• 14 Amar A, Segman R H, Shtrussberg S, Sherman L, Safirman C, Lerer B, Brautbar C. An association between clozapine-induced agranulocytosis in schizophrenics and HLA-DQB1*0201. (thieme-connect.de)
  • Vulnerability to infection is extremely high in patients with agranulocytosis, which is the virtual absence of neutrophils in peripheral blood, with ANC typically lower than 100/μL. (medscape.com)
  • Granulocytopenia is a generic term that refers to all granulocytes, including neutrophils, monocytes, eosinophils, and basophils. (arrhythmia.center)
  • Granulocytopenia, which can be seen in patients with Graves' disease during treatment with antithyroid agents, could be a self resolving transient episode or can imply the beginning of life threatening agranulocytosis requiring a change in treatment modality. (e-enm.org)
  • As neutrophil levels decrease, the susceptibility of patients with acquired agranulocytosis to bacterial infections becomes even greater. (orthopedicshealth.com)
  • A rare case of Interferon-alpha-Induced Hyper thy roidism in patients with a chronic hepatitis C with granulocytopenia and transaminasemia treated successfully with radioiodine. (nel.edu)
  • The fear of agranulocytosis and the need for intensive blood monitoring is the single most important barrier for prescribers and patients alike and leads to underprescription of the only effective and approved medication for treatment-resistant schizophrenia. (bvsalud.org)
  • Diagnosis of transient granulocytopenia was made by a normal granulocyte count following a single injection of G-SCF, and the patient was treated with conservative therapy. (e-enm.org)
  • Other drugs that interfere with, or inhibit, granulocyte colony formation may induce agranulocytosis. (orthopedicshealth.com)
  • In rare cases of acute acquired agranulocytosis, destructive action of certain white blood cell antibodies (leukocyte isoantibodies) may be induced by certain drugs such as phenylbutazone, gold salts, sulfapyridine, aminopyrine, meralluride, and dipyrine. (orthopedicshealth.com)
  • If you are having treatment or taking medicine that could cause agranulocytosis, your health care provider will use blood tests to monitor you. (medlineplus.gov)
  • Symptoms that are associated with rapidly falling white blood cell levels (granulocytopenia) may include the development of infected ulcers in the mucous membranes that line the mouth, throat, and/or intestinal tract. (orthopedicshealth.com)
  • We summarize evidence that the risk of agranulocytosis is smaller than perceived at the time of reintroduction, is concentrated in the first 18 weeks of treatment, is not greater than with other antipsychotics thereafter and that frequent blood monitoring has not demonstrably decreased the rate of agranulocytosis. (bvsalud.org)
  • The first symptoms of acquired agranulocytosis are usually those associated with a bacterial infection such as general weakness, chills, fever, and/or extreme exhaustion. (orthopedicshealth.com)
  • Agranulocytosis is defined as having an absolute neutrophil count (ANC) below 500/μL. (allenpress.com)
  • 5 Alvir J MJ, Lieberman J A. Agranulocytosis: Incidence and risk factors. (thieme-connect.de)
  • A Case of Transient Granulocytopenia during Treatment of a Patient with Graves' Disease and Type 1 Diabetes Mellitus - Differential Diagnosis from Agranulocytosis by a Single Injection of G-CSF. (e-enm.org)
  • We introduce a case of transient granulocytopenia, which was detected in a patient with Graves'Disease, accompanied by underlying type 1 diabetes mellitus, during treatment with PTU. (e-enm.org)
  • and it has become a standard treatment for acquired agranulocytosis. (orthopedicshealth.com)
  • The treatment of acquired agranulocytosis includes the identification and elimination of drugs or other agents that induce this disorder. (orthopedicshealth.com)
  • 2 Krupp P, Barnes P. Leponex-associated granulocytopenia: a review of the situation. (thieme-connect.de)
  • Major adverse reactions (which occur with much less frequency than the minor adverse reactions) include inhibition of myelopoiesis (agranulocytosis, granulocytopenia, thrombocytopenia, and aplastic anemia), drug fever, lupus-like syndrome, insulin autoimmune syndrome (which can result in hypoglycemic coma), hepatitis (jaundice may persist for several weeks after discontinuation of the drug), periarteritis, and hypoprothrombinemia. (drugcentral.org)
  • Clozapine is a particularly effective antipsychotic medication but its use is curtailed by the risk of clozapine-induced agranulocytosis/granulocytopenia (CIAG), a severe adverse drug reaction occurring in up to 1% of treated individuals. (liverpool.ac.uk)
  • Further evidence of human leukocyte antigen-encoded susceptibility to clozapine-induced agranulocytosis independent of ancestry. (cdc.gov)
  • The human leukocyte antigen class II genes containing the DRB1*08032 allele were found to be associated with methimazole-induced agranulocytosis. (medscape.com)
  • Pembrolizumab-induced agranulocytosis in a pulmonary pleomorphic carcinoma patient who developed interstitial lung disease and ocular myasthenia gravis. (annals.org)
  • What Risk Factors Are Associated With Antithyroid Drug-Induced Agranulocytosis? (medscape.com)
  • [ 9 ] Patients who display signs or symptoms of agranulocytosis should discontinue the antithyroid agent and seek immediate medical attention. (medscape.com)
  • 19. [Retrospective analysis of 18 cases with agranulocytosis induced by antithyroid drugs]. (nih.gov)
  • Association of HLA-B and HLA-DRB1 polymorphisms with antithyroid drug-induced agranulocytosis in a Han population from northern China. (cdc.gov)
  • [ 3 ] A retrospective study found an incidence of agranulocytosis of 0.35% and 0.37% with methimazole and PTU, respectively. (medscape.com)
  • In a retrospective review of 21,800 patients receiving ATDs (duration, 15.7 ± 8.4 months), Bahrami [ 7 ] found that the majority of agranulocytosis occurred within the first few weeks of ATD therapy. (medscape.com)
  • One small retrospective review found that 100% of patients with ATD-induced agranulocytosis reported fever and 89% reported a sore throat. (medscape.com)
  • Tsuboi and colleagues [ 5 ] determined that patients receiving an initial methimazole dose of 30 mg had a significantly higher incidence of agranulocytosis compared with those who received an initial dose of 15 mg. (medscape.com)
  • 40 mg daily had over 8 times higher risk for agranulocytosis than patients receiving lower doses. (medscape.com)
  • Patients receiving PTU or methimazole should be educated about the signs and symptoms of agranulocytosis. (medscape.com)
  • A rare case of Interferon-alpha-Induced Hyperthyroidism in patients with a chronic hepatitis C with granulocytopenia and transaminasemia treated successfully with radioiodine. (nel.edu)
  • With monitoring by international standards, recent risks of clozapine-associated agranulocytosis in Argentina were lower, but fatality rates were higher than that in other regions of the world. (bvsalud.org)