• CYP2C9 inhibitors increase its concentrations and therefore the risk for bleeding: amiodarone. (wikipedia.org)
  • CYP3A4 inhibitors also increase the risk for bleeding: clarithromycin, ketoconazole, grapefruit juice, also amiodarone. (wikipedia.org)
  • Pacerone (amiodarone HCl) is an antiarrhythmic drug indicated for treatment of recurrent ventricular fibrillation and recurrent hemodynamically unstable ventricular tachycardia only when these conditions have not responded to documented adequate doses of other available antiarrhythmics or when alternative agents could not be tolerated. (rxlist.com)
  • Our Pacerone (Amiodarone HCl) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
  • Pacerone® (Amiodarone HCl) Tablets are a member of a class of antiarrhythmic drugs with predominantly Class III (Vaughan Williams' classification) effects, available for oral administration in 100 mg and 200 mg strengths of amiodarone hydrochloride. (rxlist.com)
  • Amiodarone hydrochloride, the active ingredient in Pacerone® Tablets, is a benzofuran derivative: 2-butyl-3-benzofuranyl 4-[2-(diethylamino)-ethoxy]-3,5-diiodophenyl ketone hydrochloride. (rxlist.com)
  • In 2002, the FDA issued its first warning about the risk of rhabdomyolysis to healthcare professionals not to administer more than 20 mg/day of simvastatin to patients receiving heart drugs containing amiodarone such as Cordarone and Pacerone. (lawyersandsettlements.com)
  • Pacerone, Cordarone, and Nexterone are some of the brands of amiodarone that are available. (pipelinepharma.com)
  • As a doctoral candidate at Oxford University, Dr. Bramah Singh determined that amiodarone and sotalol had antiarrhythmic properties and belonged to a new class of antiarrhythmic agents (what would become the class III antiarrhythmic agents). (chemeurope.com)
  • [3] Today the mechanisms of action of amiodarone and sotalol remain unknown. (chemeurope.com)
  • You should not receive this medicine if you are allergic to amiodarone or iodine, or if you have a serious heart condition such as 'AV block' (unless you have a pacemaker), a history of slow heart beats, or if your heart cannot pump blood properly. (cigna.com)
  • Your doctor will probably start you on a high dose of amiodarone and gradually decrease your dose as the medication begins to work. (medlineplus.gov)
  • Your doctor will order certain tests, such as blood tests, X-rays, and electrocardiograms (EKGs, tests that record the electrical activity of the heart) before and during your treatment to be sure that it is safe for you to take amiodarone and to check your body's response to the medication. (medlineplus.gov)
  • Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with amiodarone and each time you refill your prescription. (medlineplus.gov)
  • Amiodarone may also be used for purposes not listed in this medication guide. (cigna.com)
  • Be sure to read all medication guides or instruction sheets for oral amiodarone. (cigna.com)
  • Grapefruit Juice: Is It Affecting Your Medication? (webmd.com)
  • So, talk to your doctor about the possibility of using a different medication if avoiding grapefruit juice is not an option. (webmd.com)
  • Grapefruit can seriously affect how this medication works. (medicineshoppe.ca)
  • Amiodarone is an antiarrhythmic agent (medication used for irregular heart beat) used for various types of tachyarrhythmias (fast forms of irregular heart beat), both ventricular and supraventricular (atrial) arrhythmias. (chemeurope.com)
  • Avoid consuming grapefruit juice while you areusing this medication. (medbroadcast.com)
  • The anti-arrhythmic medication amiodarone is well-known. (pipelinepharma.com)
  • Before taking AMIODARONE: You should not use This medical drug if you are allergic to it This drug may also be used for purposes that may not have been listed in this medication guide. (pipelinepharma.com)
  • Unless your doctor tells you otherwise, avoid eating grapefruit or drinking grapefruit juice while taking this medication. (pipelinepharma.com)
  • The selection of AMIODARONE offerings can be narrowed down with the use of filters and easily weighed against one another according to medication prices and commercial terms. (pipelinepharma.com)
  • grapefruit will increase the level or effect of cobimetinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
  • grapefruit will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
  • grapefruit increases levels of lomitapide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
  • Because you will receive amiodarone injection in a clinical setting, you are not likely to miss a dose. (cigna.com)
  • The dose of amiodarone administered is tailored to the individual and the dysrhythmia that is being treated. (chemeurope.com)
  • In case of treatment with digoxin its dose should be decreased by 50% when amiodarone is taken. (med-d.com)
  • What is the most important information I should know about amiodarone injection? (cigna.com)
  • Amiodarone injection is for use only in life-threatening situations. (cigna.com)
  • What is amiodarone injection? (cigna.com)
  • What should I discuss with my healthcare provider before using amiodarone injection? (cigna.com)
  • In an emergency situation, it may not be possible before you are treated with amiodarone injection to tell your caregivers if you are pregnant or breast-feeding. (cigna.com)
  • How is amiodarone injection given? (cigna.com)
  • Amiodarone injection is often given directly into a large vein in the upper chest (central IV line). (cigna.com)
  • If you need surgery (including laser eye surgery), tell the surgeon ahead of time that you have received amiodarone injection. (cigna.com)
  • After treatment with amiodarone injection, your doctor may switch you to an oral form of amiodarone to take by mouth. (cigna.com)
  • What should I avoid while using amiodarone injection? (cigna.com)
  • Amiodarone Hydrochloride Injection by Mylan is no longer being manufactured for sale in Canada. (rxhealthmed.ca)
  • Amiodarone is used to treat and prevent certain types of serious, life-threatening ventricular arrhythmias (a certain type of abnormal heart rhythm when other medications did not help or could not be tolerated. (medlineplus.gov)
  • Amiodarone is used to treat or prevent ventricular tachycardia or ventricular fibrillation. (cigna.com)
  • Based on Singh's work, the Argentinian physician Dr. Mauricio Rosenbaum began using amiodarone to treat his patients who suffered from supraventricular and ventricular arrhythmias, with impressive results. (chemeurope.com)
  • Amiodarone is used to treat - Ventricular tachycardia and ventricular fibrillation in the heart. (pipelinepharma.com)
  • [6] This makes amiodarone one of the few drugs approved by the FDA without rigorous randomized clinical trials. (chemeurope.com)
  • Amiodarone is in a class of medications called antiarrhythmics. (medlineplus.gov)
  • Amiodarone belongs to the family of medications known as antiarrhythmics . (rxhealthmed.ca)
  • Most Americans who drink grapefruit juice do so for breakfast -- a time of day when many people also take medications . (webmd.com)
  • Grapefruit juice, it turns out, can affect some medications. (webmd.com)
  • Amiodarone may cause your arrhythmia (irregular heart rhythm) to worsen or may cause you to develop new arrhythmias. (medlineplus.gov)
  • You will probably be hospitalized for one week or longer when you begin your treatment with amiodarone. (medlineplus.gov)
  • Do not take grapefruit juice during amiodarone treatment because blood levels of amiodarone may increase, causing an increase in side effects. (rxhealthmed.ca)
  • [4] [5] By 1980, amiodarone was commonly prescribed throughout Europe for the treatment of arrhythmias, but in the U.S. amiodarone remained unapproved by the Food and Drug Administration , and physicians were forced to directly obtain amiodarone from pharmaceutical companies in Canada and Europe. (chemeurope.com)
  • In December of 1985, amiodarone was approved by the FDA for the treatment of arrhythmias. (chemeurope.com)
  • Blood levels of digoxin are increased at concurrent treatment with digoxin and Amiodarone. (med-d.com)
  • Amiodarone is used to help keep the heart beating normally in people with life-threatening heart rhythm disorders of the ventricles (the lower chambers of the heart that allow blood to flow out of the heart). (cigna.com)
  • By blocking potassium rectifier currents, amiodarone inhibits the heart from repolarizing during phase 3 of the cardiac action potential. (pipelinepharma.com)
  • But in August 2008, the FDA issued another warning because it continued to receive reports of the muscle disease in patients taking both simvastatin and amiodarone. (lawyersandsettlements.com)
  • Based on papers written by Dr. Rosenbaum developing Singh's theories, physicians in the United States began prescribing amiodarone to their patients with potentially life-threatening arrhythmias in the late 1970s. (chemeurope.com)
  • In the mid 1980s, the European pharmaceutical companies began putting pressure on the FDA to approve amiodarone by threatening to cut the supply to American physicians if it were not approved. (chemeurope.com)
  • The usage of this pharmaceutical substance: Read the Guide and, if available, the Patient Information Leaflet that will be provided by your pharmacist before you start taking AMIODARONE. (pipelinepharma.com)
  • Amiodarone is most readily available in the pharmaceutical marketplace. (pipelinepharma.com)
  • These also enable you to check the dossier status of this medicine, and the GMP approvals of the different variants of AMIODARONE. (pipelinepharma.com)
  • The FDA was reluctant to officially approve the use of amiodarone, since initial reports had shown increased incidence of serious pulmonary side-effects of the drug. (chemeurope.com)
  • The amount of this drug in your bloodstream can be increased by eating grapefruit. (pipelinepharma.com)
  • Tell your doctor if you have or have ever had any type of lung disease or if you have ever developed lung damage or breathing problems while taking amiodarone. (medlineplus.gov)
  • Amiodarone may remain in your body for some time after you stop taking it, so your doctor will watch you carefully during this time. (medlineplus.gov)
  • Avoid drinking grapefruit juice, tanning and excessive UV irradiation, be careful doing work which requires high concentration of attention (driving and others). (med-d.com)