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  • allogeneic
  • Microtransplantation(MST) is an advanced technology to treat malignant hematological diseases and tumors by infusing patients with granulocyte colony-stimulating factor (G-CSF) mobilized human leukocyte antigen (HLA)-mismatched allogeneic peripheral blood stem cells following a reduced-intensity chemotherapy or targeted therapy. (wikipedia.org)
  • tissue
  • This testing can identify circulating lymphocytes with a different HLA type than the tissue cells of the host. (wikipedia.org)
  • The interplay of APC, T cells and cytokines is such that, in a mouse transplant model - with mismatch only between donor T cells and host APC, but not between donor and host gut-donor T cells still efficiently killed host gut cells, suggesting that tissue destruction can be achieved with a by-stander effect (Teshima et al, 2002b). (slideshare.net)
  • It is similar to an autoimmune connective tissue disease. (psychiatryadvisor.com)
  • Immune cells (white blood cells) in the donated tissue (the graft) recognize the recipient (the host) as foreign (nonself). (wikipedia.org)
  • Due to its proinflammatory action, a proinflammatory cytokine tends to make the disease itself or the symptoms correlated to a disease worse by causing fever, inflammation, tissue destruction, and in some cases, even shock and death. (wikipedia.org)
  • Such components include: Microenvironmental factors like tonicity, pH, oxygen pressure and the redox status of immune cells Mechanical factors, such as tissue pressure, cellular stiffness and cell motility Cell membrane physics such as membrane composition and particles The research field of immunophysics aims to investigate the influence of these physicochemical parameters on the function of the immune system in health and disease. (wikipedia.org)
  • antigens
  • The presentation of host antigens by host APC can be further enhanced by host gamma/delta T cells, as recently shown in the mouse (Maeda et al, 2005). (slideshare.net)
  • Gleichmann E, Gleichmann H, Wilke W. Autoimmunization and lymphomagenesis in parent-to-F1 combinations differing at the major histocompatibility complex: model for spontaneous disease caused by altered self-antigens? (springer.com)
  • Ferrara
  • The early work of Ferrara and coworkers showed that inflammatory cytokines play a crucial role in the initial, amplification and cytotoxic phases of the disease (reviewed in Ferrara, 2002). (slideshare.net)
  • transplant
  • The acute or fulminant form of the disease (aGvHD) is normally observed within the first 100 days post-transplant, and is a major challenge to transplants owing to associated morbidity and mortality. (wikipedia.org)
  • donor's
  • Donor's Requirements: Mismatched HLA with recipient Age between 18 and 60 years old Good overall state of health No major heart or lung surgical history No infectious diseases such as HIV, Hepatitis or syphilis, etc. (wikipedia.org)
  • inflammation
  • Decreased Paneth cell defensin expression in ileal Crohn's disease is independent of inflammation, but linked to the NOD2 1007fs genotype. (springer.com)
  • Atg16L1 mediates the cellular degradative process of autophagy and is considered a critical regulator of inflammation based on its genetic association with inflammatory bowel disease. (mskcc.org)
  • Crohn's disease is a chronic inflammation of the digestive track. (wikipedia.org)
  • Treatment
  • The information should not be used for either diagnosis or treatment or both for any health related problem or disease. (medindia.net)
  • A 45-year-old man received growth factor-mobilized blood cells from an HLA-matched unrelated male donor after conditioning with 12 Gy total body irradiation and cyclophosphamide for treatment of acute myeloid leukemia with persistent disease. (bloodjournal.org)
  • On June 29, 2011, Mesoblast announced that it received clearance from the Food and Drug Administration to begin a Phase 2 trial with its MPC cells for treatment of disc degenerative disease. (wikipedia.org)
  • Kv1.3 is also considered a therapeutic target for the treatment of obesity, for enhancing peripheral insulin sensitivity in patients with type-2 diabetes mellitus, and for preventing bone resorption in periodontal disease. (wikipedia.org)
  • Immunophysical research is considered to open new perspectives for the investigation of the pathomechanisms of immune-mediated inflammatory diseases, help to develop novel detection methods and diagnostic tools in these diseases and advance the treatment possibilities of such diseases. (wikipedia.org)
  • Ibrutinib is used to treat chronic lymphocytic leukemia, Waldenstrom's macroglobulinemia, and as a second-line treatment for mantle cell lymphoma, marginal zone lymphoma, and chronic graft vs host disease. (wikipedia.org)
  • patients
  • In patients with multiple sclerosis (MS), disease-associated myelin-specific T cells from the blood are predominantly co-stimulation-independent effector-memory T cells that express high numbers of Kv1.3 channels. (wikipedia.org)
  • In children with type-1 diabetes mellitus, the disease-associated insulin- and GAD65-specific T cells isolated from the blood are effector-memory T cells that express high numbers of Kv1.3 channels, and the same is true of T cells from the synovial joint fluid of patients with rheumatoid arthritis. (wikipedia.org)
  • Patients often have a refractory disease course but some patients may respond to phototherapy. (wikipedia.org)
  • mechanisms
  • Immunophysics is a novel interdisciplinary research field using immunological, biological, physical and chemical approaches to elucidate and modify immune-mediated mechanisms and to expand our knowledge on the pathomechanisms of chronic immune-mediated diseases such as arthritis, inflammatory bowel disease, asthma and chronic infections. (wikipedia.org)
  • skin
  • During his PhD he worked on skin grafts in guinea pigs, demonstrating that when black skin was grafted onto white skin, the white skin became black. (wikipedia.org)
  • treat
  • He also describes how the institution's world-class multidisciplinary team of experts excels in treating this complicated disease and how doctors work continuously to better understand and more effectively treat it. (cityofhope.org)
  • Therapies to treat inflammatory diseases include monoclonal antibodies that either neutralize inflammatory cytokines or their receptors. (wikipedia.org)
  • cells
  • IL-18 has also been found to increase the Alzheimer's disease-associated amyloid-beta production in human neuron cells. (wikipedia.org)
  • coronary
  • She headed the NIH advisory board for another multi-center clinical study that showed statins could slow course of atherosclerosis in coronary artery bypass grafts. (wikipedia.org)
  • severe
  • Patients who have had multiple corneal graft failure and severe corneal vascularization form one group of prospective KPro candidates. (kpro.org)
  • The other group has severe ocular surface disease so that a corneal graft will meet the same fate as the cornea it set out to replace. (kpro.org)
  • citation needed] In contrast, others with Hunter syndrome develop severe mental impairment and have life expectancies of 15 years or less, often due to neurodegeneration or physical complications from the disease. (wikipedia.org)
  • This process is used for red blood cell diseases such as sickle cell crises or severe malaria. (wikipedia.org)
  • deficiency
  • To be considered a primary immunodeficiency, the cause of the immune deficiency must not be secondary in nature (i.e., caused by other disease, drug treatment, or environmental exposure to toxins). (wikipedia.org)
  • When the arylsulfatase A enzyme level is normal but the sulfatides are still high - meaning that they are not being broken down because the enzyme is not activated - the resulting disease is saposin B deficiency, which presents similar to MLD. (wikipedia.org)
  • cause
  • antioxidants - compounds that protect against cell damage inflicted by molecules called oxygen-free radicals, which are a major cause of disease and aging. (nyhq.org)
  • The abnormal deposits that cause the disease were discovered in 1912 by Frederic Lewy. (wikipedia.org)
  • Dehydration, radiotherapy involving the salivary glands, chemotherapy and several diseases can cause hyposalivation or a change in saliva consistency and hence a complaint of xerostomia. (wikipedia.org)
  • people
  • Some studies test new drugs or surgical procedures and devices, while others look for better ways to prevent diseases in people who have either never had a disease or are trying to prevent one from coming back. (advancingyourhealth.org)
  • In the late part of the disease, people may depend entirely on others for their care. (wikipedia.org)
  • Most people with prostate cancer do not end up dying from the disease. (wikipedia.org)
  • Though the terms "attenuated" or "mild" are used by physicians in comparing people with Hunter syndrome, the effects of even mild disease are quite serious. (wikipedia.org)
  • Since then Lepra has grown to be an international charity giving a voice to people living at the intersection of disease, poverty and prejudice by helping them to improve their health, lives and livelihoods. (wikipedia.org)
  • medications
  • In those in whom the disease has spread to the bones, pain medications, bisphosphonates and targeted therapy, among others, may be useful. (wikipedia.org)
  • often
  • However, these 'fake' cancers can develop into full blown hodgkins and non-hodgkins lymphoma disease which are often fatal. (healthlinkusa.com)
  • health
  • The cardiac extracellular matrix (ECM) not only provides mechanical support, but also transduces essential molecular signals in health and disease. (jci.org)
  • problems
  • The walls of the airway may become thickened, as well, leading to breathing problems while sleeping (obstructive airway disease) and noisy breathing generally. (wikipedia.org)
  • present
  • Within the context of the stories, Gammenon is the Celestial tasked with collecting samples of all life forms present on a planet during a Celestial Host and is present during at least the First and Fourth Hosts to visit Earth. (wikipedia.org)
  • Finally, a "possible" diagnosis is made when the patient has only some of the characteristics of a disease are present, but not all. (wikipedia.org)
  • spread
  • Dutch elm disease (DED) is caused by a member of the sac fungi (Ascomycota) affecting elm trees, and is spread by elm bark beetles. (wikipedia.org)
  • Dutch elm disease was first noticed in continental Europe in 1910, and spread slowly and eventually extending to all other countries except Greece and Finland. (wikipedia.org)