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  • kinase pathway
  • BRAF and NRAS are common targets for somatic mutations in benign and malignant neoplasms that arise from melanocytes situated in epithelial structures, and lead to constitutive activation of the mitogen-activated protein (MAP) kinase pathway. (nih.gov)
  • affinity
  • They are often N-terminally acylated, usually with myristate and/or palmitoylate, and these fatty acid modifications are probably important for membrane association and high-affinity interactions with other proteins. (embl.de)
  • pertussis
  • Many alpha subunits are substrates for ADP-ribosylation by cholera or pertussis toxins. (embl.de)
  • Publications] Y.Watanabe: 'Changes of ADP-ribosylation of GTP-binding protein by pertussis toxin in human platelets during long term treatment of manic depression with lithium carbonate. (nii.ac.jp)
  • cDNA
  • The complete sequences of 60 new cDNA clones from brain which code for large proteins. (genes2cognition.org)
  • As an extension of a sequencing project of human cDNA clones which encode large proteins of unidentified genes, we herein present the entire sequences of 60 cDNA clones for the genes named KIAA1879-KIAA1938. (genes2cognition.org)
  • The cDNA clones were isolated from size-fractionated cDNA libraries derived from human fetal brain, adult whole brain and amygdala, and their protein-coding sequences were predicted. (genes2cognition.org)
  • Molecular
  • G protein alpha subunits are 350-400 amino acids in length and have molecular weights in the range 40-45 kDa. (embl.de)
  • The main difference in the molecular sizes of yeast GP1 alpha (472 amino acids) and rat brain Gi alpha (355 amino acids) is due to the presence of a stretch of 110 extra amino acid residues in yeast GP1 alpha, which are inserted near the NH2-terminal one-third of mammalian Gi alpha. (pnas.org)
  • homologous
  • The GTP-binding domain is homologous to Ras-like small GTPases, and includes switch regions I and II, which change conformation during activation. (embl.de)
  • cellular
  • These cellular and behavioral phenotypes identify Gαo as the primary G-protein α-subunit mediating the detection of peptide and protein pheromones by sensory neurons of the VNO. (duke.edu)