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  • protein
  • Growth arrest-specific 6 (GAS6) is a member of the vitamin K-dependent protein family that is involved in the regulation of the cardiovascular system, including vascular remodeling, homeostasis, and atherosclerosis. (ahajournals.org)
  • 2 In recent studies, cardiac hypertrophy has been shown to be related to various signaling pathways involving the mitogen-activated protein kinase (MAPK), phosphoinositide 3 kinase/AKT, protein kinase C, nuclear factor-κβ, cAMP-response element binding protein, transforming growth factor-β/Smad, and calcineurin/nuclear factor of activated T cells pathways. (ahajournals.org)
  • Growth arrest-specific 6 (GAS6) was identified as a member of the vitamin K-dependent protein family that shares 42% structural similarity with protein S, a vitamin K-dependent anticoagulant protein. (ahajournals.org)
  • Involvement of p38 mitogen-activated protein kinase in basic fibroblast growth factor-induced interl. (biomedsearch.com)
  • The HER2 receptor is the protein product of the HER2 proto-oncogene and a member of the epidermal growth factor receptor family of transmembrane tyrosine kinases. (aacrjournals.org)
  • Objective: Growth arrest-specific 6 (Gas6) is a newly discovered vitamin K-dependent protein, which is a ligand for TAM receptors [Tyro3 (Sky), Axl, and Mer] from the tyrosine kinase family. (tjh.com.tr)
  • Ama : Gas6 proteini (growth arrest specific 6), K vitaminine ba ml protein ailesinin yeni bir yesi olup resept r tirozin kinazlardan TAM resept rlerinin [Tyro3 (Sky), Axl ve Mer] bir ligand d r. (tjh.com.tr)
  • cells
  • Martin Röcken and his team at the Department of Dermatology, Eberhard Karls University Tuebingen, found that anti-cancer immunity is capable of driving cancers and single cancer cells into a permanent growth arrest (1). (innovations-report.com)
  • Even more important: when isolated from cancer prone animals, the 'senescent cancer cells' remained growth arrested without any further therapy, even when transferred into immune deficient, healthy mice. (innovations-report.com)
  • Cells expressing wild-type Akt were not susceptible to the growth-arresting effect of NGF, whereas parental PC12 cells and notably cells expressing mutant Akt were so affected. (biomedsearch.com)
  • Lactoferrin inhibits G1 cyclin-dependent kinases during growth arrest of human breast carcinoma cells. (biomedsearch.com)
  • The authors found that the noncoding RNA growth arrest-specific 5 (Gas5), which accumulates in cells that have been deprived of nutrients or growth factors, bound to the glucocorticoid receptor and competed with DNA glucocorticoid response elements for binding to the receptor, thereby inhibiting glucocorticoid-mediated transcription. (sciencemag.org)
  • Raf-1-induced growth arrest in human mammary epithelial cells is p16-independent and is overcome in immortal cells during conversion. (nih.gov)
  • Flow cytometric analysis demonstrates that cells arrest in both G1 and G2. (nih.gov)
  • CD50, CD54, and CD102, were all expressed on XG2 cells, only a blocking anti-CD102 mAb inhibited the CD40-induced growth arrest. (aacrjournals.org)
  • Our data demonstrate that CD40 triggering on XG2 cells induced a myeloma cell growth arrest mediated by lymphocyte function-associated antigen 1 and intercellular adhesion molecule 2 interactions. (aacrjournals.org)
  • Here, we induce metabolic arrest of yeast cells by lowering their intracellular pH. (frontiersin.org)
  • We then determine the differences in the intracellular mass density and stiffness of active and metabolically arrested cells using optical diffraction tomography and atomic force microscopy. (frontiersin.org)
  • However, increasing the intracellular mass density alone is not sufficient for maintenance of the growth-arrested state in yeast cells. (frontiersin.org)
  • In the study described here, we explored the effect of HER2 overexpression on the sensitivity of breast cancer cells to the growth-inhibitory effects of 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO), a synthetic triterpenoid, both in vitro and in vivo in a xenograft model of breast cancer. (aacrjournals.org)
  • In vivo studies with liposomally encapsulated CDDO showed complete abrogation of the growth of the highly tumorigenic MCF7/HER2 cells in a xenograft model of breast cancer. (aacrjournals.org)
  • These findings provide the first in vitro and in vivo evidence that CDDO effectively inhibits HER2 tyrosine kinase activity and potently suppresses the growth of HER2-overexpressing breast cancer cells and suggest that CDDO has a therapeutic potential in advanced breast cancer. (aacrjournals.org)
  • An alternative splicing mechanism gives rise to two mature mRNAs which contain either 11 or 12 exons, and both are found in the cytoplasm of growth-arrested cells. (asm.org)
  • In Friend leukemia and NIH 3T3 cells, the levels of gas5 gene mRNA were high in saturation density-arrested cells and almost undetectable in actively growing cells. (asm.org)
  • Run-on experiments indicated that the gas5 gene is transcribed at the same level in both growing and arrested cells. (asm.org)
  • Smad
  • These data suggest that TGF-β/Smad signaling is blocked downstream of Smad complex formation or that an alternate signaling pathway other than TGF-β/Smad may transmit TGF-β-induced cell cycle arrest in the ovarian epithelium. (aacrjournals.org)
  • tomography
  • Three patients who had fat grafts implanted at operation for partial bone growth arrest had computed tomography scanning of the operated bone 3-10 years after operation so that the fate of the grafts could be clarified. (ovid.com)
  • Receptors
  • Basal mRNA levels of TGF-β receptors I and II, downstream signaling components Smad2, 3, 4, 6, 7, and the transcriptional corepressors Ski and SnoN did not show a statistically significant difference between HOSE and CSOC, and cannot explain their differential susceptibility to TGF-β-induced cell cycle arrest. (aacrjournals.org)
  • Overexpression
  • The Raf-induced arrest is independent of viral oncogene mediated inactivation of p53 and pRB, or c-myc overexpression. (nih.gov)
  • One of the most common molecular alterations associated with the malignant phenotype of breast cancer is the overexpression of epidermal growth factor receptor-2 (also known as HER2). (aacrjournals.org)
  • epithelial
  • Many epithelial carcinomas, including ovarian, are refractory to the antiproliferative effects of transforming growth factor (TGF) β. (aacrjournals.org)
  • parallel
  • dense lines parallel to the growth plates of long bones on radiographs, representing temporary slowing or cessation of longitudinal growth. (drugs.com)
  • The density in Hounsfield Units in the enlarged cavities showed that the fat grafts had grown in parallel with regained bone growth. (ovid.com)
  • data
  • On the other side, recent data from cancer immune therapy suggest that the therapy is primarily efficient under conditions where the immune therapy causes permanent growth arrest of the metastases (8, 9). (innovations-report.com)