LeukopeniaNeutropeniaAssociation between clozapine-induced agranulocytosisNeutrophilsGranulocytesBoneClozapinePatientsGranulocyteInfectionsAcuteBloodFeverChronicExposureAbsolute neutrRiskTreatmentReviewDrugsNeutropeniaThrombocytopeniaClozapine-Induced AgranulocytosisCause agranulocytosisMethimazole-induced agranulocytosisInterstitialAntithyroidJaundiceSevereRetrospectivePropylthiouracilPatientsOccurSignificantlyWhiteStudiesLowerIndividuals
Leukopenia5
- We assessed adverse event reports for agranulocytosis, granulocytopenia, leukopenia, and neutropenia from the FDA Adverse Event Reporting System (FAERS) for a 1-year time period before (October 2014 to September 2015, pre-REMS) and after (October 2015 to September 2016, post-REMS) the implementation of the clozapine REMS program. (allenpress.com)
- 1 Although the label specifically mentions neutropenia, there are 3 additional hematologic abnormalities that are clinically similar but have different defining parameters: agranulocytosis, granulocytopenia, and leukopenia. (allenpress.com)
- 6. The method of claim 1 wherein the myelosuppression is anemia, granulocytopenia, thrombocytopenia, leukopenia, agranulocytosis or neutropenia. (patentsencyclopedia.com)
- it's also of a therapeutic effect on the leukopenia state, granulocytopenia and agranulocytosis caused due to various reasons, megakaryocytic system changes caused due to various reasons, such as idiopathic thrombocytopenic purpura, etc., as well as marrow fibrosis and bone marrow infection caused due to various reasons. (plant-extracts.com)
- Leukopenia, which develops acutely, is often caused by drugs with the development of agranulocytosis, acute infections or acute leukemia. (arrhythmia.center)
Neutropenia7
- Neutropenia is sometimes called agranulocytosis or granulocytopenia because neutrophils make up about 60% of white blood cells and have granules inside their cell walls. (wordinfo.info)
- Neutropenia is sometimes called agranulocytosis or granulocytopenia because neutrophils make up about 60% of WBCs and have granules inside their cell walls. (the-medical-dictionary.com)
- However, the term granulocytopenia is often used synonymously with neutropenia and, in that sense, is again confined to the neutrophil lineage alone. (medscape.com)
- Granulocytopenia causes a concurrent decrease in the number of neutrophils in the circulating blood (neutropenia). (orthopedicshealth.com)
- A variety of drugs can cause acquired agranulocytosis and neutropenia by destroying special cells in the bone marrow that later mature and become granulocytes (precursors). (orthopedicshealth.com)
- Therefore, the terms granulocytopenia and neutropenia are often interchangeable. (arrhythmia.center)
- Agranulocytosis, the complete absence of granulocytes, belongs to a specific subgroup of neutropenia, which has a unique differential diagnosis. (arrhythmia.center)
Association between clozapine-induced agranulocytosis1
- 14 Amar A, Segman R H, Shtrussberg S, Sherman L, Safirman C, Lerer B, Brautbar C. An association between clozapine-induced agranulocytosis in schizophrenics and HLA-DQB1*0201. (thieme-connect.de)
Neutrophils2
- Vulnerability to infection is extremely high in patients with agranulocytosis, which is the virtual absence of neutrophils in peripheral blood, with ANC typically lower than 100/μL. (medscape.com)
- Granulocytopenia is a generic term that refers to all granulocytes, including neutrophils, monocytes, eosinophils, and basophils. (arrhythmia.center)
Granulocytes2
- When the body has too few granulocytes, the condition is called agranulocytosis. (medlineplus.gov)
- Acquired agranulocytosis is a rare, drug-induced blood disorder that is characterized by a severe reduction in the number of white blood cells (granulocytes) in the circulating blood. (orthopedicshealth.com)
Bone1
- Any chemical or drug that depresses the activity of the bone marrow may cause agranulocytosis. (orthopedicshealth.com)
Clozapine6
- 6 Gerson S L. G-CSF and the management of clozapine-induced agranulocytosis. (thieme-connect.de)
- 13 Claas F H, Abbott P A, Witvliet M D, D'Amaro J, Barnes P M, Krupp P. No direct clinical relevance of the human leucocyte antigen (HLA) system in clozapine-induced agranulocytosis. (thieme-connect.de)
- 16 Guest I, Sokoluk B, MacCrimmon J, Utrecht J. Examination of possible toxic and immune mechanisms of clozapine-induced agranulocytosis. (thieme-connect.de)
- 19 Schuld A, Kraus T, Hinze-Selch D, Haack M, Pollmächer T. Granulocyte colony-stimulating factor plasma levels during clozapine- and olanzapine-induced granulocytopenia. (thieme-connect.de)
- After the introduction of clozapine eight Finnish patients died after developing agranulocytosis. (bvsalud.org)
- 4) National registries which control the haematologic monitoring are unnecessary and do not help to reduce clozapine-induced agranulocytosis. (bvsalud.org)
Patients4
- Granulocytopenia, which can be seen in patients with Graves' disease during treatment with antithyroid agents, could be a self resolving transient episode or can imply the beginning of life threatening agranulocytosis requiring a change in treatment modality. (e-enm.org)
- As neutrophil levels decrease, the susceptibility of patients with acquired agranulocytosis to bacterial infections becomes even greater. (orthopedicshealth.com)
- A rare case of Interferon-alpha-Induced Hyper thy roidism in patients with a chronic hepatitis C with granulocytopenia and transaminasemia treated successfully with radioiodine. (nel.edu)
- The fear of agranulocytosis and the need for intensive blood monitoring is the single most important barrier for prescribers and patients alike and leads to underprescription of the only effective and approved medication for treatment-resistant schizophrenia. (bvsalud.org)
Granulocyte2
- Diagnosis of transient granulocytopenia was made by a normal granulocyte count following a single injection of G-SCF, and the patient was treated with conservative therapy. (e-enm.org)
- Other drugs that interfere with, or inhibit, granulocyte colony formation may induce agranulocytosis. (orthopedicshealth.com)
Infections1
- People with acquired agranulocytosis are susceptible to a variety of bacterial infections, usually caused by otherwise benign bacteria found in the body. (orthopedicshealth.com)
Acute1
- In rare cases of acute acquired agranulocytosis, destructive action of certain white blood cell antibodies (leukocyte isoantibodies) may be induced by certain drugs such as phenylbutazone, gold salts, sulfapyridine, aminopyrine, meralluride, and dipyrine. (orthopedicshealth.com)
Blood3
- If you are having treatment or taking medicine that could cause agranulocytosis, your health care provider will use blood tests to monitor you. (medlineplus.gov)
- Symptoms that are associated with rapidly falling white blood cell levels (granulocytopenia) may include the development of infected ulcers in the mucous membranes that line the mouth, throat, and/or intestinal tract. (orthopedicshealth.com)
- We summarize evidence that the risk of agranulocytosis is smaller than perceived at the time of reintroduction, is concentrated in the first 18 weeks of treatment, is not greater than with other antipsychotics thereafter and that frequent blood monitoring has not demonstrably decreased the rate of agranulocytosis. (bvsalud.org)
Fever1
- The first symptoms of acquired agranulocytosis are usually those associated with a bacterial infection such as general weakness, chills, fever, and/or extreme exhaustion. (orthopedicshealth.com)
Chronic1
- Chronic acquired agranulocytosis generally progresses more slowly than acquired agranulocytosis. (orthopedicshealth.com)
Exposure1
- Acquired agranulocytosis is almost invariably caused by exposure to drugs and/or chemicals. (orthopedicshealth.com)
Absolute neutr1
- Agranulocytosis is defined as having an absolute neutrophil count (ANC) below 500/μL. (allenpress.com)
Risk1
- 5 Alvir J MJ, Lieberman J A. Agranulocytosis: Incidence and risk factors. (thieme-connect.de)
Treatment4
- A Case of Transient Granulocytopenia during Treatment of a Patient with Graves' Disease and Type 1 Diabetes Mellitus - Differential Diagnosis from Agranulocytosis by a Single Injection of G-CSF. (e-enm.org)
- We introduce a case of transient granulocytopenia, which was detected in a patient with Graves'Disease, accompanied by underlying type 1 diabetes mellitus, during treatment with PTU. (e-enm.org)
- and it has become a standard treatment for acquired agranulocytosis. (orthopedicshealth.com)
- The treatment of acquired agranulocytosis includes the identification and elimination of drugs or other agents that induce this disorder. (orthopedicshealth.com)
Review1
- 2 Krupp P, Barnes P. Leponex-associated granulocytopenia: a review of the situation. (thieme-connect.de)
Drugs2
- Transient granulocytopenia could be a manifestation of hyperthyroidism itself, or a mild side effect of antithyroid drugs. (e-enm.org)
- Acquired agranulocytosis may be caused by a variety of drugs. (orthopedicshealth.com)
Neutropenia6
- Do individuals develop neutropenia or agranulocytosis after lithium is discontinued? (psychiatrist.com)
- We conducted a PubMed search through December 10, 2017, using the MESH terms "clozapine" AND "lithium" AND "neutropenia" OR "agranulocytosis. (psychiatrist.com)
- Twenty-seven 5-7 , 10-33 articles described reports of lithium augmentation in clozapine rechallenge after neutropenia or agranulocytosis ( Supplementary Table 1 ), totaling 94 individual patients. (psychiatrist.com)
- Similar to Manu et al, 6 we found that lithium augmentation to clozapine can be a successful strategy after neutropenia or agranulocytosis. (psychiatrist.com)
- The use of lithium in patients taking clozapine has raised a number of concerns, including lithium potentially masking impending neutropenia or agranulocytosis. (psychiatrist.com)
- anemia , aplastic anemia, agranulocytosis , neutropenia , leukopenia (including granulocytopenia), pancytopenia, thrombocytopenia, and eosinophilia , due to an allergic reaction. (scopeheal.com)
Thrombocytopenia1
- Major adverse reactions (which occur with much less frequency than the minor adverse reactions) include inhibition of myelopoiesis (agranulocytosis, granulocytopenia, thrombocytopenia, and aplastic anemia), drug fever, lupus-like syndrome, insulin autoimmune syndrome (which can result in hypoglycemic coma), hepatitis (jaundice may persist for several weeks after discontinuation of the drug), periarteritis, and hypoprothrombinemia. (drugcentral.org)
Clozapine-Induced Agranulocytosis2
- Clozapine is a particularly effective antipsychotic medication but its use is curtailed by the risk of clozapine-induced agranulocytosis/granulocytopenia (CIAG), a severe adverse drug reaction occurring in up to 1% of treated individuals. (liverpool.ac.uk)
- Further evidence of human leukocyte antigen-encoded susceptibility to clozapine-induced agranulocytosis independent of ancestry. (cdc.gov)
Cause agranulocytosis2
- If you are having treatment or taking medicine that could cause agranulocytosis, your health care provider will use blood tests to monitor you. (medlineplus.gov)
- Particular care should be exercised with patients who are receiving additional drugs known to cause agranulocytosis. (drugcentral.org)
Methimazole-induced agranulocytosis1
- The human leukocyte antigen class II genes containing the DRB1*08032 allele were found to be associated with methimazole-induced agranulocytosis. (medscape.com)
Interstitial1
- Pembrolizumab-induced agranulocytosis in a pulmonary pleomorphic carcinoma patient who developed interstitial lung disease and ocular myasthenia gravis. (annals.org)
Antithyroid4
- What Risk Factors Are Associated With Antithyroid Drug-Induced Agranulocytosis? (medscape.com)
- [ 9 ] Patients who display signs or symptoms of agranulocytosis should discontinue the antithyroid agent and seek immediate medical attention. (medscape.com)
- 19. [Retrospective analysis of 18 cases with agranulocytosis induced by antithyroid drugs]. (nih.gov)
- Association of HLA-B and HLA-DRB1 polymorphisms with antithyroid drug-induced agranulocytosis in a Han population from northern China. (cdc.gov)
Jaundice1
- Two of the most serious complications reported from its use are jaundice and agranulocytosis. (annals.org)
Severe1
- Have had blood problems called agranulocytosis or severe granulocytopenia after taking Clozapine. (chestervetclinic.com)
Retrospective3
- [ 3 ] A retrospective study found an incidence of agranulocytosis of 0.35% and 0.37% with methimazole and PTU, respectively. (medscape.com)
- In a retrospective review of 21,800 patients receiving ATDs (duration, 15.7 ± 8.4 months), Bahrami [ 7 ] found that the majority of agranulocytosis occurred within the first few weeks of ATD therapy. (medscape.com)
- One small retrospective review found that 100% of patients with ATD-induced agranulocytosis reported fever and 89% reported a sore throat. (medscape.com)
Propylthiouracil2
- What risk factors are associated with agranulocytosis in patients receiving propylthiouracil or methimazole ? (medscape.com)
- Granulocytopenia and hemolytic anemia as complications of propylthiouracil therapy. (nih.gov)
Patients4
- Tsuboi and colleagues [ 5 ] determined that patients receiving an initial methimazole dose of 30 mg had a significantly higher incidence of agranulocytosis compared with those who received an initial dose of 15 mg. (medscape.com)
- 40 mg daily had over 8 times higher risk for agranulocytosis than patients receiving lower doses. (medscape.com)
- Patients receiving PTU or methimazole should be educated about the signs and symptoms of agranulocytosis. (medscape.com)
- A rare case of Interferon-alpha-Induced Hyperthyroidism in patients with a chronic hepatitis C with granulocytopenia and transaminasemia treated successfully with radioiodine. (nel.edu)
Occur1
- [ 3 ] Agranulocytosis usually occurs within 90 days of treatment initiation but can occur a year or more later. (medscape.com)
Significantly1
- Factors associated significantly and independently with agranulocytosis were female sex, older age, and use of other drugs in addition to clozapine. (bvsalud.org)
White1
- In such cases, white-blood-cell and differential counts should be obtained to determine whether agranulocytosis has developed. (drugcentral.org)
Studies3
- Some studies have found a relationship between ATD-induced agranulocytosis and dose. (medscape.com)
- [ 8 ] Other studies did not find an association between ATD-induced agranulocytosis and patient age. (medscape.com)
- Clozapine Pharmacogenetic Studies in Schizophrenia: Efficacy and Agranulocytosis. (cdc.gov)
Lower1
- With monitoring by international standards, recent risks of clozapine-associated agranulocytosis in Argentina were lower, but fatality rates were higher than that in other regions of the world. (bvsalud.org)
Individuals1
- fatalities related to agranulocytosis averaged 4.2 (95% CI 0.0-9.2) per 100 000 treated individuals/year. (bvsalud.org)