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  • Lysates
  • Lysates of such desensitized cells were quantitatively immunoprecipitated with an antiserum recognizing both Sos1 and Sos2 proteins or a specific anti-Sos2 antiserum. (umassmed.edu)
  • Insulin
  • Immunoblot analysis of these precipitates revealed that insulin causes a marked hyperphosphorylation of Sos1 and a 50% decrease in Grb2 associated with Sos proteins under these conditions. (umassmed.edu)
  • Mice
  • Mice deficient in GDNF, GFRα1 or the RET protein itself exhibit severe defects in kidney and enteric nervous system development. (wikipedia.org)
  • cellular
  • Most recently, our lab has been studying the mechanisms that mediate apoptosis activation in response to cellular stress caused by DNA damage or protein misfolding. (gene.com)
  • kinases
  • The molecules discussed include Src family kinases, Syk, Grb2 adaptor protein, and Tec family kinases Bmx and Btk. (lu.se)
  • In fact, recent evidence has implicated various mitogen-activated protein (MAP) kinases (ERK) in cell survival in vivo. (rupress.org)
  • Growth
  • This protein kinase is activated by insulin and various growth and survival factors to function in a wortmannin-sensitive pathway involving PI3 kinase (2,3). (cellsignal.com)
  • Upon initiation of angiogenesis with basic fibroblast growth factor (bFGF) on the chick chorioallantoic membrane (CAM), endothelial cell mitogen-activated protein (MAP) kinase (ERK) activity was detected as early as 5 min yet was sustained for at least 20 h. (rupress.org)
  • A ngiogenesis is influenced by both growth factors and adhesion proteins associated with the extracellular matrix (ECM). (rupress.org)
  • Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. (abcam.com)
  • amino acids
  • Each protein is divided into three domains: an N-terminal extracellular domain with four cadherin -like repeats and a cysteine -rich region, a hydrophobic transmembrane domain and a cytoplasmic tyrosine kinase domain, which is split by an insertion of 27 amino acids . (wikipedia.org)
  • The structure is that of a dimer formed between two protein molecules each spanning amino acids 703-1012 of the RET molecule, covering RETs intracellular tyrosine kinase domain. (wikipedia.org)
  • molecule
  • Hh proteins are synthesized as 45 kDa precursors that undergo auto-cleavage to generate a 19 kDa amino-terminal peptide (Hh-N) and a carboxy-terminal peptide (Hh-C). The amino-terminal peptide becomes covalently attached to a cholesterol molecule at its carboxy terminus and acetylated at its amino terminus. (cellsignal.com)
  • One protein molecule, molecule A is shown in yellow and the other, molecule B in grey. (wikipedia.org)
  • insulin
  • Immunoblot analysis of these precipitates revealed that insulin causes a marked hyperphosphorylation of Sos1 and a 50% decrease in Grb2 associated with Sos proteins under these conditions. (umassmed.edu)
  • family
  • Background: Cofilin and actin-depolymerization factor (ADF) are members of a family of essential conserved small actin-binding proteins that play pivotal roles in cytokinesis, endocytosis, embryonic development, stress response, and tissue regeneration (1). (cellsignal.com)
  • Arginine methylation of histones H3 (Arg2, 17, 26) and H4 (Arg3) promotes transcriptional activation and is mediated by a family of protein arginine methyltransferases (PRMTs), including the co-activators PRMT1 and CARM1 (PRMT4) (4). (cellsignal.com)
  • PP1 and PP2 are the most abundant and ubiquitous serine/threonine protein phosphatases in this family. (hindawi.com)
  • This gene is a member of the GRB2-associated binding protein (GAB) gene family. (thermofisher.com)
  • subunit
  • Autophagy marker Light Chain 3 (LC3) was originally identified as a subunit of microtubule-associated proteins 1A and 1B (termed MAP1LC3) (4) and subsequently found to contain similarity to the yeast protein Apg8/Aut7/Cvt5 critical for autophagy (5). (cellsignal.com)
  • inhibitory
  • Background: The NF-κB/Rel transcription factors are present in the cytosol in an inactive state complexed with the inhibitory IκB proteins (1-3). (cellsignal.com)
  • degradation
  • SQSTM1 was subsequently found to interact with ubiquitin, providing a scaffold for several signaling proteins and triggering degradation of proteins through the proteasome or lysosome (8). (cellsignal.com)