Granular cell tumor. Medical search. Frequent questions

Eleven (21.6%) cases showed evidence of cytologic atypia and fulfilled the criteria for a diagnosis of atypical giant cell tumor. (medscape.com)
Early diagnosis prior to surgery is valuable for the distinction of malignant from benign tumor. (opendentistryjournal.com)
Conclusion: Granular cell tumor is a rare tumor of the larynx and should be considered a differential diagnosis in all adult men with long-standing dysphonia. (ucc.edu.ar)
The diagnosis of pituitary adenoma is usually straightforward on H&E stained sections, which readily identify the monomorphic adenoma cell population. (cap.org)
Reporting more detailed histologic data can help clarify the biology of this tumor and aid in its histopathologic diagnosis. (thejcdp.com)
Tumour classification systems provide the foundation for tumour diagnosis and patient therapy and a critical basis for epidemiological and clinical studies. (ersjournals.com)
Hemoptysis, while uncommon, more often occurs with a squamous cell carcinoma and can potentially lead to earlier diagnosis, whereas wheezing or stridor occurs more often with the adenoid cystic variant. (msdmanuals.com)

These tumors, on occasion, may appear similar to neoplasms of renal (relating to the kidneys) origin or other soft tissue neoplasms. (wikipedia.org)
Objectives Granular cell tumors are rare neoplasms of neural origin. (medscape.com)
Introduction and importance: Granular cell tumors (GCT) are rare neoplasms. (ucc.edu.ar)
Odontogenic tumors, including odontogenic myxomas (OMs) are regarded as rare neoplasms in the human body. (thejcdp.com)

These lesions characteristically consist of polygonal cells with bland nuclei, abundant cytoplasm and fine eosinophilic cytoplasmic granules. (wikipedia.org)
Granular cell tumors are uncommon lesions, although the head and neck region accounts for approximately 50% of all lesions. (medscape.com)
Granular cell tumors are slow-growing lesions (0.5-1 mm per year) that are neither painful nor tender. (medscape.com)
For many years, these lesions were referred to as granular cell myoblastoma. (medscape.com)
We present the largest case series to date comprising 50 patients with benign and atypical soft tissue granular cell tumors in an effort to better define the pathologic features in this subset of lesions. (medscape.com)
Granular cell tumors (GCTs) are rare lesions believed to be of neural origin. (medscape.com)
Odontogenic tumors and allied lesions. (thejcdp.com)
Genotyping of 69 histiocytic lesions revealed that 23/48 Langerhans cell lesions were BRAF -V600E-mutant whereas all non-Langerhans cell lesions (including dendritic cell sarcoma, juvenile xanthogranuloma, Rosai-Dorfman disease, and granular cell tumor) were wild-type. (oncotarget.com)
In conclusion, BRAF mutations in histiocytic proliferations are restricted to lesions of the Langerhans-cell type. (oncotarget.com)
A review of the literature reveals only a few reports of this tumor, and there has been scanty discussion of the imaging findings of posterior pituitary astrocytomas compared with lesions of the anterior pituitary gland. (ajnr.org)
In addition of the categories of squamous dysplasia and carcinoma in situ , two additional lesions were added to the group of pre-invasive lesions: atypical adenomatous hyperplasia (AAH) and diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH). (ersjournals.com)

The granular cell tumor is characterized by the presence of sheets or clusters of plump, polygonal cells with a granular cytoplasm. (medscape.com)
Congenital epulis also contains sheets and/or clusters of plump cells with a granular cytoplasm and rounded or oval nuclei. (medscape.com)
Histopathologic evaluation showed sheets and nests of cells with abundant eosinophilic and granular cytoplasm in a uniform distribution throughout the lesion. (johnshopkins.edu)
There were foci of eosinophilia, stellate cytoplasm, and occasional gemistocytic morphology, and many cells were positive for glial fibrillary acidic protein (GFAP). (ajnr.org)
The tumor cells have abundant pale eosinophilic or amphophilic granular or vacuolated cytoplasm. (webpathology.com)

These cells generally are uniform and do not exhibit significant atypical features. (medscape.com)
Conclusions Compared with granular cell tumors overall, the soft tissue subset shows a larger average size and higher propensity for incomplete resections, with atypical features being relatively common. (medscape.com)
A granular cell tumor that arises from a peripheral nerve and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. (beds.ac.uk)
atypical adenomatous hyperplasia and diffuse idiopathic pulmonary neuroendocrine cell hyperplasia. (ersjournals.com)

It is also known as Abrikossoff's tumor, granular cell myoblastoma, granular cell nerve sheath tumor, and granular cell schwannoma. (wikipedia.org)
Granular cell tumors of the tongue: fibroma or schwannoma. (harvard.edu)
A statistically significant increased risk for ipsilateral use of mobile phones, the same side of the brain as the phone was used, was published for malignant brain tumors ( 4 ) and vestibular schwannoma ( 5 ). (spandidos-publications.com)

Caltabiano R, Cappellani A, Di Vita M, Lanzafame S. The unique simultaneous occurrence of a squamous cell carcinoma and a granular cell tumor of the tongue at the same site: a histological and immunohistochemical study. (medscape.com)
When it develops beneath the epidermis or mucous membrane, it can lead to proliferation of the squamous cells and mimic squamous cell carcinoma. (uchicago.edu)
[ 2 ] Granular cell tumor with an overlying squamous cell carcinoma has been reported. (medscape.com)
Nasopharyngeal carcinomas (NPC) are non-keratinizing squamous cell carcinomas of the nasopharynx associated with Epstein-Barr virus (EBV). (researchgate.net)
Other forms of cancer that can cause a bump in the tongue include squamous cell carcinoma, mast cell tumor and a granular cell tumor. (petcarerx.com)
Squamous cell carcinomas tend to metastasize to regional lymph nodes and directly invade mediastinal structures, leading to high local and regional recurrence rates. (msdmanuals.com)

Breast granular cell tumors arise from intralobular breast stroma and occurs within the distribution of the cutaneous branches of the supraclavicular nerve. (wikipedia.org)
List of cutaneous conditions Glassy cell carcinoma Rapini, Ronald P. (wikipedia.org)
Childhood cutaneous Abrikossoff tumor]. (medscape.com)
Cutaneous clear-cell granular cell tumors: the histologic description of an unusual variant. (uchicago.edu)

Granular cell tumors (GCTs) affect females more often than males. (wikipedia.org)
GCTs of the soft tissue are rare and not well characterized, representing only 0.5% of all soft tissue tumors. (medscape.com)
Granular Cell Tumors (GCTs) of the orbit are rare-entity soft-tissue tumors, and few reports have been published in the literature. (opendentistryjournal.com)

Malignant granular cell tumor (MGCT) is a high-grade mesenchymal tumor of Schwann cell origin. (newhopemedicalcenter.com)
Mesenchymal tumors include structures arising from mesodermal-derived precursor cells that develop into cartilage, bone, or other connective tissues. (newhopemedicalcenter.com)
Despite the mesenchymal nature of these tumors, they rarely occur in the soft tissue, and as a result, this subset is not well characterized. (medscape.com)

Tumors of the soft tissues composed of large eosinophilic cells. (beds.ac.uk)

In 1926, Abrikossoff first described granular cell tumors. (medscape.com)
Granular cell tumor (Abrikossoff tumor) of the clitoris. (lvhn.org)

Granular cell tumors are derived from neural tissue, as can be demonstrated by immunohistochemistry and ultrastructural evidence using electron microscopy. (wikipedia.org)
Malignant granular cell tumor of soft tissue: diagnostic criteria and clinicopathologic correlation. (wikipedia.org)
Granular cell tumor (GCT) is a rare soft tissue neoplasm of Schwann cell origin. (usp.br)
The granular cell tumor (GCT) is an uncommon benign neoplasm of soft tissue. (bvsalud.org)
Methods All cases of soft tissue granular cell tumors from the Ohio State Medical Center and the Medical College of Wisconsin over a 10-year period were reviewed for histologic and clinical findings. (medscape.com)
Our findings suggest that soft tissue granular cell tumors may be slightly more aggressive than their dermal or organ-confined counterparts. (medscape.com)
The technique of placing cells or tissue in a supporting medium so that thin sections can be cut using a microtome. (harvard.edu)
Cell and Tissue Display: An Alternative Multipurpose Tool for Microscopy. (harvard.edu)
A non-cancerous (benign) soft tissue tumour is a growth that does not spread (metastasize) to other parts of the body. (cancer.ca)
They are grouped by the type of soft tissue where the tumour started. (cancer.ca)
Lipoma is the most common type of non-cancerous soft tissue tumour. (cancer.ca)
Desmoid-type fibromatosis is a soft tissue tumour that is usually non-cancerous. (cancer.ca)
Hemangioma is a common non-cancerous soft tissue tumour caused by an abnormal buildup of blood vessels. (cancer.ca)
Soft tissue sarcoma is a disease in which malignant (cancer) cells form in the soft tissues of the body. (dana-farber.org)
It starts in bone cells that make new bone tissue. (dana-farber.org)
Ewing tumors are most common in bone but can also form in soft tissue. (dana-farber.org)
Betatrophin is a newly characterized circulating hormone that is produced in tissue such as for example adipose tissues and liver organ and stimulates pancreatic beta-cell proliferation. (acancerjourney.info)
P-selectin, soluble endothelial protein C receptor, soluble thrombomodulin, plasminogen activator inhibitor 1, ADAMTS-13, von Willebrand factor, tissue factor, soluble intercellular adhesion molecule 1, and vascular cell adhesion molecule 1 were more elevated in LF patients than in controls. (cdc.gov)
Pathologic changes seen on autopsy lack major cell and tissue injury but include signs of pleural effusion, pulmonary edema, ascites, and gastrointestinal mucosa bleeding ( 5 , 6 ), all indications of systemic vascular leakage. (cdc.gov)
Acute leukopenia, with almost total absence of granular leukocytes, leukoblastic groups and lymphoid tissue in the bone marrow, was reported in the case of a 36-year-old chemist who had worked with radium for 14 years (Reitter and Martland 1926). (cdc.gov)

There is also a cancerous type of glomus tumour called malignant glomus tumour. (cancer.ca)

Malignant granular cell tumors are extremely uncommon, accounting for less than 2% of granular cell tumors. (medscape.com)
Oral granular cell tumor is too uncommon to accurately assess an incidence rate. (medscape.com)

Oral granular cell tumors: a clinicopathologic and immunocytochemical study. (medscape.com)
Freitas VS, dos Santos JN, Oliveira MC, Santos PP, Freitas Rde A, de Souza LB. Intraoral granular cell tumors: clinicopathologic and immunohistochemical study. (medscape.com)

Primitive non-neural granular cell tumour (PNGCT) is a rare tumour of uncertain lineage. (bmj.com)
Myxoma, the tumor of primitive mesenchyme. (thejcdp.com)

Benign granular cell tumors have a recurrence rate of 2% to 8% when resection margins are deemed clear of tumor infiltration. (wikipedia.org)
While extensive surgery is not indicated, recurrence of granular cell tumors has been reported several years after removal. (medscape.com)

A third transcription factor, pituitary cell-restricted T box factor (Tpit), drives corticotroph adenomas but its antibody is not yet commercially available as an IHC marker. (cap.org)
The majority of previously classified "null cell" adenomas - negative for all hormonal markers - are now recognized as SF1 - driven and therefore would be classified as gonadotroph adenomas. (cap.org)
Pleomorphic adenomas and granular cell and benign cartilaginous tumors also occur. (msdmanuals.com)

Viable and necrotic tumor assessment from whole slide images of osteosarcoma using machine-learning and deep-learning models. (utsouthwestern.edu)

Pseudoepitheliomatous hyperplasia, a frequent finding in granular cell tumors, generally is not present over the congenital epulis. (medscape.com)

A somewhat similar lesion, congenital epulis, occurs less frequently than the granular cell tumor and occurs on the alveolar ridge of newborns. (medscape.com)
Treatment for granular cell tumors and congenital epulis is surgery. (medscape.com)
however, congenital epulis is negative for S-100 and other markers found in the granular cell tumor. (medscape.com)
Congenital epulis (CE) is a rare benign tumor that arises from the gum pads of neonates especially on the anterior maxillary regions and in females. (ispub.com)
Congenital epulis also called congenital granular cell tumour of the newborn is a rare benign gingival cell tumor that most commonly occurs along the anterior alveolar ridges of a neonate. (ispub.com)
Congenital epulis (CE) is a rare benign gingival tumor that occurs on the gum pads of a neonate. (ispub.com)

The etiology of oral granular cell tumors is unknown. (medscape.com)
Etiology Human papillomavirus (HPV) infects epithelial cells. (msdmanuals.com)

Malignant granular cell tumors, which fortunately are rare, may have a very benign histologic appearance. (medscape.com)
Histologic evaluation of the excised breast mass revealed a benign granular cell tumor. (usp.br)

Vered M, Carpenter WM, Buchner A. Granular cell tumor of the oral cavity: updated immunohistochemical profile. (medscape.com)
Granular-cell tumours: an immunohistochemical study. (medscape.com)
Granular cell tumor: immunohistochemical assessment of inhibin-alpha, protein gene product 9.5, S100 protein, CD68, and Ki-67 proliferative index with clinical correlation. (medscape.com)
PD-L1 Antibodies to Its Cytoplasmic Domain Most Clearly Delineate Cell Membranes in Immunohistochemical Staining of Tumor Cells. (harvard.edu)
Large cell neuroendocrine carcinoma (LCNEC) is now recognized as a histologically high grade non small cell carcinoma showing histopathological features of neuroendocrine differentiation as well as immunohistochemical neuroendocrine markers. (ersjournals.com)

Granular Cell Tumor of the Orbit: Review of the Literature and a Proposed Treatment Modality. (beds.ac.uk)

Granular cell tumor is a tumor that can develop on any skin or mucosal surface, but occurs on the tongue 40% of the time. (wikipedia.org)
Clinical photograph of a granular cell tumor on the tongue of a 38-year-old man. (medscape.com)
Approximately 70% of oral granular cell tumors occur in the tongue. (medscape.com)
GCT is usually a slow-growing, painless tumor involving the skin and soft tissues that is mostly located in the head and neck region, especially the tongue. (usp.br)
Granular cell tumor of the tongue in a 6-year-old girl--a case report. (medscape.com)
Dive A, Dhobley A, Fande PZ, Dixit S. Granular cell tumor of the tongue: Report of a case. (medscape.com)
Granular cell tumor of the tongue (Abrikossoff's tumor). (minervamedica.it)

was described our hospital for even more administration of tumor that was diagnosed, histopathologically, simply because low quality glioma. (acancerjourney.info)

Our study group has since the end of the 1990s published results from case-control studies on use of wireless phones and brain tumor risk ( 3 ). (spandidos-publications.com)
Pediatric Brain Tumor Cancer Stem Cells: Cell Cycle Dynamics, DNA Repair, and Etoposide Extrusion. (worthington-biochem.com)

Objective: Laryngeal verrucous carcinoma (LVC) comprises 1% to 4% of all laryngeal tumors. (researchgate.net)
may give rise to cancer cell growth within the dut, known as ductal carcinoma in situ (DCIS). (brainscape.com)
Secretory carcinoma of the breast is a rare tumor that was initially described in children but the majority of cases have been reported in adults. (webpathology.com)
Secretory carcinoma of breast may be related to acinic cell carcinoma of salivary glands . (webpathology.com)
The large cell carcinoma class has been enriched with several variants, including the LCNEC and the basaloid carcinoma, both with a dismal prognosis. (ersjournals.com)
As compared to the previous edition, changes include a better definition of pre-invasive lesion, a reclassification of adenocarcinoma, the description of two new tumour types as variants of large cell carcinoma, large cell neuroendocrine carcinoma (LCNEC) and basaloid carcinoma, and a new class called pleomorphic carcinoma. (ersjournals.com)

Granular cell tumors occur more commonly in blacks than in whites. (medscape.com)
Granular cell tumors occur twice as frequently in females than in males. (medscape.com)

Treatment of benign esophageal tumors by endoscopic techniques. (uchicago.edu)

Unlike traditional breast cancers, granular cell tumors are mostly found in the upper inner quadrant of the breast. (wikipedia.org)
Colorectal cancers are one of the most prevalent tumour types worldwide and, despite the emergence of targeted and biologic therapies, have among the highest mortality rates. (researchgate.net)
The airway can be affected by primary tracheobronchial tumors, primary tumors that are adjacent to and invade or compress the airway, or cancers that metastasize to the airway. (msdmanuals.com)

In cases where the patient comes to surgery after long-term dopamine agonist therapy, stromal fibrosis and cytoplasmic shrinkage causing the cells to resemble lymphocytes may be evident. (cap.org)
Natural killer cells are large granular lymphocytes capable of killing tumor cells and certain virally infected cells in a manner not restricted by the major histocompatibility complex (MHC). (lu.se)

An orbitotomy with complete excision of the tumor was performed. (johnshopkins.edu)

It is a relatively indolent tumor with an excellent overall prognosis . (webpathology.com)

Primary airway tumors should be treated definitively with surgical resection if possible. (msdmanuals.com)

Vaginal granular cell tumors are generally rare. (wikipedia.org)
Malignancy is rare and constitutes only 2% of all granular cell tumors. (wikipedia.org)
The authors report the echographic characteristics of a rare orbital granular cell tumor and correlate these findings with histopathology. (johnshopkins.edu)
1 2 3 4 5 The tumor is very rare and was described for the first time by Neumann in 1871and so is also called Neumann's tumor. (ispub.com)
Summary: Astrocytoma, or pituicytoma, of the posterior pituitary is a relatively rare entity consisting of poorly characterized glial tumor cells. (ajnr.org)
Elastofibroma is a rare non-cancerous tumour that grows slowly. (cancer.ca)
Rhabdomyoma is a rare non-cancerous tumour that starts in skeletal muscle. (cancer.ca)
Primary tracheal tumors are rare. (msdmanuals.com)

Microscopically, section shows spindle cell proliferation. (omicsonline.org)

Granular cell tumor of uncertain malignant potential. (uchicago.edu)

Both malignant and benign versions of the tumor exist, where malignant tumors are characterized histologically by features such as spindling, high nuclear to cytoplasmic ratios, pleomorphism, and necrosis. (wikipedia.org)

Granular cell tumors are typically solitary and rarely larger than three centimeters. (wikipedia.org)

The patient underwent a second TSS, and histology of the specimen revealed neoplastic proliferation of astrocytes and spindle-shaped cells with fascicles. (ajnr.org)

The head and neck region accounts for approximately 45-65% of all sites for granular cell tumors. (medscape.com)
Unusual tumor affecting any site of the body, but most often encountered in the head and neck. (uchicago.edu)
Peripheral Nerve Sheath Tumors of Head and Neck: Imaging-Based Review of World Health Organization Classification. (beds.ac.uk)

Differentiation impairs low pH-induced Ca2+ signaling and ERK phosphorylation in granule precursor tumour cells. (ox.ac.uk)
We have recently shown that in human granule precursor tumour cells a fall in extracellular pH triggers increases in intracellular Ca(2+) concentration through activation of G-protein coupled proton-sensing receptors coupling to phospholipase C. This pH-dependent rise in cytosolic Ca(2+) led to activation of the extracellular signal-regulated kinase ERK, providing a mechanistic explanation of how extracellular acidification can promote tumour growth. (ox.ac.uk)
We now find that differentiation of granule precursor tumour cells profoundly affects their ability to respond to extracellular acidification with gene transcription. (ox.ac.uk)

Most primary airway tumors are not resectable because of metastasis, locally advanced stage, or patient comorbidities. (msdmanuals.com)

Granular cell tumors now generally are accepted as being of neural origin, either Schwann cell or neuroendocrine. (medscape.com)

There has been substantial evolution of concepts in neuroendocrine lung tumour classification. (ersjournals.com)

A similar molecular genetic abnormality has been found in both tumors - a recurrent balanced chromosomal translocation, t(12;15)(p13;q25) , which leads to the formation of ETV6-NTRK3 fusion gene. (webpathology.com)

However, proliferative growth and development of an ulcer indicates likely malignancy as this type of tumor can be either benign or malignant. (wikipedia.org)
Malignancy is limited to approximately 1-2% of all granular cell tumors. (medscape.com)

Ewing sarcoma includes several types of bone tumors. (dana-farber.org)

Anatomy1

Diseases12

Chemicals and Drugs1

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Disciplines and Occupations1

Diagnosis7

Neoplasms4

Lesions11

Cytoplasm5

Atypical4

Schwannoma3

Squamous6

Cutaneous4

GCTs3

Mesenchymal3

Eosinophilic1

Abrikossoff2

Tissue20

Glomus1

Uncommon2

Clinicopathologic2

Primitive2

Recurrence2

Adenomas3

Osteosarcoma1

Hyperplasia1

Congenital epulis6

Etiology2

Histologic2

Immunohistochemical5

Orbit1

Tongue7

Glioma1

Brain tumor2

Carcinoma6

Occur2

Endoscopic1

Cancers3

Lymphocytes2

Excision1

Prognosis1

Resection1

Rare8

Spindle cell1

Malignant potential1

Necrosis1

Solitary1

Proliferation1

Head and neck3

Precursor3

Metastasis1

Neural origin1

Neuroendocrine1

Abnormality1

Malignancy2

Bone1