• 2001), and iii) the detection of N-linked glycosylation on an overexpressed extracellular domain of human FGFR4 suggested that the function of this receptor might also be regulated by glycosylation, similar to what occurs with other FGFRs (Tuominen et al. (atlasgeneticsoncology.org)
  • We conclude that EGF stimulates in vitro receptor autophosphorylation by inducing kinase-inactive receptor monomers to associate and form receptor dimers, in which conformation the autophosphorylation activity is enhanced. (pnas.org)
  • Different isoforms of the C. elegans FGF receptor are required for attraction and repulsion of the migrating sex myoblasts. (nih.gov)
  • These two receptor isoforms dimerize upon binding the PDGF dimer, leading to three possible receptor combinations, namely -αα, -ββ and -αβ. (wikidoc.org)
  • This book updates and extends the current literature and describes important novel approaches to the study of growth factors and their receptors, including the use of RNA aptamers as receptor antagonists, and the development of receptor superantagonists. (waterstones.com)
  • in other words, they were engineered in such a way that they lacked the TrkB receptor only in specific cell types at specific times. (scienceblogs.com)
  • The mutants lacking the TrkB receptor in the NPCs were then treated with fluoxetine (Prozac), imipramine (a tricyclic antidepressant) or saline (salt water) for 3 weeks and the amount of time they took to begin feeding was recorded and compared to healthy control mice. (scienceblogs.com)
  • Activation of the receptor is important for the innate immune response in human skin. (wikipedia.org)
  • We show that the FGFR-4 Arg(388) polymorphism, which is present in most prostate cancer patients, results in increased receptor stability and sustained receptor activation. (nih.gov)
  • Uncoupling of Grb2 from the Met receptor in vivo reveals complex roles in muscle development. (springer.com)
  • Abnormal polarization of EGF receptors and autocrine stimulation of cyst epithelial growth in human ADPKD. (springer.com)
  • Amphiregulin also appears to abrogate the stimulatory effect of TGF-alpha on the growth of several aggressive epithelial carcinomas that overexpress EGF receptor. (pnas.org)
  • Ronald Duman and his colleagues chronically administered different classes of antidepressants to rats, and found that this stimulated the growth of new neurons in the hippocampus. (scienceblogs.com)
  • In the second strain of mutants, in which the receptor was deleted in adulthood, there was a significant decrease in the number of newly-generated hippocampal neurons. (scienceblogs.com)
  • In the third strain, deletion of the receptor from differentiated neurons had no apparent effect. (scienceblogs.com)
  • The ligand-binding sites of the receptors are located to the three first immunoglobulin-like domains. (wikidoc.org)
  • 293T cells were transfected with V5-tagged FGFR-4 Arg 388 or Gly 388 and cell surface receptors labeled with biotin. (nih.gov)
  • These findings suggest that amphiregulin may interact with a separate receptor in certain cell types. (pnas.org)
  • Amphiregulin only partially competes with EGF for binding EGF receptor, and amphiregulin does not induce anchorage-independent growth of normal rat kidney cells (NRK) in the presence of TGF-beta. (pnas.org)
  • BDNF and other growth factors play essential roles during embryogenesis, but their functions are not restricted to development, and BDNF in particular has previously been implicated in depression. (scienceblogs.com)
  • CBD can be used as a novel therapeutic option to inhibit growth and metastasis of highly aggressive breast cancer subtypes including TNBC. (greenmedinfo.com)