Metabolic alterations in cancer cells are numerous and include aerobic glycolysis, reduced oxidative phosphorylation, and increased generation of biosynthetic intermediates needed for cell growth and proliferation. (biomedcentral.com)
Cells1
While we could not detect an altered phenotype in the PEPC1 knockout strains at ambient, low or high DIC concentrations, PEPC2 and the double-knockout strains grown under ambient air or lower DIC availability, showed reduced growth and photosynthetic affinity to DIC, while behaving similarly as WT cells at high DIC concentrations. (uni-konstanz.de)
Factor2
We also found that miR-301a-3p targets the proapoptotic UPR factor growth arrest and DNA-damage-inducible alpha ( GADD45A ). (biomedcentral.com)
However, two cytosolic PPIases, PpiB and trigger factor, in Bacillus subtilis have been shown not to possess an essential function under normal growth conditions, but they become essential for cell viability under starvation conditions [ 13 ]. (biomedcentral.com)
Binding-epidermal1
14. [Expression and significance of heparin binding-epidermal growth factor-like growth factor in paclitaxel-resistant ovarian cancer]. (nih.gov)
Epidermal growth f1
Human epidermal growth factor receptor 2-targeted (HER2-targeted) therapy is the mainstay of treatment for HER2+ breast cancer. (bvsalud.org)
Inhibition3
6. Caffeic acid phenethyl ester induced cell cycle arrest and growth inhibition in androgen-independent prostate cancer cells via regulation of Skp2, p53, p21Cip1 and p27Kip1. (nih.gov)
13. Tunicamycin potentiates paclitaxel-induced apoptosis through inhibition of PI3K/AKT and MAPK pathways in breast cancer. (nih.gov)
Importantly, inhibition of DPAGT1 with tunicamycin acted synergistically with trastuzumab treatment to block HER2 signaling and reverse resistance. (bvsalud.org)
HER21
These findings reveal a prominent mechanism for HER2 shedding and suggest that targeting DPAGT1 might be a promising strategy against trastuzumab-resistant breast cancer. (bvsalud.org)
Vitro3
5. Honokiol inhibits in vitro and in vivo growth of oral squamous cell carcinoma through induction of apoptosis, cell cycle arrest and autophagy. (nih.gov)
16. Mifepristone inhibits ovarian cancer cell growth in vitro and in vivo. (nih.gov)
The family of peptides consists of two closely related peptides, each 23 amino acids, that inhibit growth of numerous species of bacteria and fungi in vitro. (nih.gov)
Stress1
We found that a double mutant of Arabidopsis IRE1A and IRE1B ( ire1a/ire1b ) is more sensitive to the ER stress inducer tunicamycin than the wild-type. (nature.com)
Estrogen1
15. Annonacin induces cell cycle-dependent growth arrest and apoptosis in estrogen receptor-α-related pathways in MCF-7 cells. (nih.gov)