• Graft rejection. (lookformedical.com)
  • It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (lookformedical.com)
  • Potential recipients of kidney transplants undergo an extensive immunologic evaluation that primarily serves to avoid transplants that are at risk for antibody-mediated hyperacute rejection. (medscape.com)
  • CMI) , cellular i. immune responses that are initiated by an antigen-presenting cell interacting with and mediated by T lymphocytes ( e.g., graft rejection, delayed-type hypersensitivity). (theodora.com)
  • Epitope spreading might also play a role in chronic graft rejection. (nature.com)
  • or actively by prior immunization of the recipient with graft antigens which evoke specific antibodies and form antigen-antibody complexes which bind to the antigen receptor sites of the T-cells and block their cytotoxic activity. (umassmed.edu)
  • Tissue grafts or foreign antigens placed into sites with immunologic privilege can survive and thrive without the immune system attacking them or shutting down the host organ. (ondrugdelivery.com)
  • Experts do not fully understand the complexities of immunologic privilege but they do know that the ocular microenvironment regulates antigens within the eye via anti-inflammatory proteins and neuropeptides. (ondrugdelivery.com)
  • It is also important to note that immunologic privilege helps to avoid severe inflammatory reactions to foreign antigens but it does not prevent such reactions altogether. (ondrugdelivery.com)
  • An induced state of non-reactivity to grafted tissue from a donor organism that would ordinarily trigger a cell-mediated or humoral immune response. (lookformedical.com)
  • Nevertheless, the composition of the immunologic tumor microenvironment undergoes changes upon radiotherapy, chemotherapy, or even after anti-angiogenic therapy ( 6 ). (frontiersin.org)
  • The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host. (lookformedical.com)
  • The grafting of skin in humans or animals from one site to another to replace a lost portion of the body surface skin. (lookformedical.com)
  • The second area of study is to understand the regulation of the immune response to cellular and solid organ grafts. (stanford.edu)
  • Researchers believe immunologic privilege is an evolutionary protective measure developed to protect specific sites from inflammation and potential organ failure. (ondrugdelivery.com)
  • Modern research into mechanisms of immune tolerance offers the promise of reprogramming the immune system, so as to harness the body's natural tolerance mechanisms in the service of graft acceptance. (ox.ac.uk)
  • The primary objectives of this study are: - To determine the proportion of children with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) related death, rehospitalization or major complications after infection with SARS-CoV-2 and/or Multisystem Inflammatory Syndrome in Children (MIS-C), and - To determine immunologic mechanisms and immune signatures associated with disease spectrum and subsequent clinical course during the year of follow-up. (stanford.edu)
  • The assays studied were graft-vs-host reaction (GvHR) and mixed lymphocyte (MLR) reaction, spontaneous cellular cytotoxicity and antibody-dependent cell-mediated cytotoxicity, and mitogen responsiveness to Con A, PHA, and PWM. (aai.org)
  • Active suppression of host-vs graft reaction in pregnant mice. (mcmaster.ca)
  • This graph shows the total number of publications written about "Graft Enhancement, Immunologic" by people in this website by year, and whether "Graft Enhancement, Immunologic" was a major or minor topic of these publications. (umassmed.edu)
  • enzyme: minor from Health Enhancement Systems. (sheppardengineering.com)
  • Graft failure was more common after treosulfan (n = 11), than after busulfan (n = 2) while all patients were rescued by second procedures except one busulfan patient. (bvsalud.org)
  • Ultrasonography (US), CT, MRI, cholangiography, angiography and scintigraphy are the most common radiological modalities used to evaluate the hepatic graft. (medscape.com)
  • It is asymptomatic with a benign course and occurs most often in young adults, with a median age at diagnosis in the 3rd or 4th decade(3).HHV-8-associated Castleman disease is more aggressive, occurs predominantly in immunosuppressed / human immunodeficiency virus (HIV)-positive patients and manifests commonly with generalized lymphadenopathy, constitutional symptoms, and hematologic and/or immunologic abnormalities. (iriakerala.org)
  • cells of indicating Your Blood recognition Foam: Midland, MI: Health Enhancement Systems. (sheppardengineering.com)
  • If this explanation were true we would expect extra immunosuppressive preconditioning of recipients to reduce the incidence of relapse, as well as preventing graft rejection. (ox.ac.uk)
  • Knowledge from basic, preclinical and clinical studies aimed at characterizing the relative role of the direct and the indirect allorecognition pathways in enhancing or preventing graft rejection could lead to the development of specific interventions to modulate immune recognition after transplantation and ultimately increase graft survival. (nih.gov)
  • Although recognition of alloantigen can lead to deleterious effects on a graft, there are several examples of tolerance induction following exposure of the recipient to donor alloantigen prior to transplantation, either by infusion with whole cells or by treatment with MHC-derived synthetic peptides. (nih.gov)
  • Studies of clinical and immunologic aspects of allogeneic hematopoietic cell transplantation with nonmyeloablative conditioning. (nih.gov)
  • 4. Graft-versus-host disease after autologous bone marrow transplantation: a realistic expectation? (nih.gov)
  • 5. Enhancement of cyclosporin A-induced autologous graft-versus-host disease after peripheral blood stem cell transplantation by utilizing selected CD34(+) cells. (nih.gov)
  • 6. Cyclosporin A-induced graft-versus-host disease following autologous bone marrow and stem cell transplantation in hematological malignancies of childhood. (nih.gov)
  • 7. Allogeneic haematopoietic cell transplantation for multiple myeloma: reducing transplant-related mortality while harnessing the graft-versus-myeloma effect. (nih.gov)
  • 9. Interleukin-17-producing T-helper cells as new potential player mediating graft-versus-host disease in patients undergoing allogeneic stem-cell transplantation. (nih.gov)
  • 14. Systemic aspergillosis in a patient with non-Hodgkin's lymphoma developing acute graft-versus-host disease after autologous peripheral blood stem cell transplantation. (nih.gov)
  • 1. Autologous graft-versus-host disease: harnessing anti-tumor immunity through impaired self-tolerance. (nih.gov)
  • 10. Effect of combined cytostatic cyclosporin A and cytolytic suicide gene therapy on the prevention of experimental graft-versus-host disease. (nih.gov)
  • 11. Modulation of graft-versus-host disease: role of regulatory T lymphocytes. (nih.gov)
  • 13. Autologous graft-vs-host disease: mechanisms and potential therapeutic effect. (nih.gov)
  • 16. Cyclosporine-induced autologous graft-versus-host disease in patients with acute myeloid leukemia undergoing non-myeloablative chemotherapy without progenitor cell reinfusion. (nih.gov)
  • 18. Syngeneic/Autologous Graft-vs-Host Disease: Mobilization of Autoimmune Mechanisms as Antitumor Immunotherapy. (nih.gov)
  • 19. A revision of Billingham's tenets: the central role of lymphocyte migration in acute graft-versus-host disease. (nih.gov)
  • Donor T cells prevent disease recurrence via graft-versus-leukemia (GVL) effect. (nih.gov)
  • Donor T cells also contribute to graft-versus-host disease (GVHD), a debilitating and potentially fatal complication. (nih.gov)
  • Pathologically confirmed cases of PACNS have been reported in patients with Hodgkin disease, amyloid angiopathy , and graft-versus-host disease. (medscape.com)
  • The IL‐12/18 preactivated NK cells mitigate aGVHD (Acute Graft vs. Host) despite the severity of the disease. (jeffreydachmd.com)
  • Our other effort in the enhancement of GVT effects in B-cell malignancies involves the use of idiotype (Id) vaccines in the treatment of multiple myeloma. (nih.gov)
  • Thus additional research is needed to distinguish the contributions of direct and indirect recognition to allograft survival and to determine how this knowledge could lead to improvements in existing therapies as well as the development of new therapies to prolong graft survival. (nih.gov)
  • 3. Hematopoietic stem cell graft manipulation as a mechanism of immunotherapy. (nih.gov)
  • This finding suggests an alternative explanation for the graft-versus-leukemia effect other than a direct attack on leukemia cells. (ox.ac.uk)
  • IL‐12/18 preactivated NK cells mediated stronger GVL (Graft vs. Lymphoma) effect than control NK cells mainly due to their elevated activation/cytotoxicity and sustained proliferative potential. (jeffreydachmd.com)
  • My second area of research has focused on optimizing the graft-versus-tumor (GVT) effect. (nih.gov)
  • [ 2 ] With refinements in technique, fat grafting has become the procedure of choice for an array of problems, including facial scarring, lip augmentation, and facial rhytids (such as several otherwise difficult-to-address areas, including the nasolabial fold and glabellar furrows). (medscape.com)
  • These changes have significant immunologic effects in vivo and in culture. (tgf-betasignal.com)
  • Resolution of Nonmass Enhancement Extension. (bktimes.net)
  • Already at 2 wk after graft take, the number of NK cells had find more reached (supra)normal levels but NK-cell subsets were skewed. (tgf-betasignal.com)
  • NIEHS offers a broad range of job opportunities, career enhancement programs, and research training grants and programs in environmental health sciences and administration. (nih.gov)
  • 17. Unexpected role of TNF-alpha in graft versus host reaction (GVHR): donor-derived TNF-alpha suppresses GVHR via inhibition of IFN-gamma-dependent donor type-1 immunity. (nih.gov)
  • Graff and colleagues reported studies on an mCRPC patient who is in his sixth year of a complete clinical prostate cancer response to treatment with only three cycles of ipilimumab after experiencing autoimmune hepatitis. (healthyprostateclub.com)
  • Throughout the early part of the 20th century, attempts were made to correct other conditions, including hemifacial atrophy and breast defects, but modern fat grafting did not develop until the early 1980s with the popularity of liposuction. (medscape.com)
  • NIEHS has a goal to ensure job opportunities and career enhancements programs for both our work force and our community. (nih.gov)
  • In many cases glasses or contact lenses may help you to see more clearly, but there are times when these do not work and the cornea needs to be replaced (graft/transplant). (sankarfoundation.org)