Growth factors glial cell line derived neurotrophic factor. Medical search. Frequent questions

Enovin, a member of the glial cell-line-derived neurotrophic factor (GDNF) family with growth promoting activity on neuronal cells. (wikipedia.org)
Here we show that these neurons express the receptor components for glial-derived neurotrophic factor (GDNF) signaling (RET, GFRα-1, and GFRα-2). (jneurosci.org)
GDNF, but not nerve growth factor (NGF), can prevent several axotomy-induced changes in these neurons, including the downregulation of IB4 binding, TMP activity, and somatostatin expression. (jneurosci.org)
GDNF also prevents the slowing of conduction velocity that normally occurs after axotomy in a population of small diameter DRG cells and the A-fiber sprouting into lamina II of the dorsal horn. (jneurosci.org)
The aim of this study is to learn if rat BMSC express brain-derived neurotrophic factor (BDNF) and glia-derived nerve factor (GDNF) and determine if this expression varies according to the number of culture passages. (sld.cu)
GDNF production in individual cells in the culture was analyzed by Immunocytochemistry. (sld.cu)
El objetivo de este trabajo consistió en demostrar si las CEMO expresan los factores neurotróficos derivados de cerebro y de línea de células gliales (BDNF y GDNF, respectivamente) y determinar si esta expresión varía en relación con el número de pases en cultivo. (sld.cu)
La producción de GDNF por las células individuales en cultivo se analizó mediante Inmunocitoquímica. (sld.cu)
Sin embargo, la producción de GDNF solo tuvo lugar en los pases 7 y 12. (sld.cu)
On the other hand, the glial cell line-derived neurotrophic factor (GDNF) has the strongest trophic effect on dopaminergic neurons (10). (sld.cu)
Persephin (PSPN) is a neurotrophic factor that belongs to the glial cell line-derived neurotrophic factor (GDNF) family. (creative-bioarray.com)
On day E10.5 of murine development, the metanephric mesenchyme secretes glial cell line-derived neurotrophic factor (GDNF). (j-organoid.org)
In this category of experimentation, besides the use of locally delivered trophic factors (such as brain-derived neurotrophic factor (BDNF)-, glial cell line-derived neurotrophic factor (GDNF)-, and fibroblast growth factor (FGF)-peptides or growth factors-gene-encoding vectors) [ 8 ], regionally grafted fetal or embryonic stem cell-derived neuronal precursors are frequently used [ 9 - 18 ]. (biomedcentral.com)
Cerebrolysin is a mixture of peptides purified from pig brains, including brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), nerve growth factor (NGF), and ciliary neurotrophic factor (CNTF). (epiphanyasd.com)
In contrast, laminin alone is not sufficient to stimulate significant neurite growth from lectin Griffonia simplicifolia 1B4 positive neurons (IB4+ve), although it is still required to elicit a growth response from these cells in the presence of Glial Cell Line Derived Neurotrophic Factor (GDNF) (e.g., neurite growth occurred only when cells were plated on laminin in the presence of GDNF). (mun.ca)
The sodium channels SNS/PN3 and NaN/SNS2 are regulated by the neurotrophic factors-nerve growth factor (NGF) and glial-derived neurotrophic factor (GDNF), and may play an important role in the development of pain after nerve injury or inflammation. (ox.ac.uk)
and also back-signals the cell nuclei to express more GDNF by effectively creating a loop. (ibogaine-thailand.net)
The GDNF family ligands (GFLs) function through a glycosyl-phosphatidylinositol-(GPI) anchored coreceptor, GDNF family receptor alpha (GFRα), and rearranged during transfection (RET), a well-known receptor tyrosine kinase involved in kidney development, spermatogonial stem cell maintenance, and the development and maintenance of the sympathetic, parasympathetic, and enteric nervous systems [ 1 , 2 ]. (medsci.org)
We propose that RET receptors expressed ectopically on ureteric bud trunk cells sequester GDNF, reducing its availability to the normal target cells at the bud tips. (ox.ac.uk)
This suggests that RET signaling is not only necessary but is sufficient to induce ureteric bud growth, and that the orderly, centripetal growth of the bud tips is controlled by the spatially and temporally regulated expression of GDNF and RET. (ox.ac.uk)
BDNF, together with glial cell line-derived neurotrophic factor (GDNF) and other supplements, is commonly used to differentiate human pluripotent stem cell (hPSC)-derived neural progenitor cells into neurons (Brafman). (stemcell.com)

In recent years, the MAPK family has been found to be an important signal-regulating enzyme between cell surface receptors and determinants of gene expression ( 8 ). (spandidos-publications.com)
In protein science, Neurotrophins are a family of closely related growth factor proteins , that in the body, induce the survival, development and function of neurons, by activating at least two different classes of receptors, the Trk family of receptor tyrosine kinases and the p75NTR, a member of the TNF receptor superfamily. (wellnessadvantage.com)
Estrogens (targeting Estrogen Receptors beta (ER-β) can act as neuroprotective agents, promoting synaptic plasticity and neurite outgrowth, and health benefits derived from flavonoids, as the flavonol epigallocatechin gallate (EGCG), phytoestrogens of natural origin are partially explained by their interaction with membrane ER. (epiphanyasd.com)
Axon Guidance Molecules and Receptors (controls axon growth directions by attracting or repelling growth cones on the tips of axons) - netrins, ephrins, semaphorins, etc. (abnova.com)
However, it is becoming increasingly clear that these factors and their receptors are also widely found to express across many different cancers with further research. (medsci.org)

It has been described that the brainderived neurotrophic factor (BDNF) regulates neurotransmitter release and dendritic and axonal growth. (sld.cu)
As we have seen in previous posts the various growth factors (BDNF, NGF, IGF-1 etc) are disturbed in autism and they play a key role in various signaling cascades. (epiphanyasd.com)
BDNF acts as a survival factor for human embryonic stem cells when plated on either feeder cells or Corning® Matrigel® (Pyle et al. (stemcell.com)
A) The biological activity of Human Recombinant BDNF was tested by its ability to promote the proliferation of a neuroblastoma cell line stably expressing TrkB (BR6). (stemcell.com)

Artemin has also been found to support the survival neurons in later stages of development and can enhance neuron growth better than neural growth factor during later stages of development. (wikipedia.org)
However, during target innervation, sympathetic neurons become dependent on neural growth factor for survival support. (wikipedia.org)
Monocytes deliver bioactive nerve growth factor through a brain capillary endothelial cell-monolayer in vitro and counteract degeneration of cholinergic neurons. (uibk.ac.at)
Rotenone induces cell death of cholinergic neurons in an organotypic co-culture brain slice model. (uibk.ac.at)
In addition, the addition of VEGF to the culture medium can increase the survival rate of neurons in the cerebral cortex as well as the number and length of ganglion cell processes, to promote nerve growth. (spandidos-publications.com)
In the body, the nerve tissue protein , Nerve Growth Factor (NGF) belongs to family of factors known as neurotrophins , is a small secreted amino acid complex important for the growth (a growth factor ), maintenance, and survival of certain target neurons (nerve cells), such as the found in the sympathetic and parasympathetic nervous system. (wellnessadvantage.com)
In our body, the neurotrophins were first identified as survival factors for sympathetic and sensory neurons, and have since been shown to control a number of aspects of survival, development, and function of neurons in both the central and peripheral nervous systems. (wellnessadvantage.com)
PSPN only promotes the growth and survival of central dopaminergic and motor neurons, but not peripheral neurons. (creative-bioarray.com)
Our findings revealed that TGF-β1 is effective in the treatment of neuropathic by targeting both neurons and glial cells. (biomedcentral.com)
As a result of either primary injury to sensory neurons via mechanical insults or as a secondary consequence of apoptotic cell death, damaged neurons release a number of substances such as cytokines, chemokines, excitatory amino acids and ATP, which can in turn trigger surrounding glial activation [ 12 ]. (biomedcentral.com)
Magnetic resonance imaging volume reconstruction and immunofluorescence analysis of grafted cell survival showed near complete injury-cavity-filling by grafted cells and development of putative GABA-ergic synapses between grafted and host neurons. (biomedcentral.com)
A separate group of experimental treatment modalities is aimed at improving the local neurotrophic activity at and around the injury epicenter with the primary goal of increasing the survival of partially injured axons and/or neurons. (biomedcentral.com)
In this thesis, I initially investigated whether attachment to permissive culture substrates is sufficient to promote neurite outgrowth from DRG neurons, and whether this interaction is able to enhance the response of neurons to added neurotrophic factors, such as NGF. (mun.ca)
Adult Dorsal Root Ganglion (DRG) neurons plated on surfaces coated with a thin film of laminin exhibited increased neurite outgrowth, this growth was correlated with increased expression of laminin binding integrin subunits. (mun.ca)
In performing these experiments it was observed that not all DRG neurons were responding to laminin and NGF with increased neurite growth. (mun.ca)
As neurons in the adult rat DRG can be classified into at least three separate subpopulations based on morphologic and phenotypic differences, a cell selection approach was utilized to show that laminin-induced neurite growth occurs in the absence of added trophic factors only in heavy chain neurofilament positive and calcitonin gene related peptide positive DRG neurons (NGF-responsive population). (mun.ca)
Further analysis indicated that Src was potentially a key point of collaboration between NGF and laminin induced neurite growth in NGF-responsive adult DRG neurons. (mun.ca)
In this series of studies we have identified specific signalling events and environmental requirements associated with neurite growth for different subpopulations of adult DRG neurons, pointing to potential therapeutic targets while identifying why any one treatment alone maybe insufficient to totally repair peripheral nerve damage. (mun.ca)
Cells called "microglia" that normally support and nourish neurons start attacking neurons and eating their synapses. (concussionisbraininjury.com)
The brain is normally a happy little place of neurons that send messages that give us our emotions, thoughts, senses, movements, heartbeat, etc. and their supporting glia cells along with tiny but mighty defenders. (concussionisbraininjury.com)
Neurotrophic Factors (a family of proteins that induce the survival, development, and function of neurons) - neurotrophins, glial cell-line derived neurotrophic factor family ligands, neuropoietic cytokines, etc. (abnova.com)
It also has a role in neurogenesis by promoting survival and growth of dorsal root ganglion cells, and hippocampal and cortical neurons (Binder & Scharfman). (stemcell.com)

et al "Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations" Genomics. (wellnessadvantage.com)
In addition, significant changes in persephin, glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor mRNA expression were observed. (mcmaster.ca)
Levels of neurotrophins (brain-derived neurotrophic factor, neurotrophin-3, nerve growth factor, glial cell line-derived neurotrophic factor) were determined by ELISA assays. (anaisdedermatologia.org.br)

Growth factors and cytokines/ chemokines as surrogate biomarkers in cerebrospinal fluid and blood for diagnosing Alzheimer´s disease and mild cognitive impairment. (uibk.ac.at)
The ovarian microenvironment affects the proliferation and differentiation of OGSCs, and immune cells and related cytokines are important components of the microenvironment. (biomedcentral.com)
With increasing time, the fluorescence intensity of cells gradually increased, and the cytokines IL-2 and TNF-α significantly promoted the proliferation of OGSCs. (biomedcentral.com)

Like other FGF family members, basic fibroblast growth factor possess broad mitogenic and cell survival activities, and is involved in a variety of biological processes, including embryonic development , cell growth , morphogenesis , tissue repair , tumor growth and invasion. (wikidoc.org)
Neurotrophic factors promote neuronal survival and stimulate axonal growth (6). (sld.cu)
A family of closely related nerve growth factors that promote NEURON survival. (childrensmercy.org)
Therefore, the MAPK family governs almost all the physiological functions and processes such as cell adaptation, proliferation, differentiation, survival, and programmed cell death. (spandidos-publications.com)
This cytokine is produced without using animal derived components in culture process.Four colony-stimulating factors possessing the ability to promote survival, proliferation and differentiation of bone marrow progenitor cells have been identified: GM-CSF, G-CSF, M-CSF and IL-3. (fujifilm.com)
The glial cell line-derived neurotrophic factors (GDNFs), a family of neurotrophic factors, were initially thought to be able to regulate the growth, survival, and differentiation of neural-derived cell types. (medsci.org)

et al "Human chromosome 19 contains the neurotrophin-5 gene locus and three related genes that may encode novel acidic neurotrophins" Somat Cell Mol Genet. (wellnessadvantage.com)
These factors include neurotrophins, such as Nerve Growth Factor (NGF), and adhesion molecules, such as laminin. (mun.ca)

However, despite having the promising outcome of preclinical studies, the clinical application of stem cell therapy remained elusive due to little or no progress in clinical trials. (hindawi.com)
The objective of this study was to provide a generalized critique for the role of mesenchymal stem cell therapy in ischemic stroke injury, its underlying mechanisms, and constraints on its preclinical and clinical applications. (hindawi.com)
Thus, we attempted to present an overview of previously published reports to evaluate the progress and provide molecular basis of mesenchymal stem cells (MSCs) therapy and its application in preclinical and clinical settings, which could aid in designing an effective regenerative therapeutic strategy in the future. (hindawi.com)
However, effective dose and appropriate time of MSCs delivery are the main challenges in the clinical translation of stem cell therapy. (hindawi.com)
We aim to provide the basis for establishing a future study to promote the clinical translation of stem cell therapy in ischemic brain diseases. (hindawi.com)
Because of this alternative use of MSCs, Caplan and Sorell [ 14 ] suggested a renaming of MSCs to medicinal signaling cells to suggest a new era of MSC clinical relevance due to their immunomodulatory properties. (biomedcentral.com)
Here we characterized the effect of intraspinal grafting of clinical grade human fetal spinal cord-derived neural stem cells (HSSC) on the recovery of neurological function in a rat model of acute lumbar (L3) compression injury. (biomedcentral.com)
Since neurotrophic factors are the primary architects of neurogenesis, synaptic plasticity, learning, and memory, the findings from preclinical and clinical studies that assess changes in neurogenesis and neurotrophic factors and their relationship to cognitive performance in schizophrenia, and how these mechanisms might be impacted by APD treatment, may provide valuable clues in developing therapies to combat cognitive deficit in schizophrenia. (benthamscience.com)
In this context, results from initial clinical trials with neurotrophic factors and their future potential to improve cognition and psychosocial functioning in schizophrenia are discussed. (benthamscience.com)

[3] [5] FGF2 binds to and exerts effects via specific fibroblast growth factor receptor (FGFR) proteins which themselves constitute a family of closely related molecules. (wikidoc.org)

Increases in the mRNA and protein expression of the novel neurotrophic factors, conserved dopamine neurotrophic factor and mesencephalic astrocyte-derived neurotrophic factor, were detected in the hippocampus and/or striatum. (mcmaster.ca)

Interactions between the immune and nervous systems occur at multiple levels, where different types of immune/glial cells and immune-derived substances are implicated in various stages of pathogenesis [ 3 ]. (biomedcentral.com)
It is worth noting that the proliferation and differentiation of stem cells cannot be separated from the surrounding microenvironment, and immune system related cells are an important part of the microenvironment of the OGSCs nest [ 14 ]. (biomedcentral.com)
SCFAs are well known for their anti-inflammatory functions by modulating immune cell chemotaxis, reactive oxygen species (ROS) release as well as cytokine release. (cytoplan.co.uk)
Neurotransmitters go out of balance as a result while the attacking cells send messages through the brain and into the immune system to proliferate the attack. (concussionisbraininjury.com)
Microglia are tiny immune cells in the brain and body that make up one-tenth of all brain cells. (concussionisbraininjury.com)

Intraspinal grafting of human neural stem cells represents a promising approach to promote recovery of function after spinal trauma. (biomedcentral.com)
Other Targets Relating to Neural Stem Cell Development. (abnova.com)
450+ antibodies for neural stem cells as the main phenotypes of the nervous system. (abnova.com)

GDNFs are unique in having neurotrophic properties and have potential use for gene therapy in neurodegenerative disease. (wikipedia.org)

Artemin is a neurotrophic factor in the glial cell line-derived neurotrophic factor family of ligands which are a group of ligands within the TGF-beta superfamily of signaling molecules. (wikipedia.org)

FGF2 , also known as basic fibroblast growth factor (bFGF) and FGF-β, is a growth factor and signaling protein encoded by the FGF2 gene . (wikidoc.org)
Fibroblast growth factor protein was first purified in 1975, but soon afterwards others using different conditions isolated basic FGF, Heparin-binding growth factor-2, and Endothelial cell growth factor-2. (wikidoc.org)
It was also shown to act on preosteoblasts - in the form of an increased proliferation - after binding to fibroblast growth factor receptor 1 and activating phosphoinositide 3-kinase . (wikidoc.org)
Basic fibroblast growth factor has been shown to interact with casein kinase 2, alpha 1 , [13] RPL6 [14] and ribosomal protein S19 . (wikidoc.org)
Meanwhile, the ureteric bud secretes Wnt-9b and fibroblast growth factor 9 (FGF9), which differentiate the metanephric mesenchyme into pretubular aggregates. (j-organoid.org)

SCFAs might directly influence the brain by reinforcing Blood Brain Barrier (BBB) integrity, modulating neurotransmission, influencing levels of neurotrophic factors and promoting memory consolidation. (cytoplan.co.uk)

40+ antibodies for semaphorins that act as axonal growth cone guidance molecules. (abnova.com)

Bone marrow stromal cells (BMSC) are multipotent stem cells and are considered good candidates for cell restoration in injured brain tissue. (sld.cu)
Bone marrow stromal cells (BMSC) are adult stem cells with characteristics that make them an attractive candidate in cellular therapy for neurological diseases (1). (sld.cu)
Neuropeptide Y and Neuropeptide Y Y5 Receptor Interaction Restores Impaired Growth Potential of Aging Bone Marrow Stromal Cells. (abnova.com)

This factor promotes the growth and branching of the ureteric bud. (j-organoid.org)
During kidney development, factors from the metanephric mesenchyme induce the growth and repeated branching of the ureteric bud, which gives rise to the collecting duct system and also induces nephrogenesis. (ox.ac.uk)

Hypoxia inducible factor-1 (HIF-1) is an oxygen-sensitive transcriptional regulator that regulates more than 70 downstream target genes, including vascular endothelial growth factor, erythropoietin, glucose transporter and so on ( 5 ). (spandidos-publications.com)

VEGF is purified from bovine pituitary follicular cells in 1959 and is a vascular endothelial cell-specific mitogen that promotes the growth of vascular endothelial cells. (spandidos-publications.com)
Produced by endothelial cells, monocytes, fibroblasts and T lymphocytes, GM-CSF is also known to inhibit neutrophil migration and boost mature cell functions. (fujifilm.com)

[10] FGF2, in conjunction with BMP4 , promote differentiation of stem cells to mesodermal lineages. (wikidoc.org)

both neurotrophic factors only are present after passage 7 which should be taken into account for their utilization as a therapeutic option of neurodegenerative diseases. (sld.cu)

HSP90 inhibition may also enhance synaptic protein expression via activation of heat shock factor 1 (HSF-1) transcriptional regulation 16 . (nature.com)
However, abnormal expression or aberrant activation of these molecules may convert normal growth signals to undesirable signals inducing overgrowth, becoming an important contributor to a variety of human cancers. (medsci.org)

We have reported that clinically relevant concentrations of valproic acid (VPA) up-regulate the G-protein-coupled melatonin MT1 receptor in rat C6 glioma cells. (mcmaster.ca)
Li Q, Cao Z, Zhao S. The Emerging Portrait of Glial Cell Line-derived Neurotrophic Factor Family Receptor Alpha (GFRα) in Cancers. (medsci.org)
Glial cell line-derived neurotrophic factor family receptor alpha (GFRα) members have been widely connected to the mechanisms contributing to cell growth, differentiation, cell migration and tissue maturation. (medsci.org)
Based on whether it cooperates with the second receptor RET, GFRα has also been widely linked to the mechanisms that contribute to cell growth, differentiation and migration and tissue maturation. (medsci.org)
Imatinib inhibits abl, kit, and platelet-derived growth factor receptor (PDGFR) tyrosine kinase. (medscape.com)

Furthermore, it was revealed that treatment with vitexin induced hypoxia inducible factor 1α subunit (HIF‑1α) and vascular endothelial growth factor (VEGF) protein expression, and suppressed phosphorylated‑p38 MAP kinase (p38) protein expression in sevoflurane‑induced newborn rat. (spandidos-publications.com)

Over 500 products have been investigated for neuroprotective effects including those from the categories of free radical scavengers, anti-excitotoxic agents, apoptosis (programmed cell death) inhibitors, anti-inflammatory agents, neurotrophic factors, metal ion chelators, ion channel modulators, and gene therapy. (researchandmarkets.com)

Endoplasmic reticulum stress activates autophagy but not the proteasome in neuronal cells: implications for Alzheimer's disease. (abnova.com)

Recently, a growing number of studies are focusing on mesenchymal stem cell-based therapies for neurodegenerative disorders. (hindawi.com)
The recent decade has seen encouraging outcomes of mesenchymal stem cell therapy that holds promise to alleviate the burden of neurological disorders Moreover, initial study data of preclinical trials have also indicated the effectiveness, tolerance, and safety of MSC-based therapy [ 10 ]. (hindawi.com)

The anterior intermediate mesoderm, which expresses LIM homeobox 1 ( Lhx1 ) and paired box gene 2 ( Pax2 ), develops into the ureteric bud lineage, which forms the ureteric epithelium through branching and growth. (j-organoid.org)
This caused a variable inhibition of ureteric bud growth and branching reminiscent of, but less severe than, the RET knockout phenotype. (ox.ac.uk)
Expression of a Hoxb7/RET-PTC2 transgene, encoding a ligand-independent form of RET kinase, caused the development of abnormal nodules, outside the kidney or at its periphery, containing branched epithelial tubules apparently formed by deregulated growth of the ureteric bud. (ox.ac.uk)
During nephrogenesis, multiple genes, transcription factors, and growth factors control the essential interaction between the ureteric bud and the metanephric mesenchyme. (medscape.com)

From a research, medical, and business standpoint, mesenchymal stem cell (MSC)-based therapies are fascinating. (biomedcentral.com)

Several lines of evidence suggest that neurotrophin administration may be of some therapeutic benefit in the treatment of peripheral neuropathy. (jneurosci.org)
Therapeutic measures for the prevention of hair cell loss are currently limited. (noiseandhealth.org)
We suggest that therapeutic agents such as TGF-β1 having multipotent effects on different types of cells could work in synergy to regain homeostasis in local spinal cord microenvironments, therefore contributing to attenuate neuropathic pain. (biomedcentral.com)

Osr1 -expressing cell clusters spatially regulate Six2 expression, which in turn induces the cap mesenchymal population. (j-organoid.org)

Mulitkinase inhibitor that targets several tyrosine kinase inhibitors implicated in tumor growth, pathologic angiogenesis, and metastatic progression. (medscape.com)

Since the first publication on generating kidney-like cell aggregates from pluripotent stem cells, various modifications have been made to develop more complex and detailed kidney structures. (j-organoid.org)

While acknowledging progress in the other areas mentioned, this work will focus on the current debates concerning sourcing, MSC alterations of angiogenesis, cell differentiation/stimulation, and strategies to improve MSC differentiation. (biomedcentral.com)

Promote growth and differentiation of colonocytes (cells that line the colon) by providing fuel thereby supporting the integrity of the digestive lining. (cytoplan.co.uk)
promote self-repair of residing tissue cells. (revitalife.co.in)

et al "6-shogaol, a neuroactive compound of ginger (jahe gajah) induced neuritogenic activity via NGF responsive pathways in PC-12 cells" BMC Complement Altern Med. (wellnessadvantage.com)
Recent mechanistic insights into the trophic activities of these cells point to ultimate regulation by nitric oxide, nuclear factor-kB, and indoleamine, among other signaling pathways. (biomedcentral.com)
However, both the PI3-K/Akt and MEK/MAPK signalling pathways were required for neurite growth from the IB4+ve cell population. (mun.ca)

Artemin is expressed in smooth muscle cells and secreted along blood vessels and in cells near sympathetic axonal projections so that the sympathetic axons can reach their target tissue cells. (wikipedia.org)
The response of target cells is further regulated by their microenvironment, involving the extracellular matrix, which may be modified by MSC-produced matrix metalloproteinases (MMPs) and tissue inhibitor of MMPs. (biomedcentral.com)
MSCs can be defined by their ability to adhere to tissue culture plastic, their expression of several cell surface molecular epitopes-cluster of differentiation CD73, CD90, and CD105, and others-as well as their lack of several surface markers, including CD45 [ 6 ]. (biomedcentral.com)
Differentiation and integration of grafted cells in the host tissue were validated with immunofluorescence staining using human-specific antibodies. (biomedcentral.com)

Herein, we presented an overview of a previously published work regarding the role of stem cell therapy in ischemic stroke and its underlying molecular mechanisms. (hindawi.com)

After differentiation, BMP4 and FGF2 treated cells generally produce higher amounts of osteogenic and chondrogenic differentiation than untreated stem cells. (wikidoc.org)

In lumbar dorsal root ganglia, virtually all IB4-labeled cells express RET mRNA, and the majority of these cells (79%) also express GFRα-1, GFRα-2, or GFRα-1 plus GFRα-2. (jneurosci.org)

In the body, a Nerve Growth Factor (NGF) functions as a signaling molecule, and play a role as a sympathetic and sensory nerve growth factor, with additional activities both within and outside the nervous system. (wellnessadvantage.com)

Both resident and bone marrow-derived microglia are involved in the central component of sensitization that enhances neuronal excitability. (biomedcentral.com)

Pain management, osteochondral, nerve, or blood vessel support by MSCs derived from both autologous and allogeneic sources have been examined. (biomedcentral.com)
Revita does not claim that any application or potential application, using autologous stem cells are approved by the FDA. (revitalife.co.in)

Kidney tubuloids derived from adult stem cells offer the advantage of long-term culture and expansion, but they include only tubular structures and lack glomerular components. (j-organoid.org)

Large diameter DRG cells mostly possess myelinated axons and respond principally to low threshold stimuli. (jneurosci.org)
Small diameter DRG cells, in contrast, have unmyelinated axons and are principally nociceptors and thermoceptors. (jneurosci.org)
Like growth and guidance of developing axons, regeneration after axonal injury is predominantly influenced by factors located in a neuron's extracellular environment. (mun.ca)
These specialized cells have thin projections called dendrites and axons. (abnova.com)

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