• Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal bone marrow disorder, resulting from an acquired, somatic X-linked mutation of the PIG-A gene in an hematopoietic stem cell. (clinicaltrials.gov)
  • This study will examine blood cells of patients with paroxysmal nocturnal hemoglobinuria (PNH) after they receive a blood transfusion to determine if certain proteins (GPI-linked proteins) in the transfused blood transfer to the patient's blood cells. (clinicaltrials.gov)
  • Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal bone marrow disorder, resulting from an acquired, somatic X-linked mutation of the PIG-A gene in an hematopoietic stem cell. (clinicaltrials.gov)
  • Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal disorder of the hematopoietic stem cell (Hartmann and Arnold 1977) resulting in the production of blood cells which are defective in that they lack or are markedly deficient in glycan-phosphatidylinositol (GPI)-linked surface proteins (Rosse 1990a). (springer.com)
  • Carothers DJ, Hazra SV, Andreson SW, Medof ME (1990) Synthesis of aberrant decay-accelerating factor proteins by affected paroxysmal nocturnal hemoglobinuria leucocytes. (springer.com)
  • Like the other papillary thyroid carcinoma forms of Ret, Ret/ptc2 is activated through fusion of the Ret tyrosine kinase domain to the dimerization domain of another protein. (asm.org)
  • Ret/ptc2, encoded by one of the fusion genes, contains 596 residues, with the N-terminal 239 residues derived from the type Iα regulatory subunit of cyclic AMP (cAMP)-dependent protein kinase (RIα) and the C terminus derived from the Ret tyrosine kinase domain. (asm.org)
  • Symmetry-breaking charge transfer in the excited state of directly linked push-pull porphyrin arrays. (bioportfolio.com)
  • δEF1/ZFH-1 Zn-finger-homeodomain proteins are distinguished by two arrays of highly similar C2H2-type Zn-finger domains and a centrally located homeodomain, and can act as transcriptional repressors through recruitment of the corepressor C-terminal binding protein (CtBP). (biologists.org)
  • By Western blot analysis and kinase assays, we demonstrate the ability of these factors to induce the phosphatidylinositol 3 kinase (PI 3-kinase) and the extracellular regulated kinase (ERK)-mitogen-activated protein (MAP) kinase pathways activation. (jneurosci.org)
  • This feature of GPI linkage may be potentially useful for the delivery of therapeutic proteins to vascular endothelium. (uab.edu)
  • They function as receptors for the complex of lipopolysaccharide (LPS) and LPS-binding protein. (harvard.edu)
  • Herein, we revealed a symmetry-breaking charge transfer (SBCT) process in the excited state of a directly linked push-pull porphyrin dyad (AD) and triad (ADA) via spectroscopic measurements including steady-state absorption and fluorescence, time-resolved fluorescence (TRF), femtosecond transient absorption (fs-TA), and time-resolved infrared (TRIR) measurements. (bioportfolio.com)
  • Here evidence is presented that GPI-linked proteins can undergo intermembrane transfer in vivo. (uab.edu)
  • Cell-surface proteins are of great biomedical importance, as demonstrated by the fact that 66% of approved human drugs listed in the DrugBank database target a cell-surface protein. (pnas.org)
  • As a training set, we used experimentally verified high-confidence cell-surface proteins from the Cell Surface Protein Atlas (CSPA) and trained a random forest classifier on 131 features per protein and, specifically, per topological domain. (pnas.org)
  • SURFY was used to predict a human surfaceome of 2,886 proteins with an accuracy of 93.5%, which shows excellent overlap with known cell-surface protein classes (i.e., receptors). (pnas.org)
  • Human IgG1 Fc fusion protein (immunoadhesins) of VE-JAM/JAM 2 (VE-JAM/JAM 2.Fc) or JAM 3 (JAM 3.Fc) was prepared, as previously described ( 3 ), and purified over a protein A column (Amersham Pharmacia Biotech, Piscataway, NJ). (jimmunol.org)
  • We applied a machine-learning approach utilizing domain-specific features to develop the accurate surfaceome predictor SURFY and used it to define the human in silico surfaceome of 2,886 proteins. (pnas.org)
  • These types of mutations are associated with papillary thyroid carcinoma (PTC), and the fusion oncoproteins generated are termed RET/PTC proteins. (wikipedia.org)
  • Germ line mutations in ret are linked to two classes of genetic diseases. (asm.org)
  • Investigation of requirements for Ret/ptc2 mitogenic activity, using coexpression with dominant negative forms of Ras and Raf, indicated that these proteins are required for mitogenic signaling by Ret/ptc2. (asm.org)
  • Login to edit your profile (add a photo, awards, links to other websites, etc. (harvard.edu)