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  • precursor
  • Dental follicle cells serve as precursor cells of periodontal tissues and have characteristics of stem cells: self-renewal and multilineage differentiation potential suggesting the presence of stem cells in the dental follicle cells. (medsci.org)
  • metabolism
  • T-helper type 2 (Th2) cytokines, including interleukin (IL)-13 and IL-4, produced in adipose tissue, are critical regulators of intra-adipose and systemic lipid and glucose metabolism. (diabetesjournals.org)
  • promotes
  • The formation of embryoid bodies (EBs) within 2days was the key indication of the differentiation process and then the treatment was carried out under the influence of different factors for example retinoic acid and fibroblast growth factor-2 within 4days in cell culture media in 6 groups and finally the EBs were transferred on poly-L-lysine coated dishes within 5 days to promotes the differentiation. (phypha.ir)
  • receptor
  • Apert syndrome, associated with fibroblast growth factor receptor (FGFR) 2 mutations, is characterized by premature fusion of cranial sutures. (jci.org)
  • 2) The type II receptor phosphorylates the GS domain of the type I receptor, activating the serine/threonine kinase activity of the type I receptor. (els.net)
  • 3) Smad1, ‐2, ‐3, ‐5 and ‐8 are directly phosphorylated by the type I receptor. (els.net)
  • mutation
  • In contrast, the number of alkaline phosphatase- positive calvaria cells was fourfold higher than normal in mutant fetal calvaria cells with the most frequent Apert FGFR-2 mutation (Ser252Trp), suggesting increased maturation rate of cells in the osteoblastic lineage. (jci.org)
  • genes
  • One of the important factors in this process is the set of signal molecules which inform cells of where they are in a developing body and give them instructions as to which genes they should activate. (sunyorange.edu)
  • exogenous
  • Preosteoblastic calvaria cells isolated from Apert infants and fetuses showed normal cell growth in basal conditions or in response to exogenous FGF-2. (jci.org)
  • results
  • Control assays and synthetic DNA templates were designed to facilitate the assessment of the key experimental factors impacting your real-time PCR results. (bio-rad.com)
  • Ministry
  • 2. Key Laboratory of Clinical Laboratory Science of the Ministry of Education, Chongqing Medical University, China. (medsci.org)
  • ligands
  • In mammals, the canonical Notch signaling is mainly composed of five Notch ligands [Jagged1 and 2, and Delta-like (DLL)1, 3 and and four Notch receptors (Notch1-4) ( 3 , 4 ). (spandidos-publications.com)
  • cell growth
  • Understanding the basic mechanisms through which TGFβ mediates cell growth, shape, migration and differentiation should lead to therapeutic interventions for a number of common diseases. (els.net)
  • tissues
  • That is, biological engineering technique has been employed for regeneration of periodontal tissues [ 2 , 3 ]. (medsci.org)
  • role
  • Emerging evidence suggests that the IL-33-driven type 2 innate lymphoid cell (ILC2)/eosinophil axis plays a role in browning of white adipose tissue (WAT), thereby preventing development of obesity ( 9 , 10 ). (diabetesjournals.org)
  • tumor
  • Adipose-infiltrating macrophages secrete inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin (IL)-6 ( 4 ). (diabetesjournals.org)
  • BMPR2
  • This mechanism acts through the growth factor receptors subunits BMPR1A, BMPR2 and ACVR2A and the activation of SMAD1-SMAD5-SMAD8 complex and MAPK14/p38 (By similarity). (uniprot.org)
  • cardiovascular disease
  • Elevated Plasma Levels of MMP-12 Are Associated With Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects With Type 2 Diabetes. (lu.se)
  • type
  • Adipose tissue in lean mice and humans contains a higher proportion of M2/M1 macrophages, which are associated with local production of T-helper type 2 (Th2) cytokines by eosinophils ( 1 ). (diabetesjournals.org)
  • Transforming growth factor beta (TGFβ) is the prototype for a family of multifunctional secreted peptides that control many aspects of growth and development in a cell‐type‐specific manner. (els.net)
  • cells
  • We analyzed proliferation and differentiation of calvaria cells derived from Apert infants and fetuses with FGFR-2 mutations. (jci.org)
  • In 2008, Yao et al [ 7 ] for the first time confirmed the existence of dental follicle stem cells (DFCs), and the rat dental follicle cells could be induced to differentiate into adipocytes and neurons in vitro, which further confirm that the dental follicle cells have the mesenchyma derived cells which possess the potent differentiation potential. (medsci.org)
  • Wnt-1 and Wnt-3a functions in the differentiation of neural crest cells and in establishing a dorso -ventral axis in the neural tube (Saint- Jeannet , 1997). (sunyorange.edu)