4-aminosalicylic acid has also been used in the treatment of inflammatory bowel disease (ulcerative colitis and Crohn's disease), but has been superseded by other drugs such as sulfasalazine and mesalazine. (wikipedia.org)
The usual oral dose of sulfasalazine for active ulcerative colitis in adults is two to four grams per day in divided doses. (nih.gov)
Sulfonamides with 5-aminosalicyclic acid are the structural components of sulfasalazine, which is widely used for long term management of inflammatory bowel disease. (nih.gov)
Background : Sulfasalazine, consisting of 5-aminosalicylic acid bound to sulfapyridine by a diazo bond, was first used for treatment of ulcerative colitis within the early Nineteen Forties and later discovered efficient in placebo-managed trials for acute illness and for long-time period maintenance of remission. (page.tl)
Ulcerative colitis4
Mucosal production of arachidonic acid (AA) metabolites, both through the cyclooxygenase pathways, i.e., prostanoids, and through the lipoxygenase pathways, i.e., leukotrienes (LTs) and hydroxyeicosatetraenoic acids (HETEs) is increased in patients with ulcerative colitis, and it is possible that mesalamine diminishes inflammation by blocking cyclooxygenase and inhibiting prostaglandin (PG) production in the colon. (nih.gov)
Background: On this research we examine the prices and benefits of topical mesalazine mixed with oral mesalazine therapy for active ulcerative colitis (UC), and once every day (OD) mesalazine 2 grams versus twice every day (BID) for sustaining UC remission. (page.tl)
The recommended adult dose of Asacol in the treatment of active ulcerative colitis is 2.4 grams per day (2 tablets of Asacol three times a day) for 6 weeks. (closerpharmacy.com)
To maintain remission of mildly to moderately active ulcerative colitis, the recommended dose of Asacol is 1.6 grams per day. (closerpharmacy.com)
Activity against both gram-positive2
Sulfonamides have a wide range of antimicrobial activity against both gram-positive and -negative organisms. (nih.gov)
Methods & results: 21 mafenide-based compounds were prepared via condensation reactions and screened for antimicrobial efficacy, which demonstrated promising activity against both Gram-positive and Gram-negative pathogens, pathogenic fungi and mycobacterial strains (minimum inhibitory concentrations from 3.91 µM). (bvsalud.org)
The active ingredient in sfROWASA ® (mesalamine) Rectal Suspension, a disposable (60 mL) unit, is mesalamine, also known as 5-aminosalicylic acid (5-ASA). (nih.gov)
Each rectal suspension unit contains 4 grams of mesalamine. (nih.gov)
Production of arachidonic acid2
it is also a potent COX inhibitor, and this action may decrease local production of arachidonic acid-derived chemotactic factors for eosinophils present in sebum. (medscape.com)
Metabolites of drug may decrease inflammation by blocking the production of arachidonic acid metabolites in colon mucosa. (medscape.com)
Folic3
4-Aminosalicylic acid is believed to work by blocking the ability of bacteria to make folic acid. (wikipedia.org)
They are considered bacteriostatic and appear to act by inhibition of bacterial biosynthesis of folic acid, which is needed for cell growth, at least in those bacteria that are sensitive to sulfonamides. (nih.gov)
Because humans rely upon dietary folic acid, they are usually resistant to the adverse effects of inhibition of folate synthesis. (nih.gov)
Dose3
the usual adult dose is therefore approximately 2 to 4 grams four times a day. (wikipedia.org)
One woman who was lactating, but not breastfeeding (time postpartum not stated) took a single 4 gram oral dose of aminosalicylic acid. (nih.gov)
The maximum pediatric dose should not exceed 2.4 grams per day. (closerpharmacy.com)
ETHYL1
cited above, employ a method of synthesizing mPEG carboxylic acids which comprises converting mPEG-OH to an ethyl ester of mPEG carboxylic acid, by base-catalyzed reaction of mPEG-OH with an a-halo ethyl ester, followed by base-promoted hydrolysis of the ester. (allindianpatents.com)
It was initially thought that resistance of 4-aminosalicylic acid came from a mutation affecting dihydrofolate reductase (DHFR). (wikipedia.org)
Ninety-three percent of atypical XDR Beijing diagnosis of 594 extensively drug- resistant (XDR) TB isolates had mutations that confer resistance to 10 anti-TB cases (MDR plus additional resistance to a fluoroquino- drugs, and some isolates also were resistant to para -ami- nosalicylic acid. (cdc.gov)
Mtb is an aerobic bacillus with high lipid content in its cell wall, resulting in high lipophilicity and resistance to alcohol, acids, alkali, and certain disinfectants. (ajgreenchem.com)
Bacterial1
Balsalazide is a prodrug that is converted into 5-aminosalicylic acid through bacterial azo reduction. (medscape.com)
Purity1
However, this approach provides mPEG acids of only about 85% purity, with the main contaminant being mPEG-OH, which cannot be separated from the mPEG carboxylic acid using typical purification methods such as precipitation, crystallization or extraction. (allindianpatents.com)
Bacilli2
Acid-fast bacilli (AFB) smear and culture using sputum obtained from the patient. (medscape.com)
Definite TB is considered in patients with culture or molecular line probe assay positive for Mycobacterium tuberculosis , or in patients with at least 1 sputum smear positive for acid-fast bacilli. (mims.com)
Doses1
Adults: 1.6 grams (four 400 mg capsules) daily, in two to four divided doses. (nih.gov)
Acetone2
It does not react with acetone or b‑hydroxybutyric acid. (meditests.com)
Ketone bodies such as acetoacetic acid, beta-hydroxybutyric acid, and acetone can appear in urine in small amounts. (meditests.com)
Esters3
In particular, active esters and other carboxylic acid derivatives of PEG have been used to attach PEG to proteins bearing amino groups. (allindianpatents.com)
Accordingly, these tertiary alkyl esters are conventionally cleaved with acid, typically with TFA. (allindianpatents.com)
Each gram of lidocaine and prilocaine cream, 2.5%/2.5% contains lidocaine 25 mg, prilocaine 25 mg, polyoxyethylene fatty acid esters (as emulsifiers), carbomer 934 (as a thickening agent), sodium hydroxide to adjust to a pH approximating 9, and purified water. (nih.gov)
Tuberculosis4
4-Aminosalicylic acid, also known as para-aminosalicylic acid (PAS) and sold under the brand name Paser among others, is an antibiotic primarily used to treat tuberculosis. (wikipedia.org)
The main use for 4-aminosalicylic acid is for the treatment of tuberculosis infections. (wikipedia.org)
In the United States, 4-aminosalicylic acid is indicated for the treatment of tuberculosis in combination with other active agents. (wikipedia.org)
Aminosalicylic acid was used as part of multi-drug regimens to treat 2 pregnant women with multidrug-resistant tuberculosis throughout pregnancy and postpartum. (nih.gov)
at Detroit, Mich. SHIPPED : Between 5-22-59 and 6-4-59, from Auburn, Mass., by Cowley Phar- maceuticals, Inc. LABEL IN PART: "1,000 Tablets Salamin Sodium Each Tablet Contains: Sodium Para-Aminosalicylic Acid 0.5 grams (7.72 grains). (nih.gov)
United States Pharmacopeia requires sodium para- ammosalicylic acid tablets to contain from 95 to 105 percent of labeled amount of the drug. (nih.gov)
502(a)-the label statement "Each tablet contains: Sodium Para- Aminosalicylic Acid 0.5 grams (7.72 grains)" was false and misleading. (nih.gov)
Alcohol1
5,278,303, 5,605,976 and 5,681,567 report the preparation of PEG carboxylic acids containing little or no starting material (PEG alcohol) by employing a tertiary alkyl haloacetate to prepare a tertiary alkyl ester-fonctionalized PEG, which is then hydrolyzed with acid, preferably trifluoroacetic acid (TFA). (allindianpatents.com)
Clinical1
Aminosalicylic acid was introduced to clinical use in 1944. (wikipedia.org)
Adverse effects1
Limited information indicates that maternal aminosalicylic acid therapy produces low levels in milk and would not be expected to cause any adverse effects in breastfed infants, especially if the infant is older than 2 months. (nih.gov)
Carbon1
Mtb has a complex cell wall made up of mycolic acids (long-chain fatty acids with 60 to 90 carbon atoms), glycolipids, peptidoglycan, and proteins. (ajgreenchem.com)
Patients1
Patients with glucose-6-phosphate dehydrogenase deficiency should avoid taking aminosalicylic acid as it causes haemolysis. (wikipedia.org)
Amounts1
PEG carboxylic acids obtained commercially frequently contain residual amounts of PEG-OH, which complicates the preparation of derivatives or bioconjugates based on these materials. (allindianpatents.com)
Avoid1
Also, avoid ingredients such as para-aminosalicylic acid and Benzocaine and procaine, which are also used as local anesthetics. (dermanities.com)
Made1
4-Aminosalicylic acid was first made in 1902, and came into medical use in 1943. (wikipedia.org)
Salt1
Typically, this carboxylate salt is then treated with an inorganic acid in aqueous solution, to convert the carboxylate salt to a carboxylic acid, thereby forming a carboxylic acid functionalized polymer. (allindianpatents.com)