RejectionImmunosuppressionAnti-graftGvHDVersus host diseaseRecipientTransplantation ToleranceImmunologicalSurvivalAntigensUnresponsivenessCoronaryABSTRACTAcuteInduction of ToleranceDonorMechanismsRootstocksAutoimmune diseasesImmunologicDiseaseGlucose ToleTregSkinClinicalTransplant toleranceInduceDiseasesTissueCellsOrgansSignificantlyIschemiaPathogensPatientsCorruptionTreatmentFrequentWorkLossPlants
Rejection8
- The novel Cymerus™ manufacturing facilitates production of a virtually limitless supply of consistent human induced pluripotent stem cell (iPSC)-derived mesenchymal stem cells, which could play a key role in selective immunosuppression and graft repair during rejection. (biomedcentral.com)
- Existing immunosuppressive drugs for organ transplantation may achieve sufficient immunosuppression to prevent organ rejection or limit autoreactivity, but they are typically not successful in achieving long-term survival of the graft or preventing progression of fibrosis and chronic rejection [ 3 ]. (biomedcentral.com)
- Epitope spreading might also play a role in chronic graft rejection. (nature.com)
- Mice lacking C1q or C3 show accelerated rejection of minor H disparate skin grafts and resistance to induction of tolerance. (imperial.ac.uk)
- The induction and maintenance of immune tolerance to transplanted tissues constitute an active process involving multiple mechanisms that work cooperatively to prevent graft rejection. (jci.org)
- Once the graft has escaped the initial acute phase rejection reactions, a cumulative unresponsiveness to the graft develops as the recipient is continually exposed to donor MHC, a stable state that sometimes depends on the development of antigen-specific T-suppressor cells [ 371 , 5349 - 5354 ]. (nanomedicine.com)
- If infection occurs, immunosuppression must be suspended whereupon an implanted graft is usually lost due to rejection [ 371 ]. (nanomedicine.com)
- Injections of ALG into a graft recipient have a powerful suppressive effect on graft rejection [ 402 ]. (nanomedicine.com)
Immunosuppression4
- Collectively, these data confirmed that iPSC-derived MSC-mediated immunosuppression has potential to establish immune tolerance and rescue allograft from sustained hypoxic/ischemic phase, and subsequently limits long-term airway epithelial injury and collagen progression, which therapeutically warrant a study of Cymerus iPSC-derived MSCs as a potential management option for immunosuppression in transplant recipients. (biomedcentral.com)
- donor type kidneys were transplanted 3 months later without immunosuppression to test for tolerance. (atcmeetingabstracts.com)
- To our knowledge, this is the first report to indicate that donor DCs induced tolerance of kidneys without immunosuppression in a large animal. (atcmeetingabstracts.com)
- Shortly before graft infusion, GVHD prophylaxis (immunosuppression) is started. (hindawi.com)
Anti-graft3
- How will the anti-graft campaign unfold after the 19th CPC National Congress? (chinadaily.com.cn)
- BEIJING (REUTERS) - Chinese officials trying to hide dishonest spending with tricks such as throwing extravagant parties in private will be targeted in a sustained campaign to root out hedonism, the top anti-graft watchdog said on Monday (Dec 11). (straitstimes.com)
- Although the anti-graft drive had improved the atmosphere in society, there could be "no intermission and no rests", the official said. (straitstimes.com)
GvHD7
- Graft-versus-host disease ( GvHD ) is a syndrome , characterized by inflammation in different organs. (wikipedia.org)
- GvHD can also occur after a blood transfusion , known as Transfusion-associated graft-versus-host disease or TA-GvHD if the blood products used have not been gamma irradiated or treated with an approved leukocyte reduction system. (wikipedia.org)
- Graft-versus-host disease (GVHD) causes failed reconstitution of donor plasmacytoid dendritic cells (pDCs) that are critical for immune protection and tolerance. (bvsalud.org)
- In addition to complications seen from exposure to chemotherapy and radiation, patients undergoing allogeneic transplantation can experience unique late effects secondary to graft versus host disease (GVHD) and autoimmunity. (medscape.com)
- Graft versus host disease (GVHD), a severe immunogenic complication of allogeneic hematopoietic stem cell transplantation (HSCT), represents the most frequent cause of transplant-related mortality (TRM). (hindawi.com)
- Graft versus host disease (GVHD) represents the most frequent cause of TRM. (hindawi.com)
- Stopping rules were built into the study so that if too many patients either rejected their grafts or developed moderate to severe GVHD, the study would move to the 2nd cohort. (nih.gov)
Versus host disease11
- Mouse colon impacted by acute graft-versus-host disease. (wikipedia.org)
- Micrographs of grades of skin graft-versus-host disease: Ranging from grade I GvHR (with minimal vacuolization in the epidermis) to grade II GvHR (with vacuolization and dyskeratotic bodies) to grade III GvHR (with sub epidermal cleft formation) and finally to grade IV GvHR (with separation of the dermis from the epidermis). (wikipedia.org)
- In the clinical setting, graft-versus-host disease is divided into acute and chronic forms, and scored or graded on the basis of the tissue affected and the severity of the reaction. (wikipedia.org)
- In the classical sense, acute graft-versus-host disease is characterized by selective damage to the liver , skin (rash), mucosa , and the gastrointestinal tract . (wikipedia.org)
- Newer research indicates that other graft-versus-host disease target organs include the immune system (the hematopoietic system , e.g., the bone marrow and the thymus ) itself, and the lungs in the form of immune-mediated pneumonitis . (wikipedia.org)
- [6] Chronic graft-versus-host disease also attacks the above organs, but over its long-term course can also cause damage to the connective tissue and exocrine glands . (wikipedia.org)
- Graft-versus-host disease depletes plasmacytoid dendritic cell progenitors to impair tolerance induction. (bvsalud.org)
- The chronic form of graft-versus-host disease (cGvHD) normally begins 90 to 600 days post-transplant. (wikipedia.org)
- Chronic graft- versus -host disease (cGvHD) is a major cause of morbidity after hematopoietic stem cell transplantation (HSCT). (haematologica.org)
- As a result, HSCT is often attributed to an increased risk of health complications, the most severe being chronic graft- versus -host disease (cGvHD). (haematologica.org)
- Posttransplant cyclophosphamide (PTCy) is associated with a low incidence of chronic graft-versus-host disease (cGVHD) following hematopoietic stem cell (HSC) transplantation. (jci.org)
Recipient5
- White blood cells of the donor's immune system which remain within the donated tissue (the graft) recognize the recipient (the host) as foreign (non-self). (wikipedia.org)
- Donor DC-VTL were prepared by tolerizing recipients to a class I-mismatched thymic graft and then transferring the graft to a thymus-matched recipient, such that the allo VTL contained donor DCs at the corticomedular junction but all of the epithelial cells were recipient-type. (atcmeetingabstracts.com)
- or actively by prior immunization of the recipient with graft antigens which evoke specific antibodies and form antigen-antibody complexes which bind to the antigen receptor sites of the T-cells and block their cytotoxic activity. (umassmed.edu)
- Transplantation is the transfer of living cells, tissues, or organs from one person, the donor, to another, the recipient (e.g., a blood transfusion), or from one part of the body to another (e.g., skin grafts) with the goal of restoring a missing function [ 361 ]. (nanomedicine.com)
- The graft diameter is 7.5 mm for the recipient and 8.0 mm for the donor in both groups. (who.int)
Transplantation Tolerance3
- We have demonstrated that thymus plays an important role in transplantation tolerance in MHC inbred large animals. (atcmeetingabstracts.com)
- Cutting edge: transplantation tolerance through enhanced CTLA-4 expression. (umassmed.edu)
- Blockade of CD40-mediated signaling is sufficient for inducing islet but not skin transplantation tolerance. (umassmed.edu)
Immunological2
- There are two mechanisms that maintain immunological tolerance denominated central and peripheral tolerance. (frontiersin.org)
- C) Operational Tolerance (~10% patients): patients who develop immunological unresponsiveness (tolerance) towards graft, so for whom the immunosuppressive therapy can be reduced or withdrawn. (europa.eu)
Survival3
- Here, we demonstrated the impact of iPSC-derived human MSCs on the development of immune tolerance and long-term graft survival in mouse orthotopic airway allografts. (biomedcentral.com)
- The most important challenge is to achieve the long-term survival of the transplanted organ (also known as graft or allograft). (europa.eu)
- For the 10% of patients showing an operational tolerance, immunosuppressive drugs could be gradually reduced or withdrawn without compromising graft survival. (europa.eu)
Antigens2
- Immunoproteomic Identification of Noncarbohydrate Antigens Eliciting Graft-Specific Adaptive Immune Responses in Patients with Bovine Pericardial Bioprosthetic Heart Valves. (mayo.edu)
- These mechanisms are similar to inherent tolerance toward self antigens and have a requirement for active immunoregulation, largely T cell mediated, that promotes specific unresponsiveness to donor alloantigens. (jci.org)
Unresponsiveness1
- Immune tolerance co-evolved as a safety system that maintains a state of immune unresponsiveness to autoantigens and self-tissues ( 2 , 3 ). (frontiersin.org)
Coronary4
- Coronary artery bypass grafting was performed. (bmj.com)
- Coronary artery bypass grafting (CABG) involves bypassing native coronary arteries that have high-grade stenosis or occlusion not amenable to angioplasty with stent insertion. (msdmanuals.com)
- Traditional coronary artery bypass grafting involves thoracotomy via a midline (median) sternotomy. (msdmanuals.com)
- The left internal mammary artery is typically used as a pedicled graft to the left anterior descending coronary artery. (msdmanuals.com)
ABSTRACT1
- Yamada K, Sekijima M, Kawai A, Tanabe T, Tasaki M, Villani V, Hanekamp I, Shimizu A, Sachs D. Chimeric Thymus Versus Antigen Presenting Thymus for the Induction of Tolerance: Donor DCs in Vascularized Thymus Grafts Play an Essential Role in the Induction of Tolerance [abstract]. (atcmeetingabstracts.com)
Acute2
- Nuclear factor κB (NF-κB) activation is a deleterious molecular mechanism that drives acute kidney injury (AKI) and manifests in transplanted kidneys as delayed graft function. (researchgate.net)
- For conditioning for transplantation, patients were given a reduced dosage of chemotherapy so that the acute tolerance of the transplantation was very good. (disabled-world.com)
Induction of Tolerance1
- CONCLUSIONS: The presence of donor DCs likely plays an essential role in the induction of tolerance in this model. (atcmeetingabstracts.com)
Donor3
- One promising cellular therapy is the use of regulatory T cells to induce a state of donor-specific tolerance to the transplant. (lu.se)
- MATERIALS and METHODS: MGH MHC-inbred swine were used and allogeneic tolerance was assessed across a class I mismatched barrier using (1) donor-antigen presenting thymii (Donor Ag-VTL) and (2) donor thymic dendritic cells presenting thymii (Donor DC-VTL). (atcmeetingabstracts.com)
- The main risk still remains the "graft-versus-host reaction", in which donor cells attack the patient's own cells, which are foreign to them. (disabled-world.com)
Mechanisms4
- Mechanisms of tolerance differences in cucumber seedlings grafted on r" by YAN LI, XUEMEI TIAN et al. (tubitak.gov.tr)
- Mechanisms of peripheral tolerance include inactivation of autoantigen-recognizing T and B cells by the induction of apoptosis, anergy or conversion into immunosuppressive regulatory cells. (frontiersin.org)
- In this study, we investigated the mechanisms of thymic dependent tolerance utilizing the VTL technique. (atcmeetingabstracts.com)
- These findings define the mechanisms by which PTCy restores homeostasis of the B cell lineage and reestablishes immune tolerance. (jci.org)
Rootstocks3
- However, it is still unclear why cucumber plants grafted on different rootstocks usually exhibit different tolerance. (tubitak.gov.tr)
- 3. Identify rootstocks for use with grafted vegetables with resistance or tolerance to pathogens and root-knot nematodes. (usda.gov)
- Characterize rootstocks and associated microbiome for resistance or tolerance to soilborne pathogens of importance in the Southeastern U.S. 3b. (usda.gov)
Autoimmune diseases2
- Loss of immune tolerance to autoantigens associated with a specific organ results in the activation of organ-specific T and B cells that in turn cause organ-specific inflammation and the development of autoimmune diseases such as multiple sclerosis (MS) ( 5 ), rheumatoid arthritis (RA) ( 6 ), psoriasis ( 7 ), and type 1 diabetes (T1D) ( 8 ). (frontiersin.org)
- Thus, therapeutics that induce, restore, and maintain immune tolerance toward these autoantigens represent the "Holy Grail" of treatments for autoimmune diseases. (frontiersin.org)
Immunologic3
- Graft Enhancement, Immunologic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
- This graph shows the total number of publications written about "Graft Enhancement, Immunologic" by people in this website by year, and whether "Graft Enhancement, Immunologic" was a major or minor topic of these publications. (umassmed.edu)
- Below are the most recent publications written about "Graft Enhancement, Immunologic" by people in Profiles. (umassmed.edu)
Disease5
- Not to be confused with Host-versus-graft disease . (wikipedia.org)
- Studies in two models of multiple sclerosis, experimental autoimmune encephalomyelitis (EAE) and Theiler's murine encephalitogenic virus-induced demyelinating disease (TMEV-IDD) have shown conclusively that epitope spreading plays a pathological role in ongoing disease and that blocking this process by inducing tolerance to spread myelin epitopes or blocking costimulation of T cells (necessary for epitope spreading) blocks (EAE) or inhibits (TMEV-IDD) ongoing clinical disease. (nature.com)
- Early tolerance to glutamic acid decarboxylase (GAD) in the non-obese diabetic (NOD) mouse model of diabetes has been shown to block epitope spreading and disease progression. (nature.com)
- Nature Hills supplies grafted trees with clonal root-stocks to help insure disease tolerance and ample harvests. (naturehills.com)
- There are more than 60 species of ash worldwide, and scientists believe that all of them are susceptible to the disease, with varying degrees of tolerance. (forestresearch.gov.uk)
Glucose Tole1
- Your provider may do a glucose tolerance test to see if you have diabetes. (medlineplus.gov)
Treg4
- Deletional strategies employed at or around the time of transplant reduce the number of potentially graft destructive T cells and facilitate the action of Treg subsets. (jci.org)
- Cell number, as denoted on the y axis, represents an illustration as to how the relative ratio of effector versus Treg subsets alters during the establishment of transplant tolerance and is not meant for comparison between groups. (jci.org)
- To identify the cells responsible for PTCy-induced B cell tolerance, we selectively depleted Treg populations that were graft or HSC derived using DEREG mice. (jci.org)
- PTCy rescued B lymphopoiesis from graft-derived Treg deletion. (jci.org)
Skin3
- Tolerance of sk-incompatible skin grafts. (jax.org)
- In severe cases, the lesion may be removed by surgery, followed by moving (grafting) skin from other parts of body to the operated area. (medlineplus.gov)
- Photocarcinogenesis in human adult skin grafts. (who.int)
Clinical2
- Islets prepared for transplantation into type 1 diabetes patients are exposed to compromising intrinsic and extrinsic factors that contribute to early graft failure, necessitating repeated islet infusions for clinical insulin independence. (researchgate.net)
- 4. Postoperative medication tolerance evaluated by the patient's reported symptoms and by clinical evaluation during each follow-up visit scheduled weekly for the first 2 months, then every 2 months until the completion of 1 year. (who.int)
Transplant tolerance1
- Utilizing this technique, we have reported VTL-induced transplant tolerance across allogeneic barriers in miniature swine. (atcmeetingabstracts.com)
Induce1
- Using mice models, Dr. Fitzhugh et al showed for the first time that sirolimus and post-transplant cyclophosphamide work synergistically to induce tolerance (Fitzhugh CD et al. (nih.gov)
Diseases1
- We are further investigating the potential of this therapy in improving immune tolerance and graft versus host diseases associated with corneal transplantation. (stanford.edu)
Tissue2
- Li C, Alfonso-Garcia A, McMasters J, Bec J, Weyers B, Uyesaka L, Griffiths L , Panitch A, Marcu L. Simultaneous intraluminal imaging of tissue autofluorescence and eGFP-labeled cells in engineered vascular grafts inside a bioreactor. (mayo.edu)
- Induction of anti-inflammatory T helper (T H )2 responses via epitope spreading may be an important intrinsic immunoregulatory mechanism geared to limit tissue destruction and promote re-establishment of tissue-specific immune tolerance. (nature.com)
Cells5
- Second, T cell therapies using Tregs (either polyclonal, antigen-specific, or genetically engineered to express chimeric antigen receptors) to establish active dominant immune tolerance or T cells (engineered to express chimeric antigen receptors) to delete pathogenic immune cells. (frontiersin.org)
- Peripheral tolerance evolved to counteract autoantigen-recognizing T or B cells that escape central tolerance. (frontiersin.org)
- During the maintenance phase of tolerance, these Tregs, either naturally occurring or induced, can thus act more efficiently on a greatly reduced number of effector T cells. (jci.org)
- Immediately after the graft has been implanted, it is necessary to prevent sensitization of pre-existing mature T cells capable of recognizing the graft. (nanomedicine.com)
- In due course, the stem cells in the bone marrow reconstitute the peripheral lymphoid system but the newly formed T cells seem to accept the graft as self [ 403 ]. (nanomedicine.com)
Organs2
- Central tolerance occurs during lymphocyte development in the primary lymphoid organs (i.e. thymus and bone marrow), where T or B cell clones that recognize autoantigens with high-affinity are deleted. (frontiersin.org)
- Peripheral tolerance occurs in the secondary lymphoid organs (e.g. spleen, lymph nodes, and mucosal/gut associated lymphoid tissues) and peripheral tissues. (frontiersin.org)
Significantly1
- With the new improved method studied here, tolerance was significantly improved. (disabled-world.com)
Ischemia1
- We have established a technique of isolated vascularized thymic lobe transplantation (VTL) that allows us to study thymic dependent tolerance without changes in thymic structure due to ischemia following thymic transplantation. (atcmeetingabstracts.com)
Pathogens1
- Evidence suggest that a patient's genetic predisposition together with environmental factors, such as exposure to pathogens that exhibit molecular mimicry, disturb immune tolerance ( 4 ). (frontiersin.org)
Patients3
- A) Classical response (~40% patients): graft is not rejected but requiring immunosuppressive therapy for the whole patient´s life. (europa.eu)
- One of the 3 patients engrafted but lost the graft at 7 months post-transplant. (nih.gov)
- Based on the three patients losing their grafts, stopping rules were met and the study moved to the 2nd cohort where 1 dose of Cy was given at 50mg/kg on day 3 post-transplant. (nih.gov)
Corruption2
- We will continue to see that there are no no-go zones, no ground left unturned, and no tolerance shown for corruption. (chinadaily.com.cn)
- And last evening, CS Wahome issued a statement saying she supports zero tolerance to corruption and that she has not prejudiced any graft investigation. (co.ke)
Treatment1
- We demonstrated that iPSC-derived MSC treatment leads to significant increases in hTSG-6 protein, followed by an upregulation of mouse Tregs and IL-5, IL-10, and IL-15 cytokines, which augments graft microvascular blood flow and oxygenation, and thereby maintained a healthy airway epithelium and prevented the subepithelial deposition of collagen at d90 post transplantation. (biomedcentral.com)
Frequent1
- The key idea of GRAB is to adopt weighted frequent itemset mining for the most time-consuming step in the grafting algorithm, which is designed to solve large-scale \(L_1\) -RERM problems by an iterative approach. (springer.com)
Work1
- Concealing spending by holding lavish dinners in private homes, passing off pampering at a spa as "recuperation" from work and going sightseeing while on business trips are all in the sights of the graft busters. (straitstimes.com)
Loss1
- To overcome this computational difficulty, we propose an algorithm, GRAfting for Binary datasets (GRAB) , which efficiently learns CBMs within the \(L_1\) -regularized loss minimization framework. (springer.com)
Plants1
- Determine nutritional requirements and capacity of grafted plants to mitigate abiotic stress related to water quality. (usda.gov)