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  • kinase
  • Publications] K.Shimazaki,A.Ishida,S.G.Rhee,T.Takenawa,and N.Kawai: 'Changes in IP3 3-kinase immunoreactivity following transient ischeamia in gerbil hipocampus' NeuroReport. (nii.ac.jp)
  • sevenless , a cell-specific homeotic gene of Drosophila , encodes a putative transmembrane receptor with a tyrosine kinase domain. (springer.com)
  • Basler K, Hafen E. Control of photoreceptor cell fate by the sevenless protein requires a functional tyrosine kinase domain. (springer.com)
  • In inside-out patches, the PKC-dependent enhancement of cation channel open probability could be prevented by the src homology 3 (SH3) domain, presumably by disrupting a link between the channel and the kinase. (jneurosci.org)
  • To determine whether the association between the kinase and the cation channel involves specific forms of protein-protein interactions, we have tested the ability of different interaction domains and motifs to interfere with the functional link between channel and kinase in excised, inside-out patches. (jneurosci.org)
  • Our data indicate that the cation channel-kinase "association" requires src homology 3 (SH3) domain protein-protein interactions, and that disruption of this interaction prevents channel modulation and attenuates the long-lasting depolarization produced by cation channel activation. (jneurosci.org)
  • Experiments with FRS2 alpha-deficient fibroblasts demonstrate that FRS2 alpha plays a critical role in FGF-induced mitogen-activated protein (MAP) kinase stimulation, phosphatidylinositol-3 (PI-3) kinase activation, chemotactic response, and cell proliferation. (sdbonline.org)
  • Ras-mediated activation of DH-PH-Sos did not require activation of mitogen-activated protein kinase but it was dependent on activation of phosphoinositide 3-kinase. (embl-heidelberg.de)
  • ubiquitously
  • Using these binding motives, the ubiquitously expressed Grb2 acts as an intermediate between cell-surface activated receptors and downstream targets. (eurekaselect.com)
  • cellular
  • Grb2 is recruited to lipid rafts during signaling events, and activation of MEK1/2 by different mechanisms within lipid rafts may lead to different cellular responses. (sdbonline.org)
  • sequence
  • Sequence analysis of the fusion MLL/EEN transcript in our patient reveals that exon 6 of MLL is fused to the N- terminal end of EEN, a fusion that would create a chimeric protein that includes the major functional domain of EEN. (hku.hk)
  • peptide
  • We show a proof-of-concept study on the amphiphysin-1 SH3 domain interacting with its peptide ligands. (genes2cognition.org)
  • Modeling and prediction of binding affinities between the human amphiphysin SH3 domain and its peptide ligands using genetic algorithm-Gaussian processes. (genes2cognition.org)
  • In this article, we discuss the application of the Gaussian process (GP) and other statistical methods (PLS, ANN, and SVM) for the modeling and prediction of binding affinities between the human amphiphysin SH3 domain and its peptide ligands. (genes2cognition.org)
  • iii) both SVM and GP have a good performance for SH3 domain binding peptide dataset. (genes2cognition.org)
  • Involvement
  • Involvement of the c-Src-Crk-C3G-Rap1 signaling in the nectin-induced activation of Cdc42 and formation of adherens junctions. (springer.com)
  • First, Grb2 and compiled maximum tumor conformations induced by Grb2 involvement were introduced. (eurekaselect.com)
  • extracellular
  • Dynamic changes in the cell membrane are prominent during cell adhesion and spreading in response to extracellular stimuli [ 2 , 3 ]. (ijbs.com)
  • neuronal
  • Publications] H.Tsubokawa,K.Oguro,H.P.C.Robinson,T.Matuzawa,S.G.Rhee,T.Takenawa and N.Kawai: 'Inositol 1,3,4,5-tetrakisphosphate as a mediator of neuronal death in ischemic hippocampus' Neuroscience. (nii.ac.jp)