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PseudomonasPathogenicVibrioQuorum SensingSignaling moleculesOuter membrane vesiclesBiofilmsVirulencePredominantHomoserine lactonesAeruginosaEscherichiaBiofilm formationMicroorganismsBehaviorsGenesAntibacterialPenicillinSpeciesAbstractHost-bacteriaSecretionArchaeaSignalsExtracellularEnvironmentsAutoinducerSynergisticAdherenceAHLsEnterobacteriaceaeDiffuseBehaviorRESISTANCEEncounterMicrobiomePercentageFoundAntibioticStrainSurfacesFunctionalMolecularCellCommunicateFindings

Pseudomonas7

• N -acylhomoserine lactone (AHL)-mediated quorum sensing (QS) tightly regulates the expression of multiple virulence factors in the opportunistic pathogenic bacterium Pseudomonas aeruginosa . (nature.com)
• Research in the Paczkowski laboratory focuses on the mechanisms of regulation of quorum sensing (QS) in Gram-negative bacteria, such as Pseudomonas aeruginosa , Vibrio cholerae , Aeromonas hydrophila , and Chromobacterium violaceum . (wadsworth.org)
• However, no inhibition of viability was observed against Gram-negative bacteria Acinetobacter baumannii, Escherichia coli, and Pseudomonas aeruginosa, showing that etrasimod preferably acts against Gram-positive bacteria. (helsinki.fi)
• One of the potent isolate, SJ4 was identified as Pseudomonas stutzeri SJ4, it is a short rod, gram negative bacterium. (jmbfs.org)
• see Merry's post on ly-so-ge-ny in STC - are induced for propagation via SdiA-sensing of AHLs that were either produced by co-cultivated Pseudomonas bacteria or deliberately added to a pure culture. (asmblog.org)
• Pseudomonas aeruginosa is a gram-negative bacterium predominant in soil, vegetation, and water. (usp.br)
• Pseudomonas aeruginosa é uma bactéria gram-negativa predominante no solo, vegetação e água. (usp.br)

Pathogenic6

• S. gordonii is a major cause of dental plaque and its adherence is essential for many other pathogenic bacteria to also adhere to teeth. (wikipedia.org)
• The topics covered are multidisciplinary and wide-ranging,and includes quorum sensing phenomenon in pathogenic bacteria, food spoilers, and agriculturally relevant bacteria. (taylorfrancis.com)
• The infamous gram-negative pathogenic bacteria Vibrio cholerae uses quorum sensing for virulence during a cholera infection. (asm.org)
• The disruption of quorum sensing mechanism can be a solution to the emerging problem of multi-drug resistance among pathogenic bacteria. (jmbfs.org)
• IBN110 in the control of AHL-producing pathogenic bacteria. (elsevierpure.com)
• Gram-negative plant pathogenic bacteria regulate specific gene expression in a population density-dependent manner by sensing level of Acyl-Homoserine Lactone (HSL) molecules which they produce and liberate to the environment, called Quorum Sensing (QS). (pestinfo.org)

Vibrio5

• AI-2 was first discovered in the light producing system of the bacteria Vibrio harveyi. (wikipedia.org)
• The structure-activity relationships (SARs) were probed in various Gram-negative bacteria, including P. aeruginosa and Vibrio harveyi, indicating that the pyrrolinone-N acyl chain is critical for full agonist activity, while the other acyl chain is dispensable or can result in antagonist activity, depending on the bacterial system. (figshare.com)
• Genom att studera symbiosförhållandet mellan bläckfisken Euprymna scolope och bakterien Vibrio fisheri, ökade förståelsen kring hur celldensiteten hos bakterierna ledde till det aktiverade gensvaret, vilket visade sig i en självlysande förmåga hos den typen av bakterier. (slu.se)
• This understanding was developed by studying the symbiosis relationship between the squid Euprymna scoloes and the bacterium Vibrio fisheri. (slu.se)
• For example, Escherichia coli - and likewise its Sal-mo-nel-la cousins - lacks a homolog of the Vibrio fischeri LuxI synthetase for the common au-to-in-du-cer in Gram-negative bacteria, N-acyl homoserine lactone ( AHL ). (asmblog.org)

Quorum Sensing21

• Interspecies quorum sensing is a type of quorum sensing in which bacteria send and receive signals to other species besides their own. (wikipedia.org)
• It has been discovered that bacteria can not only interact via quorum sensing with members of their own species but that there is a kind of universal molecule that allows them to gather information about other species as well. (wikipedia.org)
• The book on Trends in Quorum Sensing and Quorum Quenching: New Perspectives and Applications focuses on the recent advances in the field of quorum sensing in bacteria and the novel strategies developed for quorum sensing inhibition. (taylorfrancis.com)
• Overview of how quorum sensing works in bacteria. (asm.org)
• Biofilm production comes to a simultaneous halt across all V. cholerae bacteria, and a new sequence of quorum sensing moves V. cholerae through its infectious process. (asm.org)
• Quorum sensing är bakteriers förmåga att kommunicera med varandra och ger dem möjligheten att uppvisa en form av multicellularitet. (slu.se)
• Men det krävs vidare forskning och en djupare förståelse för hur quorum sensing kan användas som måltavla för läkemedel på ett säkert sätt för patienten och miljön innan det kommer tas i bruk. (slu.se)
• Quorum sensing is the ability of bacteria to communicate with each other and thereby exhibit a form of multicellularity. (slu.se)
• Bacteria both produce and sense signals about these density-dependent conditions in a process called quorum sensing. (umass.edu)
• Chapter 1 provides an introduction to the mechanisms utilized by bacteria referred to as quorum sensing. (umass.edu)
• Besides signaling molecules affecting phytohormone regulons or other secondary metabolites with e.g. antibiotic activities, N-acyl homoserine lactones, which are widely found in Gram-negative bacteria as quorum sensing compounds, have profound effects on plant development and systemic resistance. (iobc-wprs.org)
• On the other hand, etrasimod was shown to inhibit quorum sensing (QS) signaling in Chromobacterium violaceum, suggesting that it may block the biofilm formation by targeting QS in certain Gram-negative bacteria. (helsinki.fi)
• How bacteria talk to each other: regulation of gene expression by quorum sensing. (microbiologyresearch.org)
• Quorum sensing plays a crucial role in the virulence nature of P. aeruginosa as it helps the bacteria to produce virulence factors and biofilm formation. (ijpsr.com)
• Bacteria within a biofilm communicate by quorum sensing leading to phenotypic modifications and changes in gene expression. (thepigsite.com)
• Rhodobacter sphaeroides 2.4.1 is a Gram negative facultative photoheterotrophic bacterium that has been shown to have an N-acyl homoserine lactone-based quorum sensing system called cer for community escape response. (uth.edu)
• Quorum sensing is the mechanism bacteria use to communicate and act in groups. (asmblog.org)
• His work in Quorum sensing tackles topics such as Gram-negative bacteria which are related to areas like Cell biology and Stress resistance. (research.com)
• Quorum sensing is a signalling mechanism that controls diverse biological functions, including virulence, via N-acylhomoserine lactone (AHL) signal molecules in Gram-negative bacteria. (elsevierpure.com)
• With the aim of isolating strains or enzymes capable of blocking quorum sensing by inactivating AHL, bacteria were screened for AHL degradation by their ability to utilize N-3-oxohexanoyl-L-homoserine lactone (OHHL) as the sole carbon source. (elsevierpure.com)
• Acylated homoserine lactones (AHLs) are self-generated signal molecules that mediate population density-dependent gene expression (quorum sensing) in a variety of Gram-negative bacteria. (unibas.it)

Signaling molecules1

• This is accomplished by the secretion of signaling molecules which trigger a response in nearby bacteria at high enough concentrations. (wikipedia.org)

Outer membrane vesicles2

• Scientists have described the utility of gram-negative bacteria-derived outer membrane vesicles as vaccines and methods to expand their applications. (news-medical.net)
• MVs are released from the outer membrane of bacterial cells, such as outer membrane vesicles (OMVs) from Gram-negative bacteria, and from the cytoplasmic membrane of cells, such as MVs from Gram-positive bacteria. (nature.com)

Biofilms5

• However, if either one of the bacteria has the LuxS gene they can form biofilms suggesting again this molecule is used for communication between unrelated species. (wikipedia.org)
• Bacteria have evolved multiple strategies for causing infections that include producing virulence factors, undertaking motility, developing biofilms and invading host cells. (nature.com)
• Biofilms are a mixture of complex communities of organisms mostly composed of diverse bacteria that vary depending on the surrounding environmental conditions induced by physical and chemical factors. (intechopen.com)
• Observation of biofilms dates back to the seventeenth century when Antonie van Leeuwenhoek observed bacteria from the plaque biofilm of his teeth under his primitive microscope [ 2 ]. (intechopen.com)
• An important factor of bacterial virulence is the formation of biofilms which are aggregates of microorganisms incorporated into an extracellular matrix that protects bacteria from hostile environments. (usp.br)

Virulence1

• Also AI-2 signaling seems to control many virulence factors in bacteria so blocking this signal could lead to new ways to control bacterial infections such as cholera. (wikipedia.org)

Predominant2

• The predominant luminescent bacteria observed were gram-negative short rod. (niscpr.res.in)
• A single predominant microbe should be noted at Gram staining, although mixed flora may be observed with anaerobic infection caused by aspiration. (medscape.com)

Homoserine lactones2

• Gram-negative bacteria use homoserine lactones, while gram-positive bacteria use peptides as autoinducers to start the gene activation. (slu.se)
• Occurrence of N-Acyl-L-Homoserine Lactones in Extracts of Some Gram-Negative Bacteria Evaluated by Gas Chromatography/Mass Spectrometry. (unibas.it)

Aeruginosa1

• Both complexes is screened for antibacterial activities against Gram-positive (B. substilis) and Gram-negative (P. aeruginosa, S. typhimurium, S. sonnei, Y. enterocolitica) bacterial strains. (uludag.edu.tr)

Escherichia1

• Its maintenance cost is low, as C. elegans is very small (approximately 1 mm long), feeds on inexpensive bacteria, such as Escherichia coli , and can be stored long-term at −80°C or in liquid nitrogen. (molcells.org)

Biofilm formation2

• With so many genes involved, it is perhaps not surprising that biofilm formation is regarded as a developmental process (Figure 1 ), not unlike that observed in the formation of fruiting bodies containing spores by the soil bacterium Myxococcus xanthus and sporulation in Bacillus subtilis [ 6 ]. (biomedcentral.com)
• The effects of these complexes on QS-regulated behaviors of bacteria such as swarming, and biofilm formation is also examined. (uludag.edu.tr)

Microorganisms1

• these microorganisms can be co-aggregate to bacteria in dental biofilm, being considered as an important factor for colonization process of periodontal pockets. (bvsalud.org)

Behaviors1

• QS allows bacteria to synchronously alter gene expression patterns that underpin collective behaviors. (wadsworth.org)

Genes4

• The general understanding is that the cell density of the bacteria leads to the activated genes resulting in the luminescent ability. (slu.se)
• Figure 1 shows the basic regulatory circuit for QS in bacteria, but more intricate systems exist with respect to the chemical signals, the signal relay mechanisms, and the target genes controlled by bacterial QS systems. (asmblog.org)
• From a genome database search based on the conserved motif, putative AhlD-like lactonase genes were found in several other bacteria, and AHL-degrading activities were observed in Klebsiella pneumoniae and Bacillus stearothermophilus. (elsevierpure.com)
• mvaT is a major regulator, exerting negative control in many genes described. (usp.br)

Antibacterial2

• In conclusion, our study reports for the first time the potential of etrasimod as a repurposed antibacterial compound against Gram-positive bacteria. (helsinki.fi)
• Bacteria within the biofilm are protected from disinfectants and have a fundamentally reduced antibacterial sensitivity compared with planktonic, free-living, bacteria. (thepigsite.com)

Penicillin2

• It also displayed a potent activity against other Gram-positive bacteria, including penicillin- and methicillin-resistant S. aureus strains, S. epidermidis, and Enterococcus faecalis, with a minimum inhibitory concentration (MIC) ranging from 5 to 10 mu M (2.3-4.6 mu g/mL). (helsinki.fi)
• First-line antimicrobials for S pneumoniae , the most prevalent cause of bacterial pneumonia, are, for the penicillin-susceptible form of the bacterium, penicillin G and amoxicillin. (medscape.com)

Species4

• This discovery led to the proposal of AI-2 as a universal form of communication between bacteria species. (wikipedia.org)
• The autoinducers gives the bacteria its species specificity when it comes to communication. (slu.se)
• The scarcity of studies on bioluminescent bacteria in fish species along the coastal and marine environment of Nigeria prompted the assessment of abundance of bioluminescent bacteria and possible isolation on three common coastal fish species ( Drepane africana , Sardinella maderensis and Mugil cephalus ) displaying luminescence. (niscpr.res.in)
• This study highlights the occurrence of bioluminescent bacteria in skin of tropical coastal fish species in Nigerian coastal waters and also serves as a fundamental basis for future studies on the biotechnological application of this unique characteristics. (niscpr.res.in)

Abstract1

• abstract = "New classes of antibiotics are urgently needed in the fight against multidrug-resistant bacteria. (helsinki.fi)

Host-bacteria2

• The overall correlation of the SAR with respect to prokaryotic and eukaryotic targets may hint at coevolutionary processes and intriguing host-bacteria relationships. (figshare.com)
• Growing λ-ly-so-ge-nic host bacteria led to accumulation of free phages in the culture due to spontaneous prophage induction in a small percentage of the cells, i.e., the production and re-lease of progeny phages into the medium by host cell lysis. (asmblog.org)

Secretion1

• His Bacteria research includes elements of Secretion, Enterobacteriaceae and Botany. (research.com)

Archaea2

• In bacteria and archaea , structural proteins with related functions are usually encoded together within the genome in a block called an operon and are transcribed together under the control of a single promoter , resulting in the formation of a polycistronic transcript ( Figure 12.30 ). (pressbooks.pub)
• They can be found very early in Earth's fossil records (about 3.25 billion years ago) as both Archaea and Bacteria, and commonly protect prokaryotic cells by providing them with homeostasis, encouraging the development of complex interactions between the cells in the biofilm. (wikipedia.org)

Signals1

• We use a combination of bacterial genetics, biochemistry, structural biology, and chemical biology to understand how bacteria respond appropriately to signals in a complex environment. (wadsworth.org)

Extracellular2

• A biofilm is a collection of bacteria and/or fungi that exists in a multicellular or community form, encased in an extracellular polysaccharide matrix that they themselves synthesise. (thepigsite.com)
• Over the next few hours or days there is growth and division of the attached bacteria followed by the production of extracellular polymer substances (EPS). (thepigsite.com)

Environments1

• Bacteria have evolved complex systems to sense these conditions, and to trigger appropriate developmental programs to help them survive, grow, and respond in changing environments. (umass.edu)

Autoinducer3

• For many bacteria, the change in gene expression includes downregulation of autoinducer synthesis in a negative feedback loop. (asm.org)
• It is done by chemical transmitters called autoinducers, which differ between gram-negative and grampositive bacteria based on the molecular structure of the autoinducer. (slu.se)
• QS in Gram-negative organisms in-vol-ves two regulatory components: the tran-scrip-tio-nal activator protein (receptor protein) and the autoinducer (AI) molecule produced by the AI-synthase. (asmblog.org)

Synergistic1

• The most potent QS agonists, doscadenamides S10-S12, along with doscadenamides F and S4 with partial or complete saturation of the acyl side chains, exhibited the most pronounced synergistic effects with TRAIL in triple negative MDA-MB-231 breast cancer cells. (figshare.com)

Adherence1

• Formation of a biofilm starts with adherence of bacteria followed by production of the polysaccharide matrix. (thepigsite.com)

AHLs1

• Quantification of AHL production using liquid chromatography-mass spectrometry confirmed that cerPAC effectively reduced the level of AHLs produced by the bacteria. (nature.com)

Enterobacteriaceae1

• His work carried out in the field of Enterobacteriaceae brings together such families of science as Wild type, Mutant, Medicago truncatula and Bacteria. (research.com)

Diffuse1

• Gram-negative bacteria produce acyl-homoserine lactone autoinducers that can passively diffuse through their thin cell wall. (asm.org)

Behavior1

• And when they recognize those molecules are there, all the bacteria in the environment will take on a behavior in unison. (asmblog.org)

RESISTANCE2

• Accordingly, scientists, today published a new study in the journal Cell Host and Microbe in March 2020, showing that drugs that prevent the acquisition of DNA-borne antibiotic resistance traits from their surroundings by bacteria can stop mice from becoming resistant to the action of the antibiotics. (news-medical.net)
• More and more, bacteria are finding ways around this approach, resulting in a huge antibiotic resistance problem. (wadsworth.org)

Encounter1

• Free floating or planktonic bacteria encounter this monolayer and form a reversible, sometimes transient attachment to it. (thepigsite.com)

Microbiome2

• Within three weeks the yeast-based nutritional supplement influenced the bacteria of the gut microbiome in a tendency towards mean values. (fortunepublish.com)
• Dysbiosis, toxic effects, inflammation, and infectious diseases are contingent on the number of bacteria and the composition of the microbiome. (fortunepublish.com)

Percentage1

• The initial percentage of a certain bacterium was compared with the difference at the end of the study using correlation statistics. (fortunepublish.com)

Found4

• However the bacteria were also found to recognize a second auto inducer AI-2. (wikipedia.org)
• In every bacterium found so far that produces the AI-2 signaling molecule the LuxS gene was also found. (wikipedia.org)
• The pathway for synthesizing AI-2 was found to be identical in V. harveyi, E. coli, Salmonella typhimurium, V. cholerae, and Enterococcus faecalis providing further evidence that this molecule may be a universal signal among bacteria. (wikipedia.org)
• All bacteria are found to be more sensitive to complex 2 than complex 1. (uludag.edu.tr)

Antibiotic1

• Sputum Gram stain and culture should be performed before initiating antibiotic therapy. (medscape.com)

Strain1

• Here, we used a Gram-positive strain, Dietzia sp. (nature.com)

Surfaces1

• Zobell ( 2 ) observed that the number of bacteria on surfaces was dramatically higher than in the surrounding medium (in this case, seawater). (cdc.gov)

Functional2

• If neither bacteria possess a functional copy of the LuxS gene they cannot form a biofilm. (wikipedia.org)
• the bacteria organize themselves into a coordinated functional community. (wikipedia.org)

Molecular1

• The 2020 Gruber Genetics Prize is being awarded to geneticist Bonnie Bassler, Ph.D. of Princeton University and the Howard Hughes Medical Institute, for her groundbreaking work on how bacteria "talk" to each other using molecular "languages. (news-medical.net)

Cell2

• In contrast, gram-positive bacterial autoinducers are made of peptide and must be actively transported through their peptidoglycan cell wall using the ATP-binding cassette (ABC) transporter system . (asm.org)
• Small talk: cell-cell communication in bacteria. (microbiologyresearch.org)

Communicate1

• Learning how bacteria correctly interpret these blends of AIs and elicit appropriate gene expression responses is essential to understand how bacteria communicate, and, more globally, to understand how all organisms decode environmental stimuli. (wadsworth.org)

Findings1

• In our findings, mvaT has a negative influence on regulating rsmA, since its inactivation leads to a higher expression of the upstream region of rsmA. (usp.br)