- Granulocyte colony-stimulating factor (G-CSF or GCSF), also known as colony-stimulating factor 3 (CSF 3), is a glycoprotein that stimulates the bone marrow to produce granulocytes and stem cells and release them into the bloodstream. (wikipedia.org)
- Functionally, it is a cytokine and hormone, a type of colony-stimulating factor, and is produced by a number of different tissues. (wikipedia.org)
- Mouse granulocyte-colony stimulating factor (G-CSF) was first recognised and purified in Walter and Eliza Hall Institute, Australia in 1983, and the human form was cloned by groups from Japan and Germany/United States in 1986. (wikipedia.org)
- Recent work with transgenic mice demonstrated that disruption of the production of granulocyte-macrophage colony-stimulating factor (GM-CSF) or the common beta-subunit of the GM-CSF receptor caused alveolar proteinosis that was histologically similar to that seen in human patients. (nih.gov)
- The cytokine granulocyte-colony stimulating factor (G-CSF) is known to have trophic and neuroprotective properties in the brain, and we recently identified it as a modulator of neuronal and behavioral plasticity. (jneurosci.org)
- Here, we report that granulocyte-colony stimulating factor (G-CSF), a pleiotropic cytokine with known trophic and neuroprotective properties in the brain, acts directly on dopaminergic circuits to enhance their function. (jneurosci.org)
- Granulocyte-Colony Stimulating Factor (G-CSF) is a cell hormone that increases the cell number of PMN and that stimulates the individual PMN. (scirp.org)
- Stief, T. (2018) Granulocyte Colony-Stimulating Factor Multiplies Normal Blood ROS Generation at Less than 1 µg/l. (scirp.org)
- Oral cancer cells secrete granulocyte colony stimulating factor (G-CSF), a growth factor that recruits neutrophils from bone marrow to the cancer microenvironment. (frontiersin.org)
- In a pilot study with five oral cancer patients undergoing radiotherapy (RT) three were given Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) as a protective agent to reduce the mucosal inflammation during radiotherapy. (amrita.edu)
- Objective We performed a randomised trial in very preterm, small for gestational age (SGA) babies to determine if prophylaxis with granulocyte macrophage colony stimulating factor (GM-CSF) improves outcomes (the PROGRAMS trial). (bmj.com)
- Administration of granulocyte macrophage colony stimulating factor (GM-CSF) after birth raises neutrophil counts but does not improve neonatal or 2-year developmental outcomes. (bmj.com)
- Granulocyte macrophage colony stimulating factor (GM-CSF) administered after birth does not alter 5-year neurocognitive outcomes. (bmj.com)
- Mice deficient in granulocyte-macrophage colony stimulating factor (GM-CSF) develop pulmonary alveolar proteinosis (PAP). (wiley.com)
- Granulocyte Colony-Stimulating Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
- This graph shows the total number of publications written about "Granulocyte Colony-Stimulating Factor" by people in this website by year, and whether "Granulocyte Colony-Stimulating Factor" was a major or minor topic of these publications. (uchicago.edu)
- Below are the most recent publications written about "Granulocyte Colony-Stimulating Factor" by people in Profiles. (uchicago.edu)
- Planned Granulocyte Colony-Stimulating Factor Adversely Impacts Survival after Allogeneic Hematopoietic Cell Transplantation Performed with Thymoglobulin for Myeloid Malignancy. (uchicago.edu)
- Increase in short-term risk of rejection in heart transplant patients receiving granulocyte colony-stimulating factor. (uchicago.edu)
- Granulocyte Colony-Stimulating Factor Use after Autologous Peripheral Blood Stem Cell Transplantation: Comparison of Two Practices. (uchicago.edu)
- Scholars@Duke publication: Plerixafor Plus Granulocyte Colony-Stimulating Factor for Patients with Non-Hodgkin Lymphoma and Multiple Myeloma: Long-Term Follow-Up Report. (duke.edu)
- The purpose of this report is to analyze long-term clinical outcomes of patients exposed to plerixafor plus granulocyte colony-stimulating factor (G-CSF) for stem cell mobilization. (duke.edu)
- Low affinity receptor for granulocyte-macrophage colony-stimulating factor. (cusabio.com)
- Intradermal transgenic expression of granulocyte-macrophage colony-stimulating factor induces neutrophilia, epidermal hyperplasia, Langerhans' cell/macrophage accumulation, and dermal fibrosis. (mcmaster.ca)
- For the quantification of Granulocyte colony-stimulating factor (G-CSF) in Culture Supernatant, Cell Lysates, Serum, Plasma (EDTA), Plasma (Heparin). (biosensis.com)
- Dr. Huntington Potter at the University of Colorado Anschutz Medical Center has shown that GM-CSF (recombinant human Granulocyte-Macrophage Colony-Stimulating Factor such as the commercially available Leukine) can slow or reverse Alzheimer's disease (AD) (CU#4306H). (technologypublisher.com)
- Patients with neutropenia may benefit from treatment with granulocyte colony-stimulating factor (G-CSF). (medscape.com)
- Granulocyte/macrophage - Colony-stimulating factor (GM-CSF) is a hematopoietic factor that is produced by activated T-cells, B-cells, mast cells, macrophages, fibroblasts, and endothelial cells. (neobiotechnologies.com)
- In addition to supporting colony formation of granulocyte/macrophage progenitors, GM-CSF is a growth factor for erythroid, megakaryocyte, and eosinophil progenitors. (neobiotechnologies.com)
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Colony Stimulating Factor 3, Granulocyte (GCSF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. (novosides.eu)
- Description: A sandwich ELISA kit for detection of Colony Stimulating Factor 3, Granulocyte from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (novosides.eu)
- Description: A sandwich quantitative ELISA assay kit for detection of Rat Colony Stimulating Factor 3, Granulocyte (GCSF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. (novosides.eu)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Colony Stimulating Factor 3, Granulocyte (GCSF) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. (novosides.eu)
- Granulocyte colony-stimulating factor (G-CSF) administration increased ovarian preantral follicles and anti-Müllerian hormone (AMH) in animal models with diminished ovarian reserve. (biomedcentral.com)
- Granulocyte colony-stimulating factor (GCSF) is currently used to treat neutropenia due to chemotherapy and has been successfully used for patients who require bone marrow transplants. (sciencedaily.com)
- A study from Florida Atlantic University's Schmidt College of Medicine holds promise for a new way to treat stroke using an already FDA-approved drug -- granulocyte colony-stimulating factor (GCSF). (sciencedaily.com)
- The present invention relates to a chimeric protein of recombinant human granulocyte colony stimulating factor comprising of hG-CSF fused to an affinity fusion tag at its amino terminus. (allindianpatents.com)
- Granulocyte colony stimulating factor (G-CSF) is a 20 kDa glycoprotein cytokine that stimulates growth and development of granulocyte progenitors in the bone marrow (Nagata et al. (allindianpatents.com)
- EP0237545, published on 1987-09-23 by Lawrence M Souza discloses the production of pluripotent granulocyte colony stimulating factor using E.coli as a host organism. (allindianpatents.com)
- describes a novel colony stimulating factor (CSF) that has the ability to promote the differentiation and proliferation of human bone marrow cells to neutrophils, and a method to produce the same from a novel cell line which has been established from tumor cells in patients with oral cancer, The most published studies have used filgrastim as it was the first form of G-CSF to be approved. (allindianpatents.com)
- Objective To study the pharmacokinetics of a novel recombinant human granulocyte colonystimulating factor (rhG-CSFa) in rats and to determine the proteolytic rates of rhG-CSFa in the whole blood and serum of rats in vitro. (cams.cn)
- Methods The pharmacokinetics of rhG-CSFa and conventional (wild type,WT) granulocyte colonystimulating factor (G-CSF) were investigated in Sprague-Dawley rats which received either intravenous or subcutaneous injection of rhG-CSFa or WT G-CSF at three different doses (20,50,or 100 μg/kg). (cams.cn)
- Pharmacokinetic Study of a Novel Recombinant Human Granulocyte Colony-stimulating Factor in Rats[J].Chinese Medical Sciences Journal, 2010, 25(1): 13-19. (cams.cn)
- Chronic Toxicity of a Novel Recombinant Human Granulocyte Colony-stimulating Factor in Rats [J]. Chinese Medical Sciences Journal, 2011, 26(1): 20-27. (cams.cn)
- The chemical reactions and pathways resulting in the formation of granulocyte macrophage colony-stimulating factor, cytokines that act in hemopoiesis by controlling the production, differentiation, and function of two related white cell populations, granulocytes and monocytes-macrophages. (planteome.org)
- Link to all annotated objects annotated to granulocyte macrophage colony-stimulating factor biosynthetic process. (planteome.org)
- Link to all direct and indirect annotations to granulocyte macrophage colony-stimulating factor biosynthetic process. (planteome.org)
- Mostafa F, Farid L (2017) Effect of Intrauterine Infusion of Granulocyte Colony Stimulating Factor on IVF Outcomes in Infertile Women. (peertechzpublications.com)
- It looks that the clinical pregnancy rates were significantly higher by intracavitary infusion of granulocyte colony stimulating factor. (peertechzpublications.com)
- Granulocyte colony-stimulating factor (G-CSF) is a hematopoietic cytokine appears in materno-fetal interface during embryo implantation and early pregnancy suggesting it may have a role in decidua and placental development [6]. (peertechzpublications.com)
- Granulocyte-macrophage colony-stimulating factor (GM-CSF) promotes the proliferation and differentiation of hematopoietic progenitor cells and the generation of neutrophils, eosinophils, and macrophages. (stemcell.com)
- These substances include, for instance, granulocyte- colony-stimulating factor (G-CSF), which is added so that the donors own bone marrow will make and produce more stem cells that will end up in the bloodstream. (differencebetween.net)
- The advantage is that granulocyte- colony-stimulating factor (G-CSF) does not have to be given to the donor since the procedure involves going to the source of the stem cells, which is the bone marrow. (differencebetween.net)
- In the case of a stem cell transplant, granulocyte- colony-stimulating factor has to be given to the donor a few days before the procedure. (differencebetween.net)
- Granulocyte macrophage colony-stimulating factor (GM-CSF) is an immunoregulatory cytokine with a pivotal role in initiation and perpetuation of inflammatory diseases. (ucl.ac.uk)
- Effects of granulocyte/macrophage colony-stimulating factor on the de" by K Takahashi, K Miyakawa et al. (jax.org)
- Effects of granulocyte/macrophage colony-stimulating factor on the development and differentiation of CD5-positive macrophages and their potential derivation from a CD5-positive B-cell lineage in mice. (jax.org)
- Takahashi K, Miyakawa K, Wynn AA, Nakayama KI, Myint YY, Naito M, Shultz LD, Tominaga A, Takatsu K. Effects of granulocyte/macrophage colony-stimulating factor on the development and differentiation of CD5-positive macrophages and their potential derivation from a CD5-positive B-cell lineage in mice. (jax.org)
- Granulocyte-colony stimulating factor is a growth factor (G-CSF) with a plethora of beneficial effects, including neuroprotection. (imedpub.com)
- The aim of the present study was to measure levels of granulocyte-macrophage colony-stimulating factor (GM-CSF) in nasal lavage of patients affected by chronic eosinophilic sinonasal inflammation to clarify the relationship with eosinophilic tissue infiltration and clinical features. (unicatt.it)
- Recent studies indicate that some hematopoietic growth factors, namely granulocyte macrophage colony stimulating factor (GMCSF) and granulocyte colony stimulating factor (GCSF), are abundantly released in the tumor microenvironment and play a key role in regulating tumor-nerve interactions and tumor-associated pain by activating receptors on dorsal root ganglion (DRG) neurons. (biomedcentral.com)
- Stimulation of granulopoiesis by transforming growth factor beta: synergy with granulocyte/macrophage-colony-stimulating factor. (ox.ac.uk)
- Granulocyte-macrophage colony stimulating factor induces both HLA-DR expression and cytokine production by human monocytes. (ox.ac.uk)
- The effect of recombinant human granulocyte-macrophage colony stimulating factor (GM-CSF) on the expression of HLA-DR, and the production of the cytokines interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF alpha) by human peripheral blood monocyte-enriched populations was investigated. (ox.ac.uk)
- Ritodrine therapy was immediately stopped, and she was given an intravenous injection of antibiotics and granulocyte colony-stimulating factor. (hindawi.com)
- We started an intravenous injection of an antibiotic (cefazolin (CEZ) 2 g/day) and intramuscular injection of 75 μ g/body of granulocyte colony-stimulating factor (G-CSF). (hindawi.com)
- Moreover, although interleukin 7 (IL-7) supports the generation of such myeloid intermediates, we show that their developmental branching from the main intrathymic T-cell pathway is linked to the up-regulation of the myelomonocytic granulocyte macrophage-colony-stimulating factor (GM-CSF) receptor, to the down-regulation of the IL-7 receptor and to the lack of pre-T-cell receptor α (pTα) gene transcriptional activation. (ashpublications.org)
- We isolated total CD34 + cells, CD34 + ,CD33 + cells, and CD34 + ,CD33 - cells individually from normal human bone marrow cells by fluorescence-activated cell sorter (FACS), and examined the effects of granulocyte colony-stimulating factor (G-CSF), interleukin-3 (IL-3), and IL-5 on in vitro colony formation of these cells. (elsevierpure.com)
- Interleukin-18 (interferon-gamma-inducing factor) is produced by osteoblasts and acts via granulocyte/macrophage colony-stimulating factor and not via interferon-gamma to inhibit osteoclast formation. (ox.ac.uk)
- IL-18 has been reported to induce interferon-gamma (IFN-gamma) and granulocyte/macrophage colony-stimulating factor (GM-CSF) production in T cells, and both agents also inhibit OCL formation in vitro. (ox.ac.uk)
- Two hematopoietic colony-stimulating factors, granulocyte colony- stimulating factor (G-CSF) and granulocyte-macrophage CSF (GM-CSF), have been shown to accelerate leukocyte and neutrophil recovery after high-dose chemotherapy and autologous bone marrow (BM) support. (johnshopkins.edu)
- The team discovered that 40 of the 62 trials (65%) had unequal rules for dose medication, granulocyte colony-stimulating factor (G-CSF) use, or both. (medscape.com)
- Filgrastim is a recombinant, non-pegylated human granulocyte colony stimulating factor (G-CSF) analogue manufactured by recombinant DNA technology. (janusinfo.se)
- The donor had scheduled a trip to Sri Lanka, and was to return 3 days before the scheduled start of granulocyte-colony-stimulating factor, or G-CSF, application. (cdc.gov)
- In co-cultures of either the murine pre-B cell line J13, fetal liver cells, or adult peritoneal or bone marrow cells with ST2 mouse bone marrow stromal cells in the presence of granulocyte/macrophage colony-stimulating factor (GM-CSF), the development of CD5+ macrophages was demonstrated by immunohistochemical staining and flow cytometry. (jax.org)
- Several types of non-hematopoietic tumors secrete hematopoietic colony stimulating factors, which act on myeloid cells and tumor cells[ 7 ]. (biomedcentral.com)
- CD34 + ,CD33 + cells formed granulocyte colonies in the presence of G-CSF. (elsevierpure.com)
- Both CD34 + ,CD33 + cells and CD34 + ,CD33 - cells formed granulocyte/macrophage colonies in the presence of IL-3. (elsevierpure.com)
- Eosinophil (Eo) colonies were only formed by CD34 + ,CD33 - cells in response to IL-3, but scarcely formed by CD34 + cells in the presence of IL-5. (elsevierpure.com)
- CD34 - ,CD33 + cells derived from CD34 + ,CD33 + cells by preincubation with G-CSF or IL-3 formed Eo colonies in the presence of IL-5 but not IL-3. (elsevierpure.com)
- CD34 - ,CD33 + cells derived from CD34 + ,CD33 - cells by preincubation with IL-3 also formed Eo colonies by support of IL-5 as well as IL-3. (elsevierpure.com)
- Stromal cells exposed to metabolites at these same concentrations were also cultured simultaneously with fresh bone marrow cells in agar to measure the effect on the ability of stromal cells to support growth of granulocyte monocyte colony forming cells. (cdc.gov)
- Trisomy 8+ cells showed a significant positive correlation with apoptotic CD34+ cells and capacity for colony formation. (who.int)
- The essence of MDS is damage of In the current work we examined All our patients were of the high-risk colony-forming units [4], but the defect haematopoietic stem cells of high-risk group and none of them was eligible of the haematopoietic stem cells is not MDS cases for apoptotic and anti-apop- for stem cell transplantation. (who.int)
- the progenitor cell is tentatively designated granulocyte burst-forming unit. (ox.ac.uk)
- In the simultaneous culture system, stromal cell exposure to hydroquinone and benzoquinone produced dose dependent decreases in granulocyte monocyte colonies. (cdc.gov)
- At a concentration of 0.00005mol catechol decreased colony formation 40 percent, but greater concentrations had similar effects. (cdc.gov)
- 1,2,4- Benzenetriol induced a 15 to 35 percent increase in colony formation at a concentration of 0.0000031mol, but further increases in the dose produced colony numbers equal to those for controls. (cdc.gov)
- 1,2,4-Benzenetriol and catechol were not effected at lower doses, but at 0.0001mol they reduced granulocyte monocyte colony formation to 45 and 20 percent of control values, respectively. (cdc.gov)
- 8+ avaient une corrélation positive importante avec les cellules CD34+ apoptotiques et la capacité à stimuler la formation de colonies. (who.int)
- The white blood cell and granulocyte count nadirs were 1,660/ μ l and 438/ μ l. (hindawi.com)
- Morphological examination showed an increase in granulocyte colonies. (ox.ac.uk)
- White blood cells The G-CSF-receptor is present on precursor cells in the bone marrow, and, in response to stimulation by G-CSF, initiates proliferation and differentiation into mature granulocytes. (wikipedia.org)
- It is a glycoprotein , growth factor and cytokine produced by a number of different tissues to stimulate the bone marrow to produce granulocytes and stem cells . (en-academic.com)
- The G-CSF-receptor is present on precursor cells in the bone marrow , and, in response to stimulation by G-CSF, initiates proliferation and differentiation into mature granulocytes . (en-academic.com)
- In this report, we show that biosynthetic (recombinant) human G-CSF enhances colony formation by normal human bone marrow and the human myeloid leukemic cell lines, HL-60 and KG-1, as well as nonhematopoietic small cell lung cancer lines, H128 and H69. (ashpublications.org)
- In all groups, the effect of G-CSF therapy on the survival, the number of the MRSA colonies in the lung, liver, heart, spleen, and peritoneal cultures, the histopathology of the lung, liver, heart and spleen was investigated. (biomedcentral.com)
- Western blot analysis and mouse colony. (karger.com)