• Huang, Y., Marumo, K. & Murai, M. Antitumor effects and pharmacological interaction of xiao-chai-hu-tang (sho-saiko-to) and interleukin 2 in murine renal cell carcinoma. (kampo.ca)
  • Metastasis accounts for 90% of cancer-associated mortality in patients with renal cell carcinoma (RCC). (thno.org)
  • Renal cell carcinoma (RCC) is one of the most frequently diagnosed cancers worldwide, and the incidence rates have been steadily increasing [ 1 - 3 ]. (thno.org)
  • The relationship between blood pressure and risk of renal cell carcinoma. (who.int)
  • Epidemiology of Renal Cell Carcinoma: 2022 Update. (who.int)
  • Mycotoxin Exposure and Renal Cell Carcinoma Risk: An Association Study in the EPIC European Cohort. (who.int)
  • Biomarkers of the transsulfuration pathway and risk of renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. (who.int)
  • Lewis lung carcinoma is a tumor that spontaneously developed as an epidermoid carcinoma in the lung of a C57BL mouse. (wikipedia.org)
  • Orthotopic models focus upon correctly modeling the tumor microenvironment by injecting or implanting tumors into the corresponding organ that they originated from (i.e. implanting a Lewis lung carcinoma into the lung of another C57BL mouse). (wikipedia.org)
  • These mice were selected for their genetic background proximity to C57BL/6J mice. (wikipedia.org)
  • Navelbine and carboplatin, two chemotherapeutics currently on the market, were tested in C57BL mice with Lewis lung carcinoma tumors in their hind flank. (wikipedia.org)
  • We tested the role of systemic fetuin in tumor cell growth and metastasis by injecting Lewis lung carcinoma (LLC) cells into fetuin-A null and their wild-type (WT) littermate control C57BL/6 mice via the tail vein, s.c., and intrasplenic routes. (ac.ke)
  • This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. (lookformedical.com)
  • Approximately 80-90% of newly diagnosed lung cancers are classified as NSCLC, primarily consisting of adenocarcinoma, squamous cell carcinoma, or large cell carcinoma histologies. (frontiersin.org)
  • We were also able to define immunogenic membrane proteins from lung (squamous and adenoCa) as well as prostate neoplasms. (jcancer.org)
  • Cutaneous squamous cell carcinoma (SCC) is an invasive malignant neoplasm of epidermal keratinocytes showing squamous phenotypic differentiation (see the following image). (medscape.com)
  • Bowen disease (BD) is a squamous cell carcinoma in situ (SSCIS) with full-epidermal thickness dysplasia that has the potential for significant lateral spread before invasion. (medscape.com)
  • This image shows a central keratotic squamous cell carcinoma with a raised, undermined periphery in a background of severely sun-damaged skin. (medscape.com)
  • See Squamous Cell Carcinoma , Bowen Disease , and Actinic Keratosis for more information. (medscape.com)
  • The majority (70%) of cutaneous squamous cell carcinoma (SCC) occurs on the head and neck, with an additional 15% found on the upper extremities. (medscape.com)
  • [ 3 ] occupational exposure, medical treatment (psoralen + ultraviolet A [PUVA]), or tanning beds is principally responsible for the development of squamous cell carcinoma (SCC). (medscape.com)
  • A phase II study showed that patients with resected local-regionally advanced head and neck squamous cell carcinoma (HNSCC) had improved survival when pembrolizumab was added to adjuvant RT (NCT02641093). (nature.com)
  • Excretory stem cells give rise to squamous cell and mucoepidermoid carcinomas, while intercalated stem cells give rise to pleomorphic adenomas, oncocytomas, adenoid cystic carcinomas, adenocarcinomas, and acinic cell carcinomas. (medscape.com)
  • Squamous cell carcinomas arise from excretory duct cells, pleomorphic adenomas arise from the intercalated duct cells, oncocytomas arise from the striated duct cells, and acinic cell carcinomas arise from acinar cells. (medscape.com)
  • After therapy, the incidence of pleomorphic adenomas, mucoepidermoid carcinomas, and squamous cell carcinomas is increased. (medscape.com)
  • Tobacco and alcohol, which are highly associated with head and neck squamous cell carcinoma, have not been shown to play a role in the development of malignancies of the salivary glands. (medscape.com)
  • It was discovered in 1951 by Dr. Margaret Lewis of the Wistar Institute and became one of the first transplantable tumors. (wikipedia.org)
  • This study aimed to determining the bacterial oncolytic capability of C. ghonii for the treatment of experimental solid tumors. (bvsalud.org)
  • C. ghonii spores specially germinated and were distributed in the tumors, and elicited the immune responses after intratumoral injection in tumor-bearing mice. (bvsalud.org)
  • Serum fetuin-A also influenced the growth of LLC cells injected s.c.: fetuin-A-null mice developed small s.c. tumors only after a substantial delay. (ac.ke)
  • Local invasion and distant metastasis are the cause of death in most malignant tumors. (biomedcentral.com)
  • Malignant tumors consist of cancer cells and tumor-associated host cells, both participating in invasion and distant metastasis. (biomedcentral.com)
  • RCC tumors from patients showed downregulation of HSPA12A, which was associated with advanced tumor node metastasis stage. (thno.org)
  • Here, we show that natural expression of NKG2D ligands on tumors provides an effective target for some cytokine-stimulated NK cells to recognize and suppress tumor metastases. (silverchair.com)
  • Myeloid cells are a heterogeneous population of bone marrow-derived cells that play a critical role during growth and metastasis of malignant tumors. (hindawi.com)
  • In 1971, Dr. Judah Folkman observed that neovascularization occurs around tumors and proposed that new blood vessel growth is necessary to supply nutrients and oxygen to tumor cells during exponential tumor growth [ 6 ]. (hindawi.com)
  • In syngeneic mouse subcutaneous tumors formed by a mixture of A11 and P29 cells, the mitochondria-related EVs released from A11 cells reached distantly positioned P29 cells and CAFs. (biomedcentral.com)
  • Targeting of CD169+ macrophages in order to inhibit tumor Lewis lung carcinoma growth also caused depletion of bone and bone marrow in mice. (wikipedia.org)
  • This review is primarily focused on various mechanisms by which plakoglobin may inhibit tumorigenesis and metastasis. (oncotarget.com)
  • PMos have been shown to inhibit cancer metastasis but the role of IMo is unclear. (bmj.com)
  • To date, no strategy has been developed to inhibit cancer metastasis through enhancing PMo/IMo differentiation. (bmj.com)
  • According to a 2015 review article, Lewis lung carcinoma is the only reproducible syngeneic lung cancer model, meaning that it is the only reproducible lung cancer model that utilizes a transplant that is immunologically compatible. (wikipedia.org)
  • For example, cancer therapies that exhibited promising results in mouse models can and have failed in clinical trials due to physiological differences in the activity of the targeted gene product. (wikipedia.org)
  • The Lewis lung carcinoma tumor model's role in cancer has been its use for research into tumor metastasis and angiogenesis properties. (wikipedia.org)
  • Toll-like receptor 4 mediates cancer-induced muscle wasting in a Lewis lung carcinoma model. (wikipedia.org)
  • A study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and overtreatment plays in nutritional deficiency and chemical exposure related 'diseases. (wakeup-world.com)
  • An Italian study published in the journal Reproductive Biology and Endocrinology, titled " Levothyroxine and lung cancer in females: the importance of oxidative stress ," has raised a concerning possibility: levothyroxine (T4), one of the world's most commonly prescribed forms of hormone replacement, may be raising the risk of lung cancer in millions of men and women being treated for low thyroid function (hypothyroidism). (wakeup-world.com)
  • The study looked at the prevalence of breast, colorectal, gastric and lung cancer in 18 Italian Regions during 2010 and correlated this data with sales of LT4 in 2009, focusing on women aged 30-84. (wakeup-world.com)
  • They then correlated drug sales with cancers, eliminating the contribution of age and smoking for lung cancer risk. (wakeup-world.com)
  • In discussing their findings, the authors noted that they could not exclude the possibility that the condition of hypothyroidism could favor the development of lung cancer. (wakeup-world.com)
  • T4 has been reported as one of the several endogenous factors capable of supporting proliferation of lung cancer cells. (wakeup-world.com)
  • An old clinical observation on the relationship between lung cancer and thyroid function reported that patients were characterized by a low concentration of T3 and an increased T4/T3 ratio due to a decrease of 5′-monodeiodination (DI). (wakeup-world.com)
  • DI activity in lung cancer was found to be lower than in peripheral lung tissue. (wakeup-world.com)
  • 9] [10] [11] Although we should never forget that LT4 is a life-saving thyroid hormone replacement, and that one should not exclude that the pathological reason that leads to the prescription of LT4 could favor the lung cancer development also. (wakeup-world.com)
  • The current standard of care for locally advanced non-small cell lung cancer (NSCLC) includes radiation, chemotherapy, and surgery in certain individualized cases. (frontiersin.org)
  • One hundred years ago, lung cancer was a rare malignancy ( 1 ). (frontiersin.org)
  • Lung cancer today is the leading cause of cancer death in the United States, with over 158,000 estimated deaths in 2016 ( 2 ). (frontiersin.org)
  • Prior to the advent of cytotoxic chemotherapy, lung cancer at all stages was treated surgically or by radiation alone ( 5 , 6 ). (frontiersin.org)
  • TNM staging was introduced in 1974 and it helped shape the way lung cancer was managed. (frontiersin.org)
  • Stage III lung cancer, though heterogeneous in its classification, includes non-metastatic but locally advanced disease with involvement of N1-N3 nodal stations and/or T3 and T4 primaries. (frontiersin.org)
  • Presently, stage III lung cancer is managed with a combination of chemotherapy, radiation therapy, and sometimes surgery but the two major challenges in improving outcomes of the treatment of this disease remain local control and metastatic spread. (frontiersin.org)
  • Autoradio-graphic distribution of hematoporphyrin derivative innormal and tumor tissue of the mouse // Cancer Res. (kiev.ua)
  • Via direct actions on cancer cells and indirect actions on the tumor microenvironment, radiation has the potential to enhance epithelial-to-mesenchymal transition, invasion, migration, angiogenesis and metastasis. (biomedcentral.com)
  • Metastatic cancer cells are released from the primary tumor or from other metastases, at an undefined moment of its development, to arrive in the circulation and home at distant sites, where the ecosystem permits them to survive and either remain dormant as micro-metastases or grow to form macro-metastases (Mareel et al. (biomedcentral.com)
  • Recruitment of CD11b + CD11c + myelomonocytic cells to the metastatic site was also found after whole thorax irradiation at a dose of 15 Gy of mice that significantly enhanced seeding and metastatic growth of intravenously injected cancer cells. (biomedcentral.com)
  • The prognosis of RCC is poor because approximately 25% of patients present with metastases at the time of diagnosis, and another 30-35% of patients underwent resection for localized or locally invasive kidney cancer will develop potentially fatal metachronous distant metastases [ 5 , 6 ]. (thno.org)
  • Ferritin-based protein C nanoparticles (PCNs), known as TFG and TFMG, were generated and tested in Lewis lung carcinoma (LLC) allograft and MMTV-PyMT spontaneous breast cancer models. (biomedcentral.com)
  • PCNs significantly inhibited hypoxia and increased pericyte coverage, leading to the inhibition of tumor growth and metastasis, while increasing survival in LLC allograft and MMTV-PyMT spontaneous breast cancer models. (biomedcentral.com)
  • Some people use Panax ginseng to treat breast cancer and prevent ovarian cancer , liver cancer , lung cancer , and skin cancer . (emedicinehealth.com)
  • Most of the anti-angiogenic agents approved for cancer treatment rely on targeting vascular endothelial growth factor (VEGF) actions, as VEGF signaling is considered the main angiogenesis promotor. (mdpi.com)
  • We successfully established subcutaneous and thoracic xenografts with human nonsmall cell lung cancer cell line xenografts in athymic nude mice in only 10 days. (wjtcm.net)
  • From this preliminary study, it appears that combination of dimer oxime and topotecan may be used as chemotherapeutic agents against nonsmall cell lung cancer. (wjtcm.net)
  • [1] Dihydroartemisinin has shown therapeutic activity against gallbladder cancer metastasis. (wjtcm.net)
  • Furthermore, we identified that FOXO1, a key molecule controlling cellular energy metabolism, mediated the effect of IFN-γ induced IL-27 expression, and that NR4A1, a key molecule controlling PMo differentiation and inhibiting cancer metastasis, inhibited the pro-NK cell and anti-metastasis activity of IFN-IMo by suppressing CXCL9 expression. (bmj.com)
  • Our study has not only shown novel mechanisms for a classical antitumor cytokine but also provided potential target for developing superior monocytic cell therapy against cancer metastasis. (bmj.com)
  • we wanted to explore whether STAT3 can be related to lymph node micrometastasis of non-small cell lung cancer (NSCLC). (cusabio.com)
  • Furthermore, upregulation of PD-L1 by cancer cells results in cancer invasion and correlates with poor prognostic outcomes in breast, gastric, meningioma, non-small-cell lung carcinoma (NSCLC) and soft-tissue sarcoma patients [9,26-29]. (studylib.net)
  • Opium use and risk of lung cancer: A multicenter case-control study in Iran. (who.int)
  • Design and methodological considerations for biomarker discovery and validation in the Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) Program. (who.int)
  • Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer. (who.int)
  • In the in vivo tests, melittin inhibited rapid tumor growth and was correlated with decreased angiogenesis marker levels, VEGF and CD31. (wikipedia.org)
  • In addition, the triterpenoid fraction (800 micrograms/mL) inhibited angiogenesis induced by Matrigel (a soluble basement membrane extract of the Engelbreth-Holm-Swam (EHS) tumor) supplemented with vascular endothelial growth factor (VEGF) and heparin in an in vivo model. (nih.gov)
  • Genistein is an isoflavonoid found in soybeans, has antiangiogenic activity including angiogenesis inhibition, induction of apoptosis, inhibition of bFGF- and VEGF-driven cell proliferation, PDGF, G2, c-fos expression, NF-κB activation and growth factor signaling pathways. (ppt-health.com)
  • The hypothesis could be that in lungs the increase of hypoxia-induced factor (HIF-1) which is determined by T4 can make oxygen much more available, increasing locally the oxidative stress together with a dangerous angiogenesis stimulation. (wakeup-world.com)
  • Elimination of the primary tumor, either by irradiation or by surgery, shifts the balance towards pro-angiogenesis and growth of the lung metastases (Table 1 ) (Camphausen et al. (biomedcentral.com)
  • Conventional therapeutic approaches for tumor angiogenesis, which are primarily focused on the inhibition of active angiogenesis to starve cancerous cells, target the vascular endothelial growth factor signaling pathway. (biomedcentral.com)
  • Myeloid cells promote tumor growth by stimulating tumor angiogenesis, suppressing tumor immunity, and promoting metastasis to distinct sites. (hindawi.com)
  • Angiogenesis, the growth of new blood vessels, occurs at different stages during embryonic development, physiological processes such as wound healing and reproduction, and numerous diseases, including inflammation, tumor progression, and metastasis [ 1 ]. (hindawi.com)
  • Although tumor cells were first thought to drive the cellular events underpinning tumor angiogenesis and growth, considerable evidence has now emerged for the central role of tumor infiltrating myeloid cells such as monocytes, macrophages, and neutrophils in this phenomenon [ 8 - 12 ]. (hindawi.com)
  • This suggested that EPCs are able to differentiate into endothelial cells and that such cells are incorporated into sites of active angiogenesis including ischemia, tumor angiogenesis, and metastasis in adult organisms [ 16 , 17 ]. (hindawi.com)
  • Main methods: Anticancer activity of the I. obliquus extract was examined in mouse models of Lewis lung carcinoma growth and spontaneous metastasis after 3 weeks of continuous extract intake at the dose of 6 mg/kg/day, which corresponded to that ingested daily with Chaga infusion in Japan. (researchgate.net)
  • The authors also cite animal experimental research which has shown that T4 increases the oxidative stress[6] and spontaneous pulmonary metastases in mice. (wakeup-world.com)
  • Furthermore, the frequency of predicted pathogenic mtDNA mutations was significantly correlated with distant metastasis in patients with non-small cell lung carcinoma (NSCLC) and colon cancers [ 2 ]. (biomedcentral.com)
  • Over the last 17 years, stereotactic body radiation therapy (SBRT) has shown a high degree of safety and local control for stage I lung cancers and other localized malignancies. (frontiersin.org)
  • Tumor progression was observed after subcutaneous injection into the dorsal subcutis for 107 wild type, 129/Black Swiss mice. (wikipedia.org)
  • These results suggest that metastasis-enhancing pathogenic mtDNA derived from metastatic tumor cells is transferred to low-metastatic tumor cells and stromal cells via S-EVs in vitro and in the tumor microenvironment, inferring a novel mechanism of enhancement of metastatic potential during tumor progression. (biomedcentral.com)
  • The triterpenoid fraction (100 and 200 mg/kg) of the fruit bodies of Ganoderma lucidum inhibited primary solid-tumor growth in the spleen, liver metastasis and secondary metastatic tumor growth in the liver in intrasplenic Lewis lung carcinoma (LLC)-implanted mice. (nih.gov)
  • Unfortunately, ~50% of all patients develop distant metastases and are ineligible for surgical treatment ( 4 , 5 ). (spandidos-publications.com)
  • One of the first molecules implicated in enhancement of distant metastasis after irradiation of the primary tumor was angiostatin, produced by the primary tumor and keeping metastasis dormant. (biomedcentral.com)
  • Recent evidence suggests that plakoglobin may suppress tumorigenesis and metastasis by multiple mechanisms, including the suppression of oncogenic signaling, interactions with various proteins involved in tumorigenesis and metastasis, and the regulation of the expression of genes involved in these processes. (oncotarget.com)
  • Genetic deletion of ADAMTS1 in the host microenvironment resulted in a drastic decrease of tumor growth and metastasis. (oncotarget.com)
  • Similarly, intrasplenic injection of LLC cells resulted in rapid colonization of the liver with metastasis to the lungs within 2 weeks in the WT but not fetuin-A null mice. (ac.ke)
  • This aggravates hypoxia within the tumor core and ultimately leads to increased tumor proliferation and metastasis. (biomedcentral.com)
  • Specific growth factors, such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), stimulate the proliferation and migration of naturally quiescent endothelial cells, resulting in the formation of new vessel structures during embryonic development and tumor growth [ 7 ]. (hindawi.com)
  • Further, a combination of npCpG and influenza H1N1 hemagglutinin antigen showed excellent humoral and cellular immunity, evoking high levels of antibodies and cytokines and inducing a great expansion of splenocytes in immunized mice. (bvsalud.org)
  • Several in vitro studies have demonstrated that artemisinin and its derivatives possess promising anticancer, antiproliferative, and antiapoptotic properties in tumor cell lines of colon, breast, and lung. (wjtcm.net)
  • Lung and breast carcinoma have been reported to be responsible for 53-75.2% of all MPEs [3,4]. (medscimonit.com)
  • I]n rats lung the deiodination of LT4 is the lowest compared to all the other tissues. (wakeup-world.com)
  • 8] This means that the amount of LT4 reaching the lungs following an external supplementation cannot to be transformed into LT3 as in the other tissues, and make lungs very vulnerable to possible toxic effects of LT4. (wakeup-world.com)
  • Upon culture in endothelial growth media, these cells expressed endothelial lineage markers, such as CD31, Tie2, and VEGF receptor 2 (VEGFR2), and incorporated into blood vessels in ischemic tissues. (hindawi.com)
  • Mitochondrial DNA (mtDNA) carrying certain pathogenic mutations or single nucleotide variants (SNVs) enhances the invasion and metastasis of tumor cells, and some of these mutations are homoplasmic in tumor cells and even in tumor tissues. (biomedcentral.com)
  • In fact, a 1996 study found that the carcinoma predominantly metastasized into the lungs after tail vein injections. (wikipedia.org)
  • This article reviews the current knowledge and experimental research about the mechanisms by which fatty acids and their derivatives control specific gene expression involved during carcinogenesis. (springer.com)
  • In contrast, while some studies have suggested a tumor promoting activity of plakoglobin in a cell/malignancy specific context, it generally acts as a tumor/metastasis suppressor. (oncotarget.com)
  • Mucoepidermoid carcinoma is the most common salivary gland malignancy in children. (medscape.com)
  • A membrane-based antibody array for the parallel determination of the relative levels of selected mouse cytokines and chemokines. (rndsystems.com)
  • The Mouse Cytokine Array, Panel A utilizes capture antibodies spotted onto a nitrocellulose membrane to allow high-throughput multi-analyte profiling of 40 cytokines, chemokines, and more in a single sample. (rndsystems.com)
  • We identified critical key factors and cytokines for our candidate cytokine activity by using gene-knockout mice and neutralization antibodies. (bmj.com)
  • Mice that consume the human equivalent of 2-3 cups of tea/day show inhibition of VEGF by as much as 70%, and reduction of tumor cell invasion by 50% . (ppt-health.com)
  • We extended our investigation in vivo and confirmed that mice injected with USP19 depleted cells display increased tumor-free survival, as well as a delay in the onset of the tumor formation and a significant reduction in the appearance of metastatic foci, indicating that tumor cell invasion and dissemination is impaired. (nature.com)
  • We and others previously showed that certain mitochondrial DNA (mtDNA) somatic mutations or single nucleotide variants (SNVs) enhanced the invasion and metastasis of mouse and human cell lines, e.g. (biomedcentral.com)
  • Panax ginseng is also used for depression , anxiety , general fatigue and chronic fatigue syndrome (CFS), multiple sclerosis , for boosting the immune system, and for fighting particular infections in a lung disease called cystic fibrosis. (emedicinehealth.com)
  • Fucoidans also modulate growth factors required for healing and tissue regeneration, while blocking those associated with visible aging. (lifeextension.com)
  • In particular, interleukin (IL)-2 or IL-12 suppressed tumor metastases largely via NKG2D ligand recognition and perforin-mediated cytotoxicity. (silverchair.com)
  • Hypoxia stimulates hypoxia inducible factor (HIF)-dependent expression of CXCL12 and KITL promoting mobilization from the bone marrow and recruitment to primary tumor and metastatic sites of CXCR4 + CD11b + bone marrow-derived cells and KITbCD11b + cells assisting vasculogenesis and metastasis respectively (Kuonen et al. (biomedcentral.com)
  • Using a syngeneic B16F1 melanoma model in wild type and ADAMTS1 knockout mice we found distinct stroma versus tumor functions for this protease. (oncotarget.com)
  • However, the clinical management of RCC metastasis is challenging. (thno.org)
  • subtilis Ð Ð V Ð -7724 lectin was administered to tumor-bearing mice or to mice which underwent surgical resection of the primary tumor. (bvsalud.org)
  • Sorensen R., Iani V., Moan J. Kinetics of photobleachingof protoporphyrin IX in the skin of nude mice ex-posed to different fluence rates of red light // Ibid. (kiev.ua)
  • In this study, human tumor cells (NCI-H640, 1 × 10 7 in 100 μL) are implanted subcutaneously, or 1 × 10 7 in 50 μL in the thoracic cavity, in athymic nude mice (nu/nu). (wjtcm.net)
  • C. ghonii spores decreased tumor volumes and increased tumor necrosis and inhibition rates in tumor-bearing mice. (bvsalud.org)
  • Thus, in tumor-bearing mice, 60% tumor reduction was observed, while in metastatic mice, the number of nodules decreased by 25% compared to the control group. (researchgate.net)
  • In the experimental metastasis assay, the lungs of the WT mice were filled with metastatic nodules, whereas the lungs of the fetuin-A null mutant mice were virtually free of colonies at the end of 2 weeks. (ac.ke)
  • It does so by directly activating muscle catabolism and stimulating an innate immune response in the mice. (wikipedia.org)
  • In cases of lung metastasis, large tumor masses underwent necrosis, with some of them hemorrhaging and even fewer exhibiting acute inflammation. (wikipedia.org)
  • Also, the nanoadjuvant combined with ovalbumin antigen led to a potent cytotoxic T-cell response, substantially inhibited tumor growth, and improved the survival rate of mice in a melanoma model. (bvsalud.org)
  • The activity of the mouse product did not translate to the activity of the human counterpart. (wikipedia.org)
  • Recombinant Human Wnt-3a (Catalog # 5036-WN) induces alkaline phosphatase production by the MC3T3-E1 mouse preosteoblast cell line. (novusbio.com)
  • The most widely used models are the human tumor xenograft mouse model. (wjtcm.net)
  • In our study, the BP-and CEsupplemented diets have been expressed as mg C3GE/g DW and comprised of 1.69 mg total anthocyanins (C3GE) per mouse per day which is equivalent to 320 mg total anthocyanin per day for a human. (researchgate.net)
  • Monocytes are a heterogeneous cell population comprising of at least three subsets: classical monocytes (CMo, CD14 high CD16- in humans, Ly6C high TREML4- in mice), intermediate monocytes (IMo, CD14 high CD16+ in human, Ly6C+TREML4+in mice), and patrolling monocytes (PMo, CD14 dim CD16+ in human, Ly6C-TREML4+in mice). (bmj.com)
  • Moreover, I. obliquus extract-treated mice demonstrated the increase in tumor agglomeration and inhibition of vascularization. (researchgate.net)
  • Today, resveratrol is attracting attention for its unique ability to mimic the gene expression effects of caloric restriction, the only intervention that has been shown in peer-reviewed studies to prolong maximum life span and/or produce anti-aging effects in a variety of organisms, including mice, rats, dogs, and monkeys. (lifeextension.com)
  • The coadministration of cisplatin with PCNs induced a synergistic suppression of tumor growth by improving drug delivery as evidenced by increased blood prefusion and decreased vascular permeability. (biomedcentral.com)
  • To examine the mechanism by which fetuin-A influences LLC colonization and growth, we showed that LLC tumor cells adhere to fetuin-A in a Ca2+-dependent fashion, resulting in growth of the tumor cells. (ac.ke)
  • Measured by its ability to induce alkaline phosphatase production by MC3T3‑E1 mouse preosteoblast cells. (novusbio.com)
  • This interaction enables the recruitment of T cells to the inflamed lung, which is significant in understanding immune responses [1] . (cusabio.com)
  • Activated T cells continue circulating throughout the whole system and sequentially function in unirradiated metastases. (nature.com)
  • It remains unclear whether metastasis-enhancing pathogenic mutant mtDNA in tumor cells is intercellularly transferred between tumor cells and stromal cells. (biomedcentral.com)
  • When MitoTracker Deep Red-labeled high-metastatic Lewis lung carcinoma A11 cells carrying the ND6 G13997A mtDNA mutation were cocultured with CellLight mitochondria-GFP-labeled low-metastatic P29 cells harboring wild-type mtDNA, bidirectional transfer of red- and green-colored vesicles, probably mitochondria-related EVs, was observed in a time-dependent manner. (biomedcentral.com)
  • In a study published in 2006 in the journal Cell, researchers in France found that resveratrol protects mice against diet-induced insulin resistance and obesity. (lifeextension.com)
  • This depletion disrupted bone homeostasis and caused bone weight loss and a bone density decrease in mice. (wikipedia.org)
  • We tested our candidate cytokine activity in vivo using multiple mice models. (bmj.com)