• These findings indicate that the miR-501-3p/CREPT/cyclin D1 axis plays a crucial role in the progression of prostate cancer and may serve as potential therapeutic target. (nih.gov)
  • 1. Inhibition of Cdc42-intersectin interaction by small molecule ZCL367 impedes cancer cell cycle progression, proliferation, migration, and tumor growth. (nih.gov)
  • Previous studies have confirmed that ion channels fulfill an important role in the development and progression of cancer, including the infinite proliferation of cells and their invasion and metastasis ( 14 - 16 ), and ion channels have been approved as effective drug targets for cancer therapy ( 17 , 18 ). (spandidos-publications.com)
  • Study cell division with antibodies for detecting cyclins and cyclin-dependent kinases that control cycle progression, bioactive and stable recombinant proteins that stimulate or suppress cell division, and specialized dyes that can track cell proliferation. (biolegend.com)
  • Dimerisation results in the activation of intracellular tyrosine kinase, autophosphorylation and activation of signal transduction molecules, ultimately leading to cell cycle progression, reduced apoptotic capacity, angiogenesis and the metastatic phenotype. (nih.gov)
  • A disintegrin and metalloprotease 12 (ADAM12) has been associated with tumor development and progression. (mdpi.com)
  • The aim of the current study was to evaluate the impact of ADAM12 on cancer progression, prognosis, and therapeutic targets in colorectal cancer (CRC). (mdpi.com)
  • Our results show that ADAM12 overexpression enhanced proliferation, inhibited apoptosis, and acted as a positive regulator of cell cycle progression in CRC cells. (mdpi.com)
  • Tumor microenvironment (TME) Oncology research solutions TABLE OF CONTENTS Molecular drivers of cancer pathogenesis Cancer progression is associated with the interplay between tumor cells and the surrounding environment, which requires signal transduction pathways to relay messages throughout the cell.1,2 Cell signaling pathways regulate everything from cell growth to proliferation to survival. (technologynetworks.com)
  • Many of the genes commonly mutated encode Purpose and scope INTRODUCTION components or targets of the PI3K/AKT and Ras/ERK pathways, causing dysregulation of cellular signaling.1 This dysregulation drives cancer progression by influencing the behavior of tumor cells through cell proliferation, survival, migration, differentiation, metabolism, polarity, angiogenesis, and the tumor microenvironment. (technologynetworks.com)
  • The study identified 2 genes known to contribute to tumor progression and 8 known to be present in tumor cells but which have unknown functions. (frontiersin.org)
  • We designed a simple model of tumour progression during treatment, based on descriptions of the key phenomena of proliferation, quiescence, cell killing and resistance, and giving as output the macroscopically measurable tumour volume and growth fraction. (biomedcentral.com)
  • These events favor tumor progression and chemoresistance. (mdpi.com)
  • Studies suggest that it is involved in the progression of cells through the step-by-step process they take to replicate themselves (called the cell cycle) and that it plays roles in repairing damaged DNA and controlling the activity of genes. (medlineplus.gov)
  • Cancer cell metabolism and cancer cell cycle progression, which are essential for tumor formation, are conventionally thought to be regulated primarily by distinct signaling complexes,' Lu said. (mdanderson.org)
  • In breast cancer it has been proposed that the presence of cancer stem cells may drive tumor initiation, progression and recurrences. (oncotarget.com)
  • Chronic inflammation over the years results in altered immune responses and increases risk of tumor formation and progression. (metabiom.org)
  • proteasome inhibition interferes with cell cycle progression, upregulates tumor suppressors such as p53, and diminishes activation of pro-proliferation pathways such as those controlled by NFB and extracellular signal-regulated kinases (ERKs) [3], [4]. (scienza-under-18.org)
  • The K + channel plays an important role in the regulation of cell cycle progression , apoptosis , and immunoreactions involved in tumorigenesis . (emf-portal.org)
  • Everolimus is indicated for the treatment of hormone receptor-positive, HER2/neu negative advanced breast cancer, in combination with exemestane, in postmenopausal women without symptomatic visceral disease after recurrence or progression following a non-steroidal aromatase inhibitor. (medicines.org.uk)
  • It possesses a dual role in tumourigenesis, through initiation via increased instability and aneuploidy, and progression through induction of growth factors. (bham.ac.uk)
  • This notion is supported by data indicating that p21-null mice are more prone to spontaneous and induced tumorigenesis, and p21 synergizes with other tumor suppressors to protect against tumor progression in mice. (aacrjournals.org)
  • 3 complexes regulates progression through the cell cycle (reviewed in Refs. (aacrjournals.org)
  • Active cyclin/Cdk complexes phosphorylate and inactivate members of the retinoblastoma protein (Rb) family that are negative regulators of G 1 and S-phase progression, leading to induction of E2F-regulated gene expression and cell proliferation. (aacrjournals.org)
  • CKIs bind and inhibit the activity of cyclin/Cdk complexes and negatively regulate cell cycle progression (reviewed in Refs. (aacrjournals.org)
  • Consistently, multiple pathways commonly associated with tumor progression were revealed as common features in the majority of the tumors. (biomedcentral.com)
  • Background: Hypoxia has been shown to facilitate tumor progression. (medsci.org)
  • Hypoxia-regulated microRNA-210 (miR-210) may play an important role in carcinogenesis and tumor progression. (medsci.org)
  • MiR-210 is also correlated with tumor progression. (medsci.org)
  • Disease progression and tumor metastasis are commonly observed after surgery. (medsci.org)
  • GSK-3β is particularly important in tumor progression and modulation of oncogenes (including beta-catenin, cyclin D1 and c-Myc), cell cycle regulators (e.g. p27Kip1) and mediators of epithelial-mesenchymal transition (e.g. zinc finger protein SNAI1, Snail). (outcomes4me.com)
  • Insulin-like growth factor-1 (IGF-I) signalling is important for cancer initiation and progression. (biomedcentral.com)
  • There is a considerable amount of evidence that the insulin-like growth factor (IGF) family is important for cancer development and progression and IGF signalling is known to involve complex regulatory networks with numerous interacting ligands, receptors and binding proteins [ 1 , 2 ]. (biomedcentral.com)
  • Further highlighting the importance of the IGF-I axis, the IGF-I receptor (IGF-IR) is crucial in cancer development and progression. (biomedcentral.com)
  • Some of the new approaches depend on tumor biology and aim specifically to inhibit tumor growth and metastasis by targeting the tumor microenvironment or vasculature (leaving normal cells unaffected) or focusing on specific protein or signal transduction pathways. (medscape.com)
  • 11. R-Ketorolac Targets Cdc42 and Rac1 and Alters Ovarian Cancer Cell Behaviors Critical for Invasion and Metastasis. (nih.gov)
  • 15. Rac1-mediated cytoskeleton rearrangements induced by intersectin-1s deficiency promotes lung cancer cell proliferation, migration and metastasis. (nih.gov)
  • In the comprehensive signaling network of tumorigenesis, metastasis, apoptosis and angiogenesis, deguelin is pivotal in inducing apoptotic cell death and prohibiting their malignant transformation. (spandidos-publications.com)
  • The cells mediated by irradiation induced resistance to radiation and apoptosis and increased metastasis in lung cancer cells. (nih.gov)
  • ADAM12 overexpression was significantly associated with the cancer stage, depth of invasion, lymph node metastasis, distant metastasis, and poor survival in CRC patients. (mdpi.com)
  • Regardless of cell type, the tumorigenic changes that drive cancer growth and metastasis are complex. (technologynetworks.com)
  • Cancer is a complex entity and regardless of cancer type, there are frequently observed cellular changes involved in tumorigenesis, tumor growth, and metastasis. (technologynetworks.com)
  • In this study we found that KLF4 is significantly downregulated in prostate cancer cell lines and in prostate cancer tissues especially those with metastasis. (ca.gov)
  • These results suggest that KLF4 functions as an inhibitor of tumor cell growth and migration in prostate cancer and decreased expression has prognostic value for predicting prostate cancer metastasis. (ca.gov)
  • Our scientists pursue every aspect of cancer research-from exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. (mskcc.org)
  • The obtained data indicate a beneficial use of the drug combination reparixin and paclitaxel to counteract brain tumour metastasis due to CSC, probably due to the combined effects of the two drugs, the pro-apoptotic action of paclitaxel and the cytostatic and anti-migratory effects of reparixin. (oncotarget.com)
  • Circ_0119872 knockdown suppressed the cell proliferation and metastasis In addition, miR-582-3p was identified as a downstream target of circ_0119872. (bvsalud.org)
  • Hypoxia is one of the most important environmental factors that induce cancer metastasis [ 6 ]. (medsci.org)
  • Its prominent properties are A lack of cell differentiation Local invasion of adjoining tissue Metastasis, which is spread to distant sites through. (msdmanuals.com)
  • Although most circulating cancer cells die, an occasional cell may penetrate into tissues, generating a metastasis at a distant site. (msdmanuals.com)
  • This family, which includes epidermal growth factor receptor (EGFR), plays a pivotal role in normal cell growth, lineage determination, repair, and functional differentiation. (medscape.com)
  • Oncogenes are responsible for cell proliferation and differentiation. (wikipedia.org)
  • Many microRNAs (miRNAs) target mRNAs involved in processes aberrant in tumorigenesis, such as proliferation, survival, and differentiation. (eur.nl)
  • These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. (thermofisher.com)
  • These proteins play important roles regulating proliferation during normal development and differentiation and after genotoxic stress. (aacrjournals.org)
  • PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. (shu.edu)
  • The HER (erbB) family of transmembrane receptor tyrosine kinases is one of the cytostatic targets in tumor cell growth and survival. (medscape.com)
  • 3. A Rac1/Cdc42 GTPase-specific small molecule inhibitor suppresses growth of primary human prostate cancer xenografts and prolongs survival in mice. (nih.gov)
  • 4. Targeting Cdc42 with the small molecule drug AZA197 suppresses primary colon cancer growth and prolongs survival in a preclinical mouse xenograft model by downregulation of PAK1 activity. (nih.gov)
  • A recent analysis shows that in the US, despite increased expenditure for anti-cancer drugs in recent years, the effects on survival have been very modest. (newswise.com)
  • Osteosarcoma is the most common primary malignant tumor of bone, the long-term survival of which has stagnated in the past several decades. (nature.com)
  • Genetic drivers are mutations or fusions that confer a survival advantage to "drive" malignant proliferation. (medscape.com)
  • RNAa mediated KLF4 activation in prostate cancer cells led to inhibited cell proliferation/survival and migration/invasion, and altered expression of several cell-cycle-related genes regulated by KLF4. (ca.gov)
  • In vitro analysis indicated that RNAa-mediated overexpression of KLF4 inhibited prostate cancer cell proliferation and survival and altered the expression of several downstream cell-cycle-related genes. (ca.gov)
  • The hypoxia-inducible factors (HIF) act as hypoxia sensors that orchestrate a coordinated response increasing the pro-survival and pro-invasive phenotype of cancer cells, and determine a broad metabolic rewiring. (mdpi.com)
  • Although it is unclear exactly how changes in BAP1 function lead to BAP1 tumor predisposition syndrome, researchers speculate that altered activity of proteins normally regulated by BAP1 deubiquitination may promote cell proliferation or survival, resulting in tumor formation. (medlineplus.gov)
  • Results: LAMC2 was consistently upregulated in human and mouse experimental models as well as in human PDAC specimens, and associated with tumor grade and survival. (unav.edu)
  • To this end, we developed novel technologies that combine the transcriptome and metabolome for identifying the events occurring in CSCs that support cell survival during exposure to therapy. (nature.com)
  • The available data indicate that IL-8, expressed by tumour cells and induced by chemotherapeutic treatment, is a key regulator of the survival and self-renewal of the population of CXCR1-expressing CSC. (oncotarget.com)
  • Here, we show that DLBCLs are dependent on mitochondrial lysine deacetylase SIRT3 for proliferation, survival, self-renewal, and tumor growth in vivo regardless of disease subtype and genetics. (fry-it.com)
  • Five-year survival rates of patients with stage Ta-T1, T2, T3, and T4 tumors were 60-90%, 43-75%, 16-33%, and 0-4% respectively [ 5 ]. (medsci.org)
  • Aberrant overexpression of GSK-3β has been shown to promote tumor growth and chemotherapy resistance in various solid tumors including colon, ovarian, and pancreatic cancers and glioblastoma through differential effects on the pro-survival nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and c-Myc pathways as well on tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and p53-mediated apoptotic mechanisms. (outcomes4me.com)
  • GSK-3β helps maintain malignant cell survival and proliferation, particularly in terms of mediating resistance to standard anti-cancer therapies, through the NF-κB pathway. (outcomes4me.com)
  • [ 58 ] Third, statins block the DNA-binding activity of NF-ĸB and Activator protein-1 (AP-1), which results in decreased transcription of genes that regulate cell proliferation. (medscape.com)
  • This task can be accomplished by replacing tumor suppressor genes that have been lost or mutated, selectively inserting genes that produce cytotoxic substances, or modifying the immune system to destroy the tumor cells. (medscape.com)
  • The mutated DNA affects genes involved with the cell cycle, classified as either oncogenes or tumor suppressor genes. (wikipedia.org)
  • Tumor suppressor genes prevent cells with erroneous cell cycles from replicating. (wikipedia.org)
  • Signaling pathways ultimately lead to the activation of transcription factors that regulate genes involved in the cell cycle. (biolegend.com)
  • We investigated biological behaviors such as cell cycle, proliferation, radiation sensitivity, apoptosis and migration, hypoxia signal pathway in the lung cancer cells treated with chronic intermittent hypoxia, as well as the role of hypoxia inducible factor 1 there, hypoxia-inducible genes analyzed by real-time RT-PCR chip in H446 cells treated with the model. (nih.gov)
  • Although 99.7% of cervical cancer cases were found to be associated with HPV (human papillomavirus) infection [ 2 ], the interactions of multiple factors in vivo and in vitro that activate oncogenes and inactivate cancer suppressor genes could not be ignored in the long process of cervical cancer development. (oncotarget.com)
  • Genetic alterations to cellular genes may be inherited or arise spontaneously because of DNA damage from an environmental carcinogen or mutation from replication errors.1 Many common genetic lesions in cancer involve signaling proteins. (technologynetworks.com)
  • Driver events in pediatric malignancies can occur through loss of function in tumor suppressor genes or gain of function in proto-oncogenes. (medscape.com)
  • Tumor suppressor genes encode proteins that normally provide negative control of cell proliferation. (medscape.com)
  • Proto-oncogenes are genes that function normally in healthy cells to promote growth and proliferation. (medscape.com)
  • While they are normally regulated by other genes, including tumor suppressor genes, proto-oncogenes can be activated to become oncogenes that are less sensitive to this regulation. (medscape.com)
  • Transcription factors, proteins that bind to the regulatory sequences of target genes, compose the largest class of oncogenes identified in pediatric tumors. (medscape.com)
  • identified 189 frequently mutated genes associated with these cancers, most of which were not previously known. (frontiersin.org)
  • The research indicates that quadruplexes are more likely to occur in genes of cells that are rapidly dividing, such as cancer cells. (cam.ac.uk)
  • Cancers are usually driven by genes called oncogenes that have mutated to increase DNA replication - causing cell proliferation to spiral out of control, and leading to tumour growth. (cam.ac.uk)
  • Increased infiltration of intratumoral CD8+ and Ki67+CD8+T cells was observed for both treatment regimens, accompanied by the up-regulation of T cell activation genes and gene signatures. (unav.edu)
  • RAS and its downstream cascades transmit cellular signals, resulting in increased transcription of genes involved in cell growth and division. (njit.edu)
  • Up-regulation of the MDR1 and CYP2C8 genes were shown to be potential mechanisms of paclitaxel resistance in the resistant cells. (iiarjournals.org)
  • The target genes of miR-193a-3p are involved in melanogenesis and cancer-related signaling pathways. (bvsalud.org)
  • All of these studies revealed associations between molecular profiles and biological behavior of different tumors, without a detailed integration of regulated genes and signaling pathways. (biomedcentral.com)
  • It's modes of action include downregulation of NF-κB and decreasing the expression NF-κB target genes including cyclin D1, Bcl-2, anti-apoptotic protein (XIAP) and B-cell lymphoma-extra large (Bcl-XL) leading to inhibition of tumor growth in multiple solid tumor cell and lymphoma lines and patient derived xenograft (PDX) models. (outcomes4me.com)
  • Among the up-regulated genes in the stromal fibroblasts we observed a significant enrichment in proliferation associated genes. (biomedcentral.com)
  • Expression patterns of genes induced by IGF-I in primary breast and lung fibroblasts accurately predict outcomes in breast and lung cancer patients. (biomedcentral.com)
  • The four genes were selected as those which researchers believe to have the greatest likelihood of accurately predicting individual patient response to specific anti-cancer drugs. (cancer.org)
  • These tumors can develop on the skin, subcutaneously, or on a blood vessel within an organ and are highly malignant. (wikipedia.org)
  • Deguelin induced cell apoptosis by blocking anti-apoptotic pathways, such as PI3K-Akt, IKK-IκBα-NF-κB and AMPK-mTOR-survivin, while inhibiting tumor cell propagation and malignant transformation through p27-cyclinE-pRb-E2F1 cell cycle control and HIF-1α-VEGF anti-angiogenic pathways. (spandidos-publications.com)
  • The aberrant expression and function of ion channels leads to impairment of these processes, allowing normal cells to transform into malignant derivatives that exhibit uncontrolled proliferation and spread, which are hallmarks of cancer ( 13 ). (spandidos-publications.com)
  • BACKGROUND: The risk factors for operation complications of high-dose-rate dimensional (3D) interstitial brachytherapy for lung malignant tumors are still unclear. (bvsalud.org)
  • Colorectal cancer is a common malignant tumor in the digestive system, which seriously endangers human health. (ijpsonline.com)
  • Their loss of function is a well described mechanism of malignant proliferation. (medscape.com)
  • Somatic BAP1 gene mutations have been found in uveal melanoma, malignant mesothelioma, and clear cell renal cell carcinoma tumors in the absence of a germline BAP1 gene mutation. (medlineplus.gov)
  • OBJECTIVES: Malignant melanoma (MM) is an invasive tumor that poses a threat to patient health. (bvsalud.org)
  • MM cells with circ_0119872 knockdown were established, and cell counting kit 8 (CCK-8) and transwell assays were utilized to examine the function of circ_0119872 and its effects on the malignant characteristics of MM cells. (bvsalud.org)
  • Four varieties of tumor cells were examined: malignant melanoma A375, lung caner A549, ovarian carcinoma breast and A2780 cancer MCF-7 and MDA-MB-231 cells. (racetab.org)
  • 7. Cdc42 Signaling Pathway Inhibition as a Therapeutic Target in Ras- Related Cancers. (nih.gov)
  • Because of our research history on cancer cell-cycle and our full awareness of the strong impact of the therapeutic inhibition of cancer cell proliferation, we consider it paramount that our results are properly translated into clinical settings," says Giordano. (newswise.com)
  • It is worth noting that the treatment of HCC is complex and several years of study have demonstrated that treatment of patients with HCC depends on the clinical manifestation, liver function and tumor staging, although multidisciplinary treatments exist, which mainly include surgical resection and liver transplantation, radiofrequency ablation, chemical drug targeting inhibition and immune suppression ( 3 , 7 , 8 ). (spandidos-publications.com)
  • Cell cycle inhibition - Dysregulation of the cell cycle can result in uncontrolled proliferation of cells, which will cause tumor growth and cancer. (biolegend.com)
  • Inhibition of LRIG3 gene expression via RNA interference modulates the proliferation, cell cycle, cell apoptosis, adhesion and invasion of glioblastoma cell (GL15). (nih.gov)
  • LAMC2 inhibition impaired cell cycle, induced apoptosis, and sensitized PDAC to MEK1/2 inhibitors (MEK1/2i). (unav.edu)
  • Considering that a host of intracellular proteins are affected by proteasome inhibition, coupled with evidence that knockdown of MKP3 expression enhances growth factor-stimulated ERK phosphorylation in some contexts [13] but not in others [16], led us to question whether or not the diminution of ERK signaling in MG132-treated cells could be attributed solely to upregulation of MKP3 and other DUSPs. (scienza-under-18.org)
  • With the increased understanding of molecular mechanisms and basic pathways in the pathogenesis of squamous cell cancer of the head and neck, these pathways may be modified, and rational approaches in cancer therapy at the molecular level may be created. (medscape.com)
  • Deguelin has been reported to kill cancer cells or inhibit tumor growth through targeting apoptosis, cell cycle arrest and anti-angiogenesis, including PI3K-Akt, IKK-IκBα-NF-κB and AMPK-mTOR-survivin pathways. (spandidos-publications.com)
  • Therefore, key regulatory components involved in apoptotic or anti-apoptotic pathways are necessary with a view to developing new targeting agents, with fewer side effects, eliminating cancer cells ( 9 ). (spandidos-publications.com)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • This guide highlights some of the key pathways that are commonly dysregulated in cancer. (technologynetworks.com)
  • Hyperactivation of these pathways drives tumorigenesis and supports tumor growth.2 Signaling pathway proteins that are commonly activated by physiological responses include growth factor receptor (e.g. (technologynetworks.com)
  • Finally, downstream nuclear targets of signaling pathways like the transcription factors Myc and NF-κB, chromatin remodelers, and cell cycle effectors are also commonly altered. (technologynetworks.com)
  • Decoding these cellular changes and correlating to molecular pathways are key to novel discoveries that will help develop the next generation of cancer treatments. (technologynetworks.com)
  • Benjamin D. Cancer Signaling Pathways and Crosstalk. (technologynetworks.com)
  • Use of synthetically designed "miRNAs sponges," miR mimics (agomiRs), miR antagonists ("antagomiRs"), and miR inhibitors (antimiRNAs oligonucleotides) is an innovative strategy to modulate oncogenic and tumor‐suppressive pathways. (intechopen.com)
  • Many mechanisms of paclitaxel resistance in breast cancer have been identified such as evading chemotherapeutic-induced cell death by hijacking apoptosis pathways, removing the drug quickly by efflux or metabolism, or altering drug-binding sites ( 18 ). (iiarjournals.org)
  • However, several pathways previously not linked to carcinogenesis were identified in multiple cancers suggesting an essential role of these pathways in cancer biology. (biomedcentral.com)
  • This work resulted in identification of novel superimposed functional pathways potentially linked to cancer biology. (biomedcentral.com)
  • This novel approach provides a systematic and unbiased view on cancer development by investigating signaling pathways and functional networks in an easy-to-interpret way. (biomedcentral.com)
  • MAbs and antibody toxin conjugates can be targeted to specific receptors or proteins found on cancer cells. (medscape.com)
  • Carcinogenesis is linked with DNA mutations, chromosomal translocations, dysfunctional proteins, and aberrant cell cycle regulators. (wikipedia.org)
  • Ion channels are specialized proteins found in cell membranes, which facilitate the movement of specific ions across the plasma membrane. (spandidos-publications.com)
  • Additionally, the YT521-B homology (YTH) domain family of proteins (YTHDF1/2/3 and YTHDC1/2), and insulin-like growth factor 2 mRNA binding proteins (IGF2BP1/2/3) are recognized as RNA-binding proteins that bind m 6 A sites and lead target RNA to different destination [ 9 ]. (biomedcentral.com)
  • Moreover, the expression of the p21, p27 and p53 proteins were down-regulated in Msi1 overexpressing cervical cancer cells and up-regulated in shMsi1 cervical cancer cells. (oncotarget.com)
  • We will discuss three key proteins that function as tumor suppressors implicated in the development of pediatric (and some adult) cancers: pRB, p53, and PTEN. (medscape.com)
  • By building on previous research, Biffi was able to generate antibody proteins that detect and bind to areas in a human genome rich in quadruplex-structured DNA, proving their existence in living human cells. (cam.ac.uk)
  • The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. (thermofisher.com)
  • Tumor suppressor proteins help prevent cells from growing and dividing too rapidly or in an uncontrolled way. (medlineplus.gov)
  • The Translational Immuno-oncology study section will focus on the discovery and use of therapeutic reagents, including large proteins such as antibodies, immune check point inhibitors, immune-conjugates, cytokines and tumor vaccines for prevention and treatment. (nih.gov)
  • The ubiquitin-proteasome pathway is an essential quality control mechanism directing degradation of mislocated, misfolded, and damaged proteins, and, by tempering the expression levels Carnosol of specific signaling proteins, it also exerts a level of control over cell physiology [1]. (scienza-under-18.org)
  • ERK signaling is usually inappropriately activated in a wide array of human cancers, which can be caused by an activating mutation in one of the upstream signaling proteins or through overexpression of growth factors or growth factor receptors [7], [8]. (scienza-under-18.org)
  • He is widely known for his 1979 discovery of a molecular switch called tyrosine phosphorylation that, when flipped on permanently, can trigger cancer cell proliferation by adding phosphate to the amino acid tyrosine in proteins in an uncontrolled manner. (salk.edu)
  • Hunter's lab continues to study phosphorylation of proteins in cancer, now focusing on a different type of phosphorylation in which phosphate is added to the amino acid histidine in proteins. (salk.edu)
  • The Hippo pathway consists of a large network of proteins (at least 35 in both D. melanogaster and mammals have so far been identified) that control the growth of different tissues during development and regeneration, as well as in pathological states such as cancer . (shu.edu)
  • There are shared interests with Clinical Neuroimmunology and Brain Tumors (CNBT) in the areas of neural and brain tumors. (nih.gov)
  • The researchers analyzed brain tumors in 84 patients who had been treated with radiation and chemotherapy after surgery. (mdanderson.org)
  • Bioinformatics analysis predicted that cell cycle-related and expression-elevated protein in tumor (CREPT) was a potential target gene of miR-501-3p. (nih.gov)
  • Antisense molecules are a small, complementary, single-stranded type of DNA that binds targeted messenger RNA (mRNA) within the cell and prevents specific protein translation. (medscape.com)
  • In 1989, we discovered p/60Cyclin A: a pivotal protein whose dysregulation plays a crucial role in carcinogenesis and cancer cells proliferation and tumor growth. (newswise.com)
  • The Cyclin-dependent cells proliferation is even more important when a gene for protein serving as a brake called p16 is lost," adds Giordano. (newswise.com)
  • TPX2 is a protein critical for microtubule growth and mitotic spindle function. (biolegend.com)
  • In let-7g expressing tumors, reductions in Ras family and HMGA2 protein levels were detected. (eur.nl)
  • Musashi RNA-binding protein1 (Msi1), a member of the RNA-binding protein family, has been reported to be a diagnostic marker and potential therapeutic target in some cancers, its function in cervical cancer remains unknown. (oncotarget.com)
  • RB1 encodes the protein pRB and was the first tumor suppressor gene to be molecularly defined. (medscape.com)
  • PTEN encodes a protein kinase of the same name and functions as a tumor suppressor through regulation of cell proliferation. (medscape.com)
  • They help inhibit protein synthesis in tumor cells. (prospecbio.com)
  • Tumor cell proliferation is blocked because of the interruption of asparagine-dependent protein synthesis. (prospecbio.com)
  • This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. (thermofisher.com)
  • The BAP1 protein is thought to help control cell growth and division (proliferation) and cell death. (medlineplus.gov)
  • Although the exact mechanism is unclear, the BAP1 protein acts as a tumor suppressor. (medlineplus.gov)
  • Together, the germline and somatic mutations lead to a loss of BAP1 protein function in tumor cells. (medlineplus.gov)
  • Tumor vaccines of all types (protein/peptide, viral, DNA/RNA, dendritic cell, tumor cell) and formulations to induce or amplify tumor-specific immunity. (nih.gov)
  • This first-in-human study evaluated RO7122290, a bispecific fusion protein carrying a split trimeric 4-1BB (CD137) ligand and a fibroblast activation protein alpha (FAP) binding site that costimulates T cells for improved tumor cell killing in FAP-expressing tumors. (unav.edu)
  • Previous studies by others and ourselves showed that although proteasome activity was not associated with the intensity of green fluorescent protein fused by the degron motif, cells sorted by fluorescence indeed showed high tumourigenicity and therapy resistance. (nature.com)
  • In response to epidermal growth factor (EGF), the team found, PKM2 moves into the cell nucleus and binds to beta-catenin that has had a phosphate atom and three oxygen atoms attached at a specific spot called Y333 by the protein c-Src. (mdanderson.org)
  • Sirtuin 1 (SIRT1) can be activated by RES indirectly by dissociation with the negative protein regulator, Deleted in Breast Cancer 1 (DBC1), via the cAMP/PKA/AMPK pathway ( 8 , 9 ). (iiarjournals.org)
  • To explore the mechanism of resveratrol in paclitaxel-sensitive and -resistant triple-negative breast cancer cells, the effects of RES on survivin, SIRT1, DBC1 and P-AMPK protein levels were investigated. (iiarjournals.org)
  • The mitogen-activated protein kinases (MAPKs) ERK2/MAPK1 and ERK1/MAPK3 (hereafter referred to collectively as ERK1/2) are activated by phosphorylation in a canonical Raf MEK ERK kinase cascade in response to most growth factors and cytokines, and ERK1/2 phosphorylate more than 150 cytosolic and nuclear substrates [5], [6]. (scienza-under-18.org)
  • hPTTG1 is a multifunctional protein with roles in cell cycle control, DNA repair and apoptosis. (bham.ac.uk)
  • Specifically, with fasting and calorie-restriction comes reductions in markers of diabetes and atherosclerosis along with reductions in inflammatory markers such as tumor necrosis factor (TNF) and C-reactive protein (CRP). (tigerfitness.com)
  • Protein tyrosine phosphatase, which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. (shu.edu)
  • Importantly, let-7g-mediated tumor suppression was more potent in lung cancer cell lines harboring oncogenic K-Ras mutations than in lines with other mutations. (eur.nl)
  • Passenger mutations are additional mutations found in the cancers that do not contribute to cancer proliferation. (medscape.com)
  • piloted the use of NGS to study the exomes of 140 samples of human acute myeloid leukemia (AML) cells in 2003, identifying 6 previously described and 7 undescribed mutations relevant for AMP pathogenesis. (frontiersin.org)
  • Table 1 provides a summary of cancers and gene mutations. (frontiersin.org)
  • Mutations in the BAP1 gene cause BAP1 tumor predisposition syndrome. (medlineplus.gov)
  • These mutations, which are present in essentially every cell of the body, are classified as germline mutations. (medlineplus.gov)
  • Researchers genetically profiled nearly 300 basal cell carcinoma (BCC) samples , and found additional recurrent mutations - including ones in MYCN, PTPN14, and LATS1 - that appear to drive disease. (shu.edu)
  • 7, 8, 9] Overexpression of EGFR is recognized in more than 80% of squamous cell cancers, and this overexpression is associated with a poor prognosis. (medscape.com)
  • Tumour EGFR expression correlates with poor prognosis and resistance to therapy. (nih.gov)
  • They also discovered that levels of beta-catenin phosphorylation and PKM2 in the cell nucleus are correlated with brain tumor malignancy and prognosis and might serve as biomarkers for customized treatment with Src inhibitors. (mdanderson.org)
  • IL-8, up-regulated in breast cancer, and associated with poor prognosis, increases CSC self-renewal in cell line models. (oncotarget.com)
  • Patients bearing an oestrogen receptor negative breast tumour have a worse prognosis when their tumour is positive for IGF-IR [ 24 ]. (biomedcentral.com)
  • The clinical studies discussed above have been complemented by basic research studies that focus on the mechanisms by which statins exert anti-tumor effects. (medscape.com)
  • Applications that focus on mechanisms of tumor resistance to cellular therapies such as CAR-T cells may be reviewed in TIR. (nih.gov)
  • The new findings integrate the two major mechanisms for regulating cancer cell growth by a key metabolic enzyme. (mdanderson.org)
  • Interestingly, these anticancer effects and their mechanisms seem to be cell-type dependent. (iiarjournals.org)
  • The cyclin-dependent kinase inhibitor p21 is induced by both p53-dependent and -independent mechanisms following stress, and induction of p21 may cause cell cycle arrest. (aacrjournals.org)
  • Our aim was to develop a functional cancer map focusing on signaling and metabolic events across multiple cancer types to provide a deeper understanding of common and distinct molecular mechanisms leading to carcinogenesis. (biomedcentral.com)
  • The purpose of BAY 293 our current research would be to investigate the result of leucine deprivation on breast tumor cells and also to elucidate the root mechanisms. (racetab.org)
  • MPa'S reSearch PrograMMe iS a key eleMent of iarc'S goalS of elucidating the MechaniSMS of carcinogeneSiS and underStanding the etiology of cancer. (who.int)
  • 5-FU inhibits tumor cell growth through at least 3 different mechanisms that ultimately disrupt DNA synthesis or cellular viability. (medscape.com)
  • In addition, forced overexpression of CYP2J2, and CYP BM3F87V or addition of epoxyeicosatrienoic acids (EET) in cultured carcinoma cell lines in vitro markedly accelerated proliferation by analyses of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, cell accounts, and cell cycle analysis, and protected carcinoma cells from apoptosis induced by tumor necrosis factor α (TNF-α) in cultures. (aacrjournals.org)
  • It exhibited significant anti-tumorigenesis and anti-proliferative activity in various types of cancer both in vitro and in vivo. (spandidos-publications.com)
  • The in vivo effect on tumorigenesis of METTL3 was evaluated using the LUAD cell xenograft mouse model. (biomedcentral.com)
  • The findings mark the culmination of over 10 years investigation by scientists to show these complex structures in vivo - in living human cells - working from the hypothetical, through computational modelling to synthetic lab experiments and finally the identification in human cancer cells using fluorescent biomarkers. (cam.ac.uk)
  • Despite the recent development of technologies giving detailed images of tumours in vivo , direct or indirect ways to measure how many cells are actually killed by a treatment or are resistant to it are still beyond our reach. (biomedcentral.com)
  • At the level of in vivo tumour growth, a typical datum is the time course of tumour volumes, measured (by callipers or in vivo imaging) in animals in the pre-clinical stage of drug development or in humans. (biomedcentral.com)
  • Silencing of Orilnc1 blocked tumor cell proliferation and growth in vitro and in vivo. (njit.edu)
  • Reparixin, a powerful CXCR1 inhibitor, was effective in reducing in vivo the tumour-initiating population in several NOD/SCID mice breast cancer models, showing that the selective targeting of CXCR1 and the combination of reparixin and docetaxel resulted in a concomitant reduction of the bulk tumour mass and CSC population. (oncotarget.com)
  • The anticancer effects of resveratrol (RES) have been extensively studied in many in vitro and in vivo human cancer models. (iiarjournals.org)
  • 9-ING-41 has significant in vitro and in vivo activity as a single agent and/or in combination with standard cytotoxic chemotherapies in a spectrum of solid tumors and hematological malignancies including bladder, breast, glioblastoma, neuroblastoma, pancreatic, sarcomas, and renal cancers as well as lymphomas. (outcomes4me.com)
  • In vitro data were correlated with in vivo findings by comparing the results with published expression datasets on human cancer biopsies. (biomedcentral.com)
  • Gain-of-function experiments showed that upregulation of miR-501-3p expression significantly decreased cell proliferation and colony formation, and induced cell cycle arrest in the G0/G1 phase. (nih.gov)
  • Previous in vitro studies have demonstrated that statins can halt cancer cell proliferation by inducing G0/G1 or G2/M arrest. (medscape.com)
  • First, simvastatin has been shown to induce G1 cell cycle arrest through reduction of CDK4/6 and Cyclin D1. (medscape.com)
  • [ 59 ] Rho GTPases normally play an important role in p27 degradation, meaning inactivity results in the accumulation of p27 and cell cycle arrest. (medscape.com)
  • [ 62 ] In summary, statins act to suppress cancer proliferation by inducing cell cycle arrest, blocking proliferation signals, and influencing gene transcription. (medscape.com)
  • Ectopic expression of let-7g in K-RasG12D-expressing murine lung cancer cells induced both cell cycle arrest and cell death. (eur.nl)
  • In contrast, reducing production of intracellular ROS using N -acetylcysteine, a scavenger of ROS, concurrently suppressed honokiol-induced cellular apoptosis, autophagy, and cell cycle arrest. (nature.com)
  • Taken together, our results revealed that honokiol caused G0/G1 phase arrest, induced apoptosis, and autophagy via the ROS/ERK1/2 signaling pathway in human osteosarcoma cells. (nature.com)
  • It specifically negatively regulates the PI3K-AKT signaling pathway to induce cell cycle arrest. (medscape.com)
  • In addition, Orilnc1 blockade reduced expression of cyclin E1 and induced G 1 -S cell-cycle arrest in tumor cells. (njit.edu)
  • In addition, Orilnc1 blockade reduced expression of cyclin E1 and induced G1-S cell-cycle arrest in tumor cells. (njit.edu)
  • RES has been shown to inhibit angiogenesis and cell proliferation, as well as induce cell-cycle arrest and apoptosis in various cancers ( 1 , 2 ). (iiarjournals.org)
  • For example, the type of cell-cycle arrest caused by RES, if any, is dependent on cancer cell-type ( 6 ). (iiarjournals.org)
  • p21 plays an essential role in growth arrest after DNA damage ( 19 - 21 ), and overexpression leads to G 1 and G 2 ( 22 ) or S-phase ( 23 ) arrest. (aacrjournals.org)
  • Targeted molecular therapy, like therapy with monoclonal antibodies, gene therapy, and other therapies, has limited or nonexistent side effects on normal cells of the body, unlike present modalities such as surgery, chemotherapy, and radiotherapy. (medscape.com)
  • Targeted molecular therapy can also act as a complement to other existing cancer therapies. (medscape.com)
  • Previous studies have shown that cancer cells could behave in the form of adaptation to hypoxia in tumor growth, which could result in their biological changes and determine their responses to the therapies. (nih.gov)
  • Discovery opens up possibilities for a new generation of targeted therapies for cancer. (cam.ac.uk)
  • The Cellular Immunotherapy of Cancer study section will focus on the many approaches to cellular therapy, including stem cell transplantation, adoptive cellular therapies and their toxicities, as well as therapeutic combinations that employ adoptive and allogeneic cell transfer. (nih.gov)
  • Adoptive cellular therapies (TILs, CAR- and TCR-engineered T cells, NK/NKT cells) using immune cells as cancer treatment. (nih.gov)
  • Cellular therapies including dendritic cells and mononuclear phagocytes. (nih.gov)
  • There are shared interests with Therapeutic Immune Regulation (TIR) in the areas of therapeutic responses and combination therapies for cancer. (nih.gov)
  • Applications studying the immunopathology and immunotherapy of central nervous system tumors (glioma, medulloblastoma, etc.) may be reviewed in either CNBT or CIC (if focus is on cellular therapies). (nih.gov)
  • Recently, the IL-8/CXCR1 axis was proposed as an attractive pathway for the design of specific therapies against breast cancer stem cells. (oncotarget.com)
  • By developing small molecule drugs that block the activity of these enzymes, researchers have been able to produce effective targeted cancer therapies, with more than 60 tyrosine kinase inhibitors now approved for clinical use, including Gleevec TM . (salk.edu)
  • Concise grouping of tumor types in cancer maps according to their molecular profile may further be helpful for the development of new therapeutic modalities or open new avenues for already established therapies. (biomedcentral.com)
  • Therefore, our work may serve as a starting point for rationalizing combination of tumor therapeutics as well as for expanding the application of well-established targeted tumor therapies. (biomedcentral.com)
  • 8. Maspin controls mammary tumor cell migration through inhibiting Rac1 and Cdc42, but not the RhoA GTPase. (nih.gov)
  • Potassium (K + ) channels have an important role in HCC, including regulating the proliferation, migration, invasion and drug resistance of HCC cells. (spandidos-publications.com)
  • Scratch test was used to detect the migration distance of cells. (ijpsonline.com)
  • Prognostic value and function of KLF4 in prostate cancer: RNAa and vector-mediated overexpression identify KLF4 as an inhibitor of tumor cell growth and migration. (ca.gov)
  • Reactivation of KLF4 also suppressed migration and invasion of prostate cancer cells. (ca.gov)
  • Finally, honokiol suppressed tumor growth in the mouse xenograft model. (nature.com)
  • In a mouse xenograft model, tumor area, volume, and weight were significantly greater for the ADAM12 overexpression group and significantly lower for the ADAM12 knockdown group. (mdpi.com)
  • We found that miR-501-3p expression was significantly downregulated in prostate cancer tissues and cell lines. (nih.gov)
  • Correlation analysis showed that miR-501-3p was inversely correlated with CREPT expression in prostate cancer tissues. (nih.gov)
  • Dogs can develop carcinomas of epithelial cells and organs, sarcomas of connective tissues and bones, and lymphomas or leukemias of the circulatory system. (wikipedia.org)
  • In this study, we found Msi1 was highly expressed in cervical cancer tissues, and over-expressing Msi1 in cervical cancer cells enhanced tumor formation and cell proliferation and accelerated cells into the S phase. (oncotarget.com)
  • In this study, we found that very strong and selective CYP2J2 expression was detected in human carcinoma tissues in 101 of 130 patients (77%) as well as eight human carcinoma cell lines but undetectable in adjacent normal tissues and nontumoric human cell lines by Western, reverse transcription-PCR, and immunohistochemical staining. (aacrjournals.org)
  • Applications focused on immunological aspects of neural tissues and diseases unrelated to tumors may be reviewed in CNBT. (nih.gov)
  • Experimental Design: LAMC2 expression was analyzed in PDAC tissues, a panel of human and mouse cell lines, and a genetically engineered mouse model. (unav.edu)
  • Instead of oral administration, probiotics can also be delivered locally at tumor sites, which can reduce non-specific pharmacological effects on non-tumor tissues. (metabiom.org)
  • In this study, we investigated the expression characteristics and biological functions of, and mechanism underlying, circ_0119872 expression in MM. METHODS: Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was employed to examine the circ_0119872, microRNA (miR)-582-3p, and E2F transcription factor 3 (E2F3) mRNA expression levels in MM tissues and cell lines. (bvsalud.org)
  • RESULTS: Circ_0119872 was remarkably upregulated in MM tissues and cell lines. (bvsalud.org)
  • Abstract] Objective: To investigate the expression of miR144-3p in bladder cancer tissues and cells and its effect on the proliferation and invasion of T24 cells. (bvsalud.org)
  • The levels of miR144-3p in bladder cancer tissues and cells were detected by qPCR methods. (bvsalud.org)
  • Conclusion: miR-144-3p has low expression level in bladder cancer tissues. (bvsalud.org)
  • The expression of miR-378a-5p, miR-630, and E2F transcription factor 3 (E2F3) in tissues and cells was measured by quantitative real-time polymerase chain reaction. (bvsalud.org)
  • A total of 649 tumor samples from more than 1400 experiments and 58 different tissues were analyzed. (biomedcentral.com)
  • Local growth is facilitated by enzymes (eg, proteases) that destroy adjacent tissues. (msdmanuals.com)
  • Numerous studies confirmed that deguelin activated the virus signaling pathway for inhibiting tumor cell proliferation with no or less toxicity ( 5 - 8 ), while demonstrating the highest activity in inhibiting DMBA-induced tumorigenesis compared with tephrosin, 13α-hydroxytephrosin and 13α-hydroxydeguelin. (spandidos-publications.com)
  • Statins may affect tumor cells directly in four main ways: 1) growth suppression, 2) apoptosis induction, 3) anti-invasive and anti-metastatic effects, and 4) anti-angiogenic effects. (medscape.com)
  • 13. Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer. (nih.gov)
  • In support, tissue microarray analysis of tumors and patient-matched controls indicated downregulation of KLF4 in metastatic tumor samples. (ca.gov)
  • Patients with advanced or metastatic solid tumors received escalating weekly intravenous doses of RO7122290 as a single agent (n = 65) or in combination with a 1200-milligram fixed dose of the anti-programmed death-ligand 1 (anti-PD-L1) antibody atezolizumab given every 3 weeks (n = 50), across a tested RO7122290 dose range of 5 to 2000 milligrams and 45 to 2000 milligrams, respectively. (unav.edu)
  • Part 3: A randomized Phase 2 study of 9-ING-41 either once or twice weekly with gemcitabine and nab-paclitaxel (GA) versus GA alone for patients with previously untreated metastatic or locally advanced pancreatic cancer is now open. (outcomes4me.com)
  • The fluoropyrimidine 5-fluorouracil remains the backbone of chemotherapy regimens for colon cancer, both in the adjuvant and metastatic setting. (medscape.com)
  • Current standard therapy for metastatic colon cancer involves combination of 5-FU/LV/CPT11 chemotherapy (see Standard Therapy). (medscape.com)
  • Because of toxicity problems associated with Saltz regimen (5-FU/LV/CPT11), now standard first-line therapy for metastatic colon cancer, maximum of 400 mg/m 2 of 5-FU and 100 mg/m 2 of CPT11 can be used as starting dose. (medscape.com)
  • Oncogenes responsible for cell growth are overexpressed in cancerous cells. (wikipedia.org)
  • Activation of proto-oncogenes is a common theme in childhood leukemias and solid tumors. (medscape.com)
  • The model was applied to a database of the time course of volumes of breast cancer in patients undergoing pre-operative chemotherapy, for which the initial estimate of proliferating cells by the measure of the percentage of Ki67-positive cells was available. (biomedcentral.com)
  • In the present study, we performed computational analyses and made predictions using transcriptome and metabolome datasets obtained from fluorescence-based visualisations of chemotherapy-resistant cancer stem cells (CSCs) in the human oesophagus. (nature.com)
  • In a clinical trial involving ovarian cancer patients, patterns of gene expression identified through molecular gene testing were compared with results of Personalized Cancer Cytometric testing (in which whole, living cancer cells are exposed to candidate chemotherapy drugs). (cancer.org)
  • Molecular testing - that is, testing for gene expression patterns - is widely studied and heavily promoted as a method to identify effective chemotherapy drugs for individual cancer patients. (cancer.org)
  • They are believed to repopulate cancers after chemotherapy and/or radiation treatment. (msdmanuals.com)
  • Current standard therapy for colon cancer involves combination chemotherapy. (medscape.com)
  • As our understanding of the molecular biology of HNSCC continues to develop, we can target the specific components of cancer cells that are not found in normal cells. (medscape.com)
  • Assistant Professor, Dept. of Cell & Cancer Biology, Univ. (cancer.org)
  • If we can re-activate this immune recognition system, that would be a really good way of getting rid of cancer cells,' says Angelika Amon, the Kathleen and Curtis Marble Professor in Cancer Research in MIT's Department of Biology, a member of the Koch Institute for Integrative Cancer Research, and the senior author of the study. (news-medical.net)
  • Our team of world-class, award-winning scientists pushes the boundaries of knowledge in areas such as neuroscience, cancer research, aging, immunobiology, plant biology, computational biology and more. (salk.edu)
  • Donald and Sheila Fuente Graduate Program in Cancer Biology, University of Miami Miller School of Medicine, Miami, Florida. (aacrjournals.org)
  • EPA published a proposal to replace its 1986 Guidelines for Carcinogen Risk Assessment to take advantage of these new scientific advances in cancer biology. (cdc.gov)
  • As the cancer volume increases, the cancer may release angiogenesis factors, such as vascular endothelial growth factor (VEGF), which promote formation of new blood vessels that are required for further growth. (msdmanuals.com)
  • The epidermal growth factor receptor (EGFR) is a member of the HER family of tyrosine kinase growth factor receptors. (nih.gov)
  • The researchers demonstrated that PKM2 is essential for epidermal growth factor receptor (EGFR)-promoted beta-catenin activation, which leads to gene expression, cell growth and tumor formation. (mdanderson.org)
  • In tumor xenografts, we observed significant growth reduction of both murine and human non-small cell lung tumors when overexpression of let-7g was induced from lentiviral vectors. (eur.nl)
  • Meta-analysis of existing cDNA microarray data also revealed that KLF4 is frequently depleted in prostate cancer tissue with more pronounced reduction in metastases. (ca.gov)
  • Reduction of drug efficacy in massive tumours was described by a simple link between the fraction of surviving cells at each treatment and the growth rate. (biomedcentral.com)
  • Mechanistically, SIRT3 depletion impaired glutamine flux to the TCA cycle via glutamate dehydrogenase and reduction in acetyl-CoA pools, which in turn induce autophagy and cell death. (fry-it.com)
  • In pre-clinical trials, deguelin markedly decreased the tumor incidence. (spandidos-publications.com)
  • Our understanding of the landscape of pediatric cancer genomics has improved markedly in the past 20 years with the advent of next generation sequencing and other high throughput genetic sequencing. (medscape.com)
  • Specific knockdown of LRIG3 by shRNA resulted in significantly increase of the GL15 invasion and adhesion activity in vitro and markedly promoted cell growth. (nih.gov)
  • Administration of BH4 to mice markedly reduces tumour growth and expands the population of intratumoral effector T cells. (metabiom.org)
  • Various techniques have been developed for targeting cancer cells: gene therapy, monoclonal antibodies (MAbs), antibody toxin conjugates, small-molecule inhibitors, antisense molecules, and tumor vaccines. (medscape.com)
  • Accordingly, cells treated with MG132 or other proteasome inhibitors exhibit higher expression of MKP3/DUSP6, an ERK1/2-specific DUSP, accompanied by lower levels of ERK phosphorylation stimulated by growth factors [12]C[14]. (scienza-under-18.org)
  • This discovery launched an entirely new field of research and has led to a new class of anti-cancer drugs known as tyrosine kinase inhibitors. (salk.edu)
  • Everolimus is indicated for the treatment of patients with advanced renal cell carcinoma, whose disease has progressed on or after treatment with VEGF-targeted therapy. (medicines.org.uk)
  • As the old inhibitor of mitochondrial complex I (NADH), rotenone contributes to electron transport chain-blocking and ATP depletion, as well as cell toxicity. (spandidos-publications.com)
  • This time the team has screened a recent clinical trial using Abemaciclib, a cell cycle inhibitor, for Mesothelioma in patients with refractory disease. (newswise.com)
  • Furthermore, pretreatment of osteosarcoma cells with PD98059, an inhibitor of ERK1/2, inhibited honokiol-induced apoptosis and autophagy. (nature.com)
  • As a proliferation inhibitor, p21 is poised to play an important role in preventing tumor development. (aacrjournals.org)
  • However, a number of recent studies have pointed out that in addition to being an inhibitor of cell proliferation, p21 acts as an inhibitor of apoptosis in a number of systems, and this may counteract its tumor-suppressive functions as a growth inhibitor. (aacrjournals.org)
  • We developed a mitochondrial-targeted class I sirtuin inhibitor, YC8-02, which phenocopied the effects of SIRT3 depletion and killed DLBCL cells. (fry-it.com)
  • They develop a sirtuin inhibitor that mimics SIRT3 depletion and kills DLBCL cells. (fry-it.com)
  • The Actuate 1801 Phase 1/2 study is designed to evaluate the safety and efficacy of 9-ING-41, a potent GSK-3β inhibitor, as a single agent and in combination with cytotoxic agents, in patients with refractory cancers. (outcomes4me.com)
  • Notably, RES was shown to inhibit tumor growth and cause cell death in an ectopic mouse model of triple- negative breast cancer ( 7 ). (iiarjournals.org)
  • Interestingly, the two exceptions wherein even hydrophilic statins present benefit, liver and prostate cancers, further support the direct effect hypothesis as these cancers possess the transporters that allow cellular entry of the hydrophilic statins. (medscape.com)
  • These are involved in fundamental cellular processes, such as nerve impulse transmission, cell proliferation, apoptosis, hormone secretion and sensory transduction ( 11 , 12 ). (spandidos-publications.com)
  • Discover scientific background and illustrations covering cellular changes associated with many of the hallmarks of cancer. (technologynetworks.com)
  • It was found that vitexicarpin may block the cell cycle in Growth 2 Phase (G2)/Mitosis (M) phase by inhibiting the expression of Cyclin-Dependent Kinase 1 (CDK1), Cellular Myelocytomatosis Oncogene (c-myc) and survivin, thereby inhibiting the proliferation and promoting the apoptosis of human non-small cell lung cancer cell line (H322) [ 3 ]. (ijpsonline.com)
  • destroy tumors by secreting exotoxins that damage the membrane structures of cancer cells and enter cells to disrupt essential cellular functions. (metabiom.org)
  • Research performed in this thesis has characterised a thyroidal hPTTG1-Tg overexpressing mouse model, showing reduced thyroid size due to reduced cellular proliferation. (bham.ac.uk)
  • The cellular kinetics of particular cancers is an important consideration in the design of antineoplastic drug regimens and may influence the dosing schedules and timing intervals of treatment. (msdmanuals.com)
  • Background: Resveratrol (RES) inhibits cell growth, induces apoptosis and augments chemotherapeutics in multiple cancer types, although its effects on drug-resistant cancer cells are unknown. (iiarjournals.org)
  • recruits CD8+ T cells, granulocytes, and macrophages to the infection area and induces the release of TNF-related apoptosis-inducing ligand (TRAIL) from neutrophils. (metabiom.org)
  • In glioma ( 28 ) and in vascular smooth muscle cells ( 29 ), p21 facilitates active cyclin-Cdk complex formation and induces cell proliferation. (aacrjournals.org)
  • SIRT3 depletion induces DLBCL cell death by reducing glutamine flux to the TCA cycle and acetyl-CoA pools. (fry-it.com)
  • In combination with mammogenic hormones, IGF induces ductal growth in mammary gland explant cultures [ 17 ]. (biomedcentral.com)
  • Open up in another window Shape 3 Leucine deprivation induces apoptosis of human being breast tumor BAY 293 cell(A and B) MDA-MB-231 or MCF-7 cells had been incubated in charge (+leu) or leucine-deficient (?leu) moderate for 48h, accompanied by dedication of cleaved caspases inside a and annexin-V assay in B. (C and D) Nude mice. (racetab.org)
  • High levels of plant dietary fibers in the gut resulted in proliferation of #Faecalibacterium prausnitzii with anti-inflammatory and anti-tumor effects. (metabiom.org)
  • However, the precise biological function of miR-501-3p in prostate cancer remains unknown. (nih.gov)
  • In this study, we aimed to investigate the regulatory effect and mechanism of miR-501-3p on cell growth of prostate cancer cells. (nih.gov)
  • Moreover, miR-501-3p was shown to negatively regulate CREPT expression in prostate cancer cells. (nih.gov)
  • Additionally, the inhibitory effect of miR-501-3p on prostate cancer cell growth was partially reversed by CREPT overexpression. (nih.gov)
  • Overall, these results suggest that miR-501-3p restricts prostate cancer cell growth by targeting CREPT to inhibit the expression of cyclin D1. (nih.gov)
  • Lymphoma Prostate cancer Brain cancer Hemangiosarcoma is a type of cancer that develops almost exclusively in dogs, the only two other species known to have it are cats and horses. (wikipedia.org)
  • Vitexicarpin inhibits the growth of human prostate cancer cell line (PC-3) cells and promotes the apoptosis by blocking the cell cycle of prostate cancer PC-3 cells in G 2 /M phase [ 5 ]. (ijpsonline.com)
  • The role of KLF4 in prostate cancer etiology remains unclear. (ca.gov)
  • In this study, we examine KLF4 levels in prostate cancer tissue and utilize RNAa as a tool for gene overexpression to investigate its function. (ca.gov)
  • Expression analysis indicated that KLF4 is significantly downregulated in prostate cancer cell lines compared with nontumorigenic prostate cells. (ca.gov)
  • An elevated IGF-I level in the plasma is linked to an increased risk of developing ductal carcinoma in situ of the breast, invasive breast cancer, colorectal cancer, prostate cancer and lung cancer [ 4 - 9 ]. (biomedcentral.com)
  • [ 71 ] While atorvastatin treatment could reduce Bcl-2 expression in MDA-MB-231 breast cancer cells, two weeks of neoadjuvant atorvastatin at 80 mg/kg in human breast cancer patients was not found to alter Bax or Bcl-2 expression. (medscape.com)
  • The results showed that the m 6 A level, as well as the methylase METTL3 were both significantly elevated in LUAD patients and lung cancer cells. (biomedcentral.com)
  • Approximately 85% of patients are diagnosed with non-small-cell lung cancer (NSCLC), of which lung adenocarcinoma (LUAD) is the most frequent histological manifestation [ 3 ]. (biomedcentral.com)
  • Eligible patients were treated with 2 cycles of IC + CCRT. (bvsalud.org)
  • They would also like to figure out how tumor cells are able to evade this immune clearance, and whether it may be possible to restart the process in patients with cancer, since about 90 percent of solid tumors and 75 percent of blood cancers are aneuploid. (news-medical.net)
  • Though challenges remain, clinicians are in the early stages of using genetic data to make treatment decisions for cancer patients. (frontiersin.org)
  • In the subgroup of patients where killing of cycling cells had the highest score, the drugs showed variable efficacy against quiescent cells. (biomedcentral.com)
  • In a clinical study, cancer patients using amygdalin did not have any benefits, but some showed cyanide toxicity. (mskcc.org)
  • Your gift will help support our mission to end cancer and make a difference in the lives of our patients. (mdanderson.org)
  • However, specific data on the formation of breast cancer brain metastases, which carry remarkable morbidity and mortality to a substantial proportion of advanced breast cancer patients, have not been generated. (oncotarget.com)
  • Nikolaev, Antonarakis, and colleagues performed mutational screening on 293 BCC samples from 236 patients using a combination of matched tumor-normal whole-exome sequencing, targeted panel sequencing, and matched tumor-normal RNA-sequencing. (shu.edu)
  • The aim of the present study was to compare the advantages and limits of a conventional chemosensitivity test with those of new biomolecular markers in predicting response to platinum regimens in a series of patients with peritoneal carcinomatosis from ovarian cancer. (cancer.org)
  • Fresh surgical biopsy specimens were obtained from 30 patients with primary or recurrent peritoneal carcinomatosis from ovarian cancer. (cancer.org)
  • In marked contrast, Personalized Cancer Cytometric testing was found by the researchers to be 90% accurate in identifying active drugs for ovarian cancer patients in this study. (cancer.org)
  • Clinicians can play a role in skin cancer prevention by counseling their patients on use of sun protection and indoor tanning avoidance. (cdc.gov)
  • Circulating cancer cells are present in many patients with advanced cancer and even in some with localized disease. (msdmanuals.com)
  • Most patients with cancer die from metastases rather than the primary cancer. (msdmanuals.com)
  • 2014). genetic StudieS are carried out, uSing tuMour SaMPleS froM PatientS with excellent clinical data that have been collected at a PoPulation level or internationally, to Provide unique data coMbining the Pathology, geneticS, clinical featureS, and ePideMiology of tuMourS. (who.int)
  • Since dysregulated apoptosis is considered to be necessary for tumor development, apoptosis, a pivotal mechanism for normal homeostasis, is crucial in the therapy of various tumors. (spandidos-publications.com)
  • 5] Targeted disruption of TP53 in the mouse leads to the development of various tumors. (medscape.com)
  • The two-hit hypothesis has now been adopted as a key mechanism for the loss of function of tumor suppressors leading to oncogenesis. (medscape.com)
  • Deguelin is known to induce apoptosis by disrupting anti-apoptosis signaling, such as the PI3K/Akt pathway in lung and breast cancer. (spandidos-publications.com)
  • Beta-catenin activation that is independent of the Wnt signaling pathway have been observed in many types of cancer. (mdanderson.org)
  • Next, a method to score deregulation of KEGG pathway maps in different tumor entities was established, which was then used to convert hundreds of gene expression profiles into corresponding tumor-specific pathway activity profiles. (biomedcentral.com)
  • The functional cancer map provides a systematic view on molecular similarities across different cancers by comparing tumors on the level of pathway activity. (biomedcentral.com)
  • The Sonic hedgehog (Hh) pathway is known to be important in basal cell carcinoma (BCC), which as an extremely common skin cancer that only rarely invades and metastasizes . (shu.edu)
  • This, the researchers noted, suggests that PTPN14 is a new tumor-suppressor gene in BCC that works by activating the Hippo-YAP pathway. (shu.edu)
  • It mediates beta-catenin dephosphorylation at adhesion junctions and acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. (shu.edu)
  • Our research shows that although PKM2 plays an important role in cancer metabolism, this enzyme also has an unexpected pivotal function - it regulates cell proliferation directly,' said senior author Zhimin Lu, M.D., Ph.D., associate professor in the Department of Neuro-Oncology at MD Anderson. (mdanderson.org)
  • Here, we used a human U6 promoter-driven DNA template approach to induce short hairpin RNA (shRNA)-triggered RNA interference (RNAi) to block LRIG3 gene expression in the human glioma cell line GL15. (nih.gov)
  • Transcriptome analyses have been extensively used to investigate gene expression in individual cells. (nature.com)
  • Furthermore, based on an IGF-I induced gene expression signature derived from primary lung fibroblasts, a separation of prognostically different lung cancers was possible ( P = 0.007 - Bhattacharjee and P = 0.008 - Garber dataset). (biomedcentral.com)
  • In the first head-to-head clinical trial comparing gene expression patterns with Personalized Cancer Cytometric testing (also known as "functional tumor cell profiling" or "chemosensitivity testing"), Personalized Cancer Cytometrics was found to be substantially more accurate. (cancer.org)
  • To investigate the effect and molecular mechanism of vitexicarpin on the biological behavior of colorectal cancer cells is the objective of the study. (ijpsonline.com)
  • The first solid tumor exomes to be investigated were from 11 breast and 11 colorectal cancer tissue samples. (frontiersin.org)
  • In these reports, the relationship between proteasome activity and ODC in oesophageal, cervical, colorectal and bone cancer was investigated. (nature.com)
  • Experimentations with wild-type probiotics have been performed against not only colorectal cancer , but also other cancers such as bladder, breast, cervical, and liver cancers. (metabiom.org)
  • Antibody-based constructs and other strategies to deliver immune stimulatory signals or to block immune suppressive receptors and cytokines, in order to promote endogenous anti-tumor immunity. (nih.gov)
  • [ 56 ] Additionally, BRCA1 overexpression in breast cancer cells has been shown to sensitize cells to lovastatin treatment through regulation of CDK4/Cyclin D1. (medscape.com)
  • LRIG3 might be involved in the regulation of EGFR signaling, and serve as a tumor suppressor gene in the pathogenesis of glioma. (nih.gov)
  • equally central to the regulation of cell signaling. (scienza-under-18.org)
  • Hunter, who is an American Cancer Society Professor and holds the Renato Dulbecco Chair, studies the molecular basis of normal cell growth control and cell cycle regulation, and what happens when these processes are disrupted-such as occurs in tumors. (salk.edu)
  • Cancer cells are characterized by massive dysegulation of physiological cell functions with considerable disruption of transcriptional regulation. (biomedcentral.com)
  • Many canine cancers are described with the same terminology and use the same classification systems as human cancers. (wikipedia.org)
  • For human and animal cells, this is usually triggered by growth factors or cytokines/chemokines. (biolegend.com)
  • EGFR is expressed on normal human cells and also across a range of malignancies. (nih.gov)
  • In the present study, we investigated the anticancer effect of honokiol (HNK), an active component isolated and purified from the magnolia officinalis on human osteosarcoma cells. (nature.com)
  • Our results showed that honokiol caused dose-dependent and time-dependent cell death in human osteosarcoma cells. (nature.com)
  • Moreover, the ability to overcome chemoresistance in human multiple myeloma cells has been demonstrated 9 . (nature.com)
  • The human epithelial cell line Caco-2 cells were divided into control group, low, middle and high dose groups of vitexicarpin, plasmid cloning DNA-circ_0000419 group, plasmid cloning DNA group, anti-microRNA-224 group, anti-microRNA-224-negative control group, vitexicarpin+small interfering-circ_0000419 group and vitexicarpin+microRNA-224 group. (ijpsonline.com)
  • Most living cells have a defined number of chromosomes: Human cells, for example, have 23 pairs. (news-medical.net)
  • The first cancer exomes were sequenced soon after the completion of the Human Genome Project in 2001. (frontiersin.org)
  • LRIG3 (leucine-rich repeats and immunoglobulin-like domains, LRIG) gene is both under-and over-expressed in human cancers and its role on tumor growth is not fully clarified. (nih.gov)
  • The researchers now know for the first time that they actually form in the DNA of human cells. (cam.ac.uk)
  • While quadruplex DNA is found fairly consistently throughout the genome of human cells and their division cycles, a marked increase was shown when the fluorescent staining grew more intense during the 's-phase' - the point in a cell cycle where DNA replicates before the cell divides. (cam.ac.uk)
  • The embryonic enzyme pyruvate kinase M2 (PKM2) has a well-established role in metabolism and is highly expressed in human cancers. (mdanderson.org)
  • This chapter has covered a comprehensive state of the art literature review of the recent studies about the role of miRNAs in HNC including oral squamous cell carcinoma (OSCC) and human nasopharyngeal carcinoma. (intechopen.com)
  • Recent studies show positive combination effects of RES and irradiation, as well as various chemotherapeutics in multiple human cancers ( 15 , 16 ). (iiarjournals.org)
  • Cell Culture and Immunoblotting NIH 3T3 mouse fibroblast and HT-1080 human fibrosarcoma cell lines were acquired from American Type Culture Collection (Manassas, VA). Mouse embryonic fibroblasts, derived from pregnant CD-1 mice (Charles River Laboratories, Wilmington, MA), were. (scienza-under-18.org)
  • Effects of sinusoidal magnetic field observed on cell proliferation, ion concentration, and osmolarity in two human cancer cell lines med. (emf-portal.org)
  • To study the effects of 50 Hz sinusoidal magnetic field (20 mT) on cell proliferation , ion concentration, and osmolarity in two human cancer cell lines . (emf-portal.org)
  • Overexpression of the human pituitary tumor-transforming gene, and its binding factor PBF, have been found in thyroid cancer. (bham.ac.uk)
  • Complete available human tumor data of the Stanford Microarray Database was downloaded and filtered for relevance, adequacy and reliability. (biomedcentral.com)
  • Basal cell carcinoma is one of the most common human cancers, affecting some 2 million people a year in the US, according to the American Academy of Dermatology, and is thought to be mainly caused by exposure to ultraviolet light. (shu.edu)
  • When the new guidelines assessing potential human cancer risk posed by envi- are final, EPA will make them available on the world ronmental agents, the concept of low-dose linearity wide Internet via its homepage ZHTTP:rrwww. (cdc.gov)
  • The proliferation, cell cycle distribution and invasion abilities were detected by MTT, Flow cytometry and Transwell chamber methods, respectively. (bvsalud.org)
  • upregulation of E2F3 could reverse the inhibitory effect of miR-144-3p overexpression on proliferation and invasion of T24 cells. (bvsalud.org)
  • It inhibits proliferation and invasion of bladder cancer cells by downregulating E2F3. (bvsalud.org)
  • Binding to EGFR by its natural ligands, mainly epidermal growth factor (EGF) or transforming growth factor (TGF)-alpha, results in a conformational change in the receptor, which promotes homo- or heterodimerisation or oligomerisation with other EGFR molecules or other HER family members. (nih.gov)
  • NF-κB is constitutively active in cancer cells and promotes anti-apoptotic molecule expression. (outcomes4me.com)
  • For example, simvastatin was shown to decrease proliferation of bladder cancer cells without inducing apoptosis. (medscape.com)
  • Methods: A total of 36 cases of bladder cancer tissue specimens and 10 cases of normal bladder epithelial tissue specimens were collected from Tangdu Hospital of Air Force Medical University during February 2018 and December 2018. (bvsalud.org)
  • In addition, bladder cancer T24 cell line and normal urothelial cell line SV-HUC-1 were also collected for this study. (bvsalud.org)
  • The incidence of bladder cancer recurrence within five years after nephroureterectomy is 20-75% [ 3 ]. (medsci.org)
  • High bladder cancer recurrence and distant metastases are the major causes of complications after primary nephroureterectomy [ 1 , 2 ]. (medsci.org)
  • Mesothelioma is a tumor that, because of its biological complexity together with social and legal implications, has always been a paramount field of research at our Institute," adds Luciano Mutti, M.D., co-author and Adjunct Professor, SHRO, Temple University. (newswise.com)
  • Cytochrome P450 (CYP) arachidonic acid epoxygenase 2J2 converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids, which exert diverse biological activities in cardiovascular system and endothelial cells. (aacrjournals.org)
  • We provide a comprehensive, easy-to-interpret functional cancer map that characterizes tumor types with respect to their biological and functional behavior. (biomedcentral.com)
  • Utilization of these functional associations to place global transcriptome data in a biological context might significantly improve the limited knowledge about common molecular changes across different tumor types. (biomedcentral.com)
  • In particular, the let-7 miRNA family has been proposed to function in tumor suppression, because reduced expression of let-7 family members is common in non-small cell lung cancer (NSCLC). (eur.nl)
  • EGFR has been recognised as an important therapeutic target in cancer. (nih.gov)
  • Taken together, our results identify Orilnc1 as a novel, nonprotein mediator of RAS/ RAF activation that may serve as a therapeutic target in RAS/RAF- driven cancers. (njit.edu)
  • The goal of gene therapy is to introduce new genetic material into cancer cells that selectively kills them without causing toxicity to the surrounding cells. (medscape.com)
  • Cancer alters the DNA of cells and the mutated genetic material is passed on to daughter cells, resulting in neoplasms. (wikipedia.org)
  • These repeated sequences caused by decreased genetic diversity within breeds, can lead to a high prevalence of certain diseases and especially cancer in breeds. (wikipedia.org)
  • The Sbarro Health Research Organization ( SHRO ) is non-profit charity committed to funding excellence in basic genetic research to cure and diagnose cancer, cardiovascular diseases, diabetes and other chronic illnesses and to foster the training of young doctors in a spirit of professionalism and humanism. (newswise.com)
  • The etiology of liver cancer is diverse, including viral infection, alcoholic and non-alcoholic fatty liver disease, aflatoxins, genetic and metabolic factors and infection, among which viral infection [via hepatitis B virus (HBV) and hepatitis C virus (HCV)] is the most important factor ( 2 , 3 ). (spandidos-publications.com)
  • At a fundamental level, cancer is caused by an accumulation of genetic changes that result in unregulated cell growth and proliferation. (medscape.com)
  • As genetic errors accumulate, aneuploid cells eventually become too unstable to keep dividing. (news-medical.net)
  • Millions of dogs develop spontaneous tumors each year. (wikipedia.org)
  • 10. E-cadherin negatively regulates neoplastic growth in non-small cell lung cancer: role of Rho GTPases. (nih.gov)
  • 17. Expression analysis of Cdc42 in lung cancer and modulation of its expression by curcumin in lung cancer cell lines. (nih.gov)
  • Finally, in an autochthonous model of NSCLC in the mouse, let-7g expression substantially reduced lung tumor burden. (eur.nl)
  • To investigate the tumor cells' adaptation to hypoxia, we recreated two models using two lung cancer cell lines in the presence of intermittent hypoxia, which is characterized by changes in oxygen pressure within the disorganized vascular network. (nih.gov)
  • the tumor size, distance of the tumor from the pleura, number of implanted needle adjustments, and distance of the implanted needle through the normal lung tissue were risk factors for hemorrhage. (bvsalud.org)
  • Tumor size, number of implanted needle adjustments, and distance through normal lung tissue were independent risk factors for hemorrhage. (bvsalud.org)
  • CONCLUSION: This study provides a reference for the clinical treatment of lung cancer by analyzing the risk factors for complications of interstitial brachytherapy. (bvsalud.org)
  • Purpose: This retrospective study aimed to investigate 18F-fluorodeoxyglucose (18F-FDG)-positron emission tomography/computed tomography (PET/CT) as a predictor of response to hypofractionated radiotherapy (HFRT) combined with programmed cell death-1 (PD-1) blockade for lung cancer. (bvsalud.org)
  • Am J Physiol Lung Cell Mol Physiol 309(3):L305-L313, PMID: 26071552, 10.1152/ajplung.00135.2015. (nih.gov)
  • Vitexicarpin also inhibits the growth of lung cancer xenografts in nude mice [ 4 ]. (ijpsonline.com)
  • [ 63-66 ] Additionally, statins have been shown to decrease phosphorylation and degradation of Bim in breast cancer cells, [ 67 ] promoting apoptosis. (medscape.com)
  • As a result, the tumor cells don't just stop growing - they decrease in size. (prospecbio.com)
  • The increase in ion concentration and osmolarity corresponded to the decrease in cell density . (emf-portal.org)
  • These systems are also believed to impact lifespan, as well as decrease cancer risk. (tigerfitness.com)
  • Functionally, we found that METTL3 could promote proliferation and inhibit ferroptosis in different LUAD cell models, while METTL3 knockdown suppressed LUAD growth in cell-derived xenografts. (biomedcentral.com)
  • Uncleaved Gli travels to the nucleus and is an inducer of transcription, increasing Cyclin D1 and stimulating the cell cycle (proliferation). (shu.edu)
  • Here, we show that let-7 functionally inhibits non-small cell tumor development. (eur.nl)
  • Accurate discrimination of functionally different tumor types may help to guide selection of targeted therapy in translational research. (biomedcentral.com)