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  • corneal grafts
  • Treating corneal grafts with a cocktail of cytokines prior to implantation may free transplant patients from the burden of immunosuppressive therapy, according to preclinical findings by a Massachusetts Eye and Ear research team. (aao.org)
  • The researchers are hopeful that this novel method of using a combination of cytokines working together to promote tolerance of corneal grafts -- by treating the donor tissue rather than the recipient -- may transition more easily to the clinical setting. (eurekalert.org)
  • Disease
  • By quantifying graft-vs-host disease alloresponses in vivo, we demonstrate that both CD4 + and CD8 + T cell-mediated alloresponses are regulated by 4-1BB/4-1BB ligand interactions to approximately the same extent. (jimmunol.org)
  • infection
  • Although several studies support the association between respiratory viruses and chronic lung rejection, the relationship between viral infection and acute rejection has not been established. (bmj.com)
  • The overall rate of viral infection in grade A0/A1 acute rejection cases was 25.4%, compared with 12.6% in grade A2 or higher rejection. (bmj.com)
  • cell
  • First results in this rat keratoplasty model show a weaker T-cell response to corneal graft antigen in three week old rats. (dog.org)
  • cause
  • Primary graft failure is a lack of engraftment with pancytopenia, marrow aplasia, and an absolute neutrophil count of less than 500/ul (with no other cause of myelosuppression) at day 28 after transplant. (oncologynurseadvisor.com)
  • often
  • At the time of clinical rejection, the nodules often presented as tertiary lymphoid structures (TLS) with lymphoid-like follicles. (sigmaaldrich.com)
  • time
  • Late graft failure is also manifested by pancytopenia and marrow aplasia that develops after initial hematopoietic recovery and at a later time course after transplant. (oncologynurseadvisor.com)