Granulocyte macrophage precursor cell granulocyte precursor cells. Medical search. Frequent questions

adipocytes (fat cells) osteoblasts (synthesize bone) osteoclasts (resorb bone) endothelial cells, which form the sinusoids. (wikipedia.org)
These derive from endothelial stem cells, which are also present in the bone marrow. (wikipedia.org)
Toll-like receptor 4 activation in microvascular endothelial cells triggers a robust inflammatory response and cross talk with mononuclear cells via interleukin-6. (musc.edu)
Granulocyte/macrophage - Colony-stimulating factor (GM-CSF) is a hematopoietic factor that is produced by activated T-cells, B-cells, mast cells, macrophages, fibroblasts, and endothelial cells. (neobiotechnologies.com)
primarily produced by monocytes, fibroblasts and endothelial cells, and by T cells, B cells, keratinocytes and mesangial cells. (imreference.com)
Interleukin-17 induces the secretion of G-CSF in epithelial, endothelial, and fibroblastic cells. (sydlabs.com)
Human endothelial progenitor cells (hEPCs) are adult stem cells, located in the bone marrow and peripheral blood. (intechopen.com)
These cells can be differentiated into mature endothelial cells, which are involved in processes of angiogenesis and vessel regeneration. (intechopen.com)
Different phenotypes and subtypes of endothelial progenitor cells (EPCs), such as early and late EPCs, have been described according to their functionality. (intechopen.com)
Thus, it has been shown that early EPCs release cytokines that promote tissue regeneration and neovasculogenesis, whereas late EPC and endothelial colony forming cells (ECFCs) contribute to the formation of blood vessels and stimulate tube formation. (intechopen.com)

CD34(-) LSCs have disordered global transcription profiles, but these profiles are enriched for transcriptional signatures of normal CD34(-) mature granulocyte-macrophage precursors, downstream of progenitors. (ox.ac.uk)
Although similar methods have detected committed pre-B cells in mouse fetal liver, earlier progenitors with additional non-B lineage options have not been demonstrated in normal tissues. (pasteur.fr)
In addition to supporting colony formation of granulocyte/macrophage progenitors, GM-CSF is a growth factor for erythroid, megakaryocyte, and eosinophil progenitors. (neobiotechnologies.com)
Granulocyte-macrophage colony forming units were the most heat resistant bone marrow progenitors tested. (elsevierpure.com)
Mivechi, NF & Li, GC 1986, ' Lack of Development of Thermotolerance in Early Progenitors of Murine Bone Marrow Cells ', Cancer Research , vol. 46, no. 1, pp. 198-202. (elsevierpure.com)
Using an expansion system previously shown to increase hematopoietic progenitors and SCID-repopulating cells (SRCs), we demonstrated that the rhodamine-low phenotype was lost, whereas AC133 expression was retained throughout culture. (bvsalud.org)

Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. (neobiotechnologies.com)
Among these, Siglec-8 is a CD33-related family member selectively expressed on human mast cells and eosinophils, and at low levels on basophils. (mdpi.com)
Since its discovery in 2000, initial in vitro studies have found that the engagement of Siglec-8 with a monoclonal antibody or with selective polyvalent sialoglycan ligands induced the cell death of eosinophils and inhibited mast cell degranulation. (mdpi.com)
Anti-Siglec-8 antibody administration in vivo to humanized and transgenic mice selectively expressing Siglec-8 on mouse eosinophils and mast cells confirmed the in vitro findings, and identified additional anti-inflammatory effects. (mdpi.com)
Cells within the hematopoietic islets in the bone marrow contain red blood cells, granulocytes ( neutrophils , eosinophils , basophils ), monocytes and macrophages , lymphocytes , platelets , and their precursors. (wikilectures.eu)
function of proliferative responses provoked in the induction cell products favor immediate type hypersensitivity reactions, phase of contact allergy, the murine local lymph node assay serving as growth and differentiation factors for mast cells and (LLNA), has been accepted as a stand-alone method for skin eosinophils, the cellular effectors of the clinical manifestations of sensitization testing (NIH, 1999). (cdc.gov)

It serves as an in vitro model for MONOCYTE and MACROPHAGE differentiation. (umassmed.edu)
Monocyte-Macrophage Precursor Cells" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ouhsc.edu)
This graph shows the total number of publications written about "Monocyte-Macrophage Precursor Cells" by people in this website by year, and whether "Monocyte-Macrophage Precursor Cells" was a major or minor topic of these publications. (ouhsc.edu)
Below are the most recent publications written about "Monocyte-Macrophage Precursor Cells" by people in Profiles. (ouhsc.edu)
It also reacts with plasmacytoid T cells, which are supposed to be of monocyte/macrophage origin. (enquirebio.com)
The myeloid precursor cell differentiates into megakaryoblast (→ megakaryocyte → thrombocyte), myeloblast (→ promyelocyte → myelocyte → metamyelocyte → rod → segment), monoblast (→ monocyte → macrophage), eosinophiloblast (→ eosinophil), mast cells (mast cells), and basophilic granulocytes. (wikilectures.eu)
HGFs include erythropoietin , thrombopoietin , G-CSF (granulocyte colony-stimulating factor), GM-CSF (granulocyte-monocyte colony-stimulating factor). (wikilectures.eu)
It includes Monocyte, Dendritic cells and Marophage. (imreference.com)

As the disease progresses and converts into leukemia, further gene mutation occurs, and a proliferation of leukemic cells overwhelms the healthy marrow. (medscape.com)
Our results indicate a reduction in vascular placental cells, especially cells responsible for structural integrity, and increase in trophoblast proliferation in animals exposed to particulate matter. (nature.com)
It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. (uchicago.edu)
In: 'Control of Proliferation in Animal Cells', Cold Spring Harbor Laboratory, pp. 393-410, 1974. (uni-mainz.de)
The inhibitory effect of IL-18 was limited to the early phase of the cocultures, which coincides with proliferation of hemopoietic precursors. (ox.ac.uk)
Human Granulocyte-Colony-Stimulating Factor (G-CSF), a 20 kDa glycoprotein containing internal disulfide bonds, induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. (sydlabs.com)
In addition, a local RAS is expressed in many tissues and mainly acts at the cellular level, where it mediates cell proliferation, growth, and metabolism. (nutriforce.cn)

citation needed] The red bone marrow is a key element of the lymphatic system, being one of the primary lymphoid organs that generate lymphocytes from immature hematopoietic progenitor cells. (wikipedia.org)
LYMPHOCYTES (B and T cells) derive continuously from the same multipotential stem cells that produce myeloid cells, including erythrocytes, granulocytes and macrophages. (pasteur.fr)
20. Melchers, F.: Biochemical characterization of immunoglobulin-producing B-lymphocytes at different stages of their differentiation.In: 'Regulation of Growth and Differentiated Function in Eukaryotic Cells,' eds. (uni-mainz.de)
T lymphocytes originate via lymphoid stem cells that migrate to the thymus and differentiate under the influence of the thymic hormones thymopoietin and thymosin. (medscape.com)
The lymphoid precursor cell differentiates into pre-T-lymphocytes (→ T-lymphocytes) and pre-B-lymphocytes (→ B-lymphocytes → plasmocytes). (wikilectures.eu)
Lymphocytes, B and T cells, can respond selectively to thousands of non-self materials. (lu.se)

Cell types that constitute the bone marrow stroma include: fibroblasts (reticular connective tissue) macrophages, which contribute especially to red blood cell production, as they deliver iron for hemoglobin production. (wikipedia.org)
Different signaling mechanisms regulating IL-6 expression by LPS between gingival fibroblasts and mononuclear cells: seeking the common target. (musc.edu)

Benharroch D, Dima E, Levy A, Ohana-Malka O, Ariad S, Prinsloo I, Mejirovsky E, Sacks M, Gopas J: Differential expression of sialyl and non-sialyl-CD15 antigens on Hodgkin-Reed-Sternberg cells: significance in Hodgkin's disease. (exbio.cz)
Researchers have shown immune complexes coating granulocytes, diminished granulocyte growth factor levels, and numerous circulating autoantibodies, including those against granulocyte surface antigens. (medscape.com)
However, it is unclear if these cells express similar surface antigens as expressed by authentic osteoclasts, since they form on plastic surfaces in the absence of bone. (elsevierpure.com)
Similar to bone-derived osteoclasts, MNC formed in long-term human bone marrow culture expressed osteoclast-specific antigens (detected by monoclonal antibodies 13c2 and 23c6) and did not express Fc receptors, T cell specific antigens, most myeloid antigens or mature macrophage antigens. (elsevierpure.com)
B cells The immune system consists of cellular components and molecular components that work together to destroy antigens. (msdmanuals.com)

The lamina propria of the small intestine is the main site of the intestinal immune system, which contains a large number of macrophages, CD4 T cells, and dendritic cells. (frontiersin.org)
In response to inflammatory stimulation, circulating monocytes gives rise of macrophage, dendritic cells and osteoclast. (imreference.com)
OBJECTIVE: The role of plasmacytoid dendritic cells (PDCs) and type I interferons (IFNs) in rheumatoid arthritis (RA) remains a subject of controversy. (cnrs.fr)

Macrophages play a significant role in many processes, such as the human immune function, parasite infection, and tissue remodeling by secreting cytokines and producing reactive oxygen and nitrogen intermediates. (frontiersin.org)
Thrombopoiesis takes place primarily in the bone marrow through a series of cell differentiation and is influenced by several cytokines. (lecturio.com)

it is also present on Langerhans cells and some myeloid precursors cells. (exbio.cz)
It reacts with myeloid precursors and peripheral blood granulocytes. (enquirebio.com)

These fractions consisted of either mononuclear cells (MO-MDSCs), resembling inflammatory monocytes, or low-density polymorphonuclear cells (PMN-MDSCs), akin to immature neutrophils. (ashpublications.org)
most of the neutrophils in the body are contained in the bone marrow, either as mitotically active (one third) or postmitotic mature cells (two thirds). (medscape.com)
A common reference range for the absolute neutrophil count (ANC), which is calculated on the basis of the percentage of neutrophils in the white blood cell count (see the Absolute Neutrophil Count calculator) is 2500-8000/µL. (medscape.com)

At the cellular level, the main functional component of bone marrow includes the progenitor cells which are destined to mature into blood and lymphoid cells. (wikipedia.org)
In human acute myeloid leukemia (AML), current models suggest transformation creates leukemic stem cell (LSC) populations arrested at a progenitor-like stage expressing cell surface CD34. (ox.ac.uk)
This suggests a new refined model of the relationship between LSCs and normal hemopoiesis in which the nature of genetic/epigenetic changes determines the disordered transcriptional program, resulting in LSC differentiation arrest at stages that are most like either progenitor or precursor stages of hemopoiesis. (ox.ac.uk)
Open-Label Phase II Prospective, Randomized, Controlled Study of Romyelocel-L Myeloid Progenitor Cells to Reduce Infection During Induction Chemotherapy for Acute Myeloid Leukemia. (uchicago.edu)
Progenitor cell (stem cell) lines in the bone marrow produce new blood cells and stromal cells. (medscape.com)
Hematopoietic cells differentiate from progenitor cells under the influence of hematopoietic growth factors (HGFs). (wikilectures.eu)
In the peritoneal cavity of GM-CSF-treated mice, the percentages of hematopoietic progenitor cells doubly positive for CD5 and CD34 or c-kit and of macrophage precursor cells doubly positive for CD5 and ER-MP58 or ER-MP20 were increased significantly during the development of CD5+ macrophages and CD5 B cells, suggesting that CD5+ macrophages and B cells may share a bipotential progenitor in vivo. (jax.org)

Parent cells in the lineage that gives rise to MONOCYTES and MACROPHAGES. (ouhsc.edu)
Dielectrophoretic characterization and separation of monocytes and macrophages using 3D carbon-electrodes. (musc.edu)

Flow cytometry: The reagent is designed for analysis of human blood cells using 4 μl reagent / 100 μl of whole blood or 10 6 cells in a suspension. (exbio.cz)
Placental transcriptomes, at day 19 of gestation, were determined using bulk RNA-seq from whole placentas of exposed (n = 4) and control (n = 4) animals and scRNAseq of three distinct placental layers, followed by flow cytometry analysis of the placental immune cell landscape. (nature.com)
In co-cultures of either the murine pre-B cell line J13, fetal liver cells, or adult peritoneal or bone marrow cells with ST2 mouse bone marrow stromal cells in the presence of granulocyte/macrophage colony-stimulating factor (GM-CSF), the development of CD5+ macrophages was demonstrated by immunohistochemical staining and flow cytometry. (jax.org)

In addition, the effects of macrophages in the occurrence and development of inflammatory bowel disease (IBD), and their role in inducing fibrosis, activating T cells, reducing colitis, and treating intestinal inflammation were also reviewed in this paper. (frontiersin.org)
The role of tumor-associated macrophages (TAMs) in cancer is often correlated with poor prognosis, even though this statement should be interpreted with care, as the effects of macrophages primarily depend on their localization within the tumor. (nutriforce.cn)

Marrow contains hematopoietic stem cells which give rise to the three classes of blood cells that are found in circulation: white blood cells (leukocytes), red blood cells (erythrocytes), and platelets (thrombocytes). (wikipedia.org)

Stromal cells may be indirectly involved in hematopoiesis, providing a microenvironment that influences the function and differentiation of hematopoietic cells. (wikipedia.org)

Macrophages, which are functional plasticity cells, have the ability to phagocytize and digest foreign substances and acquire pro-(M1-like) or anti-inflammatory (M2-like) phenotypes according to their microenvironment. (frontiersin.org)
A clear understanding of the function of macrophages, as well as their role in pathogens and inflammatory response, will delineate the next steps in the treatment of intestinal inflammatory diseases. (frontiersin.org)
In this review, we discuss the origin and development of macrophages and their role in the intestinal inflammatory response or infection. (frontiersin.org)
These cells can participate in inflammatory responses by releasing mediators that attract or activate other cells, contributing to the pathogenesis of allergic and non-allergic diseases. (mdpi.com)
Increases in Na + favor the polarization of T cells towards an inflammatory Th17 phenotype ( 10 , 21 - 23 ). (frontiersin.org)
In macrophages, HS in combination with inflammatory stimuli leads to enhanced pro-inflammatory activation and increased antimicrobial capacity ( 8 , 12 , 13 , 24 , 25 ), while limiting their regulatory features ( 26 - 29 ). (frontiersin.org)
Imiquimod induced an IFN signature and led to reduced infiltration of inflammatory cells. (cnrs.fr)
The microenvironment of a developing tumor is composed of proliferating cancer cells, blood vessels, stromal cells, infiltrating inflammatory cells, and a variety of associated tissue cells. (nutriforce.cn)

More moderate antibody staining intensity was present in cells in the red pulp in spleen and macrophages in lung. (enquirebio.com)
enQuire Bio's product, CD68 (Macrophage Marker) MonoSpecific Antibody, is available for Research Use Only (RUO-Only). (enquirebio.com)
Septilin augments granulocyte-macrophage differentiation, natural killer cell activity and antibody-dependent cytotoxicity. (generic-meds-store.com)
Septilin's stimulatory effect on the humoral immunity increases the antibody-forming cells, thereby enhancing the secretion of antibodies into the circulation. (generic-meds-store.com)
In contrast to authentic osteoclasts, MNC reacted with a monoclonal antibody (Mo1) which identifies an antigen present on myeloblasts, monocytes, granulocytes, and null cells from human peripheral blood and bone marrow. (elsevierpure.com)
MNC also reacted with the monoclonal antibody My11, which is present on CFU-GM, the granulocyte-macrophage colony-forming cell, the probable precursor for MNC. (elsevierpure.com)
It builds up resistance to disease and helps prevent reinfection, augments granulocyte-macrophage differentiation, natural killer cell activity and antibody-dependent cell cytotoxicity. (1001pills.com)
1) Antibody deficiency disorders are defects in immunoglobulin-producing B cells . (lu.se)
3) T cell deficiencies result usually in combined immunodeficiencies (CIDs), where both T cells and antibody production are defective. (lu.se)

Our research focuses on developmental pathways that regulate hematopoietic cell growth and differentiation and are disrupted in the course of neoplastic transformation, particularly in leukemias and lymphomas. (stanford.edu)

All experiments performed on red cell lysed murine splenocytes gated on mononuclear cells. (bio-rad-antibodies.com)
All experiments performed on red cell lysed murine peripheral blood in the presence of murine SeroBlock ( BUF041A ). (bio-rad-antibodies.com)

MDS may involve one, two, or all three myeloid hematopoiesis cell lineages-erythrocytic, granulocytic, megakaryocytic-depending on the subtype and stage of the disease. (medscape.com)
The future direction of the study of hematopoietic stem cells will probably make use of pluripotent stem cells to yield specific immune cell lineages and eventual clinical applications. (biomedcentral.com)

Granulocyte Colony-Stimulating Factor Use after Autologous Peripheral Blood Stem Cell Transplantation: Comparison of Two Practices. (uchicago.edu)

This phenotype is different from that expressed by macrophage polykaryons. (elsevierpure.com)
These increases in local Na + levels boost proinflammatory and antimicrobial macrophage activity and can favor polarization of T cells towards a proinflammatory Th17 phenotype. (frontiersin.org)
We are only beginning to understand the environmental cues that contribute to transient retention of macrophages in a specific phenotype. (nutriforce.cn)
Deficiencies are highly variable with regard to symptoms, phenotype, genotype, severity, etc, because many cells and molecules are required for both natural and adaptive immunity . (lu.se)

MSCs have been shown to differentiate, in vitro or in vivo, into osteoblasts, chondrocytes, myocytes, marrow adipocytes and beta-pancreatic islets cells. (wikipedia.org)
The bone marrow cell suspensions were then heated in vitro and plated for colony formation. (elsevierpure.com)
IL-18 has been reported to induce interferon-gamma (IFN-gamma) and granulocyte/macrophage colony-stimulating factor (GM-CSF) production in T cells, and both agents also inhibit OCL formation in vitro. (ox.ac.uk)

It is composed of hematopoietic cells, marrow adipose tissue, and supportive stromal cells. (wikipedia.org)
In humans, marrow is colloquially characterized as "red" or "yellow" marrow (Latin: medulla ossium rubra, Latin: medulla ossium flava, respectively) depending on the prevalence of hematopoietic cells vs fat cells. (wikipedia.org)
We are studying the role that normal chromatin structure plays in gene regulation in hematopoietic cells and how its disruption leads to altered development and cancer. (stanford.edu)
This mechanism also applies to hematopoietic cells transformed by other HOX genes, including CDX2, which is highly expressed in a majority of acute myeloid leukemias, thus providing a molecular approach based on GSK-3 inhibitory strategies to target HOX-associated transcription in a broad spectrum of leukemias. (stanford.edu)

however, lymphoid cells must migrate to other lymphoid organs (e.g. thymus) in order to complete maturation. (wikipedia.org)
Venetoclax is active in other lymphoid malignancies including several B cell non-Hodgkin lymphomas, acute lymphoblastic leukemia and multiple myeloma, with the highest intrinsic sensitivity observed in mantle cell lymphoma and Waldenstrom macroglobulinemia. (biomedcentral.com)
The availability of such cells in purified form will allow direct study of lineage choice in cells having both lymphoid and non-lymphoid options. (pasteur.fr)
11. Melchers, F.: Synthesis, transport and secretion of immunoglobulin in lymphoid cells. (uni-mainz.de)
The common stem cell produces 2 other stem cells, the myeloid stem cell and the lymphoid stem cell. (medscape.com)
At the beginning of hematopoietic cell differentiation is the pluripotent stem cell , which differentiates into lymphoid, erythroid and myeloid precursor cells . (wikilectures.eu)

Neutrophilic granulocytes are involved in the development of an immune response to damage. (wikilectures.eu)

These results indicate that GM-CSF, in combination with M-CSF, induces the development and differentiation of CD5+ macrophages in the peritoneal cavity, particularly in the omental milky spots of mice. (jax.org)
It has become clear that hypoxia shapes and induces specific macrophage phenotypes that serve tumor malignancy, as hypoxia promotes immune evasion, angiogenesis, tumor cell survival, and metastatic dissemination. (nutriforce.cn)

Septilin stimulates phagocytosis by macrophage activation, increases the polymorphonuclear cells and helps overcome infection. (generic-meds-store.com)
When the oxygen content of body tissues is low, if there is loss of blood or anemia, or if the number of red blood cells decreases, the kidneys produce and release erythropoietin, a hormone that stimulates the bone marrow to produce more red blood cells. (medscape.com)

Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. (icbinhibitor.com)

The placenta is a heterogeneous organ whose development involves complex interactions of trophoblasts with decidual, vascular, and immune cells at the fetal-maternal interface. (nature.com)
Siglecs (sialic acid-binding immunoglobulin-like lectins) are single-pass cell surface receptors that have inhibitory activities on immune cells. (mdpi.com)
Produced by immune cells. (imreference.com)
2) T cell deficiencies affect the function in killing infected cells or helping other immune cells. (lu.se)

Genetically distinct leukemic stem cells in human CD34- acute myeloid leukemia are arrested at a hemopoietic precursor-like stage. (ox.ac.uk)
Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines. (uchicago.edu)

Hematopoietic stem cells in the bone marrow can give rise to hematopoietic lineage cells, and mesenchymal stem cells, which can be isolated from the primary culture of bone marrow stroma, can give rise to bone, adipose, and cartilage tissue. (wikipedia.org)
Macrophages are phagocytes found in tissues and maintain tissue homeostasis, regulate inflammation, and play a significant role in host protection. (frontiersin.org)
It is important for identifying macrophages in tissue sections. (enquirebio.com)
Background: This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. (icbinhibitor.com)
Bone marrow consists of stem cells, which are large, "primitive," undifferentiated cells supported by fibrous tissue called stroma. (medscape.com)
There are 2 main types of stem cells and, therefore, the bone marrow consists of 2 types of cellular tissue. (medscape.com)
It eliminates damaged cells and activates fibroplastic mechanisms, angiogenesis, tissue regeneration and remodelling. (wikilectures.eu)

It stains macrophages in a wide variety of human tissues, including Kupffer cells and macrophages in the red pulp of the spleen, in lamina propria of the gut, in lung alveoli, and in bone marrow. (enquirebio.com)
Ferritin is found in most tissues where it is located inside the cells. (selfhacked.com)
Tissues, including the placenta, are comprised of diverse cell types with distinguishable developmental or functional origin that form a complex niche 1 . (nature.com)
Gram-negative bacteria not only have different factors of virulence and generate products and sub-products that are toxic to apical and periapical tissues, but also contain endotoxin in the outer membrane of their cell wall. (bvsalud.org)
High salt diets ( 1 , 2 ), renal impairment ( 3 - 6 ), inflammation, and infection ( 7 - 11 ) can induce Na + accumulation in skin tissues that can be simulated by addition of approximately 40 mM NaCl to standard cell culture media (= high salt condition, HS) ( 2 , 8 , 12 , 13 ). (frontiersin.org)
hEPCs have been used for cell-based therapies due to their capacity to contribute in the re-endothelialization of injured blood vessels and neovascularization in ischemic tissues. (intechopen.com)

On the other hand, phagosomes are formed when the pathogen is engulfed by macrophages and fuse with lysosomes to release enzymes and toxic substances, resulting in killing or having cytotoxic effects on bacteria and tumor cells. (frontiersin.org)
We believe that Bria-IMT™ helps the body to recognize and kill tumor cells by activating T cells that attack the tumor and B cells that produce anti-tumor antibodies. (smallcapvoice.com)

98% of cells are CD34(-), there are multiple, nonhierarchically arranged CD34(+) and CD34(-) LSC populations. (ox.ac.uk)

We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. (stanford.edu)
But unlike mature precursors, LSCs express multiple normal stem cell transcriptional regulators previously implicated in LSC function. (ox.ac.uk)

mast cell. (wikilectures.eu)
The products induce mast cell degranulation, and release of histamines and bradykinin , which is a vasodilator that is used to feel pain. (wikilectures.eu)

Their dual potential and unrearranged immunoglobulin loci place the precursors before exclusive B-lineage commitment in the haematopoietic hierarchy. (pasteur.fr)
8. Melchers, F.: Biosynthesis, transport and secretion of immunoglobulin in plasma cells. (uni-mainz.de)

Transcriptional Regulation of JARID1B/KDM5B Histone Demethylase by Ikaros, Histone Deacetylase 1 (HDAC1), and Casein Kinase 2 (CK2) in B-cell Acute Lymphoblastic Leukemia. (musc.edu)

EPO-secreting tumors EPO-secreting tumors Polycythemia Vera , such as renal cell carcinoma Renal cell carcinoma Renal cell carcinoma (RCC) is a tumor that arises from the lining of the renal tubular system within the renal cortex. (lecturio.com)
The induction of CD11b + Gr-1 + myeloid-derived suppressor cells (MDSCs) is an important immune-evading mechanism used by tumors. (ashpublications.org)
It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH. (teomics.com)
Thus, solid tumors seem to build up a hostile hypoxic microenvironment that hampers cell-mediated immunity and dampen the efficacy of the immune response. (nutriforce.cn)

3] Antibodies against granulocyte colony-stimulating factor (G-CSF) were measured. (medscape.com)

Only mature blood cells contain the membrane proteins, such as aquaporin and glycophorin, that are required to attach to and pass the blood vessel endothelium. (wikipedia.org)
BH3-mimetics are a novel drug class of small molecule inhibitors of BCL2 family proteins which restore apoptosis in malignant cells. (biomedcentral.com)
In brief, apoptosis is triggered when "pro-death/damage sensing" BH3-only proteins activate the downstream effector molecules BAX and BAK, which dimerize on the mitochondrial outer membrane surface and permeabilize it, triggering the release of cytochrome C, caspase activation and committing the cell to programmed death. (biomedcentral.com)
Although iron plays many important roles in the body, it can also be toxic to cells because of its capacity to generate reactive species, which can directly damage DNA and proteins. (selfhacked.com)

Erythroid precursor cells differentiate into erythroblasts (→ reticulocyte → erythrocyte). (wikilectures.eu)
Erythroid precursor cell (proerythroblast) → erythroblast → reticulocyte → erythrocyte. (wikilectures.eu)

and high glucose in mononuclear cells? (musc.edu)

The first morphologically identifiable precursors are the proerythroblast (giving rise to the erythroblast), myeloblast, monoblast, lymphoblast and megakaryoblast (precursor of the megakaryocyte). (wikilectures.eu)

Myelodysplastic syndrome and acute myeloid leukemia after receipt of granulocyte colony-stimulating factors in older patients with non-Hodgkin lymphoma. (uchicago.edu)

Tri- and bipotential myeloid intermediates between the multipotential stem cells and later unipotential cells have been identified using clonal methods in culture. (pasteur.fr)

It is genetically engineered to release granulocyte-macrophage colony-stimulating factor (GM-CSF), a substance that activates the immune system. (smallcapvoice.com)

We report the characterization and purification of fetal liver cells that generate clones containing both macrophages and B cells, identified biochemically and morphologically. (pasteur.fr)

Thioredoxin reductase-1 negatively regulates HIV-1 transactivating protein Tat-dependent transcription in human macrophages. (umassmed.edu)
GA-binding protein and p300 are essential components of a retinoic acid-induced enhanceosome in myeloid cells. (umassmed.edu)
The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. (icbinhibitor.com)
It is the primary iron-storage protein within the cell , that stores iron in a soluble , non-toxic form , and transports it to areas where it is required [ 1 ]. (selfhacked.com)
The carbohydrate composition of a myeloma protein from different subcellular fractions of plasma cells. (uni-mainz.de)
What started as a series of microscopic observations in different animal model systems has since evolved into studies of gene expression and regulation, and subsequent protein-protein interactions, cell surface protein expression profiling, and functional mapping of cell fates. (biomedcentral.com)
Although CD5+ macrophages were not present in the peritoneal cavities of normal mice, approximately 30% of the peritoneal macrophages in viable motheaten (mev/mev) mice, deficient in SHP-1 protein tyrosine phosphatase, expressed cell surface CD5 and B220, markers for B cells. (jax.org)
The structure of the recombinant human G-CSF protein expressed in E. coli, such as filgrastim, differs slightly from those of the natural glycoprotein and the recombinant human G-CSF protein expressed in mammalian cells such as CHO cells. (sydlabs.com)

Clone BM-1 reacts with myeloid precursor cells and granulocytes in bone marrow. (teomics.com)
It reacts with ACTH-producing cells (corticotrophs). (teomics.com)

These stem cells divide to eventually give rise to red blood cells, platelets, and most white blood cells in the red marrow. (medscape.com)
White blood cells last anywhere from a few hours to a few days, platelets for about 10 days, and red blood cells for about 120 days. (medscape.com)
Similarly, the bone marrow produces and releases more white blood cells in response to infections, and it produces and releases more platelets in response to bleeding. (medscape.com)

Bone marrow cells display aberrant morphology and maturation (dysmyelopoiesis), resulting in ineffective blood cell production. (medscape.com)

Effects of granulocyte/macrophage colony-stimulating factor on the development and differentiation of CD5-positive macrophages and their potential derivation from a CD5-positive B-cell lineage in mice. (jax.org)
Takahashi K, Miyakawa K, Wynn AA, Nakayama KI, Myint YY, Naito M, Shultz LD, Tominaga A, Takatsu K. Effects of granulocyte/macrophage colony-stimulating factor on the development and differentiation of CD5-positive macrophages and their potential derivation from a CD5-positive B-cell lineage in mice. (jax.org)

(B) Subset of cell surface markers used in the characterization of this developmental process. (biomedcentral.com)
Thus, a careful characterization and understanding of this macrophage differentiation state is needed in order to efficiently tailor cancer therapy. (nutriforce.cn)

The bone marrow stroma contains mesenchymal stem cells (MSCs), which are also known as marrow stromal cells. (wikipedia.org)
One type of stem cell is involved in producing blood cells and the other is involved in producing stromal cells, which are responsible for the supporting stroma. (medscape.com)
We have established by differential display polymerase chain reaction of mRNA that interleukin (IL)-18 is expressed by osteoblastic stromal cells. (ox.ac.uk)
The stromal cell populations used for comparison differed in their ability to promote osteoclast-like multinucleated cell (OCL) formation. (ox.ac.uk)
The crosstalk between stromal cells and malignant cells within this environment crucially determines the fate of tumor progression, its hostility, and heterogeneity. (nutriforce.cn)

Anatomy34

Organisms8

Diseases6

Chemicals and Drugs48

Analytical, Diagnostic and Therapeutic Techniques and Equipment16

Phenomena and Processes30

Disciplines and Occupations1

Information Science3

Endothelial10

Progenitors6

Eosinophils6

MONOCYTE8

Proliferation7

Lymphocytes6

Fibroblasts2

Antigens5

Dendritic cells3

Cytokines2

Myeloid precursors2

Neutrophils3

Progenitor7

MONOCYTES and MACROPHAGES2

Flow cytometry3

Effects of macrophages2

Erythrocytes1

Differentiation of hematopoietic1

Inflammatory8

Antibody9

Growth and differentiation1

Murine2

Lineages2

Peripheral1

Phenotype4

Vitro3

Hematopoietic cells4

Lymphoid6

Neutrophilic1

Induces2

Stimulates2

Phagocytosis1

Immune cells4

Leukemic2

Tissue7

Tissues6

Tumor Cells2

CD341

Stem cell transcriptional2

Mast cell2

Immunoglobulin2

Acute lymphobl1

Tumors4

Antibodies1

Proteins4

Erythroid2

Mononuclear cells1

Monoblast1

Colony stimula1

Bipotential1

Activates1

Fetal liver cells1

Protein8

Reacts2

Platelets3

Bone Marro1

Lineage2

Characterization2

Stromal5