Street Hospital2
- The Great Ormond Street Hospital (GOSH) The Bone Marrow Transplant (BMT) unit is the largest paediatric BMT centre in the UK. (com.kw)
- Great Ormond Street Hospital (GOSH) became the first NHS hospital in the UK to treat a paediatric patient successfully using Kymriah, a type of CAR T-cell therapy. (com.kw)
Severe5
- Congenital hyperinsulinism (HI or CHI) is a rare condition causing severe hypoglycemia (low blood sugar) in newborns due to the overproduction of insulin. (wikipedia.org)
- Congenital forms of hyperinsulinism can be transient (short-term) or persistent (long-term) and mild or severe. (wikipedia.org)
- Congenital Hyperinsulinism (CHI) is the most frequent cause of severe, persistent hypoglycemia in children. (eurospe.org)
- Hyperinsulinism (HI) is the most common cause of severe, persistent hypoglycemia in infants and children. (medscape.com)
- [ 5 ] Severe cases of congenital HI may be unresponsive to either diazoxide or octreotide and require intensive management with tube feedings, near-total pancreatectomy, or partial pancreatectomy. (medscape.com)
Genetic1
- Hyperinsulinism or congenital hyperinsulinism can be a genetic or acquired condition. (wikipedia.org)
Common cause1
- CAR T-cells have shown great promise for relapsed ALL - the most common cause of cancer death in children in the UK. (com.kw)
Persistent2
- Congenital forms of hyperinsulinism can be transient (short-term) or persistent (long-term) and mild or severe. (wikipedia.org)
- Persistent, congenital hyperinsulinism is also recognized. (medscape.com)
Infant3
- As HI is a congenital condition, an infant usually starts to show signs and symptoms within the first few days of life, although very occasionally symptoms may appear later in life. (wikipedia.org)
- Pregnancy and birth history may reveal risk factors that could predispose an infant to hyperinsulinism. (medscape.com)
- Hyperinsulinism typically resolves within 1-2 days following birth (see Infant of Diabetic Mother ). (medscape.com)