• In enzymology, a pantetheine-phosphate adenylyltransferase (EC 2.7.7.3) is an enzyme that catalyzes the chemical reaction ATP + 4'-Phosphopantetheine ⇌ {\displaystyle \rightleftharpoons } diphosphate + 3'-dephospho-CoA Thus, the two substrates of this enzyme are ATP and 4'-Phosphopantetheine, whereas its two products are diphosphate and 3'-dephospho-CoA. (wikipedia.org)
  • The systematic name of this enzyme class is ATP:pantetheine-4'-phosphate adenylyltransferase. (wikipedia.org)
  • Other names in common use include dephospho-CoA pyrophosphorylase, pantetheine phosphate adenylyltransferase, dephospho-coenzyme A pyrophosphorylase, and 3'-dephospho-CoA pyrophosphorylase. (wikipedia.org)
  • A purine nucleotide which has hypoxanthine as the base and one phosphate group esterified to the sugar moiety. (lookformedical.com)
  • Recent investigations have confirmed the effectiveness and the excellent tolerability of pantethine, a derivative of pantetheine, an essential part of the acetylation coenzyme CoA, administered P.O., in normalizing the blood lipid concentrations of patients with hyperlipidemias. (wellnessresources.com)
  • A subclass of enzymes of the transferase class that catalyze the transfer of a methyl group from one compound to another. (lookformedical.com)
  • A group of 18 patients with hyperlipidemias (9 M, 9 F), with an average age of 52.6 years, was submitted to pantethine parenteral treatment. (wellnessresources.com)
  • We found that five proteins were increased at least 2-fold in the allogeneic group at day 7 compared with days 0, 3 and 15 (after Cyclosporin A treatment) and the syngeneic group at day 7. (biomedcentral.com)
  • This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). (wikipedia.org)
  • My research group works on the forefront area of chemistry, biology and medicine related to epigenetics. (uga.edu)
  • Each group was subjected to UVB rays for 14 days on alternate times. (conferencedequebec.org)
  • In the neglected group (UV control), UV rays administered on alternative days more than a 14-day time period made your skin dark, and worth drops right down to 40 (Physique 5B). (conferencedequebec.org)
  • Pantetheinase ( EC 3.5.1.92 ) (Pantetheine hydrolase) (Vanin), which hydrolyzes specifically one of the carboamide linkages in D-pantetheine, thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. (embl.de)
  • Pantetheine, the dephosphorylated form of phosphopantetheine, however, is first taken up by intestinal cells and converted to pantothenic acid before being delivered into the bloodstream [ 2 ]. (nih.gov)
  • Pantothenic acid is vital to the synthesis and maintenance of coenzyme A ( CoA ), a cofactor and acyl group carrier for many enzymatic processes, and acyl carrier protein, a component of the fatty acid synthase complex ( Tahiliani and Beinlich, 1991 ). (nih.gov)
  • CoA biosynthesis proceeds through a highly conserved pathway, involving five enzymatic steps: pantothenic acid (vitamin B5) phosphorylation, cysteine conjugation, decarboxylation, conjugation to an adenosyl group and phosphorylation. (microbialcell.com)
  • Vanin1 (VNN1) is a pantetheinase that can catalyze the hydrolysis of pantetheine to produce pantothenic acid and cysteamine. (animbiosci.org)
  • VNN1 can catalyze the hydrolysis of pantetheine to produce pantothenic acid (vitamin B 5 ) and cysteamine (a highly effective antioxidant) [ 1 ]. (animbiosci.org)
  • In enzymology, a pantetheine-phosphate adenylyltransferase (EC 2.7.7.3) is an enzyme that catalyzes the chemical reaction ATP + 4'-Phosphopantetheine ⇌ {\displaystyle \rightleftharpoons } diphosphate + 3'-dephospho-CoA Thus, the two substrates of this enzyme are ATP and 4'-Phosphopantetheine, whereas its two products are diphosphate and 3'-dephospho-CoA. (wikipedia.org)
  • The systematic name of this enzyme class is ATP:pantetheine-4'-phosphate adenylyltransferase. (wikipedia.org)
  • Other names in common use include dephospho-CoA pyrophosphorylase, pantetheine phosphate adenylyltransferase, dephospho-coenzyme A pyrophosphorylase, and 3'-dephospho-CoA pyrophosphorylase. (wikipedia.org)
  • CoA is essential for fatty acid synthesis and degradation, transfer of acetyl and acyl groups, and a multitude of other anabolic and catabolic processes [ 3 , 4 ]. (nih.gov)
  • The acetyl CoA molecule also carries a two carbon acetyl group, which it donates to oxaloacetate, the first substrate of the citric acid cycle. (coalitionbrewing.com)
  • This acetyl group is made up of a carbon (C) and two hydrogen (H) atoms, which have been taken from pyruvate. (coalitionbrewing.com)
  • With molecular dynamics studies, we extended our structural analysis by characterizing the hNME1-CoA structure and elucidating possible orientations of the pantetheine tail, which is absent in the X-ray structure due to its flexibility. (bvsalud.org)
  • Each vitamin in the water-soluble B-vitamin group must be taken together in order for each one to work properly. (bransonpt.com)
  • The reactive thiol groups of both substrates are within hydrogen-bond distance from the side chain of His 610. (rcsb.org)
  • In the binary complex with CoA, the hydroxyl group of Ser 558 is hydrogen bonded to the nitrogen atom of one of the two peptide-like units of the substrate. (rcsb.org)
  • In this abortive ternary complex, CoA adopts a helical conformation with two intramolecular hydrogen bonds and the reactive sulfur of the pantetheine arm positioned 12 A away from the active site residues involved in the transferase reaction. (rcsb.org)
  • This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). (wikipedia.org)
  • gene lnt), a bacterial enzyme that transfers the fatty acyl group on membrane lipoproteins. (embl.de)
  • CoA is also involved in acyl group transfers, and these reactions are important in many metabolic processes, including the synthesis of ketones, amino acids and neurotransmitters. (coalitionbrewing.com)