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  • protein
  • RNA interference-mediated extinction of DREF function in vivo demonstrates a requirement for the protein for normal progression through the cell cycle and consequently for growth of imaginal discs and the derived adult organs. (nih.gov)
  • The authors found that it increases availability of a critical protein, Cip1/p21, in tumors that effectively freezes the cell cycle, and often pushes a cancer cell to self destruct. (bio-medicine.org)
  • The mammalian target of rapamycin complex 1 (mTORC1) functions as an environmental sensor to promote critical cellular processes such as protein synthesis, cell growth, and cell proliferation in response to growth factors and nutrients. (asm.org)
  • At the cellular level, mTORC1 promotes cellular anabolic processes, including ribosome biogenesis, protein and lipid synthesis, cell growth (increase in cell mass and size), and cell cycle progression, which drives cell proliferation ( 17 , 22 , 42 , 45 ). (asm.org)
  • Furthermore, immunohistochemical studies, following transfection of T98G with plasmid designed to express green fluorescent protein-fused TP53TG5, revealed cell cycle-dependent intracellular localization of this protein. (sigmaaldrich.com)
  • Treatment of cells with apigenin decreased both retinoblastoma (Rb) protein phosphorylation at Ser780 and Ser807/811 and total Rb protein in dose- and time- dependent fashion. (aacrjournals.org)
  • Two members of the Interferon regulatory factor (IRF) family, IRF-1 and ICSBP (Interferon consensus sequence binding protein) are tumor suppressors and have potent growth inhibitory effects on hematopoietic cells. (arvojournals.org)
  • Growth inhibition accompanied reduction in RI α /PKA-I expression and compensatory increases in RII β protein and PKA-II β , the RII β -containing holoenzyme. (aacrjournals.org)
  • We demonstrate that the antisense depletion of RI α in cancer cells results in increased RII β protein without increasing the rate of RII β synthesis or RII β mRNA levels. (aacrjournals.org)
  • Pulse-chase experiments revealed a 3-6-fold increase in the half-life of RII β protein in antisense-treated colon and prostate carcinoma cells with little or no change in the half-lives of RI α , RII α , and C α proteins. (aacrjournals.org)
  • In this report, we demonstrate, using cultured cancer cells, that the loss of RI α by antisense treatment results in biochemical compensation by RII β and that this compensation is attributable to an increase in the half-life of RII β protein without changes in the rate of RII β protein synthesis or RII β mRNA levels. (aacrjournals.org)
  • The advantage to this approach over modulation at the mRNA or protein level is that every cell contains only a single gDNA copy. (wikipedia.org)
  • This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner. (wikipedia.org)
  • Before the discovery of the ubiquitin proteasome system, protein degradation in cells was thought to rely mainly on lysosomes, membrane-bound organelles with acidic and protease-filled interiors that can degrade and then recycle exogenous proteins and aged or damaged organelles. (wikipedia.org)
  • This protein is part of the FASTKD family, which is known for regulating the energy balance of mitochondria under stress and cell cycle progression. (wikipedia.org)
  • It has been suggested that the protein is essential for initiation of DNA replication and that it plays a role in regulating cell cycle progression. (wikipedia.org)
  • The protein is expressed at constant levels throughout the cell cycle. (wikipedia.org)
  • The gene coding for the Dbf4 or ASK protein is regulated during the different phases of cell cycle. (wikipedia.org)
  • gene
  • The groups of specialized cells that make up the various human tissues depend on an intricate communication network to regulate gene expression that in turn mediates growth, cell-type specific function, division, and programmed cell death. (wiley.com)
  • Based on overexpression studies and target gene analyses, the transcription factor DNA replication-related element factor (DREF) has been proposed to regulate growth and replication in Drosophila melanogaster. (nih.gov)
  • Isolation and characterization of a novel TP53-inducible gene, TP53TG5, which suppresses growth and shows cell cycle-dependent transition of expression. (sigmaaldrich.com)
  • A colony-formation assay using human glioblastoma cell line T98G, which lacks wild-type TP53 and expresses no endogenous TP53TG5, revealed a growth-suppressive effect of the TP53TG5 gene product. (sigmaaldrich.com)
  • The proteasomal degradation pathway is essential for many cellular processes, including the cell cycle, the regulation of gene expression, and responses to oxidative stress. (wikipedia.org)
  • ONC201/TIC10 is active against cancer stem cells and blocks cancer stem cell gene signatures. (wikipedia.org)
  • pathways
  • His lab is now a leader in using mathematical tools to analyze signaling pathways, cell size control, and the selectivity of drugs. (wikipedia.org)
  • The importance of proteolytic degradation inside cells and the role of ubiquitin in proteolytic pathways was acknowledged in the award of the 2004 Nobel Prize in Chemistry to Aaron Ciechanover, Avram Hershko and Irwin Rose. (wikipedia.org)
  • genes
  • We show that DREF regulates the expression of genes that are required for the transition of imaginal disc cells through S phase. (nih.gov)
  • To gain better insight into the involvement of morphine in the biological characteristics of gastric cancer, we investigated effects on progression of gastric carcinoma cells and the expression of some apoptosis-related genes including caspase-9, caspase-3, survivin and NF-?B using the MGC-803 human gastric cancer cell line. (biomedsearch.com)
  • Stable transfectants were established by selection in hygromycin B. The effects of IRF-1 or ICSBP on lens cell growth, transcription of cell cycle, tumor suppressor, apoptosis, and growth inhibitory genes were examined by RNase protection assay, Western blotting, immunoprecipitation, in vitro proliferation assay and gel-shift assay. (arvojournals.org)
  • We further show that induction of the apoptotic and growth regulatory proteins is mediated by IRF-1/ICSBP interactions with IFN responsive elements in promoters of these genes. (arvojournals.org)
  • Molecular
  • Cell Cycle and Growth Control, Second Edition offers both an introduction to important concepts and detailed discussion of regulatory mechanisms at the cellular, biochemical, genetic, and molecular levels. (wiley.com)
  • We therefore studied the molecular events of apigenin action in human prostate cancer cells. (aacrjournals.org)
  • Taken together, this study provides an insight into the molecular mechanism of apigenin in modulating various tyrosine kinases and perturbs cell cycle progression, suggesting its future development and use as anticancer agent in humans. (aacrjournals.org)
  • In this study, we investigated the molecular mechanisms underlying their growth inhibitory effects in lens cells. (arvojournals.org)
  • Adipose fibroblast growth factor 21 is up-regulated by peroxisome proliferator-activated receptor γ and altered metabolic states," Molecular Pharmacology , vol. 74, no. 2, pp. 403-412, 2008. (hindawi.com)
  • Also due to their high molecular weight, uptake into cells is limited and some strategies to overcome this include DNA condensing agents, coupling of the TFO to hydrophobic residues like cholesterol, or cell permeabilization agents. (wikipedia.org)
  • fibroblast
  • This signalling pathway also differentiates epithelial and fibroblast cell responses to TGF-β stimulation . (mun.ca)
  • BetaKlotho is required for metabolic activity of fibroblast growth factor 21," Proceedings of the National Academy of Sciences of the United States of America , vol. 104, no. 18, pp. 7432-7437, 2007. (hindawi.com)
  • β Kslotho is required for fibroblast growth factor 21 effects on growth and metabolism," Cell Metabolism , vol. 16, no. 3, pp. 387-393, 2012. (hindawi.com)
  • Fibroblast growth factor 21 is induced upon cardiac stress and alters cardiac lipid homeostasis," Journal of Lipid Research , vol. 55, no. 11, pp. 2229-2241, 2014. (hindawi.com)
  • Fibroblast growth factor 21 predicts the metabolic syndrome and type 2 diabetes in Caucasians," Diabetes Care , vol. 36, no. 1, pp. 145-149, 2013. (hindawi.com)
  • Proteins
  • The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. (wikipedia.org)
  • The primary cell wall of most plant cells is freely permeable to small molecules including small proteins, with size exclusion estimated to be 30-60 kDa. (wikipedia.org)
  • assay
  • Cell growth assay, cell-cycle analysis and apoptosis assay. (nih.gov)
  • H1299 Tet-on clone cells were cultured in the absence or presence of doxycycline for a week and then cell growth was measured using an MTT assay. (nih.gov)
  • H1299 Tet-on clone cells were cultured in the absence or presence of doxycycline for 4 days and then apoptosis assay was performed using a flow cytometric analysis as described in Materials and Methods. (nih.gov)
  • We investigated the effects of TAM67 on anchorage-dependent growth using an MTT assay. (nih.gov)
  • Transcription
  • cJun, a major constituent of AP-1 transcription factor transducing multiple mitogen growth signals, is frequently overexpressed in non-small cell lung cancers (NSCLCs). (nih.gov)
  • It influences cell size and the cell cycle by binding CLN3 mRNA and inhibiting its transcription. (wikipedia.org)
  • mechanism
  • These results , in both cell culture and Drosophila , point to a novel mechanism of TGF-β signaling through PI3K/Akt . (mun.ca)
  • Potential alterations of this pathway may be a mechanism by which some cancers elude the normal growth regulatory system imposed by TGF-β . (mun.ca)
  • The mechanism by which cell death occurs in vivo after radiation or other DNA damage has remained an important question that has been studied by Michael B. Kastan, Scott W. Lowe, Karen Vousden, and others. (wikipedia.org)
  • It provides the cell with both structural support and protection, and also acts as a filtering mechanism. (wikipedia.org)
  • inhibitors
  • We investigated the effects of mTOR inhibitors on EBV-associated T and NK cell lymphomas. (aacrjournals.org)
  • We evaluated the antitumor effects of mTOR inhibitors (rapamycin and its analog, CCI-779) against these cell lines in culture and in a murine xenograft model which was established by subcutaneous injection of SNK6 cells into NOG mice. (aacrjournals.org)
  • Results: All EBV-positive and -negative T and NK cell lines tested displayed activation of the Akt/mTOR pathway, and treatment with mTOR inhibitors suppressed mTOR activation. (aacrjournals.org)
  • Cues
  • This results in a mother cell retaining the memory of the previous encounter over multiple generations, while the new daughter cells are still responsive to mating cues. (wikipedia.org)
  • significantly
  • The induction of TAM67 by doxycycline significantly reduced the percentage of cells in S phase, and increased that in G0/G1 phase in TAM67 #8, while the induction of GFP did not show such effects in GFP #3 (Figure 5B). (nih.gov)
  • Replication
  • The B period occurs between the completion of cell division and the beginning of DNA replication. (wikipedia.org)
  • The D period refers to the stage between the conclusion of DNA replication and the end of cell division. (wikipedia.org)
  • At the fastest growth rates, replication begins before the previous round of replication has completed, resulting in multiple replication forks along the DNA and overlapping cell cycles. (wikipedia.org)
  • In eukaryotic cells, DNA polymerase beta (POLB) performs base excision repair (BER) required for DNA maintenance, replication, recombination, and drug resistance. (wikipedia.org)
  • yeast cells
  • Another, more recently discovered function of WHI3 is encoding for memory in budding yeast cells. (wikipedia.org)
  • During sexual reproduction, two yeast cells signal their presence by diffusing pheromones, and it has been shown that when a cell is exposed to mating pheromones but does not perform mating, it "remembers" the event and is less likely to undergo mating afterwards. (wikipedia.org)
  • bacteria
  • Cell walls are present in most prokaryotes (except mycoplasma bacteria), in algae, plants and fungi but rarely in other eukaryotes including animals. (wikipedia.org)
  • In bacteria, the cell wall is composed of peptidoglycan. (wikipedia.org)
  • pathway
  • In total , these results define a novel pathway for TGF-β regulation of cell cycle through PI3K/Akt in normal cells . (mun.ca)
  • In conjunction with Smads , this pathway could account for the cell type specific growth responses to TGF-β . (mun.ca)
  • Experimental Design: We investigated the Akt/mTOR activation pathway in EBV-positive and -negative T and NK cell lines (SNT13, SNT16, Jurkat, SNK6, KAI3 and KHYG1). (aacrjournals.org)
  • El-Deiry's contribution was to define the role of the extrinsic cell death pathway through p53 regulation of death receptor 5. (wikipedia.org)
  • This is possible only when the cell arrests in G1, allowing it to continue down a different pathway. (wikipedia.org)
  • epithelial
  • We propose that PI3K signalling is partially responsible for the different phenotypic effects of TGF-β in mesenchymal and epithelial cells . (mun.ca)
  • Conversely , TGF-β decreased complex formation in epithelial cells . (mun.ca)
  • Extracellular Matrix
  • By the 1980s, some authors suggested replacing the term "cell wall", particularly as it was used for plants, with the more precise term "extracellular matrix", as used for animal cells, but others preferred the older term. (wikipedia.org)
  • stages
  • The bacterial cell cycle is divided into three stages. (wikipedia.org)
  • His pictures of newt lung cells undergoing the various stages of mitosis have appeared on numerous covers of the aforementioned journals alongside his articles. (wikipedia.org)
  • human
  • Cells, regardless of whether they are in an organ in the human body or a component of a bacterial colony, can sense the chemical composition of the environment, the presence of neighboring cells, and even the types of their neighboring cells. (merlot.org)
  • Sclareol is also able to kill human leukemic cells and colon cancer cells by apoptosis. (wikipedia.org)
  • viability
  • For example, Leucosporidium frigidum grows at −2 to 20 °C (28 to 68 °F), Saccharomyces telluris at 5 to 35 °C (41 to 95 °F), and Candida slooffi at 28 to 45 °C (82 to 113 °F). The cells can survive freezing under certain conditions, with viability decreasing over time. (wikipedia.org)
  • tumor growth
  • When this plasmid is inserted into a plant, the T-DNA tumor production region causes uncontrolled tumor growth normally at its base (crown) in a process known as Crown Gall Disease (Figure 3). (macalester.edu)
  • The tumor growth allows the Ti plasmid to proliferate in the host plant. (macalester.edu)
  • Her research has explored the effects of polyamines and ODC on the tumor microenvironment, as well as polyamine-targeted therapies designed to help reduce tumor growth. (wikipedia.org)
  • Another branch of Gilmour's research involves the role of the blood-clotting enzyme thrombin in tumor growth and metastasis. (wikipedia.org)
  • regulation
  • It has been associated with heterochromatin and PML-NBs (Promyelocytic Leukaemia nuclear bodies) and has been implicated in many nuclear processes including transcription and cell cycle regulation. (wikipedia.org)
  • Enzymes also allow the regulation of metabolic pathways in response to changes in the cell's environment or to signals from other cells. (wikipedia.org)
  • This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. (wikipedia.org)
  • Although senescent cells can no longer replicate, they remain metabolically active and commonly adopt an immunogenic phenotype consisting of a pro-inflammatory secretome, the up-regulation of immune ligands, a pro-survival response, promiscuous gene expression (pGE) and stain positive for senescence-associated β-galactosidase activity. (wikipedia.org)
  • tissues
  • In addition, given the risks of using animal serum for tissue engineering, autologous blood may gain favor as a source of growth factors and serum supplements needed for stimulating cells to engineer intervertebral disc tissues. (blogspot.com)
  • As these molecules are vital for life, metabolic reactions either focus on making these molecules during the construction of cells and tissues, or by breaking them down and using them as a source of energy, by their digestion. (wikipedia.org)
  • 2000
  • Cells had been transfected with hCOX2 by Lipofectamine 2000. (cancercurehere.com)
  • 2000 ). Because GadA and GadB are intracellular enzymes, and most MSG are out of the cells, the recombinant E. coli cells have to be specially treated by sonication, ethyl acetate, toluene, and thermal activation to increase the permeability (Zhao et al. (springeropen.com)
  • coli cells
  • The yield and productivity of gamma-aminobutyric acid might be significantly improved if the overexpressed GadB in E. coli cells can be excreted outside, where it can directly transforms monosodium glutamate to gamma-aminobutyric acid. (springeropen.com)
  • bacterial cells
  • The phage gene and insert DNA hybrid is then inserted (a process known as "transduction") into Escherichia coli (E. coli) bacterial cells such as TG1, SS320, ER2738, or XL1-Blue E. coli. (wikipedia.org)
  • requires the medium to be formulated for this purpose), or the appearance of turbidity (cloudiness indicating light scattering by bacterial cells) indicates that sterilization was not achieved and the sterilization cycle may need revision or improvement. (wikipedia.org)
  • cellular
  • Polyamines are ubiquitous small molecules involved in many normal cellular functions, including transcribing and translating genes, regulating ion channels and cell-to-cell interactions, and powering cell growth and replication. (wikipedia.org)
  • Similar life cycles have developed among certain amoebae, called cellular slime molds. (wikipedia.org)
  • Amino acids also contribute to cellular energy metabolism by providing a carbon source for entry into the citric acid cycle (tricarboxylic acid cycle), especially when a primary source of energy, such as glucose, is scarce, or when cells undergo metabolic stress. (wikipedia.org)
  • Cellular senescence is the phenomenon by which normal diploid cells cease to divide. (wikipedia.org)
  • As such, cellular senescence represents a change in "cell state" rather than a cell becoming "aged" as the name confusingly suggests. (wikipedia.org)
  • Consistent with this, telomerase-immortalised cells continued to age (according to the epigenetic clock) without having been treated with any senescence inducers or DNA-damaging agents, re-affirming the independence of the process of epigenetic ageing from telomeres, cellular senescence, and the DNA damage response pathway. (wikipedia.org)
  • Viroporins are small and usually hydrophobic multifunctional viralproteins that modify cellular membranes, thereby facilitating virus release from infected cells. (wikipedia.org)
  • tricarboxylic
  • They also code for citrate synthase and two subunits of 2-oxoacid:ferredoxin oxidoreductase, which plays the same role as alpha-ketoglutarate dehydrogenase in the TCA (tricarboxylic/Krebs/citric acid) cycle. (wikipedia.org)
  • nucleus
  • The response to platelet-rich plasma was greater in the case of anulus fibrosus cells than of nucleus pulposus cells. (blogspot.com)
  • At the level of the cell, Daxx is found in the cytoplasm, interacting with Fas-receptor or other cytoplasmic molecules, as well as in the nucleus, where it is interacting with some subnuclear structures. (wikipedia.org)
  • ASK1 will be transported to the nucleus when UV-irradiation is used to treat the cell. (wikipedia.org)
  • The nucleus of senescent cells is characterized by senescence-associated heterochromatin foci (SAHF) and DNA segments with chromatin alterations reinforcing senescence (DNA-SCARS). (wikipedia.org)
  • nutrient
  • Originally published in Sustainable agroecosystems in climate change mitigation , this image summarizes the nutrient cycling and plant protection features offered by a diverse and properly structured microbiome. (blogspot.com)
  • G1 phase and the other subphases of the cell cycle may be affected by limiting growth factors such as nutrient supply, temperature, and room for growth. (wikipedia.org)
  • membranes
  • Their main structural uses are as part of biological membranes both internal and external, such as the cell membrane, or as a source of energy. (wikipedia.org)
  • scarce
  • When nutrients are scarce, myxobacterial cells aggregate into fruiting bodies (not to be confused with those in fungi), a process long-thought to be mediated by chemotaxis but now considered to be a function of a form of contact-mediated signaling. (wikipedia.org)
  • antisense
  • Overexpression of p120 leads to malignant transformation of 3T3 cells while treatment with antisense p120 mRNA causes the transformed cells to revert to their original non-malignant phenotype. (wikipedia.org)
  • checkpoint
  • The restriction point (R) in the G1 phase is different from a checkpoint because it does not determine whether cell conditions are ideal to move on to the next phase, but it changes the course of the cell. (wikipedia.org)
  • Some authors will say that the restriction point and the G1/S checkpoint are one and the same, but more recent studies have argued that there are two different points in the G1 phase that check the progression of the cell. (wikipedia.org)
  • The first restriction point is growth-factor dependent and determines whether the cell moves into the G0 phase, while the second checkpoint is nutritionally-dependent and determines whether the cell moves into the S phase. (wikipedia.org)
  • The G1/S checkpoint is the point between G1 phase and the S phase in which the cell is cleared for progression into the S phase. (wikipedia.org)
  • At the G1/S checkpoint, formation of the G1/S cyclin with Cdk to form a complex commits the cell to a new division cycle. (wikipedia.org)
  • fluorescence
  • Adjustments in the Ca2+ focus had been indicated as F/F, where F was the fluorescence strength when cells had been at rest, and F was the modification in fluorescence during excitement. (cancercurehere.com)
  • malignant
  • She discovered that overexpression of ODC and c-Raf activation is sufficient to convert a normal primary keratinocyte into a malignant, invasive tumor cell. (wikipedia.org)
  • serum
  • Components and strategies Cell lifestyle MCF-7 cells had been grown up in DMEM moderate filled with 10% fetal leg serum and 1% penicillin/streptomycin serum as defined (9). (cancercurehere.com)
  • selective
  • Evaluation of cytotoxicity in Human noncancer cells indicated that the compounds 3i and 3m were practically ineffective in quiescent peripheral blood lymphocytes, and may have a selective antiproliferative activity against cancer cells. (deepdyve.com)
  • processes
  • Graham's interests include how plants make and breakdown various metabolites, how these processes are controlled and how they impact on plant growth. (wikipedia.org)
  • molecular
  • They typically travel in swarms (also known as wolf packs), containing many cells kept together by intercellular molecular signals. (wikipedia.org)
  • optimal
  • Physiological temperatures are optimal for cell growth. (wikipedia.org)
  • Sulfolobus species grow in volcanic springs with optimal growth occurring at pH 2-3 and temperatures of 75-80 °C, making them acidophiles and thermophiles respectively. (wikipedia.org)
  • compounds
  • The modification of isoCA-4 by introduction of difluoromethoxy group at the para-position (3i) and substitution of the two protons of the linker by two fluorine atoms (3m), produced the most active compounds in the series, with IC50 values of 0.15-2.2 nM (3i) and 0.1-2 nM (3m) respectively, against a panel of six cancer cell lines. (deepdyve.com)
  • Human
  • Her son, the Sage of the Six Paths, was born with the ability to produce chakra by combining physical energy (身体エネルギー, shintai enerugī), drawn from the trillions of cells that make up the human body, and mental energy (精神エネルギー, seishin enerugī), gained through experience and meditation. (wikipedia.org)
  • tissue
  • This study will also look at specific substances called biomarkers in your blood, and in the tumor tissue which are involved in the growth of tumor cells, and determine if the levels of these biomarkers are related to your response to treatment or development of side effects. (clinicaltrials.gov)
  • tyrosine
  • The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. (wikipedia.org)
  • One such inhibitor is imatinib mesylate, which occupies the tyrosine kinase domain and inhibits BCR-ABL's influence on the cell cycle. (wikipedia.org)
  • stem
  • Gilmour provided the first evidence that elevated epidermal levels of polyamines alone can positively affect the recruitment of bulge stem cells in the skin. (wikipedia.org)
  • This finding is significant with regard to the stem cell origin of skin cancer, since carcinogen-targeted stem cells can remain dormant for many years until recruited to develop into a tumor. (wikipedia.org)
  • Division
  • G1 phase together with the S phase and G2 phase comprise the long growth period of the cell cycle called interphase that takes place before cell division in mitosis (M phase). (wikipedia.org)
  • In humans, the normal physiological temperature is around 37 °C (98.6 °F). G1 phase is particularly important in the cell cycle because it determines whether a cell commits to division or to leaving the cell cycle. (wikipedia.org)
  • grown
  • Then the cells are grown on a dish with the medium that the antibiotic is resistant to and if the insertion was successful, then cells will grow. (macalester.edu)
  • organization
  • Analyses of cell cycle distribution, and morphological microtubules organization showed that compound 3m induced G2/M phase arrest and, dramatically disrupted the microtubule network. (deepdyve.com)
  • spores
  • Any surviving spores from the first treatment, or incidentally formed spores during the first incubation period, are killed in a third steaming cycle. (wikipedia.org)
  • mitosis
  • Between the beginning of the G1 phase (which is also after mitosis has occurred) and R, the cell is known as being in the G1-pm subphase, or the post-mitotic phase. (wikipedia.org)
  • metabolism
  • Platelet-rich plasma was effective in stimulating cell proliferation and extracellular matrix metabolism. (blogspot.com)
  • Metabolism (from Greek: μεταβολή metabolē, "change") is the set of life-sustaining chemical transformations within the cells of organisms. (wikipedia.org)
  • The word metabolism can also refer to the sum of all chemical reactions that occur in living organisms, including digestion and the transport of substances into and between different cells, in which case the set of reactions within the cells is called intermediary metabolism or intermediate metabolism. (wikipedia.org)
  • cancer cells
  • It works by preventing cancer cells from multiplying and it also makes them more likely to die from the treatment. (clinicaltrials.gov)
  • MAJOR CANCER BREAKTHROUGH: Scientists Find Plant That Kills 98% Of Cancer Cells In Just 16 Hours! (unews.top)
  • king May Help Cut Women's Breast Cancer Risk Cedars-Sinai increases the body's estrogen levels fostering the growth of cancer cells. (villa-agata.eu)
  • triggers
  • Biochemical triggers known as cyclin-dependent kinases (Cdks) switch on cell cycles events at the corrected time and in the correct order to prevent any mistakes. (wikipedia.org)
  • species
  • While a micropropagated plant may contain dozens of microbial species living in and around its cells, a plant growing in a healthy soil may contain hundreds of thousands of associated microbes. (blogspot.com)
  • For example, the set of carboxylic acids that are best known as the intermediates in the citric acid cycle are present in all known organisms, being found in species as diverse as the unicellular bacterium Escherichia coli and huge multicellular organisms like elephants. (wikipedia.org)
  • Cells can also be induced to senesce via DNA damage in response to elevated reactive oxygen species (ROS), activation of oncogenes and cell-cell fusion, independent of telomere length. (wikipedia.org)
  • known
  • Within the cell cycle, there is a stringent set of regulations known as the cell cycle control system that controls the timing and coordination of the phases to ensure a correct order of events. (wikipedia.org)
  • After R and before S, the cell is known as being in G1-ps, or the pre S phase interval of the G1 phase. (wikipedia.org)
  • These complexes, which help regulate cell growth in addition to creating and maintaining epithelial layers, are known as adherens junctions and they typically include at least cadherin, β-catenin, and α-catenin. (wikipedia.org)
  • homeostasis
  • These gene products are important in determining cell fates during normal development and in maintaining homeostasis, or they can lead to de-regulated growth in disorders like cancer by responding to mutations in β-catenin, APC or Axin, each of which can lead to this de-regulated β-catenin level stabilization in cells. (wikipedia.org)
  • represents
  • Additionally, our outcomes also claim that TRPC3 shows up as a fresh mediator of breasts cancer tumor cell migration/invasion and represents a potential focus on for a fresh course of anticancer agent. (cancercurehere.com)
  • function
  • of TRPC decreased the cell routine S stage and cell migration, implicating an operating function for TRP-mediated Ca2+ entrance in cell proliferation and invasion. (cancercurehere.com)
  • The most well-studied and well-established function of viroporins is the permeabilization of the cell membrane to ions and small solutes. (wikipedia.org)