Growth factor receptor tyrosine kinase. Medical search. Frequent questions

About 70% of the patients with EGFR mutations respond to EGFR tyrosine kinase inhibitors (TKIs) including gefitinib and erlotinib, whereas only 10% of those without the mutations do so. (nih.gov)
Personalized Radiation Oncology: Epidermal Growth Factor Receptor and Other Receptor Tyrosine Kinase Inhibitors. (ox.ac.uk)
A class of potent inhibitors of colony-stimulating factor-1 receptor (CSF-1R or FMS), as exemplified by 8 and 21, was optimized to improve pharmacokinetic and pharmacodynamic properties and potential toxicological liabilities. (rcsb.org)
Among them are the Sprouty proteins which mainly act as inhibitors of growth factor-dependent neuronal and glial signaling pathways. (springer.com)
Although PDGFRB fusions are rare, their identification is important in order to identify patients in whom targeted therapy with tyrosine kinase inhibitors is likely to be successful. (atlasgeneticsoncology.org)
In patients whose lung adenocarcinomas harbor epidermal growth factor receptor (EGFR) tyrosine kinase domain mutations, acquired resistance to the tyrosine kinase inhibitors (TKI) gefitinib (Iressa) and erlotinib (Tarceva) has been associated with a second-site EGFR mutation, which leads to substitution of methionine for threonine at position 790 (T790M). (aacrjournals.org)
Initial studies with the EGFR tyrosine kinase inhibitors (TKIs) gefitnib (Iressa) and erlotinib (Tarceva) demonstrated biologic and clinical activity in only a relatively limited subset of lung cancers. (medscape.com)
In general, the side-effect profile for pralsetinib is much better tolerated than pan-kinase inhibitors such as sorafenib (Nexavar) and lenvatinib (Lenvima). (medscape.com)
Although the majority of these mutations are rare in number, the therapies that act on these targets often are more tolerable than tyrosine kinase inhibitors that target primarily the vascular endothelial growth factor receptor and are likely to produce more durable responses. (medscape.com)
Which tyrosine kinase inhibitors are showing the most promise right now? (medscape.com)
Second-Generation Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer. (lclabs.com)
Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib. (lclabs.com)

Pazopanib is a vascular endothelial receptor tyrosine kinase inhibitor with anti-angiogenesis and anti-tumor activity in several preclinical models. (johnshopkins.edu)
GW786034 is a vascular endothelial growth factor receptor-focused multi-tyrosine kinase inhibitor involved in inhibiting the angiogenesis pathway. (gw786034inhibitor.com)
Phase I study of OSI-906, dual tyrosine kinase inhibitor of insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (IR) in combination with erlotinib (E) in patients with advanced solid tumors. (ox.ac.uk)
3098^ Background: OSI-906 is an oral inhibitor of IGF-1R and IR tyrosine kinases. (ox.ac.uk)
The aim of the current study was to evaluate molecular and cellular effects of OSI-774, a novel EGFR tyrosine kinase inhibitor, on nine glioblastoma multiforme (GBM) cell lines. (thejns.org)
It is a tyrosine kinase inhibitor that enters a cancer cell and binds to the part of the HER2 protein that sits just beneath the cell's outer membrane. (cancer.gov)
ZN-A-1041 is an orally administered selective tyrosine kinase inhibitor targeting the Human Epidermal Growth Factor Receptor 2 (HER2). (newswire.co.kr)
Subsequently, lapatinib, an orally bioavailable small molecule dual HER2- and EGFR/HER1-specific tyrosine kinase inhibitor, received Food and Drug Administration (FDA) approval in combination with capecitabine for patients with advanced HER2+ breast cancer. (carcinogenesis.com)
The small molecule compound, Erlotinib is a receptor tyrosine kinase inhibitor (EGFR antagonist) and belongs to molecular targeted therapy Drugs. (lookchem.com)
Neratinib, also known as HKI-272, is considered to be a second-generation inhibitor of the ErbB family of receptor kinases. (lclabs.com)
Neratinib is an irreversible inhibitor of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER-2) tyrosine kinases by targeting a cysteine residue in the ATP-binding site of the receptor. (lclabs.com)
Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase. (lclabs.com)
HKI-272, an irreversible pan erbB receptor tyrosine kinase inhibitor: Preliminary phase 1 results in patients with solid tumors. (lclabs.com)

Epidermal growth factor receptor (EGFR) gene mutations are frequent in lung cancer arising in patients of Asian ethnicity, female sex, nonsmokers, and adenocarcinoma histology. (nih.gov)
Therefore, EGFR mutation is being recognized as one of the most reliable predictive factors for treatment using EGFR-TKIs. (nih.gov)
Among them, the most data are available for the epidermal growth factor receptor (EGFR) that plays a major role for prognosis of patients after radiotherapy, but seems also to be involved in mechanisms of radioresistance, specifically in repopulation of tumour cells between radiotherapy fractions. (ox.ac.uk)
both EGFR and c-Src kinase activities. (123dok.org)
Although a number of studies have shown that patients with activating mutations in exons 18-21 of the epidermal growth factor receptor (EGFR) gene respond particularly well to gefitinib and erlotinib, a prospective, randomised study was needed to differentiate between the prognostic and predictive value of EGFR mutations. (ersjournals.com)
This review considers the current evidence linking biomarker profile to efficacy of epidermal growth factor receptor (EGFR)-targeted therapy in advanced nonsmall cell lung cancer (NSCLC) and the clinical implications of recent findings. (ersjournals.com)
In NSCLC, activation of the EGFR/HER1 pathway results in a signalling cascade that promotes tumour growth and progression 6 . (ersjournals.com)
IGF-1R:EGFR cross-talk contributes to resistance to agents targeting either pathway, supporting trials of dual receptor inhibition. (ox.ac.uk)
To look for the structural basis for HER3 signaling through heterodimerization using a catalytically energetic HER receptor we resolved the crystal framework from the heterodimeric complicated formed with the isolated kinase domains of Meclofenoxate HCl EGFR and HER3. (bio-biz-navi.com)
To comprehend the consequences of cancer-associated HER3 mutations on the molecular level we resolved the buildings of two HER3 kinase mutants each within a heterodimeric complicated using the kinase domains of EGFR. (bio-biz-navi.com)
The epidermal growth factor receptor (EGFR) tyrosine kinase (TK) plays an important role in the pathogenesis of NSCLC. (bmj.com)
Alterations in receptor tyrosine kinases (TKs), such as the epidermal growth factor receptor (EGFR) and insulin-like growth factor receptor 1, include overexpression, amplification or mutations. (bmj.com)
3 The development of molecular targeted therapies aimed at these molecular alterations has generated great optimism for the treatment of cancers such as NSCLC, and drugs targeting the EGFR tyrosine kinase domain are now available. (bmj.com)
EGFR (Epidermal growth factor receptor, HER1, ErbB1) is encoded by the EGFR gene located on chromosome 7 in humans. (thermofisher.com)
EGFR belongs to the HER/ERbB family of proteins that includes three other receptor tyrosine kinases, ERbB2, ERbB3, ERbB4. (thermofisher.com)
EGFR is a transmembrane receptor and binding of its cognate ligands such as EGF (Epidermal Growth Factor) and TGF alpha (Transforming Growth Factor alpha) to the extracellular domain leads to EGFR dimerization followed by autophosphorylation of the tyrosine residues in the cytoplasmic domain. (thermofisher.com)
Phosphorylation of EGFR at certain residues is also mediated by Src-non-receptor kinase. (thermofisher.com)
EGFR activation signals multiple downstream signaling cascades such as the Ras - ERK, PI3-K - Akt, Jak - STAT and PKC pathways that help in growth and proliferation of cells. (thermofisher.com)
Upon receptor activation and signaling, EGFR is endocytosed and targeted for degradation or recycling. (thermofisher.com)
Tumor cells from patients with acquired resistance were examined for secondary EGFR kinase domain mutations by molecular analyses. (aacrjournals.org)
Quantitative and qualitative alterations in the epidermal growth factor receptor (EGFR) commonly occur in many cancers in humans, including malignant gliomas. (thejns.org)
The effects of OSI-774 on expression of EGFR messenger (m)RNA and protein, proliferation, anchorage-independent growth, and apoptosis were examined using semiquantitative reverse transcription-polymerase chain reaction, immunocytochemical analysis, Coulter counting, soft agar cloning, and terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling/fluorescence-activated cell sorting, respectively. (thejns.org)
Suppression of anchorage-independent growth by OSI-774 was inversely correlated to the induction of EGFR mRNA during relative serum starvation (r = −0.74) and was unrelated to p53 status. (thejns.org)
The induction of EGFR mRNA may constitute a cellular mechanism to counteract the inhibitory effect of OSI-774 on the anchorage-independent growth of GBM cells. (thejns.org)
Mutations in epidermal growth factor receptor ( EGFR ), KRAS, and anaplastic lymphoma kinase ( ALK ) are mutually exclusive in patients with NSCLC, and the presence of one mutation in lieu of another can influence response to targeted therapy. (medscape.com)
It can inhibit the phosphorylation reaction through competing with adenosine triphosphate to bind to the catalytic region of the receptor tyrosine kinase, thereby blocking the down-proliferation signaling and inhibiting the activity of the tumor cell ligand-dependent HER-1/EGFR, thus achieving the inhibition of the proliferation of tumor cells. (lookchem.com)
Acquired resistance of non-small cell lung cancers to gefitinib because of a T790M mutation in the EGFR kinase domain is circumvented by neratinib. (lclabs.com)
Chemical inhibition and siRNA knockdown experiments demonstrated that STAT-3 activation is dependent on the activation of nonreceptor tyrosine-protein kinase 2 (TYK2) and epidermal growth factor receptor (EGFR) tyrosine kinases. (cdc.gov)
Our studies show that poultry dust extract controls the induction of immune and inflammatory mediator expression via a cellular pathway involving oxidative stress-mediated STAT-3 activation by TYK2 and EGFR tyrosine kinases. (cdc.gov)

A juxtamembrane segment that contains: A serine residue (Ser 985), which inhibits the receptor kinase activity upon phosphorylation A tyrosine residue (Tyr 1003), which is responsible for MET polyubiquitination, endocytosis, and degradation upon interaction with the ubiquitin ligase CBL Tyrosine kinase domain, which mediates MET biological activity. (wikipedia.org)
Integrin-mediated RON growth factor receptor phosphorylation requires tyrosine kinase activity of both the receptor and c-Src. (123dok.org)
Integrin-in-duced epidermal growth factor (EGF) and platelet-derived growth factor (PDGF) RTK phosphorylation depends on the kinase activity of the receptor (7, 13). (123dok.org)
Endogenous RPTPkappa associated with EGF receptor and HER2, resulting in suppression of basal and ErbB ligand-induced proliferation and receptor phosphorylation. (nih.gov)
Following phosphorylation of intracellular parts of the receptors triggers activation and recruitment of downstream components initiating signaling cascades. (bio-biz-navi.com)
A feature that allows the HER category of receptors to regulate different signaling outputs is normally their capability to make use of their phosphorylation sites within a combinatorial way through receptor heterodimerization. (bio-biz-navi.com)
Spry1, Spry2, and Spry4 but not Spry3 are induced transcriptionally and limit the duration and intensity mainly of ERK phosphorylation in response to growth factor (GF) stimulation (with the exception of EGF signaling). (springer.com)
Binding of Sema4D to plexin-B1 stimulates the intrinsic tyrosine kinase activity of ErbB-2, resulting in the phosphorylation of both plexin-B1 and ErbB-2. (rupress.org)
Our data indicate that ErbB-2 is an important component of the plexin-B receptor system and that ErbB-2-mediated phosphorylation of plexin-B1 is critically involved in Sema4D-induced RhoA activation, which underlies cellular phenomena downstream of plexin-B1, including axonal growth cone collapse. (rupress.org)
Although tyrosine phosphorylation of Eps15 has been implicated in EGF receptor internalization, the function of Eps15 ubiquitination is not known. (embl.de)

Orthologous to human ABL2 (ABL proto-oncogene 2, non-receptor tyrosine kinase). (nih.gov)
MST1R (RON) is a trans-membrane receptor tyrosine kinase (RTK), which is part of the c-MET proto-oncogene family. (frontiersin.org)
From NCBI Gene: The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. (nih.gov)

and transmembrane receptor protein tyrosine kinase signaling pathway. (nih.gov)

Clinically relevant improvements in survival have been attained by administering targeted therapy to the appropriate patient population: for example, the addition of trastuzumab to standard first-line chemotherapy in patients with human epidermal growth factor receptor-positive (HER2+) metastatic breast cancer 3 . (ersjournals.com)
Novel therapeutic agents, in particular those that specifically target members of the human epidermal growth factor receptor (HER (ErbB1)) pathway, have shown encouraging therapeutic efficacy. (bmj.com)
With the addition of trastuzumab, a monoclonal antibody targeting the human epidermal growth factor receptor-2 (HER2), improvements in overall survival have been observed among patients with advanced HER2-positive disease. (carcinogenesis.com)
One type of breast cancer is identified by the human epidermal growth factor receptor 2 (HER2) gene amplification. (carcinogenesis.com)
A gain of function mutation that leads to an excess of an oncoprotein is a viable target for example amplification of human epidermal growth factor receptor 2 (HER2) than a loss of function ( Figure 1 ). (scirp.org)

RNA interference (RNAi) of PTPRK accelerated cell cycle progression, enhanced response to epidermal growth factor (EGF), and abrogated TGF-beta-mediated antimitogenesis. (nih.gov)
The individual epidermal growth factor receptor (HER) tyrosine kinases homo- and hetero-dimerize to activate downstream signaling pathways. (bio-biz-navi.com)
MA5-14485 targets Epidermal Growth Factor Receptor in IHC (P) applications and shows reactivity with Human samples. (thermofisher.com)
HER2 is a member of the epidermal growth factor receptor ( ErbB ) family of genes, which encode proteins that are cell surface-bound tyrosine kinase proteins. (cancer.gov)
Mammalian epidermal growth factor receptor substrate 15 (EPS15), which is involved in cell growth regulation. (embl.de)
Mammalian epidermal growth factor receptor substrate EPS15R. (embl.de)
An important negative control mechanism in the signaling of epidermal growth factor (EGF) is the endocytosis and subsequent degradation of activated EGF receptors. (embl.de)
Tyrphostin AG556 increases the activity of large conductance Ca 2+ -activated K + channels by inhibiting epidermal growth factor receptor tyrosine kinase. (bvsalud.org)

Following MET activation, transphosphorylation occurs on Tyr 1234 and Tyr 1235 C-terminal region contains two crucial tyrosines (Tyr 1349 and Tyr 1356), which are inserted into the multisubstrate docking site, capable of recruiting downstream adapter proteins with Src homology-2 (SH2) domains. (wikipedia.org)
Receptor dimerization and autophosphorylation attracts proteins containing Src homology 2 (SH2) or phosphotyrosine binding (PTB) domains including adaptor proteins like FRS2 and GRB2. (springer.com)
In addition to plexins, various other proteins have been implicated either as receptors for semaphorins or as components of the semaphorin receptor complex ( Pasterkamp and Kolodkin, 2003 ). (rupress.org)
i) which Gab1 dependent signals are required for morphogenesis, by assessing known Gab1 associated proteins and Gab1 associated proteins identifid by tandem mass spectroscopy, ii) the molecular basis through which the tyrosine phosphatase SHP-2 is required for morphogenesis. (mcgill.ca)
Its effect on the function of other proteins in the ErbB family of proteins that may also fuel cancer cell growth is being studied. (cancer.gov)

Mutation or over-production of these molecules stimulates cell division and uncontrolled growth. (cancer.gov)
Rearranged during transfection (RET), kinase alterations, which include fusions and activating point mutation, lead to overactive RET signaling and uncontrolled cell growth. (medscape.com)

In TGF-beta-treated MCF10A mammary epithelial cells overexpressing HER2 and by chromatin immunoprecipitation, we identified novel Smad targets including protein tyrosine phosphatase receptor type kappa (PTPRK). (nih.gov)
HER2-positive (HER2+) breast cancers are defined as those that have an excess number of HER2 genes or over-produce the protein product of the HER2 gene, the HER2 cell surface receptor. (cancer.gov)
The ALTTO clinical trial was unique in that, for all of patients, there was central pathology review of the primary tumor, including re-evaluation of the cancer's estrogen receptor (ER), progesterone receptor (PR), and HER2 status, before patients were randomly assigned to one of the trial's four treatment groups. (cancer.gov)
The role of human EGFR2 (HER2), a member of the ERBB family of tyrosine kinase receptors, has been studied for NSCLC. (medscape.com)
HER2 is a member of the cErbB family of receptor tyrosine kinases, and is responsible for HER2-mediated signal transduction in the cytoplasm. (carcinogenesis.com)

The two tyrosines of the docking site have been reported to be necessary and sufficient for the signal transduction both in vitro. (wikipedia.org)
As an alternative approach, growth factor receptors or components of their signal transduction machinery may be targeted directly. (springer.com)
The signaling pathways activated by the oncogenic mutants are in part overlapping with those normally activated by these receptors, but there are also signal transduction pathways that are unique to the oncogenic mutants. (lu.se)

Chromosomal translocations involving chromosome bands 5q31-33 that contain the gene encoding the platelet-derived growth factor beta receptor (PDGFRB) are associated with a significant minority of patients with BCR/ABL1-negative chronic myeloid neoplasms. (atlasgeneticsoncology.org)

In the recent fifth edition of the World Health Organization classification, similar to the recent update to the International Consensus Classification, the category was renamed to "myeloid/lymphoid neoplasms with eosinophilia and tyrosine kinase gene fusions" and both classifications added novel subtypes with new JAK2 rearrangements (e.g. (nature.com)
Here we propose comprehensive response criteria based on the heterogenous clinical presentations of patients with MLN with eosinophilia and tyrosine kinase gene fusions. (nature.com)
PRINCETON, N.J., Sept. 30, 2022 /PRNewswire/ -- Taiho Oncology, Inc. and Taiho Pharmaceutical Co., Ltd. announced today that the U.S. Food and Drug Administration (FDA) has approved LYTGOBI ® tablets for the treatment of adult patients with previously treated, unresectable, locally advanced or metastatic intrahepatic cholangiocarcinoma (iCCA) harboring fibroblast growth factor receptor 2 (FGFR2) gene fusions or other rearrangements. (biospace.com)
LYTGOBI is indicated for the treatment of adult patients with previously treated, unresectable, locally advanced or metastatic intrahepatic cholangiocarcinoma harboring fibroblast growth factor receptor 2 (FGFR2) gene fusions or other rearrangements. (biospace.com)
Entrectinib (Rozlytrek) and larotrectinib (Vitrakvi) target neurotrophic tyrosine receptor kinase fusions, and pralsetinib and selpercatinib target RET mutations in MTC and RET fusions in RAI-refractory differentiated thyroid cancers and anaplastic thyroid cancers. (medscape.com)

Abnormal MET activation in cancer correlates with poor prognosis, where aberrantly active MET triggers tumor growth, formation of new blood vessels (angiogenesis) that supply the tumor with nutrients, and cancer spread to other organs (metastasis). (wikipedia.org)
Background Vascular endothelial growth factor (VEGF) is produced by bladder cancer cell lines in vitro and expressed in human bladder tumor tissues. (johnshopkins.edu)
The implications of this finding overshadowed the importance of mitochondria for tumor growth for a long time. (spandidos-publications.com)
We recently demonstrated that abrogating Sprouty2 function strongly inhibits intracranial tumor growth and leads to significantly prolonged survival of glioblastoma bearing mice by induction of ERK-dependent DNA replication stress. (springer.com)
We will exploit the use of substrate specific variants of the Met receptor to dissect signaling pathways essential for tumor induction and metastasis and will dissect signals that promote tumor angiogenesis. (mcgill.ca)
However, they also may have limited effectiveness in some patients whose tumor growth depends on molecules that are not exclusively targeted by the agents or whose cancer mutates to use other growth pathways. (cancer.gov)

VEGFR, vascular endothelial growth factor receptor. (aspetjournals.org)
It is actually a splice variant of the better known vascular endothelial growth factor receptor 1 (VEGF-R1). (medscape.com)

Upon interaction with MET, GAB1 becomes phosphorylated on several tyrosine residues which, in turn, recruit a number of signalling effectors, including PI3K, SHP2, and PLC-γ. (wikipedia.org)
The PDGFRβ is heavily phosphorylated on numerous tyrosine residues through both autophosphorylation and ligand-dependent processes. (biolegend.com)
Upon EGF stimulation of the cell, Eps15 becomes both phosphorylated on tyrosine residues and monoubiquitinated. (embl.de)

Transforming growth factor beta (TGF-beta) inhibits proliferation and promotes cell migration. (nih.gov)
Apratoxin A inhibits Janus kinase (JAK)/STAT signaling through rapid down-regulation of interleukin 6 signal transducer (gp130). (aspetjournals.org)

Hepatocyte growth factor receptor (HGF receptor) is a protein that in humans is encoded by the MET gene. (wikipedia.org)

Integrin engagement by ECM can modulate growth factor signaling pathways, increasing the activity of growth factor RTKs (7, 8) and their downstream intracellular mediators (9, 10). (123dok.org)
In recent years, the search for intracellular signaling integrator downstream of receptor tyrosine kinases provided valuable novel substrates. (springer.com)

and by soluble growth factors (1-5). (123dok.org)
It is soluble fms-like tyrosine kinase-1. (medscape.com)

It acts by targeting FMS like tyrosine kinase 3 (FLT3) and fibroblast growth factor receptor (FGFR). (pharmaceutical-technology.com)
The receptor tyrosine kinases KIT and FLT3 are both important regulators of development and maintenance of a number of different cell types. (lu.se)

When HGF/SF binds its cognate receptor MET it induces its dimerization through a not yet completely understood mechanism leading to its activation. (wikipedia.org)

In that case, adhesion-induced aggregation of integrins might trigger co-aggregation (5) and autophosphorylation of growth factor RTKs (13). (123dok.org)

Hepatocyte growth factor/Scatter Factor (HGF/SF) and its splicing isoform (NK1, NK2) are the only known ligands of the HGF receptor. (wikipedia.org)
Activation from the HER category of receptors takes place upon binding of extracellular ligands that Meclofenoxate HCl promote receptor oligomerization and catalytic activation from the intracellular kinase domains. (bio-biz-navi.com)

Launch Receptor tyrosine kinases play a significant role along the way of converting different extracellular cues in to the activation of distinctive intracellular signaling systems. (bio-biz-navi.com)

The molecular system behind the activating aftereffect of HER3 mutations is not described however the id of cancers mutations within this critically essential receptor underscores the necessity to know how HER3 forms energetic complexes with various other members from the HER family members under both Meclofenoxate HCl regular and oncogenic circumstances. (bio-biz-navi.com)
Deregulation of receptor tyrosine kinases in human cancers can occur through positive activation of the receptor or through the loss of negative regulatory controls. (mcgill.ca)
We will establish the molecular mechanism through which Cbl negatively regulates the Met receptor and establish if this is a mechanism for receptor deregulation in human cancers. (mcgill.ca)

Synthetic peptide corresponding to Human VEGF Receptor 2 (phospho Y951). (abcam.com)
sFlt-1 freely circulates and reduces the level of both VEGF and placental growth factor (PIGF). (medscape.com)

My lab has focused on and will continue to address these questions using the Met receptor tyrosine kinase and oncogene as a model. (mcgill.ca)

The protein possesses tyrosine kinase activity. (wikipedia.org)

Fibroblast growth factor receptor 1 contains three extracellular IMMUNOGLOBULIN C2-SET DOMAINS and is a tyrosine kinase that transmits signals through the MAP KINASE SIGNALING SYSTEM. (bvsalud.org)

MET activation by its ligand HGF induces MET kinase catalytic activity, which triggers transphosphorylation of the tyrosines Tyr 1234 and Tyr 1235. (wikipedia.org)
The kinase domains of HER3 includes many inactivating substitutions that bring about an almost comprehensive lack of catalytic activity and HER3 is normally thus denoted being a pseudokinase receptor. (bio-biz-navi.com)
Current structural knowledge of the molecular system root catalytic activation of HER category of receptors. (bio-biz-navi.com)

Integrin-based effects on growth factor re-ceptors include enhancement of cell migration (11, 12), survival (13), and proliferation (14 -17). (123dok.org)
The activity from the individual epidermal growth aspect receptors (HERs) handles indispensable signaling procedures in both developing and mature organism through the arousal of pathways that regulate mobile proliferation survival and motility ( 1 ). (bio-biz-navi.com)
Overall, suppression of anchorage-independent growth was a considerably stronger effect of OSI-774 than inhibition of proliferation. (thejns.org)
The extent of OSI-774-induced apoptosis positively correlated with both proliferation and anchorage-independent growth of GBM cell lines (r = 0.75 and 0.79, respectively). (thejns.org)

It has been reported that lung cancer cells exhibit upregulated expression of all key glycolytic enzymes [hexokinase 2 (HK2), phosphofructokinase and pyruvate kinase (PK)] ( 13 ), suggesting that the essential enzymes of the aerobic glycolytic pathway have a critical role in the development of lung carcinoma. (spandidos-publications.com)

Deregulation of these tyrosine kinases by mutations has been implicated in various human malignancies, including leukemia and melanoma. (lu.se)

There is increasing evidence to support the concept that the malignant behavior of some tumors is sustained by the deregulated activation of growth factor receptors. (mcgill.ca)

in-teraction is mediated by integrins, transmembrane nonco-valently linked heterodimeric receptors consisting of␣ and ␤ subunits (6). (123dok.org)

We will focus on signals required for anchorage independent growth, morphological cell transformation, epithelial mesenchymal transition, cell invasion and tumorigenesis. (mcgill.ca)
It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). (cancerindex.org)

The 18A2 monclonal antibody recognizes human CD140b also known as the platelet-derived growth factor receptor, beta polypeptide, PDGFR1, and PDGFRß. (biolegend.com)

RTK-dependent signaling pathways provide a variety of targets for the treatment of neurological and neuropsychiatric disorders in which neurotrophins and other growth factors are released [ 8 , 9 ] (Fig. 1 ). (springer.com)

In the 1920s, Otto Heinrich Warburg discovered that cancer cells, unlike normal cells, use the glycolytic pathway to obtain energy for growth even in the presence of oxygen, which is a phenomenon known as 'aerobic glycolysis' or the Warburg effect ( 9 ), and aerobic glycolysis is a common metabolic phenotype in NSCLC ( 11 ). (spandidos-publications.com)

Several variants of the receptor exist due to multiple ALTERNATIVE SPLICING of its mRNA. (bvsalud.org)

These two tyrosines engage various signal transducers, thus initiating a whole spectrum of biological activities driven by MET, collectively known as the invasive growth program. (wikipedia.org)
Our work in the past few years has uncovered an important regulator of invasive cell growth, the Met receptor tyrosine kinase. (mcgill.ca)

The PI3-kinase isoform p110δ is essential for cell transformation induced by the D816V mutant of c-Kit in a lipid-kinase-independent manner. (lu.se)

Anatomy14

Organisms7

Diseases14

Chemicals and Drugs152

Analytical, Diagnostic and Therapeutic Techniques and Equipment20

Phenomena and Processes45

Disciplines and Occupations1

Information Science3

Health Care3

Inhibitors12

INHIBITOR13

EGFR29

Phosphorylation10

Proto-oncogene3

Signaling pathway1

Human epidermal5

Epidermal growth8

Proteins5

Mutation2

HER25

Signal transduction3

Platelet-derived growth facto1

Fusions5

Tumor6

Vascular2

Residues3

Inhibits2

Hepatocyte growth factor r1

Downstream2

Soluble2

FLT32

Dimerization1

Autophosphorylation1

Ligands2

Intracellular1

Cancers3

VEGF2

Oncogene1

Protein possesses1

Fibroblast growth1

Catalytic3

Proliferation4

Lung1

Deregulation1

Tumors1

Heterodimeric1

Signals2

Polypeptide1

Pathways1

NSCLC1

MRNA1

Invasive2

Isoform1