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  • FRS2
  • These newyly phosphorylated sites bind cytosolic docking proteins such as FRS2, PRKCG and GRB2 which proceed to activate cell signaling pathways that lead to cellular differentiation, growth, proliferation, prolonged survival, migration, and other functions. (wikipedia.org)
  • cells
  • CBL-B expression in T cells causes ligand-induced T cell receptor down-modulation, controlling the activation degree of T cells during antigen presentation. (wikipedia.org)
  • The number and size of the lung metastases can be controlled by the number of tumor cells to be injected and the time of tumor growth. (jove.com)
  • The exact pathways and elements activated depend on the cell type being stimulated plus other factors such as the stimulated cells microenvironment and previous as well as concurrent history of stimulation Activation of the gamma isoforms of phospholipase C (PLCĪ³) (see PLCG1 and PLCG2 illustrates one mechanism by which FGFR1 activates cell stimulating pathways. (wikipedia.org)
  • Each of these is a functional element to the progression and development of cancer, which is defined as an abnormal growth of cells with a tendency to proliferate in an uncontrolled way and, in some cases, to metastasize. (wikipedia.org)
  • Through an immunological response, the body's natural killer (NK) cells, which are a type of lymphocyte, recognize and bind to the Fc portion on the antibody through an Fc receptor, CD16. (wikipedia.org)
  • 2002
  • Some receptors are recycled back to the plasma membrane with or without the ligand, whereas others are sent to the late endosomal compartment and lysosomes for degradation ( Sorkin and von Zastrow, 2002 ). (biologists.org)
  • recruitment
  • In many mitogenic signaling pathways, recruitment of GRB2 from the cytosol, where it is already bound to the guanine nucleotide exchange factor SOS-1 via its amino-terminal SH3 domain, brings SOS1 in close proximity to Ras at the plasma membrane. (atlasgeneticsoncology.org)
  • Part of a complex including TNK2, GRB2 and one receptor tyrosine kinase (RTK) such as AXL, in which GRB2 promotes RTK recruitment by TNK2. (mybiosource.com)
  • mediates
  • This interaction is proposed to be the mechanism whereby CD98 mediates cell survival and growth via currently undefined signaling pathways. (jove.com)
  • inhibition
  • Inhibition of Grb2 function impairs developmental processes in various organisms and blocks transformation and proliferation of various cell types. (wikipedia.org)
  • high affinity
  • In addition, we identify phosphoTyr317 in Shc-1 as a high-affinity substrate for the SOCS5-SH2 domain and suggest that SOCS5 may negatively regulate EGF and growth factor-driven Shc-1 signaling by binding to this site. (jove.com)
  • complexes
  • Ligand-receptor complexes destined for internalization are selectively recruited into coated pits followed by coat invagination, constriction and scission of the clathrin-coated vesicle containing cargo ( Kirchhausen, 2000 ). (biologists.org)
  • tumor growth
  • DCs pulsed with ALDH high CSC lysates induced significantly higher protective antitumor immunity than DCs pulsed with the lysates of unsorted whole tumor cell lysates in both models and in a lung metastasis setting and a s.c. tumor growth setting, respectively. (jove.com)
  • Indeed, the ability to locate and quantify tumor growth longitudinally in a single cohort of animals to completion of the study as opposed to sacrificing individual groups of animals at specific assay times has revolutionized how researchers investigate breast cancer metastasis. (jove.com)
  • Without a signal, cell cycle characteristics to enhance tumor growth are inhibited and the cancer progression is suppressed. (wikipedia.org)