MicroscopicPolyarteritis nodosaVasculitisEosinophilic granulomatosis with polyangiitisFriedrich WegenerWegener's Granulomatosis Etanercept TrialAutoimmuneRheumatologyClinicalSymptomsDiseaseRituximabPatientsRemission InductionAntineutrophil cytoplasmicManifestationsCyclophosphamideVasculitidesGranulomasTrialsCasesMicroscopic polyangiitisEosinophilicWegener's GranulomatosisANCARheumatoidVesselGranulomatousDiseasesChronicPulmonaryFormerly calledSignsRare
Microscopic14
- Granulomatosis with Polyangiitis (GPA) (Wegener's Granulomatosis) and Microscopic Polyangiitis (MPA) in adult patients in combination with glucocorticoids ( 1.4 ). (drugs.com)
- A model to predict cardiovascular events in patients with newly diagnosed wegener's granulomatosis and microscopic polyangiitis. (ox.ac.uk)
- To create a prognostic tool to quantify the 5 year cardiovascular (CV) risk in patients with newly diagnosed Wegener's granulomatosis (WG) and microscopic polyangiitis (MPA) without pre-morbid CV disease. (ox.ac.uk)
- Objectives Granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) are autoimmune vasculitides associated with antineutrophil cytoplasm antibodies that target proteinase 3 (PR3) or myeloperoxidase (MPO) found within neutrophils and monocytes. (bmj.com)
- Microscopic polyangiitis: Advances in diagnostic and therapeutic approaches. (medscape.com)
- AAV include granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (EGPA). (smw.ch)
- Treatment response and relapse in antineutrophil cytoplasmic autoantibody-associated microscopic polyangiitis and glomerulonephritis. (smw.ch)
- Apart from Wegener's, this category includes Churg-Strauss syndrome and microscopic polyangiitis. (checkorphan.org)
- Many trials include data on pooled groups of people with wegener's granulomatosis and microscopic polyangiitis. (checkorphan.org)
- To determine the reliability of self-reported diagnosis of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis: granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA) from a large, international, internet-based cohort. (vasculitisfoundation.org)
- The study is open to adults diagnosed with certain types of vasculitis, called Granulomatosis Polyangiitis (GPA), Microscopic Polyangiitis (MPA) or Eosinophilic Granulomatosis with Polyangiitis (EGPA). (cardiff.ac.uk)
- Despite the new immunosuppressive and immunomo-dulatory therapies, WG, microscopic polyangiitis (MPA) and Churg-Strauss syndrome (CSS) still carry considerable morbidity and mortality mainly due to progressive renal failure or aggressive respiratory involvement. (cyberleninka.org)
- Single nucleotide polymorphisms in the toll-like receptor 2 (TLR2) gene are associated with microscopic polyangiitis in the northern Han Chinese population. (cdc.gov)
- Protective Role of HLA-DRB1*13:02 against Microscopic Polyangiitis and MPO-ANCA-Positive Vasculitides in a Japanese Population: A Case-Control Study. (cdc.gov)
Polyarteritis nodosa3
- EULAR/PRINTO/PRES criteria for Henoch-Schönlein purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis, and childhood Takayasu arteritis: Ankara 2008. (printo.it)
- He developed effective therapies for formerly fatal inflammatory and immune-mediated diseases such as polyarteritis nodosa, granulomatosis with polyangiitis (formerly Wegener's granulomatosis), and lymphomatoid granulomatosis. (nih.gov)
- Although Henoch-Schonlein purpura (HSP) and Kawasaki disease (KD) are quite common forms of vasculitis, polyarteritis nodosa (PAN), Wegener's granulomatosis (WG) and Takayasu arteritis (TA) are diagnosed less commonly in children. (cyberleninka.org)
Vasculitis7
- Granulomatosis with polyangiitis (Wegener's granulomatosis) is a type of vasculitis which can be categorized as a sub-branch of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides. (rheumres.org)
- Granulomatosis with polyangiitis (GPA), previously known as Wegener's granulomatosis, is a type of vasculitis which can be categorized as a sub-branch of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides [1]. (rheumres.org)
- Granulomatosis with polyangiitis is the third most common type of vasculitis in Iran after Behcet's disease and cutaneous leukocytoclastic angiitis [6]. (rheumres.org)
- Granulomatosis with polyangiitis (GPA), previously known as Wegener's granulomatosis (WG), after the Nazi German physician Friedrich Wegener, is a rare long-term systemic disorder that involves the formation of granulomas and inflammation of blood vessels (vasculitis). (wikipedia.org)
- Granulomatosis with polyangiitis is characterized by necrotizing granulomatous inflammation, small- and medium-sized vessel vasculitis, and focal necrotizing glomerulonephritis, often with crescent formation. (merckmanuals.com)
- To assess the Birmingham Vasculitis Activity Score for Wegener's Granulomatosis (BVAS/WG) with respect to its selection and weighting of items. (nih.gov)
- Wegener's granulomatosis is a form of vasculitis that affects the lungs, kidneys and other organs. (checkorphan.org)
Eosinophilic granulomatosis with polyangiitis1
- Eosinophilic granulomatosis with polyangiitis (Churg-Strauss): evolutions in classification, etiopathogenesis, assessment and management. (medscape.com)
Friedrich Wegener2
- Originally, the disease was named for Friedrich Wegener who discussed the disorder in 1936 [2]. (rheumres.org)
- It is named after Dr. Friedrich Wegener, who described the disease in 1936. (checkorphan.org)
Wegener's Granulomatosis Etanercept Trial2
Autoimmune2
- If you or a loved one has been diagnosed with Wegener's Granulomatosis or Granulomatosis with Polyangiitis (GPA), it's important to learn as much as possible about this chronic autoimmune disease in order to better manage your symptoms and treatment plan. (articleinsider.com)
- Wegener's Granulomatosis and Granulomatosis with Polyangiitis are two different names for the same disease, which is an autoimmune disorder that primarily affects the blood vessels in the lungs, kidneys, and upper respiratory tract. (articleinsider.com)
Rheumatology4
- The medical records of patients admitted to the Department and Clinic of Rheumatology who were diagnosed with granulomatosis with polyangiitis between January 1, 2006 and December 31, 2016 were retrospectively studied. (rheumres.org)
- Patients were classified according to the American College of Rheumatology (ACR) 1990 classification criteria for Wegener's granulomatosis. (rheumres.org)
- Patients were classified according to the American College of Rheumatology (ACR) 1990 classification criteria for Wegener's granulomatosis [8] and 2012 Revised International Chapel Hill Consensus Conference Nomenclature [1]. (rheumres.org)
- Efficacy of Rituximab for Otolaryngologic (ENT) Manifestations of Granulomatosis with Polyangiitis (GPA, Wegener's granulomatosis), American College of Rheumatology Annual Scientific Meeting, San Diego, CA, Oct 25-30, 2013. (hss.edu)
Clinical4
- This study examined the demographic, clinical, radiographic and laboratory characteristics of patients with granulomatosis with polyangiitis (GPA) in Imam Reza Hospital, Mahshad, Iran. (rheumres.org)
- Granulomatosis with polyangiitis (Wegener): clinical aspects and treatment. (medscape.com)
- Clinical features of childhood granulomatosis with polyangiitis (Wegener's granulomatosis). (printo.it)
- Szpirt WM, Heaf JG, Petersen J. Plasma exchange for induction and cyclosporine A for maintenance of remission in Wegener's granulomatosis - a clinical randomized controlled trial. (smw.ch)
Symptoms2
- Granulomatosis with polyangiitis is usually suspected only when a person has had unexplained symptoms for a long period of time. (wikipedia.org)
- Wegener's granulomatosis is usually only suspected when a patient has had unexplained symptoms for a long period of time. (checkorphan.org)
Disease6
- Wegener's Granulomatosis and Granulomatosis with Polyangiitis are essentially the same disease, with the latter being the more modern name for the condition. (articleinsider.com)
- Granulomatosis with polyangiitis (GPA), previously known as Wegener's granulomatosis, is a rare disease. (medlineplus.gov)
- To assess the correlation and prognostic value of antineutrophil cytoplasmic antibody (cANCA) titers with disease activity in patients with Wegener's granulomatosis (WG). (nih.gov)
- Introduction Granulomatosis is a medical term for a disease where granulomas - or clusters of certain cell types - are formed. (bmj.com)
- OBJECTIVE: To identify serum ion patterns that distinguish remission from active disease in patients with Wegener's granulomatosis (WG). (duke.edu)
- Walker s health odyssey began in 1995, when he was diagnosed with Wegener s Granulomatosis, an uncommon disease that is even more rare among African Americans. (handsonhealth-sc.org)
Rituximab1
- Objective This study was conducted to evaluate the efficacy and safety of repeated and prolonged B cell depletion with rituximab (RTX) for the maintenance of long-term remission in patients with chronic relapsing granulomatosis with polyangiitis (Wegener's) (GPA). (elsevierpure.com)
Patients4
- Although the structure of the granulomas and multinucleated giant cells in granulomatosis with polyangiitis (GPA) is known, little is established about what drove granuloma formation and why it is infrequently found in patients with myeloperoxidase-antineutrophil cytoplasm antibodies. (bmj.com)
- Wegener's granulomatosis: studies in eighteen patients and a review of the literature. (smw.ch)
- Wegener granulomatosis: an analysis of 158 patients. (smw.ch)
- Anticytoplasmic antibodies (ACPA) against myelomonocytic cells were demonstrable in 54 of 72 patients with Wegener's granulomatosis (WG). (uni-luebeck.de)
Remission Induction1
- The standard treatment for Wegener's granulomatosis is cyclophosphamide and high dose corticosteroids for remission induction and less toxic immunosuppressants like azathioprine, leflunomide, methotrexate or mycophenolate mofetil. (checkorphan.org)
Antineutrophil cytoplasmic1
- Wegener's granulomatosis is part of a larger group of vasculitic syndromes, all of which feature the presence of an abnormal type of circulating antibody termed ANCAs (antineutrophil cytoplasmic antibodies) and affect small and medium-size blood vessels. (checkorphan.org)
Manifestations1
- Common and uncommon manifestations of Wegener granulomatosis at chest CT: radiologic-pathologic correlation. (medscape.com)
Cyclophosphamide1
- Novack SN, Pearson CM. Cyclophosphamide therapy in Wegener's granulomatosis. (smw.ch)
Vasculitides1
- Although Wegener's granulomatosis affects small and medium-sized vessels, it is formally classified as one of the small vessel vasculitides in the Chapel Hill system. (checkorphan.org)
Granulomas1
- These granulomas are the main reason for the appellation of "Wegener's granulomatosis," although it is not an essential feature. (checkorphan.org)
Trials1
- A systematic review of 84 trials examined the evidence for various treatments in Wegener's granulomatosis. (checkorphan.org)
Cases2
- Sinonasal Wegener granulomatosis: a single-institution experience with 120 cases. (medscape.com)
- [ 1 ] A retrospective review of 34 cases of DAH revealed nearly one-third of the cases were caused by Wegener granulomatosis. (medscape.com)
Microscopic polyangiitis21
- Patients must be considered as being best characterized as GPA and not microscopic polyangiitis (MPA) or eosinophilic granulomatosis with polyangiitis (EGPA) and must have met at least 2 of the 5 modified ACR classification criteria for GPA. (nih.gov)
- Wegener's granulomatosis (WG) and microscopic polyangiitis (MPA) are systemic small vessel vasculitides associated with ANCA (AAV). (nih.gov)
- ANCA-associated vasculitides (Wegener's granulomatosis, Churg-Strauss syndrome, microscopic polyangiitis). (uni-luebeck.de)
- The ANCA-associated vasculitides (Wegener's granulomatosis, Churg-Strauss syndrome, microscopic polyangiitis) are characterized by a broad spectrum of clinical manifestations and a highly variable clinical course. (uni-luebeck.de)
- Dive into the research topics of 'ANCA-associated vasculitides (Wegener's granulomatosis, Churg-Strauss syndrome, microscopic polyangiitis). (uni-luebeck.de)
- 2. Antineutrophil cytoplasmic autoantibody in the absence of Wegener's granulomatosis or microscopic polyangiitis: implications for the surgical pathologist. (nih.gov)
- 3. IgG subclass distribution, affinity of anti-myeloperoxidase antibodies in sera from patients with Wegener's granulomatosis and microscopic polyangiitis. (nih.gov)
- 7. The epidemiology of Wegener's granulomatosis and microscopic polyangiitis in a Southern Hemisphere region. (nih.gov)
- 9. [Wegener granulomatosis and microscopic polyangiitis. (nih.gov)
- The current trial included participants with severe granulomatosis with polyangiitis, formerly known as Wegener's granulomatosis, and microscopic polyangiitis. (nih.gov)
- Based on these results, the Food and Drug Administration in April 2011 approved rituximab in combination with steroids for the treatment of granulomatosis with polyangiitis and microscopic polyangiitis. (nih.gov)
- Microscopic polyangiitis: Advances in diagnostic and therapeutic approaches. (medscape.com)
- Nine centers enrolled 197 ANCA-positive patients with either Wegener's granulomatosis or microscopic polyangiitis. (nih.gov)
- previously known as Churg-Strauss syndrome), and microscopic polyangiitis (MPA). (pvillage.org)
- Anti- PR-3 autoantibodies have been associated with Wegener granulomatosis but less often with microscopic polyangiitis. (rapidtest.com)
- Mahr A, Guillevin L, Poissonnet M, Aymé S. Prevalences of polyarteritis nodosa, microscopic polyangiitis, Wegener's granulomatosis, and Churg-Strauss syndrome in a French urban multiethnic population in 2000: a capture-recapture estimate. (medscape.com)
- In addition to WM, a rare and incurable type of non-Hodgkin's lymphoma (NHL), Rituxan is approved for indications in chronic lymphocytic leukemia (CLL), rheumatoid arthritis, Granulomatosis with Polyangiitis (GPA or Wegener's Granulomatosis) and Microscopic Polyangiitis, and Pemphigus Vulgaris. (genengnews.com)
- Cyclophosphamide as induction therapy for Wegener's granulomatosis and microscopic polyangiitis. (ama-assn.org)
- Serological testing for anti-neutrophil cytoplasmic antibodies (ANCA) has become an important tool for supporting a diagnosis of systemic necrotizing small vessel vasculitis: Wegener's granulomatosis, microscopic polyangiitis, Churg-Strauss syndrome and oligo-symptomatic forms of these. (go.jp)
- The study is open to adults diagnosed with certain types of vasculitis, called Granulomatosis Polyangiitis (GPA), Microscopic Polyangiitis (MPA) or Eosinophilic Granulomatosis with Polyangiitis (EGPA). (cardiff.ac.uk)
- Lung disease is a very common and important feature of the antineutrophil cytoplasmic antibodies (ANCA)-associated SV (AASV), such as Wegener`s granulomatosis (WG), Churg-Strauss syndrome (CSS), and microscopic polyangiitis (MPA). (clinexprheumatol.org)
Eosinophilic4
- Eosinophilic granulomatosis with polyangiitis (formerly known as Churg-Strauss syndrome). (upmc.com)
- The differential diagnosis also includes rare vascular etiologies such as lupus pneumonitis, eosinophilic granulomatosis with polyangiitis, idiopathic pulmonary hemosiderosis, IgA nephropathy, hypersensitivity pneumonitis, pulmonary artery rupture, and diffuse alveolar hemorrhage. (appliedradiology.com)
- Eosinophilic granulomatosis with polyangiitis (Churg-Strauss): evolutions in classification, etiopathogenesis, assessment and management. (medscape.com)
- Churg-Strauss syndrome (eosinophilic granulomatosis with polyangiitis ) (single case reports). (altmeyers.org)
Wegener's Granulomatosis22
- Wegener's granulomatosis: prospective clinical and therapeutic experience with 85 patients for 21 years. (medscape.com)
- Elevated relapse rate under oral methotrexate versus leflunomide for maintenance of remission in Wegener's granulomatosis. (medscape.com)
- Granulomatosis with polyangiitis (Wegener's): an alternative name for Wegener's granulomatosis. (medscape.com)
- The American College of Rheumatology 1990 criteria for the classification of Wegener's granulomatosis. (medscape.com)
- Granulomatosis with polyangiitis (GPA) - formerly known as Wegener's granulomatosis - is a rare form of vasculitis. (patient.info)
- Granulomatosis with polyangiitis (GPA), previously known as Wegener's granulomatosis, is a rare disease. (medlineplus.gov)
- Granulomatosis with polyangiitis (GPA), previously known as Wegener's granulomatosis (WG), after the Nazi German physician Friedrich Wegener, is a rare long-term systemic disorder that involves the formation of granulomas and inflammation of blood vessels (vasculitis). (wikipedia.org)
- Background Granulomatosis with polyangiitis (GPA) formerly known as Wegener's granulomatosis (WG) belongs to the group of ANCA-associated necrotizing vasculitides. (researchensemble.com)
- Keywords: Wegener's granulomatosis Granulomatosis with polyangiitis Clinical research Clinical picture of disease Evaluation with books Background Granulomatosis with polyangiitis (GPA) previously referred to as Wegener's granulomatosis (WG) [1] is normally a necrotizing vasculitis impacting predominantly little vessels. (researchensemble.com)
- Granulomatosis with polyangiitis (GPA), previously known as Wegener's granulomatosis, is a rare and life-threatening disorder that restricts the blood flow to several organs, including the lungs, kidneys, and upper respiratory tract. (medicalnewstoday.com)
- CHCC2012 also agreed to rename Wegener's granulomatosis as granulomatosis with polyangiitis (GPA). (medicalnewstoday.com)
- 10. Cutaneous manifestations of Wegener's granulomatosis: a clinicopathologic study of 17 patients and correlation to antineutrophil cytoplasmic antibody status. (nih.gov)
- 19. Wegener's granulomatosis associated with renal cell carcinoma. (nih.gov)
- 20. Renal histology in Chinese patients with anti-myeloperoxidase autoantibody-positive Wegener's granulomatosis. (nih.gov)
- Herein we describe a well-substantiated case of cyclophosphamide-induced hepatotoxicity in a patient with Wegener's granulomatosis. (nih.gov)
- Cyclophosphamide-induced hepatitis in Wegener's granulomatosis. (nih.gov)
- Diffuse histiocytic lymphoma in a patient treated with cyclophosphamide for Wegener's granulomatosis. (nih.gov)
- For example, Wegener's granulomatosis is now more commonly termed, granulomatosis with polyangiitis, which is more pathophysiologically relevant [1]. (medscimonit.com)
- He developed effective therapies for formerly fatal inflammatory and immune-mediated diseases such as polyarteritis nodosa, granulomatosis with polyangiitis (formerly Wegener's granulomatosis), and lymphomatoid granulomatosis. (nih.gov)
- Wegener's granulomatosis may be fatal without prompt medical treatment. (bookriff.com)
- Effect of cyclophosphamide upon the immune response in Wegener's granulomatosis. (ama-assn.org)
- Wegener's Granulomatosis A rare, autoimmune, systemic medium and small size vasculitis. (nih.gov)
ANCA5
- Can you still be diagnosed with Granulomatosis with polyangiitis (GPA, formerly Wegener's) if the ANCA is negative? (vasculitisfoundation.org)
- Although ANCA is elevated in a majority of patients with granulomatosis with polyangiitis (GPA, formerly called Wegener's), it is not detectable in all patients and is not necessary to make the diagnosis. (vasculitisfoundation.org)
- Your ticket for the: Can you still be diagnosed with Granulomatosis with polyangiitis (GPA, formerly Wegener's) if the ANCA is negative? (vasculitisfoundation.org)
- The subtype c-ANCA, shows cytoplasm staining by IFA and is diagnostic for Wegener granulomatosis. (rapidtest.com)
- PR3 is the most common antigen target of ANCA in patients with granulomatosis with polyangiitis where c-ANCA is found over 90% of the time. (rapidtest.com)
Rheumatoid1
- Meta-analysis of genetic polymorphisms in granulomatosis with polyangiitis (Wegener's) reveals shared susceptibility loci with rheumatoid arthritis. (cdc.gov)
Vessel1
- Granulomatosis with polyangiitis is characterized by necrotizing granulomatous inflammation, small- and medium-sized vessel vasculitis, and focal necrotizing glomerulonephritis, often with crescent formation. (msdmanuals.com)
Granulomatous1
- Granulomatosis with polyangiitis (Wegener's) (GPA) is a systemic inflammatory disease that is characterized by necrotizing, granulomatous inflammation and vasculitis of the small to medium-sized vessels. (nih.gov)
Diseases1
- When patients present with a limited form of granulomatosis with polyangiitis (GPA) that includes upper airway disease, orbital disease, or pulmonary disease, the differential diagnosis may include infectious and neoplastic diseases and other forms of vasculitis. (medscape.com)
Chronic1
- It significantly impacts my condition, vasculitis (granulomatosis with polyangiitis/Wegener's and chronic periaortitis). (themighty.com)
Pulmonary1
- Granulomatosis with polyangiitis, while more commonly identified in adults, should be suspected in children presenting with hemoptysis, hematuria, and chest imaging showing cavitary pulmonary nodules, ground-glass opacity, and consolidation. (appliedradiology.com)
Formerly called1
- Granulomatosis with polyangiitis (GPA, formerly called Wegener's) is a rare disease of uncertain cause. (bookriff.com)
Signs1
- The signs found in granulomatosis with polyangiitis occur as a result of the inflammation of the small vessels and may affect any part of the body. (patient.info)
Rare1
- Granulomatosis with polyangiitis is a rare type of vasculitis. (bookriff.com)