expressed proteins. (uniprot.org)
  • mechanism
  • We use double electron-electron resonance spectroscopy and protein engineering to confirm predictions of our computationally determined mechanism. (mcw.edu)
  • Cholera toxin acts by the following mechanism: First, the B subunit ring of the cholera toxin binds to GM1 gangliosides on the surface of target cells. (wikipedia.org)