Tinctures of Aconite and aconitine are used externally in certain forms of neuralgia and rheumatism, and internally m small doses in cases of fever and pain. (thepharmacognosy.com)
By applying knowledge of these fragmentation pathways to the aconitines in the ethanolicextract of aconite roots, all the known aconitines were detected and also 23 unknown aconitine-typealkaloids, in which the lipo-alkaloids containing residues of 15C, 17C and 19C saturated orunsaturated fatty acids were characterized. (healthdrugpdf.com)
Aconitine-type crude extract of aconite are characterized, based on these alkaloids isolated from aconite have been shown to have potential toxicity and wide bioactivity. (healthdrugpdf.com)
collision-induced dissociation (CID) conditions are still notsufficiently clear to assist characterization of unknown aconitine-type alkaloids in aconite extracts. (healthdrugpdf.com)
Many herbal medicines and compositions are clinically effective but challenged by its safety risks, i.e., aconitine (AC) from aconite species. (springer.com)
Injection of GP-AC nanoparticles and the mixed licorice-aconite decoction, respectively, caused mild recoverable toxic effects and no death, while the aconitine, particle-free GP-AC mixture and aconite decoction induced sever toxic effects and 100 % death. (springer.com)
Aconitine (AC), known as devil's helmet, is a highly poisonous alkaloid derived from various aconite species. (springer.com)
Toxicity of the NPs was tested in vivo in comparison to pure aconitine, aconite, and licorice root decoction and reported here. (springer.com)
Alkaloids4
Like many other alkaloids, the basic nitrogen atom in one of the six-membered ring structure of aconitine can easily form salts and ions, giving it affinity for both polar and lipophilic structures (such as cell membranes and receptors) and making it possible for the molecule to pass the blood-brain barrier. (wikipedia.org)
Fragmentation pathways of aconitine-type alkaloids were investigated by electrospray ionization/ion trap multistage tandem mass spectrometry. (healthdrugpdf.com)
The capillary voltage was tines (DDAs), in which the C8 position is occupied by an fixed at 5.0 V and capillary temperature was set 200°C. acetyl group, and lipo-alkaloids, in which the C8 position is Sample solutions were infused at 3 mL/min via a syringe occupied by a fatty acid acyl group.10 The other structural pump. (healthdrugpdf.com)
Investigations of diterpene alkaloids isolated from Aconitum anthora L. and A. moldavicum L., and of aconitine-derived lipo-alkaloids. (u-szeged.hu)
Derivatives1
The acetoxyl group at the c8 position can readily be replaced by a methoxy group, by heating aconitine in methanol, to produce a 8-deacetyl-8-O-methyl derivatives. (wikipedia.org)
Mixtures2
Aconitine is also soluble in mixtures of alcohol and water if the concentration of alcohol is high enough. (wikipedia.org)
aconitines,2±4 the quantitative analysis and the stereo- Authentic samples of aconitine (AC), hypaconitine (HC) chemistry of aconitines,5±7 and the direct analysis of and mesaconitine (MA) were purchased from China Drug aconitine mixtures. (healthdrugpdf.com)
Aconitum1
Aconitine is an alkaloid toxin produced by various plant species belonging to the genus Aconitum (family Ranunculaceae), known also commonly by the names wolfsbane and monkshood. (wikipedia.org)
Interact2
Aconitine can interact with the voltage-dependent sodium-ion channels, which are proteins in the cell membranes of excitable tissues, such as cardiac and skeletal muscles and neurons. (wikipedia.org)
The ephedrine alkaloid-containing colloidal nanoparticles discovered in another licorice containing Chinese medicinal decoction [ 12 ] imply that licorice root proteins would hypothetically interact with aconitine to form aggregates thereafter affecting the toxicity. (springer.com)
Compounds2
Compound groups are useful because in some cases, lists will instead identify a group of structurally similar compounds (such as lead compounds) as all having the same hazard. (pharosproject.net)
It has been known that liquiritin from licorice forms complexation with aconitine and therefore reduces the amount of free aconitine [ 7 ], indicating that interactions between aconitine with other major amphiphilic compounds (i.e., protein) from licorice may facilitate the formation of aconitine complex of such kind, too. (springer.com)
Chemical3
If aconitine is heated in its dry state, it undergoes a pyrolysis to form pyroaconitine ((1α,3α,6α,14α,16β)-20-ethyl-3,13-dihydroxy-1,6,16-trimethoxy-4-(methoxymethyl)-15-oxoaconitan-14-yl benzoate) with the chemical formula C32H43NO9. (wikipedia.org)
Compound groups are groups of chemicals that share structural or chemical features. (pharosproject.net)
Elements from the same group of the periodic table show similar chemical characteristics. (wikimili.com)
Product1
Like with all anabolic steroids Oxymetholone is metabolised to a smaller but more potent product Aconitine, oxymetholone for sale uk. (idnow.info)
Drug1
Metahexamide ( INN ) is an anti-diabetic drug from the group of sulfonylureas . (cloudfront.net)
Samples1
Aconitine was detected in all analyzed samples (blood, urine, gastric content and kidney) and quantified in femoral blood with 86.2 μg/L (case 1) and 2.3 μg/L (case 2), respectively. (newsshare.in)
Structural1
This compound group has not yet been assigned a structural definition. (pharosproject.net)
Small1
Xylem tissues of the radial vascular bundles are composed of small groups of pitted and reticulate vessels embedded in parenchyma. (thepharmacognosy.com)
Agents1
Despite its cardiotoxic and neurotoxic risks, aconitine is popularly used as the antipyretic and analgesic agents in many Asian countries. (springer.com)
Status1
The table below indicates how each compound group is populated, and what is the status of its population. (pharosproject.net)
Room1
I remember a scene where an entire group of influential people were poisoned at a restaurant room by a bunch of chemicals. (dramabeans.com)
Effects1
The arguments opposing their former is in two groups of emptying the effects. (nexocorp.com)
Table2
The rows of the table are called periods, and the columns are called groups. (wikimili.com)
Trends run through the periodic table, with nonmetallic character increasing from left to right across a period, and from down to up across a group, and metallic character increasing in the opposite direction. (wikimili.com)
Alkaloid3
Aconitine is an alkaloid toxin produced by various plant species belonging to the genus Aconitum (family Ranunculaceae), known also commonly by the names wolfsbane and monkshood. (wikipedia.org)
7. Aconitine linoleate, a natural lipo -diterpenoid alkaloid, stimulates anti-proliferative activity reversing doxorubicin resistance in MCF-7/ADR breast cancer cells as a selective topoisomerase IIα inhibitor. (nih.gov)
You can be lured into its velvety folds, but you should be aware that all parts of the plant contain the poisonous alkaloid aconitine. (blogspot.com)
Arrhythmia3
A separate cohort was tested for vulnerability to aconitine-induced arrhythmia 24 hr after exposure. (nih.gov)
However, both 0.2 and 0.8 ppm O 3 increased sensitivity to aconitine-induced arrhythmia formation, suggesting a latent O 3 -induced alteration in myocardial excitability. (nih.gov)
Aconitine binds to the channel at the neurotoxin binding site 2 on the alpha subunit (the same site bound by batrachotoxin, veratridine, and grayanotoxin). (wikipedia.org)
Aconite is toxic just from simple contact: its chief toxic component, aconitine, is a potent neurotoxin that penetrates through the skin. (bbvaopenmind.com)
Species1
All species of these plants contain a group of neurotoxic compounds called grayanotoxins. (bigthink.com)
Form3
Like many other alkaloids, the basic nitrogen atom in one of the six-membered ring structure of aconitine can easily form salts and ions, giving it affinity for both polar and lipophilic structures (such as cell membranes and receptors) and making it possible for the molecule to pass the blood-brain barrier. (wikipedia.org)
If aconitine is heated in its dry state, it undergoes a pyrolysis to form pyroaconitine ((1α,3α,6α,14α,16β)-20-ethyl-3,13-dihydroxy-1,6,16-trimethoxy-4-(methoxymethyl)-15-oxoaconitan-14-yl benzoate) with the chemical formula C32H43NO9. (wikipedia.org)
veratrine, like aconitine,is used ynainly externally in the form of an ointment, as a localanaesthetic over neuralgic nerves. (avclark.com)