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  • Neutropenia
  • Consequently, we discuss the pharmacological use of granulopoiesis stimulating factors not only in the context of febrile neutropenia but also from the perspective of MDSC-dependent and MDSC-independent mechanisms of immunosuppression and cancer angiogenesis. (springer.com)
  • It is used as a medication to stimulate the production of white blood cells and thus prevent neutropenia following chemotherapy. (wikipedia.org)
  • cells
  • Neurons G-CSF can also act on neuronal cells as a neurotrophic factor. (wikipedia.org)
  • Long-term benefit of intracardiac delivery of autologous granulocytecolony-stimulating factor-mobilized blood CD341 cells containing cardiac progenitors on regional heart structure and function after myocardial infarct," Cytotherapy , vol. 11, no. 8, pp. 1002-1015, 2009. (hindawi.com)
  • These factors, which include interleukin 2 (IL2), are secreted by lectin- or antigen-stimulated T cells, and have various physiological effects. (wikipedia.org)
  • thyroid
  • Iwasa K, Noguchi M, Mor K et al (1995) Anaplastic thyroid carcinoma producing the granulocyte colony stimulating factor (G-CSF): report of a case. (springer.com)
  • Interestingly, expression of thyroid transcription factor-1 (TTF-1), a commonly used marker for primary lung cancers, appears to be less frequent in rhabdoid carcinomas than in most other histotypes of pulmonary cancers. (wikipedia.org)
  • Growth Factors
  • 4-6 After binding to high-affinity membrane receptors, the effects of growth factors are mediated by the activation of a series of kinases that translocate to the nucleus to phosphorylate transcription factors. (ahajournals.org)
  • This could be of interest, because G-CSF is one of the few growth factors approved for clinical use. (ahajournals.org)
  • The crystal structures of IL1A and IL1B have been solved, showing them to share the same 12-stranded beta-sheet structure as both the heparin binding growth factors and the Kunitz-type soybean trypsin inhibitors. (wikipedia.org)
  • levels
  • Plasma levels of stromal cell derived factor 1, angiopoietin 1, interleukin 8 and tumour necrosis factor α decreased after a symptom limited EST while vascular endothelial growth factor and platelet derived growth factor remained unchanged. (bmj.com)
  • gene
  • STWS is caused by a mutation in the leukemia inhibitory factor receptor ( LIFR ) gene, which is inherited in an autosomally recessive pattern. (biomedcentral.com)
  • transcription
  • IPEX (immunodysregulation polyendocrinopathy enteropathy X-linked) syndrome is a rare disease linked to the dysfunction of the transcription factor FOXP3, widely considered to be the master regulator of the regulatory T cell lineage. (wikipedia.org)