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  • anti-tumor immunity
  • To expand this immunotransplant concept to the amplification of anti-cancer immunity, researchers at Stanford University developed a pre-clinical lymphoma model using a in situ, CpG-base vaccine to induce anti-tumor immunity and demonstrated that this immunity was enhanced 10-40 fold by immunotransplant. (wikipedia.org)
  • In fact the Hopkins published preliminary results of a clinical study testing the basic immunotransplant concept in acute myeloid leukemia demonstrating encouraging signals of enhanced anti-tumor immunity. (wikipedia.org)
  • Autologous
  • Treatment of microscopic pulmonary metastases with recombinant autologous tumor vaccine expressing IL-6 and E. coli cytosine deaminase suicide genes. (bio.net)
  • I. To evaluate engraftment of human leukocyte antibody (HLA) identical peripheral blood stem cell (PBSC) allografts given after conditioning with total-body irradiation (TBI) (200cGy) +/- fludarabine (fludarabine phosphate), 90 mg/m^2 and post-grafting immunosuppression with cyclosporine (CSP)/mycophenolate mofetil (MMF) in refractory or relapsed lymphoma patients following an initial autologous peripheral blood stem cell transplant (PBSCT) for disease cytoreduction. (clinicaltrials.gov)
  • patient's
  • But proteins from graft can appear as foreign to the patient's immune system, causing rejection. (fredhutch.org)
  • Other considerations include: extent of the disease tolerance for specific medications, procedures, or therapies expectations for the course of the disease opinion or preference of the patient Treatment may include: surgery (in some cases, when bone weakening is present or fractures occur) bone grafting - a surgical procedure in which healthy bone is transplanted from another part of the patient's body into the affected area. (wikipedia.org)
  • immunity
  • The main theoretical background to the present studies was the effect of photochemotherapy on cell mediated immunity evident by an inhibition of the delayed type hypersensitivity of the skin and the ability to induce circulating immunomodulatory regulatory-T cells in human. (ki.se)
  • Complete response, tumor immunity (GvL) and survival were considered as outcomes. (ki.se)
  • Photochemotherapy and graft-verus-leukemia reaction in acute-leukemia: Tumor immunity and survival are dependent on timing of photochemotherapy of the skin. (ki.se)
  • The investigators hypothesize that tumour cells potentially evading NK-cell mediated immunity may be targeted by infused donor T-cells and eliminated by either MHC-dependent manner or through a bystander effect. (clinicaltrials.gov)
  • Tumors expressing the cytosine deaminase suicide gene can be eliminated in vivo with 5-fluorocytosine and induce protective immunity to wild type tumor. (bio.net)
  • Transplanting only ABO-compatible grafts (matching blood groups between donor and recipient) helps prevent rejection mediated by humoral immunity. (wikipedia.org)
  • recipient
  • Furthermore, should the recipient (for example, type B-positive with a type AB-positive graft) require eventual retransplantation, the recipient may receive a new organ of either blood type. (wikipedia.org)
  • survival
  • The protocol with the best reported survival in children and adults is an intra-arterial protocol where tumor response is tracked by serial arteriogram. (wikipedia.org)
  • metastatic
  • Clinical trial number NCT01527136 for "Entolimod in Treating Patients With Locally Advanced or Metastatic Solid Tumors That Cannot Be Removed By Surgery" at ClinicalTrials.gov Burdelya, L. G. (wikipedia.org)
  • Even small localized tumors are increasingly recognized as possessing metastatic potential. (wikipedia.org)
  • enchondroma
  • An enchondroma most often affects the cartilage that lines the inside of the bones. (wikipedia.org)
  • Because an individual with an enchondroma has few symptoms, diagnosis is sometimes made during a routine physical examination, or if the presence of the tumor leads to a fracture. (wikipedia.org)
  • patients
  • The purpose of this study is to find out what effects (good and bad) a stem cell transplant from an unrelated donor will have for patients with kidney cancer that has spread to other parts of the body (metastasized). (clinicaltrials.gov)
  • In a series of studies (to 2005) of this approach, up to 70% of treated patients were shown to have regressions of their tumors, many of which had been considerable in size and refractory to other therapies. (wikipedia.org)
  • These findings compare favorably with standard-of-care therapies for melanoma which generally lead to tumor regressions in only ~10-12% of patients. (wikipedia.org)
  • lesions
  • The conditions that involve multiple lesions include the following: Ollier disease (enchondromatosis) - when multiple sites in the body develop the tumors. (wikipedia.org)
  • receptors
  • Chimeric antigen receptors (CARs, also known as chimeric immunoreceptors, chimeric T cell receptors, artificial T cell receptors or CAR-T) are engineered receptors which graft an arbitrary specificity onto an immune effector cell (T cell). (wikipedia.org)
  • Typically, these receptors are used to graft the specificity of a monoclonal antibody onto a T cell, with transfer of their coding sequence facilitated by retroviral vectors. (wikipedia.org)
  • pathogens
  • Historically, the effect of vaccines -particularly against pathogens- has been assessed by measurement of their induction of a B-cell-mediated -or humoral- immune response, i.e. the production of pathogen-specific antibodies. (wikipedia.org)
  • radiation
  • Additionally, entolimod evidences a supportive care benefit in preclinical models when combined with radiation treatment and cytotoxic agents with adverse gastrointestinal (GI) effects. (wikipedia.org)
  • Tumor removal surgeries have been documented in ancient Egypt, hormone therapy and radiation therapy were developed in the late 19th Century. (wikipedia.org)
  • The effects of radiation therapy are localised and confined to the region being treated. (wikipedia.org)
  • pulmonary
  • Other severe side effects include an increased future risk of cancer, infertility, allergic reactions, and pulmonary fibrosis. (wikipedia.org)
  • Fludarabine
  • Reduced intensity conditioning containing Fludarabine, Thiotepa and Melfalan will enable sustained engraftment as well as will serve as additional anti-tumor treatment. (clinicaltrials.gov)
  • Treatment
  • Complete removal of the cancer without damage to the rest of the body (that is, achieving cure with near-zero adverse effects) is the ideal goal of treatment and is often the goal in practice. (wikipedia.org)
  • Diagnosis
  • Diagnosis of spinal cord tumors relies on electromyography, radiography, scintigraphy, myelography, and advanced imaging techniques such as (spiral) computed tomography (CT) and/or magnetic resonance imaging (MRI). (vin.com)
  • By the end of the 1960s, Marvin Gaye had fallen into a deep depression following the brain tumor diagnosis of his Motown singing partner Tammi Terrell, the failure of his marriage to Anna Gordy, a growing dependency on cocaine, troubles with the IRS, and struggles with Motown Records, the label he had signed with in 1961. (wikipedia.org)
  • nerve
  • Reactivation of latent virus within the dorsal root ganglion of the facial nerve is associated with vesicles affecting the ear canal, and termed Ramsay Hunt syndrome type II. (wikipedia.org)
  • A tumor compressing the facial nerve anywhere along its complex pathway can result in facial paralysis. (wikipedia.org)
  • Often, since facial neoplasms have such an intimate relationship with the facial nerve, removing tumors in this region becomes perplexing as the physician is unsure how to manage the tumor without causing even more palsy. (wikipedia.org)
  • Peripheral nervous system (PNS) diseases may be further categorized by the type of nerve cell (motor, sensory, or both) affected by the disorder. (wikipedia.org)
  • scalp
  • Cutaneous forms are those affecting the skin, scalp, and nails. (wikipedia.org)
  • The scalp is rarely affected by a condition known as lichen planopilaris, acuminatus, follicular lichen planus, and peripilaris, characterised by violaceous, adherent follicular scale with progressive scarring alopecia. (wikipedia.org)
  • nose
  • A costochondral graft was harvested and used to reconstruct the collapsed portion of the nose. (smbalaji.com)
  • In 1814, Joseph Carpue successfully performed operative procedure on a British military officer who had lost his nose to the toxic effects of mercury treatments. (wikipedia.org)
  • cases
  • Extradural tumors are the most prevalent type in dogs, accounting for 50% of the cases. (vin.com)
  • In severe cases of displaced fractures, reduction and replacement methodology is adopted with implantation or grafting technique," refers Dr. Gupta. (hand2shoulderclinic.in)
  • In some cases, the hydrated region can extend much further, for instance in lipids with a large protein or long sugar chain grafted to the head. (wikipedia.org)
  • identification
  • The value of survey radiographs of the spine lies in the identification of primary tumors involving bony structures of the spine (osteosarcoma, chondrosarcoma) or metastasizing tumors to vertebral bodies. (vin.com)
  • Sometimes
  • There is a clear distinction between the behaviors of the two hands in which the affected hand is viewed as "wayward" and sometimes "disobedient" and generally out of the realm of their own voluntary control, while the unaffected hand is under normal volitional control. (wikipedia.org)
  • large
  • The number of misfolded protein molecules will increase exponentially and the process leads to a large quantity of insoluble protein in affected cells. (wikipedia.org)
  • side effects
  • Encourages Healthy Cortisol Levels That Helps To Avoid Belly Fat From Becoming a massive concern for most individuals is if the supplement is protected and also if there are any negative side effects. (lasercosmetica.com)
  • Various studies have proven Garcinia Cambogia using HCA to have no substantial side effects. (lasercosmetica.com)
  • Among
  • the more tightly the DNA is bound by the nucleosome, and the more tightly a string of nucleosomes are compressed among each other, the greater the repressive effect on transcription of genes in the DNA sequences near or wrapped around the histones, and vice versa (i.e. looser DNA binding and relaxed compaction leads to a comparatively derepressed state, resulting in facultative heterochromatin or, even further derepressed, euchromatin). (wikipedia.org)
  • skin
  • Due to a combination of ageing and environmental influences such as sun damage and UV exposure our skin is susceptible to a number of skin tumors & general damage. (garylross.com)
  • Von Graefe modified the Italian method using a free skin graft from the arm instead of the original delayed pedicle flap. (wikipedia.org)