Growth differentiation factors. Medical search. Frequent questions

Growth differentiation factor 15 (GDF15) has been associated with food intake and weight regulation in response to metabolic stress. (nature.com)
Recently, metabolic research has focused on growth differentiation factor 15 (GDF15), a stress-induced cytokine belonging to the transforming growth factor beta superfamily [ 5 ]. (nature.com)
Description: Quantitativecompetitive ELISA kit for measuring Rat growth differentiation factor 15(GDF15) in samples from serum, plasma, tissue homogenates. (scalegen.com)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Growth Differentiation Factor 15 (GDF15) in serum, plasma, tissue homogenates and other biological fluids. (scalegen.com)
Growth differentiation factor 15 (GDF15) is known as a TGFβ-like cytokine acting on the TGFβ receptor to modulate target genes. (tmu.edu.tw)
GDF15 is regarded as a tumor suppressor gene in the human bladder and the caffeic acid phenethyl ester (CAPE) induces GDF15 expression to inhibit the tumor growth in vitro and in vivo. (tmu.edu.tw)
Pancreatic cancer with cachexia and elevated human growth differentiation factor 15 (GDF15). (medscape.com)

Scaffolds play an important role in tissue engineering as a substrate that can mimic the native extracellular matrix and the properties of scaffolds have been shown to affect the cell behavior such as the cell attachment, proliferation and differentiation. (wjgnet.com)

Senescent cells in aging tissues are characterized by increased inflammatory cytokine and growth factor secretion. (jax.org)
BACKGROUND: The prognostic utility of GDF-15, a member of the transforming growth factor-β cytokine family, among patients with HF is unclear. (cpxinternational.com)
Plasma growth differentiation factor 15 (GDF-15) is a member of the transforming growth factor β-superfamily, acting as a stress-responsive cytokine. (biomedcentral.com)
The CellXVivo ™ Mouse Dendritic Cell Differentiation Kit contains the media and cytokine components to generate immature and mature dendritic cells from mouse bone marrow. (rndsystems.com)
HEK pre-exposure to UVB induced expression of IL-17, a pro-inflammatory cytokine, associated with hyperproliferation and abnormal differentiation of keratinocytes. (cdc.gov)

Description: Quantitativesandwich ELISA kit for measuring Mouse Growth/differentiation factor 5(GDF5) in samples from serum, plasma, cell culture supernates, tissue homogenates. (thescientistconnect.com)
Description: A sandwich ELISA kit for detection of Growth Differentiation Factor 1 from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (thescientistconnect.com)

Senescent cells supply beneficial growth factors which promote myofibroblast differentiation. (jax.org)
Based on these findings, the Campisi team proposes that PDGF-AA derived from senescent cells stimulates local myofibroblast differentiation, allowing for greater contractility and more efficient wound closure. (jax.org)
The purpose of this study was to determine the acute and long-term effects of mitomycin C (MMC) on quiescent rabbit corneal keratocytes regarding cell proliferation, myofibroblast differentiation and DNA repair. (molvis.org)
MMC significantly blocked TGFβ-induced cell proliferation and myofibroblast differentiation in cultured quiescent keratocytes and altered the transcriptional regulation of macrophage chemotactic protein-1 (MCP-1) and alpha smooth muscle actin (αSMA). (molvis.org)

Since heparan sulfate-proteoglycan is a major component of the extracellular matrix of skeletal muscle, factors that are bound to this proteoglycan, such as basic fibroblast growth factor (bFGF), are in a strategic position for neuronal signaling. (jneurosci.org)
Mesenchymal stem/stromal cells (MSCs) are adult stem cells with the capability of self-renewal and multilineage differentiation into skeletal and/or mesodermal tissues, including bone, fat, cartilage, and muscle tissues. (aibg.it)
Myogenic differentiation is a complex and well-coordinated process for generating mature skeletal muscle fibers. (unab.cl)
Myostatin, a member of the transforming growth factor-β superfamily, is a negative regulator of skeletal muscle growth in vertebrates that exerts its inhibitory function by activating Smad transcription factors. (unab.cl)
In contrast, IGF-1 promotes the differentiation of skeletal myoblasts by activating the PI3K/Akt signaling pathway. (unab.cl)
Preincubation of skeletal myoblasts with IGF-1 blocked MSTN-induced Smad3 activation, promoting myod expression and myoblast differentiation. (unab.cl)

BMP12 and BMP13 gene transfer induce ligamentogenic differentiation in mesenchymal progenitor and anterior cruciate ligament cells. (atlasgeneticsoncology.org)
While a few studies have attempted reprogramming of glioblastoma (GBM) cells toward a neuronal fate, this approach has not yet been used to induce differentiation into other lineages and in vivo data on reduction in tumorigenicity are limited. (lu.se)
Here, we employ cellular reprogramming to induce astrocytic differentiation as a therapeutic approach in GBM. (lu.se)
To date, various studies have reported that BMP-family growth factors can induce cells isolated from dental pulp tissues to differentiate into odontoblasts. (ispub.com)
Yet it remains poorly understood how these factors can induce the various types of cells in the dental pulp to engage in a harmonized and coordinated process of dentin regeneration. (ispub.com)
In this study, we evaluated the ability of four different NCT (NiFe2O4, CoFe2O4', Ni and Co3O4') to initiate oxidative stress, induce redox-sensitive transcription factors and trigger inflammatory response in primary human epidermal keratinocytes (HEK) and melanocytes (HEM). (cdc.gov)

Growth differentiation factors (GDFs) are a subfamily of proteins belonging to the transforming growth factor beta superfamily that have functions predominantly in development. (wikipedia.org)
Freeze thaw will destroy a percentage in every cycle and should be avoided.Antibody for research use.Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. (tgf-a.com)
This kit contains the following optimized proteins and reagents to drive the efficient differentiation of mouse monocytes into dendritic cells. (rndsystems.com)
Artemin is one of four members of the glial cell line-derived-neurotrophic factor (GDNF) family of proteins. (nyu.edu)
The SMOC-1 protein attaches (binds) to many different proteins and is thought to regulate molecules called growth factors that stimulate the growth and development of tissues throughout the body. (medlineplus.gov)

The high affinity of matrix-anchored BP groups towards BMP-2 permits guided differentiation of entrapped progenitor cells in 3-D cultures. (scilifelab.se)
Stem and progenitor cell populations are often heterogeneous, which may reflect stem cell subsets that express subtly different properties, including different propensities for lineage selection upon differentiation, yet remain able to interconvert. (lu.se)
A key challenge is to understand how state, but must also afford flexibility in cell-fate choice to permit the different cell-fate options confronting stem and progenitor cell-type diversification and differentiation in response to cells are selected and coordinated such that adoption of a given intrinsic cues or extrinsic signals. (lu.se)

(C) Aggrecan-to-type II collagen gene-expression ratio in BM and AD-MSCs after culture in type I collagen hydrogels for 14 days with either no growth factor, TGF-β, GDF5, or GDF6. (biomedcentral.com)
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Growth Differentiation Factor 5 (GDF5) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. (thescientistconnect.com)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Growth Differentiation Factor 5 (GDF5) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. (thescientistconnect.com)

In addition, forced differentiation induces astrocytic functions such as induced calcium transients and ability to respond to inflammatory stimuli. (lu.se)
RANK induces NF-κB signalling and anchorage-independent growth. (nature.com)
P253R fibroblast growth factor receptor-2 mutation induces RUNX2 transcript variants and calvarial osteoblast differentiation « Dott. (carinci.org)

Growth differentiation factor 9 ( GDF9 ) is preferentially expressed in oocytes and is essential for female fertility. (bioone.org)

Growth/differentiation factor-5 (GDF-5) belongs to the bone morphogenetic protein (BMP) family, which is expressed in dental pulp tissues. (ispub.com)
Nevertheless, the effect of GDF-5 on odontoblast differentiation from dental pulp tissues remains unknown. (ispub.com)
In this study, we assayed the effect of exogenous mouse recombinant GDF-5 on cell proliferation of dental pulp cells and determined the expression levels of odontoblast differentiation marker genes in the cells of isolated mouse dental pulp tissues in the presence of GDF-5. (ispub.com)
Along with other BMPs, including BMP-2, -4 and -7, which are well known as potent osteoinductive growth factors, GDF-5 plays important roles in the development of bones, cartilage and tendons, as evidenced by the tendency for the gene and protein expression levels of GDF-5 to increase over time in these tissues. (ispub.com)
Following their discovery in the tissues of oral cancer patients, Albertson and Schmidt undertook experiments in the laboratory to confirm the role of artemin in both cancer pain and cancer growth. (nyu.edu)
In this work, pathways governing mucus cell differentiation were investigated in lung tissues from patients with IPF and other chronic pulmonary disorders. (bmj.com)
As greater understanding of the growth factors involved in wound healing emerges, future patient care may include scarless wound healing and transplant of tissues engineered from stem cell progenitors. (medscape.com)
The epidermal growth factor receptor (EGFR) is expressed in epithelial tissues as well as hair follicles. (medscape.com)

Here, we investigated the effect of GDF-5 on the proliferation of dental pulp cells and their differentiation into odontoblasts by assaying the expression levels of odontoblast marker genes. (ispub.com)
Mutations in one of these genes (growth differentiation factor 9) are significantly more frequent in mothers of DZ twins. (nih.gov)

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. (nih.gov)
Fibroblast Growth Factor 2 Levels in Patients with Major Depressive Disorder: A Meta-analysis. (nih.gov)
Fibroblast growth factor (FGF) signaling controls a vast array of biological processes including cell differentiation and migration, wound healing and malignancy. (biologists.com)
Most Fibroblast growth factors (FGFs) have N-terminal signal peptides and are secreted from cells, allowing binding to and activation of their cell surface receptors (FGFRs). (biologists.com)
Basic fibroblast growth factor (Fgf2) is required for the generation of founder cells within the dorsal pseudostratified ventricular epithelium, which will generate the cerebral cortex, but the ganglionic eminences are not affected. (jneurosci.org)
Kim and Morshead, 2003), and the fibroblast that SSEA4 associated with CD133 can be used for growth factor (FGF) receptor 4 (Cai et al. (lu.se)

Neurotrophins are secreted molecules that promote growth, differentiation, and survival of neurons. (nyu.edu)

Description: A sandwich quantitative ELISA assay kit for detection of Rat Growth Differentiation Factor 1 (GDF1) in samples from serum, plasma or other biological fluids. (thescientistconnect.com)

Here we show that the in vivo administration of MPA triggers massive induction of the key osteoclast differentiation factor RANKL (receptor activator of NF-κB ligand) in mammary-gland epithelial cells. (nature.com)
Results In IPF, the bronchiolised and enlarged distal airspaces stained for SOX2 are consistent with epithelial differentiation characteristic of conducting airway epithelium. (bmj.com)
Activation of abnormal respiratory epithelial differentiation programs may contribute to the expression of MUC5B and bronchiolisation of the distal lung, a salient feature of IPF. (bmj.com)

To date, various studies have reported that cells isolated from the dental pulp of various animals can be induced to differentiate into cells of the odontoblastic phenotype by means of various chemicals, growth factors and signaling molecules both in vitro and in vivo ( reviewed in Nakashima and Akamine, 2005). (ispub.com)

Most importantly, forced differentiation substantially reduces tumorigenicity of GBM cells in an in vivo xenotransplantation model. (lu.se)
Relative gene expression was normalized to mean housekeeping-gene expression and cells without growth-factor stimulation and plotted on a log scale. (biomedcentral.com)
Characterization of recombinant human growth differentiation factor-9 signaling in ovarian granulosa cells. (ximbio.com)
Control of growth factor binding and release in bisphosphonate functionalized hydrogels guides rapid differentiation of precursor cells in vitro. (scilifelab.se)
See More Use our definitive endoderm (DE) differentiation kit to obtain functional DE cells that are capable of downstream differentiation to hepatic, intestinal, pancreatic and pulmonary cells. (stemcell.com)
Platelet-derived growth factor (PDGF) is involved in megakaryocytopoiesis and is secreted into the culture medium during megakaryocytic differentiation of human leukemic cells. (edu.hk)
DAB2 induction and megakaryocytic differentiation was abrogated when cells were co-treated with the PDGF receptor inhibitor STI571 or when the conditioned medium was derived from TPA-plus STI571-treated cells. (edu.hk)
Previous studies have shown that human adipose stem cells (hASCs) are able to differentiate towards AF phenotype when treated with suitable growth factors. (utwente.nl)
Protocols for hepatocyte differentiation from iPS cells have been studied. (spandidos-publications.com)
These molecular defects interfere with lymphocyte development and function, blocking the differentiation and proliferation of T cells and, in some types, of B cells and NK cells. (medscape.com)
For the differentiation of dendritic cells from mouse bone marrow. (rndsystems.com)
Cytokines produced by DCs can also promote the differentiation of CD4 + T helper cells as part of immune activation. (rndsystems.com)
Mouse PBMCs were differentiated into immature mouse dendritic cells by culturing for 5 days in reagents included in the CellXVivo ™ Mouse Monocyte-derived Dendritic Cells Differentiation Kit. (rndsystems.com)
Immature dendritic cells (left, blue) and TNF-α-treated mature dendritic cells (right, red), derived from bone marrow cells cultured with the CellXVivo ™ Mouse Dendritic Cell Differentiation Kit, were stained for flow cytometry with antibodies for CD11c, B7-2/CD86, MHC class II (I-A/I-E), or CD40 (open histograms). (rndsystems.com)
Ghasemi-Mobarakeh L, Prabhakaran MP, Tian L, Shamirzaei-Jeshvaghani E, Dehghani L, Ramakrishna S. Structural properties of scaffolds: Crucial parameters towards stem cells differentiation. (wjgnet.com)
The authors sought to identify mechanisms driving the differentiation of mucus cells during the bronchiolisation process. (bmj.com)
Singularly, SPDEF, a transcription factor associated with mucus metaplasia, was rarely detected in mucus cells in IPF. (bmj.com)
Mucus cells lining abnormal airways from patients with IPF expressed MUC5B and SOX2 but lacked SAM pointed domain containing ETS transcription factor (SPDEF) and forkhead box A3(FOXA3). (bmj.com)
The SMOC-1 protein also likely promotes the maturation (differentiation) of cells that build bones, called osteoblasts . (medlineplus.gov)
Evidence the fate of stem cells has broad ramifications for biomedical suggests that during development or differentiation, cells make science from elucidating the causes of cancer to the use of very precise transitions between apparently stable ``network stem cells in regenerative medicine. (lu.se)
2008). Historically, this concept is highlighted by the experi- factors are key intrinsic regulators of these fate decisions and mental phenomenon of lineage reprogramming, for example, that fate choice involves modulating networks of transcription by the conversion of fibroblasts to muscles cells following trans- factors. (lu.se)
In reality, gene somatic cells to a pluripotent cell state by a handful of transcrip- expression is graded, making the potential gene expression tion factors (Takahashi and Yamanaka, 2006). (lu.se)

In addition, development and genetic studies have shown that GDF-5 null mutation or transgenic mice exhibit abnormal growth patterns or overgrowth of limbs, long bones, cartilage, joints and digits (Storm et al. (ispub.com)
Abnormal differentiation of the respiratory epithelium is a feature of idiopathic pulmonary fibrosis (IPF). (bmj.com)

Plasma growth differentiation factor-15 (GDF-15) biomarker levels increase in response to inflammation and tissue injury, and increased levels of GDF-15 are associated with increased risk of mortality in patients with heart failure with reduced ejection fraction (HFrEF). (biomedcentral.com)

This study shows for the first time that PDGF autocrine signaling regulates DAB2 expression during megakaryocytic differentiation. (edu.hk)
After two days of culture in HSM, the expression levels of α-fetoprotein (AFP) and albumin, which are hepatocyte markers, were upregulated, suggesting that hepatocyte differentiation was initiated ( 19 ). (spandidos-publications.com)

Ligand-activated BMP signaling inhibits cell differentiation and death to promote melanoma. (umassmed.edu)
We demonstrate that the Drosophila FGFs have different activities and that cell migration and differentiation have different ligand requirements. (biologists.com)
In embryos, these functions include mesoderm induction and patterning, cell growth, migration and differentiation. (biologists.com)
cell differentiation. (ispub.com)
These results indicate that, although GDF-5 may have no effect on cell proliferation in isolated dental pulp tissue, it could promote odontoblast differentiation. (ispub.com)
Human annulus fibrosus cell (hAFCs) cultured in commercial AF growth medium were used as positive control. (utwente.nl)
It was hypothesized that the addition of glucose and galactose promoted hepatocyte differentiation of iPS cell. (spandidos-publications.com)
miRNAs are involved in several biological processes, like cell proliferation, differentiation, apoptosis and metastatization. (degruyter.com)
Activation of mTOR-dependent pathways regulates the specification and differentiation of CD4 + T effector cell subsets. (jci.org)
Methods Pathways governing airway mucus cell differentiation include SRY (sex determining region Y)-box 2 (SOX2), Notch, forkhead box A3(FOXA3)/SAM pointed domain containing ETS transcription factor (SPDEF), epidermal growth factor (EGF) and the EGF-related neuregulins NRG1α and NRG1β. (bmj.com)
Neuregulin1α, which drives mucus cell differentiation in vitro, was expressed in normal airway submucosal glands and in lungs from patients with IPF. (bmj.com)
There are also combination therapies that affect multiple receptors such as lapatinib (approved for human epidermal growth factor receptor 2-positive [HER2+] breast cancer) and afatinib (approved for non-small cell lung cancer), which inhibit both the EGFR and HER2 receptors, and vandetanib (approved for advanced medullary thyroid cancer), which inhibits EGFR, vascular endothelial growth factor (VEGFR), and rearranged during transfection (RET) activities. (medscape.com)

High temperature requirement factor A1 (HTRA1) gene regulates angiogenesis through transforming growth factor-β family member growth differentiation factor 6. (atlasgeneticsoncology.org)

In addition we will address important areas of modern epidemiology such as the influence of early life factors on adult health and disease, but also the importance of the gene-diet-microbiota interaction for body function and health. (lu.se)

This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. (nih.gov)
Understanding how the body repairs damaged tissue and what factors influence the wound healing process helps the surgeon ensure an acceptable outcome from surgery. (medscape.com)
Macrophages continue to emit growth factors to attract fibroblasts and usher in the next phase of wound healing (see Table below). (medscape.com)

Epidermal growth factor receptor (EGFR) inhibitors are part of an emerging class of anticancer medicines known as "targeted therapy," which target pathways more specific to neoplastic proliferation than traditional chemotherapeutic agents. (medscape.com)

Growth Differentiation Factor 6 Promotes Vascular Stability by Restraining Vascular Endothelial Growth Factor Signaling. (atlasgeneticsoncology.org)
Since artemin is overexpressed in oral cancers, it is likely that artemin also promotes cancer growth. (nyu.edu)

a member of the TGF-β family of ligands, is a strong negative regulator of muscle growth. (johnshopkins.edu)

The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development. (nature.com)

Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. (tgf-a.com)

In this study, we have exploited the natural affinity of high (H) and low (L) molecular-weight hyaluronic acid (HA) towards a cluster of differentiation 44 (CD44) receptors on osteoclasts to use it as a biodegradable targeting vehicle. (scilifelab.se)

Modifications of human growth differentiation factor 9 to improve the generation of embryos from low competence oocytes. (ximbio.com)

Growth/differentiation factor-5 (GDF-5) is a member of the bone morphogenetic protein (BMP) family, which is a subgroup of the transforming growth factor- (TGF-) superfamily. (ispub.com)

Platelet-rich plasma: Growth factor enhancement for bone grafts. (bvsalud.org)

The main aim of this research project was to regenerate AF tissue in vitro using hASCs and serum free chondrogenic medium without supplementation of growth factors. (utwente.nl)
This is the first study that demonstrated that hASCs can be differentiated towards AF phenotype using serum free chondrogenic medium without growth factors. (utwente.nl)
Quiescent keratocytes cultured in serum-free media were exposed to various concentrations of MMC and then treated with transforming growth factor-β (TGFβ). (molvis.org)

In HUMANS heterozygous loss of growth differentiation factor 1 function has been associated with CONGENITAL HEART DEFECTS and TRANSPOSITION OF GREAT VESSELS. (rush.edu)

These results demonstrate that the IGF-1/PI3K/Akt pathway may inhibit MSTN signaling during myoblast differentiation, providing new insight to existing knowledge on the complex crosstalk between both growth factors. (unab.cl)
The loss of SMOC-1 could disrupt growth factor signaling, which would impair the normal development of the skeleton, limbs, and eyes. (medlineplus.gov)

GDF8 is now officially known as myostatin and controls the growth of muscle tissue. (wikipedia.org)
This event is autocrine/paracrine regulated by growth factors, principally Myostatin (MSTN) and Insulin-like Growth Factor-1 (IGF-1). (unab.cl)

Evidence for this role is seen in MICE where loss of growth differentiation factor 1 function results in right-left isomerism of visceral organs. (rush.edu)

We adjusted for standard AF clinical risk factors, BNP, and CRP. (nih.gov)
None of the novel biomarkers evaluated improved AF risk discrimination or reclassification beyond standard clinical AF risk factors and biomarkers. (nih.gov)
OBJECTIVES: This study sought to determine the relationship between growth differentiation factor (GDF)-15 and clinical outcomes in ambulatory patients with heart failure and reduced ejection fraction (HFrEF). (cpxinternational.com)
There are concerns about the use of growth factors in clinical applications because of their short half-lives, high costs and low effectiveness. (utwente.nl)
based on a number of pathologic, physiologic, and clinical factors. (msdmanuals.com)

A growth differentiation factor that plays a role in the neural differentiation, specifically in the retinal development of the EYE. (umassmed.edu)
A growth differentiation factor that plays a role in the genesis of left-right asymmetry during vertebrate development. (rush.edu)

It contributes to epidermal proliferation, differentiation, and hair growth. (medscape.com)

We are particularly interested in studies illustrating intrinsic/extrinsic cellular and molecular factors regulating stemness, growth, and differentiation of tissue-specific MSCs as well as their potential implications for tissue engineering and regenerative medicine. (aibg.it)

The tendency to conceive spontaneous dizygotic (DZ) twins is a complex trait with important contributions from both environmental factors and genetic disposition. (nih.gov)

Another method involves the introduction of transcription factors ( 6-8 ). (spandidos-publications.com)

We investigated whether circulating concentrations of soluble ST2, growth differentiation factor-15 (GDF-15), and high-sensitivity troponin I (hsTnI) are associated with incident atrial fibrillation (AF) and whether these biomarkers improve current risk prediction models including AF risk factors, B-type natriuretic peptide (BNP), and C-reactive protein (CRP). (nih.gov)
however, after including the AF risk factors and BNP and CRP, only hsTnI was significantly associated with AF (hazard ratio per 1 SD of loge hsTnI, 1.12, 95% CI 1.00-1.26, P = .045). (nih.gov)
The c statistic of the base model including AF risk factors, BNP, and CRP was 0.803 (95% CI 0.777-0.830) and did not improve by adding individual or all 3 biomarkers. (nih.gov)
Risk factors for pulmonary embolism are. (msdmanuals.com)
Multinomial logistic regression was used to determine the association between psychosocial risk factors and waterpipe, cigar, and cigarette smoking. (who.int)

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GDF157

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