BacteriaPseudomonasOpportunistic pathogenStaphylococcusMultidrug-resistant Gram-negative pathogensPlant PathogensOrganismsBacilliStreptococcusSpeciesEscherichiaAntimicrobialRodsMulti-drug resiResistant pathogensNeisseriaAeruginosaHumansInfectionIsolatesAntibioticsMechanismsResistanceAnaerobicRespiratory tractPneumoniaeEmergenceNosocomial pneumoniaImportantMicrobesVirulenceContaminationIncreasinglySurveillanceCell envelopeUnusualInvadeStainPatientsVitro
Bacteria39
- To investigate the exact isolation frequency of 16S rRNA methylase-producing, gram-negative pathogenic bacteria, we tested 87,626 clinical isolates from 169 hospitals. (cdc.gov)
- Although the production of aminoglycoside-modifying enzymes is the most common mechanism of resistance in aminoglycosides, the emergence of pan-aminoglycoside-resistant, 16S rRNA methylase-producing, gram-negative bacteria has been increasingly reported in recent years. (cdc.gov)
- In Japan, arbekacin, a semisynthetic aminoglycoside, has been approved for treatment of methicillin-resistant Staphylococcus aureus infections, and this agent is also very efficacious for gram-negative bacteria. (cdc.gov)
- Thus, this investigation was conducted to determine the exact isolation frequency of 16S rRNA methylase-producing, gram-negative pathogenic bacteria in Japanese medical facilities and assess the possibility of the future prevalence of these hazardous microbes. (cdc.gov)
- In this study, we report on the antimicrobial susceptibility of Gram-positive bacteria and Gram-negative bacteria isolated from blood specimen collected from around the world between 2012 and 2016. (biomedcentral.com)
- Darobactin is an experimental antibiotic compound that may be effective against Gram-negative bacteria. (wikipedia.org)
- Researchers identified the nematode as a possible host because they feed on insects by targeting their larvae and releasing bacteria that then confront pathogens similar to those found in humans. (wikipedia.org)
- Gram-negative bacteria have a characteristic architecture for the cell envelope, with an inner membrane, an outer membrane, and a periplasmic space in between. (wikipedia.org)
- Antibiotic resistance has become wide-spread in bacterial pathogens, and in Gram-negative bacteria such as the Enterobacteriaceae, much of this comes from acquired genes. (wikipedia.org)
- Because only Gram-negative bacteria have BamA and outer membrane beta-barrel proteins, only they are susceptible to darobactin. (wikipedia.org)
- The study of innate immunity to bacteria has focused heavily on the mechanisms by which mammalian cells detect lipopolysaccharide (LPS), the conserved surface component of Gram-negative bacteria. (nih.gov)
- The most common bacteria that make this enzyme are gram-negative such as Escherichia coli and Klebsiella pneumoniae, but the gene for NDM-1 can spread from one strain of bacteria to another by horizontal gene transfer. (wikipedia.org)
- The genus Acinetobacter comprises a complex group of Gram-negative bacteria. (nature.com)
- Some of these bacteria such as A. baumannii are nosocomial pathogens. (nature.com)
- Endotoxin is released by the lysis of Gram-negative bacteria. (frontiersin.org)
- Sugar conjugates - exploring active transport mechanisms into Gram-negative bacteria. (helmholtz-hzi.de)
- Conjugation of dyes but also drugs against Gram-negative bacteria is an opportunity to improve the detection and the treatment of bacterial infection. (helmholtz-hzi.de)
- Multidrug-resistant bacteria are spreading at alarming rates, and despite extensive efforts no new class of antibiotic with activity against Gram-negative bacteria has been approved in over fifty years. (rcsb.org)
- Here we report chemical optimization of the arylomycins-a class of natural products with weak activity and limited spectrum-to obtain G0775, a molecule with potent, broad-spectrum activity against Gram-negative bacteria. (rcsb.org)
- Other important enteric gram-negative bacteria include Enterobacter species, Klebsiella pneumoniae , Escherichia coli , Serratia marcescens , Proteus species, and Acinetobacter species. (merckmanuals.com)
- Researchers have discovered a compound capable of pushing through barriers used by Gram-negative bacteria to resist antibiotics, damaging the bugs and preventing them from spreading. (sciencedaily.com)
- In a paper published Friday in the journal PLOS Pathogens , Detweiler and her research team unveil their latest discovery -- a chemical compound that works with a host's innate immune response to push past cellular barriers that help bacteria resist antibiotics. (sciencedaily.com)
- The new paper centers around "JD1," which appears to be particularly effective at infiltrating what are known as "Gram-negative bacteria. (sciencedaily.com)
- Later studies showed that colistin can also kill Gram-positive bacteria [ 3 , 4 ]. (hindawi.com)
- In recent, the occurrence of Gram-negative multidrug-resistant pathogens which are resistant to many available antibiotics has revived its clinical application in healthcare centers, since colistin is broadly considered as one of the last-line options of antibiotic therapy for multidrug-resistant bacteria. (hindawi.com)
- Among Gram-negative bacteria (GNB), Enterobacterales ( Enterobacterales ), such as Escherichia coli ( E. coli ) and Klebsiella pneumoniae ( K. pneumoniae ), are the most clinically relevant pathogens in healthcare settings. (frontiersin.org)
- At its forefront are Gram-negative bacteria, (GNB) such as Enterobacterales ( Enterobacterales ), Pseudomonas aeruginosa , and Acinetobacter baumannii , which have become increasingly resistant to most conventional and broad-spectrum antimicrobial agents, including carbapenems ( Nordmann and Poirel, 2019 ). (frontiersin.org)
- Klebsiella pneumoniae is a gram negative bacteria and an opportunistic pathogen. (scirp.org)
- Aptuit has announced the start of a collaboration with the Molecular Surgical Laboratory of Massachusetts General Hospital (MGH), directed by Dr. Laurence Rahme, aimed at the identification and validation of novel targets in Gram-negative bacteria. (centerwatch.com)
- Bacteria are broadly categorized as Gram positive or negative based on their staining characteristics. (livestrong.com)
- Several types of Gram-positive, rod-shaped bacteria can cause human disease. (livestrong.com)
- The aim of this study was to evaluate the health status of psittacines housed in captivity, by assessment of Gram-negative bacteria from fecal microbiota through MALDI- TOF MS identification. (scielo.br)
- The gastrointestinal microbiome of psittacine free-living birds has been poorly understood, but the most of reports shows that the normal psittacine bird microbiota is composed by Gram-positive facultative bacteria, that is, aerobic and anaerobic, and producers of lactic acid ( Gerlach, 1994 GERLACH, H., 1994. (scielo.br)
- The aim of the presented study was to assess the degree of contamination by non-fermenting Gram-negative bacteria (NF-GNB) of drinking water dispensed from microfiltration devices at point-of-use. (aaem.pl)
- Association between contaminated faucets and colonization or infection by nonfermenting Gram-negative bacteria in intensive care units in Taiwan. (aaem.pl)
- Stojek NM, Szymanska J, Dutkiewicz, J. Gram-negative bacteria in water distribution systems of hospitals. (aaem.pl)
- Burkholderia cepacia complex bacteria: opportunistic pathogens with important natural biology. (aaem.pl)
- Results Gram-negative bacteria were recovered in 77% of the cases. (who.int)
- A family of gram-negative bacteria which are saprophytes, symbionts, or plant pathogens. (bvsalud.org)
Pseudomonas5
- This resulted in the clinical candidate F365 (QPX9003) with superior safety and efficacy against lung infections caused by top-priority MDR pathogens Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae. (monash.edu)
- Because aerobic gram-negative bacilli (eg, Pseudomonas aeruginosa) are the major pathogens associated with HAP, the pathophysiology of nosocomial pneumonia relates to the destructive effect on lung tissue. (medscape.com)
- We hope we will jointly discover new effective therapeutics against Gram-negative pathogens, such as Pseudomonas aeruginosa. (centerwatch.com)
- Pseudomonas aeruginosa is a gram-negative rod shape bacterium belonging to the family Pseudomonadaceae. (aquaculturemag.com)
- Pseudomonas aeruginosa is an opportunistic pathogen that often causes nosocomial infections resistant to treatment. (who.int)
Opportunistic pathogen4
- A. radioresistens is generally considered to be a commensal bacterium on human skin or an opportunistic pathogen. (nature.com)
- Klebsiella pneumoniae is an opportunistic pathogen of medical importance and the capsule and mucoid phenotype in this organism are considered as requisite virulence determinants. (scirp.org)
- This species is highly adaptable opportunistic pathogen, capable of surviving in a variety of environment, including aquaculture environment. (aquaculturemag.com)
- Stenotrophomonas maltophilia: an emerging global opportunistic pathogen. (aaem.pl)
Staphylococcus3
- We now report our seminal findings on the major constituents including terpenes identified in native, historically significant herbal medicinal plant Elder (Sambucus nigra L.) flower and elder berry in particular and their concomitant strong antimicrobial effects exhibited on various nosocomial pathogens notably upon methicillin-resistant Staphylococcus aureus MRSA, recognised globally as a clinically significant pathogen, associated with skin and soft tissue infections. (researchgate.net)
- Ethanolic extracts of Sambucus nigra L. blooms and fruits have been shown to inhibit 13 pathogens, including Staphylococcus sp. (researchgate.net)
- Gram-positive organisms such as Staphylococcus aureus and Streptococcus species are the most commonly isolated organisms in patients with pyogenic vertebral infections. (wheelessonline.com)
Multidrug-resistant Gram-negative pathogens1
- Antimicrobial resistance heterogeneity among multidrug-resistant Gram-negative pathogens: Phenotypic, genotypic, and proteomic analysis. (bvsalud.org)
Plant Pathogens1
- KYE28 (KYEITTIHNLFRKLTHRLFRRNFGYT-LR), the representative sequence of helix D of heparin co-factor II, was demonstrated to be potent against agronomically important Gram-negative plant pathogens Xanthomonas vesicatoria and Xanthomonas oryzae, capable of inhibiting disease symptoms in detached tomato leaves. (lu.se)
Organisms4
- Primary inhalation pneumonia develops when these organisms bypass normal respiratory defense mechanisms or when the patient inhales aerobic gram-negative organisms that colonize the upper respiratory tract or respiratory support equipment. (medscape.com)
- Pathogen-associated molecular patterns released by infecting organisms not only bind immune receptors on inflammatory cells but also bind receptors on cells in the heart ( 8 ). (frontiersin.org)
- Gram-negative organisms, herpes simplex virus, dermatophytes and yeasts have also been reported as causative agents. (aafp.org)
- Methicillin-sensitive S. aureus , Streptococcus pneumoniae , and Haemophilus influenzae are most commonly implicated when pneumonia develops within 4 to 7 days of hospitalization, whereas P. aeruginosa , MRSA, and enteric gram-negative organisms become more common with increasing duration of hospitalization. (merckmanuals.com)
Bacilli4
- The stomach appears to be an important reservoir of gram-negative bacilli that can ascend and colonize the respiratory tract. (medscape.com)
- [ 9 ] Alternatively, other non-necrotizing gram-negative bacilli (eg, Serratia marcescens) may be responsible for nosocomial pneumonia. (medscape.com)
- A subset of the GNB family, the order of Enterobacterales consists of Gram-negative bacilli that predominantly colonize the human gastro-intestinal tract. (frontiersin.org)
- Stenotrophomonas maltophilia - the most worrisome treat among unusual non-fermentative gram-negative bacilli from hospitalized patients: a prospective multicenter study. (aaem.pl)
Streptococcus2
- however, microorganisms that can be part of the vaginal flora, such as anaerobes, G. vaginalis, H. influenzae, enteric Gram-negative rods, and Streptococcus agalactiae also can cause PID. (cdc.gov)
- The most commonly identified pathogens are Streptococcus pneumoniae , Haemophilus influenzae . (msdmanuals.com)
Species4
- Permeability barriers of Gram-negative pathogens and approaches to bypass them A major source of resistance in Gram-negative species is the permeability barrier created by a synergistic action of slow uptake and active efflux of antibiotics across the outer membrane. (grantome.com)
- The proposed research will address a critical need to understand penetration across the cell envelope of Gram-negative species and to develop antibiotics affective against these pathogens. (grantome.com)
- Among the Gram-negative cocci, two specific bacterial species stand out as important human pathogens. (livestrong.com)
- A number of bacterial species in the broad category of Gram-negative rods can cause human infections, which range in severity and site of the body affected. (livestrong.com)
Escherichia2
- Enterohemorrhagic Escherichia coli (O157:H7) (EHEC) is a Gram-negative, rod-shaped bacterium that causes food-borne illnesses ( Figure 1 ). (ppdictionary.com)
- In stationary phase, cardiolipin synthase activity has been observed to increase approximately 10-fold in the Gram-negative model organism Escherichia coli , suggesting CL is an essential membrane component to cope with starvation 4 . (nature.com)
Antimicrobial3
- An evidence-based scientific scrutiny of Irish traditional medicines for their antimicrobial potency is urgently required for combating antibiotic resistant common nosocomial pathogens. (researchgate.net)
- Learn about the primary pathogens isolated in cystic fibrosis patients and consider these microorganisms' relative antimicrobial susceptibility. (brighttalk.com)
- To perform a microbiological evaluation of the water used in dental units, the identification of Gram-negative non-fermentative rods (GNNR) and their ability to adhere to polystyrene, and the antimicrobial activity of disinfectants on the identified strains. (bvsalud.org)
Rods1
- Flowchart for identifying Gram-negative rods stool pathogens. (cdc.gov)
Multi-drug resi3
- Furthermore, new antibacterial natural products and natural product-derived compounds are investigated mechanistically and chemically optimized to treat infections and kill multi-drug resistant pathogens. (helmholtz-hzi.de)
- Dr. Laurence Rahme, associate professor of Surgery, Microbiology and Immunobiology Harvard Medical School and Director of the MGH Molecular Surgical Laboratory, commented, "The academic collaboration with Aptuit, and in particular with its highly qualified anti-infective group, will maximize our success in developing highly innovative alternative therapies against multi-drug resistant pathogens, including those that are highly tolerant to all existing antibiotic therapies. (centerwatch.com)
- His research and investigative areas of concentration have included outbreak investigations, infection control, multi-drug resistant gram-negative pathogens, and now focus on hospital antibiotic stewardship. (cdc.gov)
Resistant pathogens1
- The objective of the current ering new classes of antimicrobials and the increasing study was, therefore, to assess the bacteriologic pro- emergence and reemergence of resistant pathogens, file, resistance pattern, and patient's outcome in Lan- mortality from infectious disease is increasing [1]. (who.int)
Neisseria1
- We also focus on iron binding receptors from gram-negative pathogens such as Neisseria, Haemophilus and Moraxella. (ualberta.ca)
Aeruginosa2
- P seudomonas aeruginosa is an opportunistic P. aeruginosa infections are often resistant to pathogen that often causes nosocomial infections treatment, 4 and carbapenem use has been strongly as- (e.g. pneumonia, bacteraemia and urinary sociated with resistance. (who.int)
- were the reported increasing rates of resistance to antibiotics used second most common pathogen isolated from device- to treat P. aeruginosa infections, such as carbapenems associated HA infections in a study of intensive care and extended-spectrum cephalosporins ( Fig. 1A-B ). In units in Philippine hospitals. (who.int)
Humans1
- Vibrio cholerae is a curve-shaped, Gram-negative bacterium well-known for its ability to cause cholera , a severe bacterial infection in humans (Figure 1). (ppdictionary.com)
Infection7
- Brain abscess may be caused by the contiguous spread of pathogens from a primary focus of infection outside of the CNS that extends into the brain. (medscape.com)
- Tests of nasopharyngeal specimens for specific pathogens are helpful when targeted therapy depends on the results (eg, group A streptococcal infection, gonococcus, pertussis). (medscape.com)
- It circumvents existing antibiotic resistance mechanisms and retains activity against contemporary multidrug-resistant Gram-negative clinical isolates in vitro and in several in vivo infection models. (rcsb.org)
- Polymyxin E, also called colistin, is an important old antibiotic known for around six decades for treatment of infection caused by Gram-negative pathogens [ 1 , 2 ]. (hindawi.com)
- Meropenem/Vaborbactam in Patients with Carbapenem-resistant Enterobacteriaceae Gram-negative Blood Stream Infection: A Case Series, S. Alosaimy et al. (globenewswire.com)
- Pathogen Type and Inappropriate Empiric Therapy (IET) in Culture-Positive Skin and Soft Tissue Infection (SSS) among Hospitalized Patients in the U.S., 2015-2017, S. Cammarata et al. (globenewswire.com)
- Knowing and understanding the full pathogen load is critical to solving a farmer's mastitis infection rate in the herd. (thebeefsite.com)
Isolates1
- Kingella kingae tends to retain crystal violet dye and, therefore, it may appear to be gram- positive, and laboratories unfamiliar with its cultural and staining features may misidentify the bacterium altogether or dismiss invasive isolates as culture contaminants. (cdc.gov)
Antibiotics2
- This project will advance understanding how antibiotics penetrate cell envelopes of antibiotic- resistant Gram-negative pathogens. (grantome.com)
- Also, antibiotics administered to cows with mastitis could result in a "no growth" result, and the farmer is left unsure whether the cow had mastitis or the antibiotic cleared the pathogen. (thebeefsite.com)
Mechanisms2
Resistance3
- Pathogens and antibiotic resistance patterns vary significantly among institutions and can vary within institutions over short periods (eg, month to month). (merckmanuals.com)
- Predicting Carbapenem Resistance Among Gram-Negative Pathogens in Complicated Urinary Tract Infections, M. Zilberberg Et Al. (globenewswire.com)
- Infections secondary to these pathogens are widely common but multidrug resistance (MDR) in Enterobacterales has become a significant challenge with increased morbidity, mortality, and cost of management. (frontiersin.org)
Anaerobic1
- Tannerella forsythia is an anaerobic, fusiform Gram-negative oral pathogen strongly associated with periodontitis, a multibacterial inflammatory disease that leads to the destruction of the teeth-supporting tissue, ultimately causing tooth loss. (karger.com)
Respiratory tract1
- We investigated the in vitro bactericidal and virucidal efficacy of povidone-iodine (PVP-I) 7% gargle/mouthwash at defined dilution against oral and respiratory tract pathogens. (springer.com)
Pneumoniae1
- KPC prévalence de la non sensibilité à l'ertapénème dans un hôpital de soins tertiaires en Égypte était principalement imputable aux mécanismes de résistance médiés par les carbapénèmases dans les isolats de K. pneumoniae . (who.int)
Emergence1
- The emergence of multidrug-resistant (MDR) Gram-negative pathogens is an urgent global medical challenge. (monash.edu)
Nosocomial pneumonia1
- President & CEO: Isao Teshirogi, Ph.D.) (hereafter "Shionogi") today announces the back to back publication of two studies in The Lancet Infectious Diseases journal highlighting the efficacy and safety of cefiderocol against some of the most difficult-to-treat Gram-negative bacterial infections, including nosocomial pneumonia (NP), bloodstream infections (BSI), sepsis, and complicated urinary tract infections (cUTI). (dutchnews.nl)
Important3
- Polymyxin E or colistin, produced by Paenibacillus polymyxa , is an important antibiotic against Gram-negative pathogens. (hindawi.com)
- Unfortunately, fast-growing pathogens aren't necessarily the most important or the only pathogens to target. (thebeefsite.com)
- Pseudomonades are considered one of the most important fish pathogens which are responsible for ulcer like diseases including ulcerative syndrome. (aquaculturemag.com)
Microbes1
- Metagenomics is the study of genetic material from environmental samples for detecting microbes, especially pathogens. (warf.org)
Virulence2
- In order to cause damage to its host, this pathogen has been characterized to produce virulence factors like periplasmic catalase and shiga-like toxins. (ppdictionary.com)
- strains (LABs), Lactobacillus plantarum (LB95) and Lactobacillus paraplantarum (LB13), previously isolated from spontaneously fermenting olive brines, and two reference probiotic strains, Lactobacillus casei Shirota and Lactobacillus rhamnosus GG, were investigated for their ability to attenuate the virulence of the aforementioned pathogens using animal cell culture assays. (microbiologyresearch.org)
Contamination1
- Effective hand hygiene minimises transmission of pathogens from contaminated hands of an infected individual through either direct person-to-person contact or indirectly via contamination of surfaces [ 9 , 10 ]. (springer.com)
Increasingly1
- Because of the improved culture methods and sensitive nucleic acid amplification assays developed in recent years, Kingella kingae , a gram-negative coccobacillus of the Neisseriaceae family, is increasingly recognized as an invasive pathogen of early childhood. (cdc.gov)
Surveillance1
- Centre for Genomic Pathogen Surveillance, Wellcome Genome Campus, Hinxton, England, United Kingdom of Great Britain and Northern Ireland. (who.int)
Cell envelope1
- Darobactin inhibits BamA and disrupts the proper formation of the Gram-negative cell envelope. (wikipedia.org)
Unusual2
- Pneumonia in immunocompromised patients is often caused by unusual pathogens but may also be caused by the same pathogens that cause community-acquired pneumonia. (msdmanuals.com)
- as well as unusual pathogens. (msdmanuals.com)
Invade1
- From the upper airways, pathogens may invade adjacent structures, such as the lungs, middle ear, or nasal sinuses, and may penetrate into the bloodstream, causing invasive diseases. (cdc.gov)
Stain2
- In this arrangement, the peptidoglycan layer is relatively thin and does not retain the crystal violet stain used in the Gram staining method of bacterial classification. (wikipedia.org)
- Sputum testing should include Gram stain, mycobacterial and fungal stains and cultures, and sometimes testing for viruses (eg, polymerase chain reaction for cytomegalovirus in a transplant patient or in a patient with AIDS). (msdmanuals.com)
Patients1
- Real-World Efficacy and Safety of Oritavancin Multiple Dose Treatment in Patients with Complicated Gram-Positive Infections, M. Sierra-Hoffman et al. (globenewswire.com)
Vitro1
- PVP-I 7% gargle/mouthwash showed rapid bactericidal activity and virucidal efficacy in vitro at a concentration of 0.23% PVP-I and may provide a protective oropharyngeal hygiene measure for individuals at high risk of exposure to oral and respiratory pathogens. (springer.com)