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Graft SurvivalGraft Occlusion, VascularBlood Vessel ProsthesisPolytetrafluoroethyleneVascular PatencyPolyethylene TerephthalatesSaphenous VeinKidney TransplantationBlood Vessel Prosthesis ImplantationPrimary Graft DysfunctionVeinsLiver TransplantationTreatment OutcomeTransplantsCoronary Artery BypassReoperationTime FactorsAnastomosis, SurgicalPostoperative ComplicationsGraft vs Host DiseaseArteriovenous Shunt, SurgicalFemoral ArteryJugular VeinsLiving DonorsRetrospective StudiesProsthesis DesignFollow-Up StudiesTransplantation, AutologousTransplantation, HeterotopicImmunosuppressive AgentsCadaverProsthesis-Related InfectionsPopliteal ArteryFetal Tissue TransplantationTissue and Organ HarvestingHeart TransplantationReconstructive Surgical ProceduresOrgan PreservationAorta, AbdominalGraft Enhancement, ImmunologicStentsHyperplasiaVascular Surgical ProceduresKeratoplasty, PenetratingIslets of Langerhans TransplantationGraft vs Host ReactionLegIliac ArteryIschemiaTransplantation, IsogeneicTransplantation ImmunologyAortic Aneurysm, AbdominalCoated Materials, BiocompatibleIliumBrain Tissue TransplantationThrombosisSurgical FlapsRats, Inbred LewHost vs Graft ReactionArterial Occlusive DiseasesCold IschemiaAortographyTunica IntimaConstriction, PathologicTissue TransplantationFibulaHistocompatibility TestingImmunosuppressionBone SubstitutesProspective StudiesBone Marrow TransplantationBiocompatible MaterialsTissue and Organ ProcurementModels, AnimalProsthesis FailureRisk FactorsTomography, X-Ray ComputedAxillary ArteryThoracic ArteriesOrgan Preservation SolutionsTransplantation ToleranceCyclosporineAortic Aneurysm, ThoracicRenal DialysisTransplantation, HeterologousTibial ArteriesLife TablesPostoperative PeriodTacrolimusRadial ArteryAmputationUltrasonography, Doppler, DuplexPolyestersAneurysmAngiographyRecurrenceHistocompatibilityAortic DiseasesMice, Inbred C57BLHepatic Veins
TransplantationGVHDHSCTChronicSkin graft-versus-TransplantAGVHDProphylaxisAutologousGastrointestinalProgenitor cellsMortalityAcute graftHematologicHostImmuneStem cellImmunologicalSevereImmunosuppressionTransplantsPeripheralClinicalTreatmentHost diseaseProgenitorCalled hematopoietic stemTransplantsRecipientsMarrowCellComplicationsRegimenOrganBlood transfusionMultipotentCellsRecipientPatientsPlateletDiseasesFailure
Transplantation53
GVHD20
  • A team of hematology marrow transplant department of the Saint-Louis Hospital AP-HP, the Paris University and INSERM (U976 unit) in collaboration with the Pasteur Institute, led the work on graft against host disease (GVHD) using liquid chromatography coupled with mass spectrometry to study the metabolome of allogeneic patients at Saint-Louis hospital AP-HP. (pasteur.fr)
  • Graft against the host (GVHD) is a major complication that may occur after a allograft, and is characterized by tissue damage induced by donor immune cells which react against those of the recipient. (pasteur.fr)
  • These results published in the journal Nature Communications highlight the major changes in the human metabolome after allograft, associated with alterations of the patient's metabolism or its microbiota, which may represent potential therapeutic targets new for the prevention or treating the graft against the host (GVHD). (pasteur.fr)
  • Oral beclomethasone dipropionate for the treatment of gastrointestinal acute graft-versus-host disease (GVHD). (nature.com)
  • However, there are many treatment -related complications , including organ disorders, graft-versus-host disease (GVHD), and infectious diseases . (bvsalud.org)
  • The participating Sydney or grade III-IV graft-versus-host-disease (GVHD) was de- center is the largest of 2 centers that perform adult alloge- fi ned as severe GVHD. (cdc.gov)
  • Vascular injury has been seen in patients with acute graft versus host disease (GVHD) in the skin. (nih.gov)
  • Graft-versus-host disease (GvHD) is a syndrome, characterized by inflammation in different organs. (wikipedia.org)
  • GvHD can also occur after a blood transfusion, known as Transfusion-associated graft-versus-host disease or TA-GvHD if the blood products used have not been gamma irradiated or treated with an approved leukocyte reduction system. (wikipedia.org)
  • Graft-versus-host disease (GVHD) prophylaxis consisted of cyclosporine and methotrexate. (medscimonit.com)
  • Although T-cell depletion (TCD) reduces the risk of GVHD after a myeloablative conditioning regimen, it is associated with an increased risk of graft failure. (qub.ac.uk)
  • Graft versus host disease (GVHD) represents the most frequent cause of TRM. (hindawi.com)
  • Shortly before graft infusion, GVHD prophylaxis (immunosuppression) is started. (hindawi.com)
  • The study, headed by researchers at Penn Medicine and Dana-Farber/Boston Children's Cancer and Blood Disorders Center, demonstrated that antibody blockade of the Notch signaling pathway improved post-transplant survival and protected against gastrointestinal GVHD in particular. (genengnews.com)
  • And even when a bone marrow transplant is curative for leukemia or lymphoma, GVHD-in which T cells in the donor graft attack the recipient's own tissues-can still be fatal. (genengnews.com)
  • My principle research interests are in the prevention and therapy of graft-versus-host disease (GVHD) and in the use of graft-versus-leukemia to eradicate blood disorders. (harvard.edu)
  • Their relevance in terms of graft-versus-host disease (GVHD). (koreamed.org)
  • We present a case of HLH secondary to graft vs host disease (GVHD) in a patient who underwent simultaneous liver-kidney transplant (SLKT). (asn-online.org)
  • Keywords: Hemophagocytic lymphohistiocytosis (HLH), graft versus host disease (GVHD). (asn-online.org)
  • However, graft-versus-host disease (GVHD) remains a major obstacle for more successful application of allo-HCT. (umaryland.edu)
HSCT6
  • Salvage therapy options include further chemo-radiotherapy and autologous or allogeneic haematopoietic SCT (HSCT). (nih.gov)
  • On one end of the spectrum, invasive aspergillosis (IA) predominantly affects patients with profound defects in immune function, such as haematopoietic stem cell transplant (HSCT) or solid organ transplant recipients, and patients undergoing chemotherapy or taking corticosteroids. (bmj.com)
  • OSAKA, Japan & CAMBRIDGE, Mass.--( BUSINESS WIRE )--Takeda ( TSE:4502/NYSE:TAK ) today announced late-breaking data from the Phase 3 GRAPHITE study presented at the 2023 Tandem Meetings, demonstrating vedolizumab achieved a statistically significant and clinically meaningful improvement in lower gastrointestinal (GI) aGvHD-free survival by Day 180 after allo-HSCT with no relevant differences in safety profile versus placebo. (businesswire.com)
  • Lower GI aGvHD represents a critical unmet need in patients undergoing allo-HSCT," said Yi-Bin Chen, MD, Director, Hematopoietic Cell Transplant & Cell Therapy Program, Mass General Cancer Center. (businesswire.com)
  • HSCT) has significantly modified the prognosis of when the pathological process involves BM or when patients with hereditary or acquired hematological, hematopoietic toxicity is the limiting factor in the oncological and immunological diseases and it is the aggressive treatment of the disease. (bvsalud.org)
  • HSCT make it an aggressive process, causing consists of painless intravenous infusion of healthy toxicity and can generate significant complications hematopoietic stem cells (HSC) extracted from bone and several side effects adding feelings of worry, marrow (BM), peripheral blood (PB) and placental anguish, anxiety, among others (KUBA et al. (bvsalud.org)
Chronic22
  • In the clinical setting, graft-versus-host disease is divided into acute and chronic forms, and scored or graded on the basis of the tissue affected and the severity of the reaction. (wikipedia.org)
  • Chronic graft-versus-host disease also attacks the above organs, but over its long-term course can also cause damage to the connective tissue and exocrine glands. (wikipedia.org)
  • The chronic form of graft-versus-host disease (cGvHD) normally begins 90 to 600 days post-transplant. (wikipedia.org)
  • 8 The pivotal trial testing ATG in the setting of unrelated donors and intensive conditioning suggested a significant reduction in the incidence of chronic graft- versus -host disease without an increase in the risk of relapse. (haematologica.org)
  • 12 Interestingly, ATG reduced the cumulative incidence of acute graft- versus -host disease while it did not affect the rate of chronic graft- versus -host disease. (haematologica.org)
  • Graft-versus-host disease is categorized into two types: acute and chronic graft-versus-host disease. (researchandmarkets.com)
  • Furthermore, in the 7MM, the 5-year prevalence of chronic graft-versus-host disease was ~23,080 in 2022, which is likely to increase to ~26,300 cases by 2032. (researchandmarkets.com)
  • The overall severity of chronic graft-versus-host disease is classified as mild, moderate, or severe based on organ-specific grading (number of organs and severity). (researchandmarkets.com)
  • Approximately ~45% of 5-year prevalent cases of chronic graft-versus-host disease belong to the moderate category. (researchandmarkets.com)
  • Skin (~59%), oral mucosa (~53%), eyes (~53%), lungs (~43%), liver (~29%), joints and fascia (~28%), and gastrointestinal (~23%) are the most often affected organs by chronic graft-versus-host disease. (researchandmarkets.com)
  • The two main types of Graft vs. Host Disease are acute Graft vs. Host Disease and Chronic Graft vs. Host Disease. (researchandmarkets.com)
  • Dr. Cowen's primary research interest involves chronic graft-versus-host disease (cGVHD) and autoinflammatory diseases. (nih.gov)
  • This is chronic graft versus host disease. (nih.gov)
  • Quality of Life in Patients With Skin of Color and Chronic Graft-vs-Host Disease. (nih.gov)
  • Calcinosis Cutis in the Setting of Chronic Skin Graft-Versus-Host Disease. (nih.gov)
  • Efficacy and Safety of 1% Progesterone Gel to the Forehead for Ocular Chronic Graft-versus-Host Disease. (harvard.edu)
  • Joint contracture in chronic graft-versus-host disease (cGVHD) is refractory to treatment, and tends to deteriorate gradually over time. (koreamed.org)
  • Four patients developed acute, grade 2 to 3, graft- versus -host disease and four patients developed extensive chronic graft- versus -host disease. (aacrjournals.org)
  • Extracorporeal photopheresis, an effective treatment for patients with chronic graft-vs-host disease, has recently been shown to benefit patients with steroid-refractory graft-vs-host disease. (ascopost.com)
  • High incidence of extensive chronic graft-versus-host disease in patients with the REG3A rs7588571 non-GG genotype. (cdc.gov)
  • Characteristics and risk of chronic graft-versus-host disease of liver in allogeneic hematopoietic stem cell transplant recipients. (cdc.gov)
  • Covariance pattern models were used to determine predictors of regret over time, including baseline characteristics and post-alloHCT outcomes (acute or chronic graft-versus-host-disease, disease recurrence). (cdc.gov)
Skin graft-versus-1
  • Micrographs of grades of skin graft-versus-host disease: Ranging from grade I GvHR (with minimal vacuolization in the epidermis) to grade II GvHR (with vacuolization and dyskeratotic bodies) to grade III GvHR (with sub epidermal cleft formation) and finally to grade IV GvHR (with separation of the dermis from the epidermis). (wikipedia.org)
Transplant11
  • The report also includes clinical guidance for adults who have received 7-valent PCV (PCV7) only and adults who are hematopoietic stem cell transplant recipients. (cdc.gov)
  • Graft-versus-host disease is a potentially serious complication in a recipient of an allograft (usually a haematopoietic stem cell transplant) that arises from the attack of recipient tissues (such as the skin, liver or gut) by donor-derived T cells. (nature.com)
  • Acute graft-versus-host disease (aGvHD) remains a barrier to success following allogeneic hematopoietic cell transplant (allo-HCT) [ 1 - 5 ]. (thejh.org)
  • Transplant platforms included human leukocyte antigen-matched sibling donors, matched unrelated donors, and double umbilical cord blood grafts. (thejh.org)
  • Total allogenic transplant cases of graft-versus-host disease in the 7MM range from ~24,440 in 2022 to ~29,600 in 2032. (researchandmarkets.com)
  • As an allogeneic transplant recipient, the patient might experience either form of Graft vs. Host Disease, either form, or neither. (researchandmarkets.com)
  • About half the people who have a hematopoietic stem cell transplant using donor cells get cGVHD. (nih.gov)
  • In a newly reported study, an experimental antibody treatment largely prevented gastrointestinal acute graft versus host disease (GI-aGVHD) in the intestines of mice and non-human primates (NHPs) given a bone marrow transplant-allogeneic hematopoietic cell transplant (allo-HCT)-but without causing broad immune suppression. (genengnews.com)
  • Currently, the only approved cure for SCD is an allogeneic hematopoietic stem cell transplant. (aacn.org)
  • Risk factors for acute graft-vs-host disease include histocompatibility antigen mismatch, older age of transplant recipient, total-body irradiation as a component of conditioning chemotherapy, gender mismatch between donor and recipient, and prior host exposure to blood products. (ascopost.com)
  • The incidence of grade 2/3 bacterial or grade 3 fungal infections 100 days following transplant was 39% with omidubicel, vs 60% with standard transplants. (medscape.com)
AGVHD1
  • However, acute graft-versus-host disease (aGVHD) can be potentially fatal in recipients. (genengnews.com)
Prophylaxis1
  • Ensuring that the calcineurin inhibitor used for graft-vs-host disease prophylaxis is within the serum therapeutic range, or restarting a systemic calcineurin inhibitor along with high-dose systemic steroids at the onset of stage II to IV acute graft-vs-host disease is preferred. (ascopost.com)
Autologous1
  • Cell Replacement Therapy for Parkinson's Disease - Evaluating the potential of autologous grafting. (lu.se)
Gastrointestinal2
  • A randomized, placebo-controlled trial of oral beclomethasone dipropionate as a prednisone-sparing therapy for gastrointestinal graft-versus-host disease. (nature.com)
  • In the classical sense, acute graft-versus-host disease is characterized by selective damage to the liver, skin (rash), mucosa, and the gastrointestinal tract. (wikipedia.org)
Progenitor cells3
  • B lood cell differentiation begins with multipotent hematopoietic progenitor cells (HPCs), which are located in the marrow spaces of the bone. (nationalacademies.org)
  • To deliver on that promise, our laboratory is collaborating with the laboratories of Markus Grompe, M.D., OHSU, and Gordon Keller, Ph.D., University Health Network, Toronto, Canada, in the development and characterization of monoclonal antibodies directed against cell surface molecules expressed by pancreatic cell subsets as well as pancreatic progenitor cells derived from pluripotent stem cells. (ohsu.edu)
  • Early fate decisions in hematopoietic stem and progenitor cells. (lu.se)
Mortality2
  • Broader use has been hampered for a long time mainly by high non-relapse mortality, offsetting the advantage of a graft-vs-lymphoma effect. (nih.gov)
  • In 2022, the 7MM mortality-adjusted treated acute graft-versus-host disease patients were ~9,830 in first-line, and these cases are expected to increase to ~11,740 cases by 2032. (researchandmarkets.com)
Acute graft13
  • Initial therapy of acute graft-versus-host disease with low-dose prednisone does not compromise patient outcomes. (nature.com)
  • Mouse colon impacted by acute graft-versus-host disease. (wikipedia.org)
  • In the 7MM, the acute graft-versus-host disease incident cases were ~10,340 in 2022, which are likely to increase to ~12,360 by 2032. (researchandmarkets.com)
  • An assessment of the degree of involvement of these organs determines the severity of acute graft-versus-host disease. (researchandmarkets.com)
  • Fig. 1: Morbilliform rash, the most common skin manifestation of acute graft-vs-host disease. (ascopost.com)
  • Fig. 2: Follicular accentuation of skin lesions may be an early but important clinical clue during the development of acute graft-vs-host disease. (ascopost.com)
  • The cornerstone of treatment for acute graft-vs-host disease is the prophylactic regimen, but once cutaneous lesions develop, treatment is based on the stage of disease. (ascopost.com)
  • Acute graft-vs-host disease results from epithelial tissue damage following conditioning chemotherapy with subsequent infusion of competent donor lymphocytes within the allograft that result in damage to the skin, gut, and liver. (ascopost.com)
  • Acute graft-vs-host disease may occur either in isolation or in combination with intestinal or hepatic disease. (ascopost.com)
  • Skin biopsy may demonstrate interface dermatitis with necrotic keratinocytes, but its utility in diagnosing acute graft-vs-host disease is controversial. (ascopost.com)
  • these include late-onset acute, recurrent acute, and persistent acute graft-vs-host disease. (ascopost.com)
  • Erythema of the ears or palms may herald the onset of acute graft-vs-host disease. (ascopost.com)
  • While a morbilliform appearance (Fig. 1) is the most common skin manifestation of acute graft-vs-host disease, other morphologies are well recognized and include violaceous lesions, reticulated variants, and severe forms that produce widespread desquamation that may mimic toxic epidermal necrolysis. (ascopost.com)
Hematologic1
  • Allogeneic hematopoietic stem cell (HSC) is a curative treatment used for many hematologic malignancies and congenital or acquired anomalies of hematopoiesis. (pasteur.fr)
Host17
  • Oral beclomethasone dipropionate for treatment of human intestinal graft-versus-host disease. (nature.com)
  • 100 days posttransplantation or severe graft-versus-host disease America ( 2 - 4 ). (cdc.gov)
  • White blood cells of the donor's immune system which remain within the donated tissue (the graft) recognize the recipient (the host) as foreign (non-self). (wikipedia.org)
  • Newer research indicates that other graft-versus-host disease target organs include the immune system (the hematopoietic system, e.g., the bone marrow and the thymus) itself, and the lungs in the form of immune-mediated pneumonitis. (wikipedia.org)
  • Not to be confused with Host-versus-graft disease . (wikipedia.org)
  • In the evolving landscape of graft-versus-host disease management, staying abreast of current and projected epidemiological trends is vital. (researchandmarkets.com)
  • Armed with historical and forecasted data, the report elucidates the severity and organ-specific grading of graft-versus-host disease cases. (researchandmarkets.com)
  • This comprehensive knowledge is paramount for informed decision-making and strategic planning in the quest to tackle graft-versus-host disease. (researchandmarkets.com)
  • This "Graft vs. Host Disease - Epidemiology Forecast - 2032" report delivers an in-depth understanding of Graft vs. Host Disease, historical and forecasted epidemiology in the United States, EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan. (researchandmarkets.com)
  • Rehabilitation Interventions in the Multidisciplinary Management of Patients With Sclerotic Graft-Versus-Host Disease of the Skin and Fascia. (nih.gov)
  • Maillard is co-senior and co-corresponding author of the team's published paper in Science Translational Medicine , which is titled " Notch signalling drives intestinal graft-versus-host disease in mice and nonhuman primates . (genengnews.com)
  • Lack of donors and the risk of graft-versus-host disease or graft failure limits this option for many people. (aacn.org)
  • All patients achieved initial mixed hematopoietic chimerism with two patients rejecting their graft and recovering host hematopoiesis. (aacrjournals.org)
  • The application of topical steroids twice daily to moist skin and covered with warm wet towels as an occlusive measure ("wet wrap") is particularly effective for patients with diffuse skin graft-vs-host disease. (ascopost.com)
  • To guide its deliberations, ACIP used the Evidence to Recommendations Framework and the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach ( 8 ) to evaluate possible benefits (prevention of herpes zoster, postherpetic neuralgia, and herpes zoster-related hospitalizations) and harms (serious adverse events [SAEs],** immune-mediated disease, graft-versus-host-disease, graft rejection, and reactogenicity) associated with RZV. (cdc.gov)
  • On the other hand, donor-derived T cells can protect the host from infection, and can also identify and attack host tumor cells, producing the beneficial graft-versus-tumor (GVT) effect. (umaryland.edu)
  • Mohammadpour H, O'Neil R, Qiu J, McCarthy PL, Repasky EA, Cao X . Blockade of Host β2-Adrenergic Receptor Enhances Graft-versus-Tumor Effect through Modulating APCs. (umaryland.edu)
Immune1
  • The increased understanding of immune tolerance and allogeneic antileukemic immune reactivity has led several investigators to develop optimized conditioning protocols and new strategies to manipulate the effector cells either within the graft or in vivo . (haematologica.org)
Stem cell3
  • In 2003 he became Director of the OHSU Hematopoietic Cell Processing Laboratory, and in 2004 he became a member of the Oregon Stem Cell Center, where he is Director of the Center's monoclonal antibody and flow cytometry core facilities and conducts independent research. (ohsu.edu)
  • A growing number of case reports reveal reactivation similar to that seen after hematopoietic stem cell therapy. (hhv-6foundation.org)
  • HLH has also been reported after kidney, liver and hematopoietic stem cell transplants. (asn-online.org)
Immunological1
  • providing evidence for an immunological graft-versus-leukemia effect (GvL). (frontiersin.org)
Severe1
  • Antithymocyte gobulin, derived from rabbits or horses against human thymocytes, has predominantly been used for the treatment of severe aplastic anemia but also within conditioning for allogeneic HCT in selected protocols, mainly for non-malignant indications. (haematologica.org)
Immunosuppression1
  • Because immunosuppression and immunodeficiency were contraindications for the previously available vaccine, zoster vaccine live, ¶ and RZV was originally recommended for immunocompetent adults aged ≥50 years, there has been an unmet need for vaccination against herpes zoster in immunocompromised adults. (cdc.gov)
Transplants2
  • The FDA approval was based on phase 3 testing that pitted the use of omidubicel in 62 patients against standard unmanipulated cord blood transplants in 63 patients following myeloablative conditioning. (medscape.com)
  • Overall, 87% of patients who received omidubicel achieved neutrophil recovery, vs 83% of patients with standard transplants. (medscape.com)
Peripheral1
  • FIGURE 2-1 Formation of the multiple peripheral blood cells from multipotent hematopoietic stem cells. (nationalacademies.org)
Clinical1
  • Well-illustrated and clinically focused, it details the basic science and clinical practice of hematology and hematopoietic cellular therapy-covering virtually all aspects of hematology in one definitive resource. (elsevierhealth.com)
Treatment1
  • Treatment-related adverse events were reported in 24.8% versus 28.4%, and treatment related serious adverse events in 8.5% versus 6.5% of patients treated with placebo versus vedolizumab, respectively. (businesswire.com)
Host disease27
  • Genome-wide single-nucleotide polymorphism analysis revealed SUFU suppression of acute graft-versus-host disease through downregulation of HLA-DR expression in recipient dendritic cells. (nih.gov)
  • 100 days posttransplantation or severe graft-versus-host disease America ( 2 - 4 ). (cdc.gov)
  • In the clinical setting, graft-versus-host disease is divided into acute and chronic forms, and scored or graded on the basis of the tissue affected and the severity of the reaction. (wikipedia.org)
  • In the classical sense, acute graft-versus-host disease is characterized by selective damage to the liver, skin (rash), mucosa, and the gastrointestinal tract. (wikipedia.org)
  • Newer research indicates that other graft-versus-host disease target organs include the immune system (the hematopoietic system, e.g., the bone marrow and the thymus) itself, and the lungs in the form of immune-mediated pneumonitis. (wikipedia.org)
  • Chronic graft-versus-host disease also attacks the above organs, but over its long-term course can also cause damage to the connective tissue and exocrine glands. (wikipedia.org)
  • The chronic form of graft-versus-host disease (cGvHD) normally begins 90 to 600 days post-transplant. (wikipedia.org)
  • Cochrane Abstracts , Evidence Central , evidence.unboundmedicine.com/evidence/view/Cochrane/432099/all/Mesenchymal_stromal_cells_as_treatment_or_prophylaxis_for_acute_or_chronic_graft‐versus‐host_disease_in_haematopoietic_stem_cell_transplant__HSCT__recipients_with_a_haematological_condition. (unboundmedicine.com)
  • 1. Novel targets in the treatment of chronic graft-versus-host disease. (nih.gov)
  • 2. Immunological effects in patients with steroid-refractory graft-versus-host disease following treatment with basiliximab, a CD25 monoclonal antibody. (nih.gov)
  • 6. Ocular graft-versus-host disease: a review. (nih.gov)
  • 7. Evolving Therapeutic Options for Chronic Graft-versus-Host Disease. (nih.gov)
  • 9. Activity of therapeutic JAK 1/2 blockade in graft-versus-host disease. (nih.gov)
  • 11. [Treatment of chronic graft-versus-host disease with protein tyrosine kinase inhibitors]. (nih.gov)
  • 12. Therapeutic benefits targeting B-cells in chronic graft-versus-host disease. (nih.gov)
  • 13. Management of graft-versus-host disease. (nih.gov)
  • 14. Regulatory B10 cells display an altered homoeostasis in acute graft-versus-host disease. (nih.gov)
  • 15. Advances in understanding the pathogenesis of graft-versus-host disease. (nih.gov)
  • 17. Recognizing and managing chronic graft-versus-host disease. (nih.gov)
  • 19. Prediction of graft-versus-host disease: a biomarker panel based on lymphocytes and cytokines. (nih.gov)
  • In the second set of experiments, the donor T cells will be genetically modified to make them safer with respect to graft-versus-host disease. (gabriellesangels.org)
  • A Phase I Study to Evaluate Two Doses of Wharton's Jelly-Derived Mesenchymal Stromal Cells for the Treatment of De Novo High-Risk or Steroid-Refractory Acute Graft Versus Host Disease. (stembook.org)
  • The invention is in the field of methods for treating and preventing GI Syndrome and Graft Versus Host Disease. (justia.com)
  • NOXAFIL® (posaconazole) Oral Suspension is indicated for prophylaxis of invasive Aspergillus and Candida infections in patients, 13 years of age and older, who are at high risk of developing these infections due to being severely immunocompromised, such as hematopoietic stem cell transplant recipients with graft-versus-host disease or those with hematologic malignancies with prolonged neutropenia from chemotherapy. (merck.com)
  • HSCT can treat the underlying cause of beta-thalassemia, but it exposes patients to risks, including treatment-related mortality, graft failure, graft versus host disease, and infection. (fool.com)
  • Certain broad-spectrum antibiotics can worsen the effects of graft-versus-host disease in allogeneic hematopoietic stem cell transplant recipients who develop the condition, researchers from Memorial Sloan Kettering Cancer Center and their colleagues have shown. (the-scientist.com)
  • However, physicians have to be aware of severe clinical problems like graft-versus-host disease as well as increased risk of infection and secondary cancers. (minervamedica.it)
Progenitor3
  • B lood cell differentiation begins with multipotent hematopoietic progenitor cells (HPCs), which are located in the marrow spaces of the bone. (nationalacademies.org)
  • The heart session focused on HIV-related atherosclerosis/coronary artery disease (CAD), the lung session centered on HIV-related chronic obstructive pulmonary disease (COPD) and pulmonary hypertension (PH), and the blood session addressed HIV-related anemia and the role of hematopoietic stem and progenitor cells both as potential reservoirs and as potential cures for the disease. (nih.gov)
  • Consistently, donor-derived T cells, including GvH clones, and CD34+ hematopoietic stem and progenitor cells (HSPCs) were simultaneously detected in the recipients' BM more than 100 days after transplant. (columbia.edu)
Called hematopoietic stem1
  • Immune system cells develop from special cells that live in the bone marrow called hematopoietic stem cells. (primaryimmune.org)
Transplants3
  • These data suggest that providers can have more confidence in expanding the donor pool for hematopoietic stem cell transplants to include unrelated matched or one-allele-mismatched donors for patients in need. (dana-farber.org)
  • Peripheral blood hematopoietic stem cell (PBSC) transplants have been shown to result in more rapid engraftment than standard bone marrow transplants (BMTs). (umn.edu)
  • All of these can also be called hematopoietic stem cell transplants . (cancer.org)
Recipients3
  • Impact of SARS-CoV-2 in hematopoietic stem cell transplant and CAR-T cell therapy recipients. (stembook.org)
  • Clinical Characteristics and Outcomes of COVID-19 in Pediatric and Early Adolescent and Young Adult Haematopoietic Stem Cell Transplant Recipients: A Cohort Study. (stembook.org)
  • SOT recipients require lifelong immunosuppression to prevent graft rejection, making them susceptible to serious viral infections including EBV PTLD. (intechopen.com)
Marrow2
  • Hematopoietic stem cells (HSCs) are rare cells found in the bone marrow that produce red blood cells, white blood cells, and platelets. (medicalxpress.com)
  • To further improve upon the success of this low-dose non-toxic treatment for patients with leukemia and lymphoma, they want to study if T cells can be engineered to specifically help the donor marrow graft attack the blood cells containing leukemia or lymphoma without attacking the rest of the patient. (gabriellesangels.org)
Cell12
  • The term, allogeneic, indicates that the stem cells given to the recipient came from someone else, the hematopoietic stem cell donor. (primaryimmune.org)
  • Hematopoietic stem cells ( HSCs ) are multipotent stem cells that give rise to all the blood cell types including myeloid (monocytes and macrophages, neutrophils, basophils, eosinophils, erythrocytes, megakaryocytes/platelets, dendritic cells), and lymphoid lineages (T-cells, B-cells, NK-cells). (medicalxpress.com)
  • 8. Outcomes of acute leukemia patients transplanted with naive T cell-depleted stem cell grafts. (nih.gov)
  • Hematopoietic stem cell transplant involves the infusion of donor hematopoietic (blood-forming) stem cells, as well as donor T cells, a type of white blood cell. (dana-farber.org)
  • Disease-modifying therapies, newer hematopoietic stem cell transplant techniques, and gene therapies offer the potential for cure and improved quality of life. (ccjm.org)
  • Current practice in vitamin D assessment and management across the Adult and Paediatric Haematopoietic Stem Cell Transplant Centres in Europe (SUNSHINE). (ebmt.org)
  • Efficacy of a second allogeneic hematopoietic cell transplant in relapsed acute myeloid leukemia: results of a systematic review and meta-analysis. (stembook.org)
  • Here we demonstrate that patients with macrochimerism had high graft-versus-host (GvH) to host-versus-graft (HvG) T cell clonal ratios in their allografts. (columbia.edu)
  • These results, combined with cytotoxic single-cell transcriptional profiles of donor T cells in recipient BM, suggest that tissue-resident GvH-reactive donor T cells migrated into the recipient circulation and BM, where they destroyed recipient hematopoietic cells through cytolytic effector functions and promoted engraftment of graft-derived HSPCs that maintain chimerism. (columbia.edu)
  • ASMase deficiency protects intestinal mucosa against radiation-induced microvascular endothelial apoptosis and crypt stem cell lethality. (justia.com)
  • Approval of L-glutamine was based on data from a randomized, placebo-controlled trial in which, over the course of 48 weeks, patients receiving L-glutamine had fewer hospital visits for pain crises that resulted in treatment with parenteral narcotics or ketorolac (median three vs four), fewer hospitalizations for sickle cell pain (median two vs three), and fewer days in hospital (median 6.5 vs 11). (medscape.com)
  • Various studies have described a relationship between platelet graft delay and CD34 + cell dose, pre-transplant disease status, source of the graft, blood group, and even the development of platelet refractoriness. (confex.com)
Complications1
  • 3 of these patients did not achieve a platelet graft, 2 of them required a thrombopoietic receptor agonist, 2 had a diagnosis of ALL and one had MM, the 3 patients died before the +100 day due to infectious complications. (confex.com)
Regimen1
  • By decreasing priority, the matching criteria were as follows: donor type, graft source, intensity of the conditioning regimen, primary diagnosis, and disease status. (cttjournal.com)
Organ1
  • Ensuing specialists later determined that this multifunctional organ contained a number of valuable resident cells, other worthy non-indigenous cellular populations and a quantity of distinct structural elements, which possessed the potential to optimize fat graft survival and eventually further tissue engineering applications in regenerative medicine. (scirp.org)
Blood transfusion1
  • The transplant itself does not require surgery for the recipient, as the hematopoietic stem cells are typically infused into a large vein in the same way that a patient receives a blood transfusion. (primaryimmune.org)
Multipotent2
  • FIGURE 2-1 Formation of the multiple peripheral blood cells from multipotent hematopoietic stem cells. (nationalacademies.org)
  • The hematopoietic tissue contains cells with long-term and short-term regeneration capacities and committed multipotent, oligopotent, and unipotent progenitors. (medicalxpress.com)
Cells9
  • Hematopoietic stem cells produce all blood cells including red blood cells, platelet-producing cells, and immune system cells such as neutrophils, T cells, B cells, and natural killer (NK) cells. (primaryimmune.org)
  • Hematopoietic stem cells can be transferred from one person to another person. (primaryimmune.org)
  • White blood cells of the donor's immune system which remain within the donated tissue (the graft) recognize the recipient (the host) as foreign (non-self). (wikipedia.org)
  • The definition of hematopoietic stem cells has undergone considerable revision in the last two decades. (medicalxpress.com)
  • Donor T cells prevent disease recurrence via graft-versus-leukemia (GVL) effect. (nih.gov)
  • Individual GvH clones appeared in ileal mucosa or PBMCs before detection in recipient BM, consistent with an intestinal mucosal origin, where donor GvH-reactive T cells expanded early upon entry of recipient APCs into the graft. (columbia.edu)
  • When you get your own stem cells back, you don't have to worry about them (called the engrafted cells or the "graft") being rejected by your body. (cancer.org)
  • It enhanced the lytic activity of natural killer cells against tumour cells. (ijpsonline.com)
  • To assess the factors associated with late platelet grafting in the post-transplant patient of hematopoietic precursor cells. (confex.com)
Recipient1
  • Furthermore, the technical components of liposuction enabled practitioners to investigate methodically its impact on improving fat harvesting, and by extension, the subsequent steps of processing, transferring, and preparing the recipient site as components of the entire grafting procedure. (scirp.org)
Patients2
  • If patients with SCD crisis are being transported by emergency medical services (EMS), they should receive supplemental oxygen and intravenous hydration en route to the hospital. (medscape.com)
  • Thrombocytopenia is almost universal in the pre-graft period in patients sometimes on TCPH, delayed platelet recovery beyond the expected time occurs in 5% to 37% of patients sometimes on TCPH. (confex.com)
Platelet5
  • Male receptor gender and elevated serum hepcidin level have also been associated as risk factors for delayed platelet graft. (confex.com)
  • The recovery time for the platelet and neutrophil graft was not statistically significant, p=0.288 and p = 0.421 respectively. (confex.com)
  • The mean time for neutrophil and platelet grafting was 11 and 13 days, respectively. (confex.com)
  • have reported that there is an inverse relationship between the amount of CD34 infused and the time of platelet grafting. (confex.com)
  • This observation was not reproducible in our population since we found that an amount greater than 5 x 10 6 CD34 conferred a 4.4-fold risk for the platelet graft to be greater than 13 days, with a p= 0.0001. (confex.com)
Diseases1
  • We have discovered that administering anti-ceramide antibody treats and prevents an array of diseases mediated by cytolytic T lymphocyte (CTLs)-induced killing and by damage to endothelial microvasculture, including radiation-induced GI syndrome, Graft vs. Host diseases, inflammatory diseases and autoimmune diseases. (justia.com)
Failure1
  • Graft failure: Graft failure may be fatal. (nih.gov)