RecombinantMacrophagesDifferentiationGCSFCytokineSecrete hematopoieticInducesNeutrophilsCellsFilgrastimReceptorPatientsMiceProgenitor cellNeutrophilProgenitorsOutcomesStem Cell TransplantMyeloidNeutropeniaELISASynergyHUMANProductionFormationTumorDoseInhibitMeSHDrugsBloodDosageDrugLeukemiaDevelopment
Recombinant8
- Recombinant GM-CSF injected into the uterine lumen of ovariectomised mice was found to elicit a dose-dependant accumulation of macrophages and granulocytes in the endometrium, in a pattern of distribution comparable to that seen in uteri after natural mating. (edu.au)
- Dr. Huntington Potter at the University of Colorado Anschutz Medical Center has shown that GM-CSF (recombinant human Granulocyte-Macrophage Colony-Stimulating Factor such as the commercially available Leukine) can slow or reverse Alzheimer's disease (AD) (CU#4306H). (technologypublisher.com)
- The present invention relates to a chimeric protein of recombinant human granulocyte colony stimulating factor comprising of hG-CSF fused to an affinity fusion tag at its amino terminus. (allindianpatents.com)
- Objective To study the pharmacokinetics of a novel recombinant human granulocyte colonystimulating factor (rhG-CSFa) in rats and to determine the proteolytic rates of rhG-CSFa in the whole blood and serum of rats in vitro. (cams.cn)
- Pharmacokinetic Study of a Novel Recombinant Human Granulocyte Colony-stimulating Factor in Rats[J].Chinese Medical Sciences Journal, 2010, 25(1): 13-19. (cams.cn)
- Chronic Toxicity of a Novel Recombinant Human Granulocyte Colony-stimulating Factor in Rats [J]. Chinese Medical Sciences Journal, 2011, 26(1): 20-27. (cams.cn)
- The effect of recombinant human granulocyte-macrophage colony stimulating factor (GM-CSF) on the expression of HLA-DR, and the production of the cytokines interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF alpha) by human peripheral blood monocyte-enriched populations was investigated. (ox.ac.uk)
- Filgrastim is a recombinant, non-pegylated human granulocyte colony stimulating factor (G-CSF) analogue manufactured by recombinant DNA technology. (janusinfo.se)
Macrophages10
- Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines. (uchicago.edu)
- Cells expressing GM-CSF receptor were identified as macrophages, granulocytes and putative dendritic cells by flow cytometric analysis using lineage and receptor subunit specific antibodies. (edu.au)
- Granulocyte/macrophage - Colony-stimulating factor (GM-CSF) is a hematopoietic factor that is produced by activated T-cells, B-cells, mast cells, macrophages, fibroblasts, and endothelial cells. (neobiotechnologies.com)
- Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. (neobiotechnologies.com)
- The chemical reactions and pathways resulting in the formation of granulocyte macrophage colony-stimulating factor, cytokines that act in hemopoiesis by controlling the production, differentiation, and function of two related white cell populations, granulocytes and monocytes-macrophages. (planteome.org)
- Granulocyte-macrophage colony-stimulating factor (GM-CSF) promotes the proliferation and differentiation of hematopoietic progenitor cells and the generation of neutrophils, eosinophils, and macrophages. (stemcell.com)
- Effects of granulocyte/macrophage colony-stimulating factor on the development and differentiation of CD5-positive macrophages and their potential derivation from a CD5-positive B-cell lineage in mice. (jax.org)
- In co-cultures of either the murine pre-B cell line J13, fetal liver cells, or adult peritoneal or bone marrow cells with ST2 mouse bone marrow stromal cells in the presence of granulocyte/macrophage colony-stimulating factor (GM-CSF), the development of CD5+ macrophages was demonstrated by immunohistochemical staining and flow cytometry. (jax.org)
- Takahashi K, Miyakawa K, Wynn AA, Nakayama KI, Myint YY, Naito M, Shultz LD, Tominaga A, Takatsu K. Effects of granulocyte/macrophage colony-stimulating factor on the development and differentiation of CD5-positive macrophages and their potential derivation from a CD5-positive B-cell lineage in mice. (jax.org)
- In suspension cultures, TGF-beta 1 and GM-CSF stimulated an increase in total viable cells with markedly enhanced neutrophilic differentiation and a concomitant decrease in the number of monocytes/macrophages by day 6 in culture. (ox.ac.uk)
Differentiation8
- G-CSF also stimulates the survival, proliferation, differentiation, and function of neutrophil precursors and mature neutrophils. (wikipedia.org)
- White blood cells The G-CSF-receptor is present on precursor cells in the bone marrow, and, in response to stimulation by G-CSF, initiates proliferation and differentiation into mature granulocytes. (wikipedia.org)
- It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. (uchicago.edu)
- It stimulates the survival, proliferation, differentiation and function of neutrophil granulocyte progenitor cells and mature neutrophils. (allindianpatents.com)
- describes a novel colony stimulating factor (CSF) that has the ability to promote the differentiation and proliferation of human bone marrow cells to neutrophils, and a method to produce the same from a novel cell line which has been established from tumor cells in patients with oral cancer, The most published studies have used filgrastim as it was the first form of G-CSF to be approved. (allindianpatents.com)
- It enhances granulocyte proliferation and differentiation [7]. (peertechzpublications.com)
- To study the relationship between hematopoietic factors and their responsive hematopoietic progenitors in the differentiation process, both purified factors and enriched progenitors are required. (elsevierpure.com)
- It was concluded that G-CSF supported the neutrophil differentiation of committed colony-forming cells, IL-3 supported that of both committed and multipotent colony-forming cells. (elsevierpure.com)
GCSF12
- Granulocyte colony-stimulating factor (G-CSF or GCSF), also known as colony-stimulating factor 3 (CSF 3), is a glycoprotein that stimulates the bone marrow to produce granulocytes and stem cells and release them into the bloodstream. (wikipedia.org)
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Colony Stimulating Factor 3, Granulocyte (GCSF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. (novosides.eu)
- Description: A sandwich quantitative ELISA assay kit for detection of Rat Colony Stimulating Factor 3, Granulocyte (GCSF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. (novosides.eu)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Colony Stimulating Factor 3, Granulocyte (GCSF) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. (novosides.eu)
- Granulocyte colony-stimulating factor (GCSF) is currently used to treat neutropenia due to chemotherapy and has been successfully used for patients who require bone marrow transplants. (sciencedaily.com)
- GCSF improved long-term behavioral outcomes while also stimulating a neural progenitor recovery response in a mouse model. (sciencedaily.com)
- A study from Florida Atlantic University's Schmidt College of Medicine holds promise for a new way to treat stroke using an already FDA-approved drug -- granulocyte colony-stimulating factor (GCSF). (sciencedaily.com)
- GCSF enhances blood cellular development and is currently used to treat neutropenia (low white blood cells) caused by chemotherapy and has successfully been used with very few side effects for patients who require bone marrow transplants to stimulate blood cell formation. (sciencedaily.com)
- The data support the hypothesis that GCSF is one of the few growth factors that can reduce infarction by decreasing endoplasmic reticulum (ER) and mitochondrial stress while improving behavioral performance. (sciencedaily.com)
- Results showed that GCSF improved neurological deficits that occur in the first few days following cerebral ischemia and improved long-term behavioral outcomes while also stimulating a neural progenitor recovery response. (sciencedaily.com)
- In recent years, many studies including ours have shown that as an endogenous growth factor and immune system modulator factor, GCSF is beneficial in models of neurological disorders such as stroke and traumatic brain injury," said Jang-Yen (John) Wu, Ph.D., corresponding author, distinguished professor of biomedical science in FAU's Schmidt College of Medicine, and a member of the FAU Brain Institute (I-BRAIN). (sciencedaily.com)
- Recent studies indicate that some hematopoietic growth factors, namely granulocyte macrophage colony stimulating factor (GMCSF) and granulocyte colony stimulating factor (GCSF), are abundantly released in the tumor microenvironment and play a key role in regulating tumor-nerve interactions and tumor-associated pain by activating receptors on dorsal root ganglion (DRG) neurons. (biomedcentral.com)
Cytokine7
- Functionally, it is a cytokine and hormone, a type of colony-stimulating factor, and is produced by a number of different tissues. (wikipedia.org)
- The cytokine granulocyte-colony stimulating factor (G-CSF) is known to have trophic and neuroprotective properties in the brain, and we recently identified it as a modulator of neuronal and behavioral plasticity. (jneurosci.org)
- Here, we report that granulocyte-colony stimulating factor (G-CSF), a pleiotropic cytokine with known trophic and neuroprotective properties in the brain, acts directly on dopaminergic circuits to enhance their function. (jneurosci.org)
- Granulocyte colony stimulating factor (G-CSF) is a 20 kDa glycoprotein cytokine that stimulates growth and development of granulocyte progenitors in the bone marrow (Nagata et al. (allindianpatents.com)
- Granulocyte colony-stimulating factor (G-CSF) is a hematopoietic cytokine appears in materno-fetal interface during embryo implantation and early pregnancy suggesting it may have a role in decidua and placental development [6]. (peertechzpublications.com)
- Granulocyte macrophage colony-stimulating factor (GM-CSF) is an immunoregulatory cytokine with a pivotal role in initiation and perpetuation of inflammatory diseases. (ucl.ac.uk)
- Granulocyte-macrophage colony stimulating factor induces both HLA-DR expression and cytokine production by human monocytes. (ox.ac.uk)
Secrete hematopoietic1
- Several types of non-hematopoietic tumors secrete hematopoietic colony stimulating factors, which act on myeloid cells and tumor cells[ 7 ]. (biomedcentral.com)
Induces1
- Intradermal transgenic expression of granulocyte-macrophage colony-stimulating factor induces neutrophilia, epidermal hyperplasia, Langerhans' cell/macrophage accumulation, and dermal fibrosis. (mcmaster.ca)
Neutrophils3
- Oral cancer cells secrete granulocyte colony stimulating factor (G-CSF), a growth factor that recruits neutrophils from bone marrow to the cancer microenvironment. (frontiersin.org)
- GM-CSF is a small glycoprotein growth factor which stimulates the production and function of neutrophils, eosinophils and monocytes. (biovendor.com)
- Granulocyte colony-stimulating factors (G-CSFs), which were first approved in 1991, are effective at reducing the risk for and duration of chemotherapy-induced febrile neutropenia, by stimulating the production and maturation of neutrophils. (jhoponline.com)
Cells19
- Neurons G-CSF can also act on neuronal cells as a neurotrophic factor. (wikipedia.org)
- The inhibitory effect of PAP-BALF occurred only when TF-1 cells were cultured with GM-CSF but not when cultured with IL-3, suggesting that PAP-BALF contains a factor that specifically interferes with GM-CSF function. (wiley.com)
- Factors in seminal plasma elicit a surge of GM-CSF expression in uterine epithelial cells after mating in mice. (edu.au)
- In synergy with other cytokines such as stem cell factor, IL-3, erythropoietin, and thrombopoietin, it also stimulates erythroid and megakaryocyte progenitor cells (Barreda et al. (stemcell.com)
- These substances include, for instance, granulocyte- colony-stimulating factor (G-CSF), which is added so that the donors own bone marrow will make and produce more stem cells that will end up in the bloodstream. (differencebetween.net)
- The advantage is that granulocyte- colony-stimulating factor (G-CSF) does not have to be given to the donor since the procedure involves going to the source of the stem cells, which is the bone marrow. (differencebetween.net)
- Besides mobilizing stem cells into the periphery, granulocyte colony-stimulating factor (G-CSF) has been shown to influence various types of innate and adaptive immune cells. (johnshopkins.edu)
- In this study, isolated G-CSF-treated CD8 + T cells were stimulated antigen-dependently with peptide-major histocompatibility complex (pMHC)-coupled artificial antigen-presenting cells (aAPCs) or stimulated antigen-independently with anti-CD3/CD28 stimulator beads. (johnshopkins.edu)
- However, IFN-gamma enhanced the cell surface expression of HLA-DR and the production of IL-1 and TNF alpha on monocyte-enriched cells stimulated by GM-CSF. (ox.ac.uk)
- Transforming growth factor beta 1 (TGF-beta 1) is known to inhibit the growth of immature hematopoietic progenitor cells, whereas more mature, lineage-restricted progenitors are not inhibited. (ox.ac.uk)
- We isolated total CD34 + cells, CD34 + ,CD33 + cells, and CD34 + ,CD33 - cells individually from normal human bone marrow cells by fluorescence-activated cell sorter (FACS), and examined the effects of granulocyte colony-stimulating factor (G-CSF), interleukin-3 (IL-3), and IL-5 on in vitro colony formation of these cells. (elsevierpure.com)
- CD34 + ,CD33 + cells formed granulocyte colonies in the presence of G-CSF. (elsevierpure.com)
- Both CD34 + ,CD33 + cells and CD34 + ,CD33 - cells formed granulocyte/macrophage colonies in the presence of IL-3. (elsevierpure.com)
- Eosinophil (Eo) colonies were only formed by CD34 + ,CD33 - cells in response to IL-3, but scarcely formed by CD34 + cells in the presence of IL-5. (elsevierpure.com)
- CD34 - ,CD33 + cells derived from CD34 + ,CD33 + cells by preincubation with G-CSF or IL-3 formed Eo colonies in the presence of IL-5 but not IL-3. (elsevierpure.com)
- CD34 - ,CD33 + cells derived from CD34 + ,CD33 - cells by preincubation with IL-3 also formed Eo colonies by support of IL-5 as well as IL-3. (elsevierpure.com)
- IL-18 has been reported to induce interferon-gamma (IFN-gamma) and granulocyte/macrophage colony-stimulating factor (GM-CSF) production in T cells, and both agents also inhibit OCL formation in vitro. (ox.ac.uk)
- Trisomy 8+ cells showed a significant positive correlation with apoptotic CD34+ cells and capacity for colony formation. (who.int)
- The essence of MDS is damage of In the current work we examined All our patients were of the high-risk colony-forming units [4], but the defect haematopoietic stem cells of high-risk group and none of them was eligible of the haematopoietic stem cells is not MDS cases for apoptotic and anti-apop- for stem cell transplantation. (who.int)
Filgrastim2
- Patients with a history of serious allergic reaction to human granulocyte colony-stimulating factors such as pegfilgrastim products or filgrastim products. (drugs.com)
- Clinical practice guidelines recommend the use of all approved granulocyte colony-stimulating factors (G-CSFs), including filgrastim and pegfilgrastim, as primary febrile neutropenia (FN) prophylaxis in patients receiving high- or intermediate- risk regimens (in those with additional patient risk factors ). (bvsalud.org)
Receptor5
- Recent work with transgenic mice demonstrated that disruption of the production of granulocyte-macrophage colony-stimulating factor (GM-CSF) or the common beta-subunit of the GM-CSF receptor caused alveolar proteinosis that was histologically similar to that seen in human patients. (nih.gov)
- Low affinity receptor for granulocyte-macrophage colony-stimulating factor. (cusabio.com)
- G-/GMCSF activates the JAK family of receptor tyrosine kinases, which unfolds its activity by not only regulating enzymes and target proteins within its local milieu, but importantly also by activating the STAT family of transcription factors, which subsequently dimerize and translocate to the cell nucleus to regulate gene expression[ 13 ]. (biomedcentral.com)
- Moreover, although interleukin 7 (IL-7) supports the generation of such myeloid intermediates, we show that their developmental branching from the main intrathymic T-cell pathway is linked to the up-regulation of the myelomonocytic granulocyte macrophage-colony-stimulating factor (GM-CSF) receptor, to the down-regulation of the IL-7 receptor and to the lack of pre-T-cell receptor α (pTα) gene transcriptional activation. (ashpublications.org)
- Receptor for granulocyte colony-stimulating factor (G-CSF). (lu.se)
Patients9
- In a pilot study with five oral cancer patients undergoing radiotherapy (RT) three were given Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) as a protective agent to reduce the mucosal inflammation during radiotherapy. (amrita.edu)
- Myelodysplastic syndrome and acute myeloid leukemia after receipt of granulocyte colony-stimulating factors in older patients with non-Hodgkin lymphoma. (uchicago.edu)
- Increase in short-term risk of rejection in heart transplant patients receiving granulocyte colony-stimulating factor. (uchicago.edu)
- Scholars@Duke publication: Plerixafor Plus Granulocyte Colony-Stimulating Factor for Patients with Non-Hodgkin Lymphoma and Multiple Myeloma: Long-Term Follow-Up Report. (duke.edu)
- The purpose of this report is to analyze long-term clinical outcomes of patients exposed to plerixafor plus granulocyte colony-stimulating factor (G-CSF) for stem cell mobilization. (duke.edu)
- Patients with neutropenia may benefit from treatment with granulocyte colony-stimulating factor (G-CSF). (medscape.com)
- Objective: Prophylaxis with granulocyte colony-stimulating factors (G-CSFs) is recommended for patients receiving myelosuppressive chemotherapy regimens with a high risk of febrile neutropenia (FN). (psu.edu)
- The aim of the present study was to measure levels of granulocyte-macrophage colony-stimulating factor (GM-CSF) in nasal lavage of patients affected by chronic eosinophilic sinonasal inflammation to clarify the relationship with eosinophilic tissue infiltration and clinical features. (unicatt.it)
- Cost-effectiveness of granulocyte colony-stimulating factors (G-CSFs) for the prevention of febrile neutropenia (FN) in patients with cancer. (bvsalud.org)
Mice2
- Mice deficient in granulocyte-macrophage colony stimulating factor (GM-CSF) develop pulmonary alveolar proteinosis (PAP). (wiley.com)
- Bone marrow progenitors obtained from mice 3 days after treatment with 5-fluorouracil responded to a combination of GM-CSF and TGF-beta 1, whereas either factor alone had no effect. (ox.ac.uk)
Progenitor cell1
- the progenitor cell is tentatively designated granulocyte burst-forming unit. (ox.ac.uk)
Neutrophil2
- Administration of granulocyte macrophage colony stimulating factor (GM-CSF) after birth raises neutrophil counts but does not improve neonatal or 2-year developmental outcomes. (bmj.com)
- Two hematopoietic colony-stimulating factors, granulocyte colony- stimulating factor (G-CSF) and granulocyte-macrophage CSF (GM-CSF), have been shown to accelerate leukocyte and neutrophil recovery after high-dose chemotherapy and autologous bone marrow (BM) support. (johnshopkins.edu)
Progenitors1
- In addition to supporting colony formation of granulocyte/macrophage progenitors, GM-CSF is a growth factor for erythroid, megakaryocyte, and eosinophil progenitors. (neobiotechnologies.com)
Outcomes4
- Objective We performed a randomised trial in very preterm, small for gestational age (SGA) babies to determine if prophylaxis with granulocyte macrophage colony stimulating factor (GM-CSF) improves outcomes (the PROGRAMS trial). (bmj.com)
- Granulocyte macrophage colony stimulating factor (GM-CSF) administered after birth does not alter 5-year neurocognitive outcomes. (bmj.com)
- Mostafa F, Farid L (2017) Effect of Intrauterine Infusion of Granulocyte Colony Stimulating Factor on IVF Outcomes in Infertile Women. (peertechzpublications.com)
- This kind of "unfair" or "unequal" trial design leaves open the question of whether the new drugs are truly superior to the older ones or if the outcomes are due to more aggressive dosing or growth factor support, the investigators say. (medscape.com)
Stem Cell Transplant1
- Granulocyte Colony-Stimulating Factor Use after Autologous Peripheral Blood Stem Cell Transplantation: Comparison of Two Practices. (uchicago.edu)
Myeloid3
- Planned Granulocyte Colony-Stimulating Factor Adversely Impacts Survival after Allogeneic Hematopoietic Cell Transplantation Performed with Thymoglobulin for Myeloid Malignancy. (uchicago.edu)
- More than half of studies testing anticancer drugs against each other have rules about dose modification and myeloid growth factors that favor the experimental drug arm, a new analysis suggests. (medscape.com)
- The authors compared dose modification rules or myeloid growth factor recommendations in the study arms, and assessed potential imbalances in drug modification rules, myeloid growth factor recommendations, or both. (medscape.com)
Neutropenia1
- Despite established guidelines for the use of granulocyte colony-stimulating factors (G-CSFs) in the prevention of febrile neutropenia, inappropriate prescribing practices have been reported. (jhoponline.com)
ELISA1
- Description: A sandwich ELISA kit for detection of Colony Stimulating Factor 3, Granulocyte from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (novosides.eu)
Synergy1
- Stimulation of granulopoiesis by transforming growth factor beta: synergy with granulocyte/macrophage-colony-stimulating factor. (ox.ac.uk)
HUMAN1
- Mouse granulocyte-colony stimulating factor (G-CSF) was first recognised and purified in Walter and Eliza Hall Institute, Australia in 1983, and the human form was cloned by groups from Japan and Germany/United States in 1986. (wikipedia.org)
Production2
- G-CSF stimulates the production of granulocytes, a type of white blood cell. (wikipedia.org)
- EP0237545, published on 1987-09-23 by Lawrence M Souza discloses the production of pluripotent granulocyte colony stimulating factor using E.coli as a host organism. (allindianpatents.com)
Formation2
- Interleukin-18 (interferon-gamma-inducing factor) is produced by osteoblasts and acts via granulocyte/macrophage colony-stimulating factor and not via interferon-gamma to inhibit osteoclast formation. (ox.ac.uk)
- 8+ avaient une corrélation positive importante avec les cellules CD34+ apoptotiques et la capacité à stimuler la formation de colonies. (who.int)
Tumor2
- These effects seem to be a result of the ability of G-CSF to alter local inflammatory signaling cascades, particularly tumor necrosis factor α. (jneurosci.org)
- Amongst these, we validate calpain 2, matrix metalloproteinase 9 (MMP9) and a RhoGTPase Rac1 as well as Tumor necrosis factor alpha (TNFα) as transcriptional targets of G-/GMCSF and demonstrate the importance of MMP9 and Rac1 in GMCSF-induced nociceptor sensitization. (biomedcentral.com)
Dose1
- The team discovered that 40 of the 62 trials (65%) had unequal rules for dose medication, granulocyte colony-stimulating factor (G-CSF) use, or both. (medscape.com)
Inhibit1
- These data suggest that IPAP is caused by expression of binding factor(s) which inhibit GM-CSF function in the lung. (wiley.com)
MeSH1
- Granulocyte Colony-Stimulating Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
Drugs1
- If the generated blood ROS concentration is too low, then fungi, bacteria or fibrin might threaten the life of the patient, and it could be of great medical interest to stimulate PMN by physiologic drugs. (scirp.org)
Blood2
- Stief, T. (2018) Granulocyte Colony-Stimulating Factor Multiplies Normal Blood ROS Generation at Less than 1 µg/l. (scirp.org)
- The white blood cell and granulocyte count nadirs were 1,660/ μ l and 438/ μ l. (hindawi.com)
Dosage1
- The BRGA helps to find out the correct stimulating G-CSF dosage for each individual. (scirp.org)
Drug2
- When testing new cancer agents, different drug modification rules or growth factor support guidance may affect the results of randomized controlled trials (RCTs). (medscape.com)
- When investigating the effect of a new drug, "you don't want to have a false sense of a drug's effect because of other factors not directly related to the drug's efficacy. (medscape.com)
Leukemia1
- People who have been administered colony-stimulating factors do not have a higher risk of leukemia than people who have not. (wikipedia.org)
Development1
- GM-CSF is able to stimulate the development of DCs that ingest, process, and present antigens to the immune system (Francisco-Cruz et al. (stemcell.com)