AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
Anti-Glomerular Basement Membrane DiseaseDuodenoscopyCrohn DiseaseCollagen Type IVAutoantigensBasement MembraneCollagenAutoantibodiesNephritis, HereditaryKidney GlomerulusEpitope MappingEpitopesGlomerular Basement MembraneMicrobial CollagenaseAntibody SpecificityIsoantibodiesEnzyme-Linked Immunosorbent AssayGlomerulonephritisAmino Acid SequenceMolecular Sequence DataAntigen-Antibody ReactionsBinding Sites, AntibodyCattleBase SequenceAntibodiesAlternative SplicingKidneyProtein-Serine-Threonine KinasesProtein ConformationRecombinant ProteinsDNA PrimersCell LineMacromolecular SubstancesImmunoglobulin GProtein Structure, TertiarySpecies SpecificityPolymerase Chain ReactionSequence Homology, Amino AcidRNA, MessengerEncyclopedias as TopicPlasmapheresis
SyndromeErnest GoodpastureGlomerulonephritisAntibodiesCenters for DiseasRenalLungsInfectious diseasesGoodpasture's DiseaseAnti-glomerularLupus1919Basement membraneMultiple SclerosisDiagnosisSymptomsLung diseaseRespiratoryCOPDAssociated with disease severityCryoglobulinemiaImmuneInflammationConnectiveRheumatoid arthritisPatientsPulmonary diseaseInflammatory Bowel D
Syndrome35
  • Goodpasture syndrome (GS) is the clinical entity of acute glomerulonephritis and pulmonary alveolar hemorrhage, and the term Goodpasture syndrome is used interchangeably with pulmonary renal syndrome. (medscape.com)
  • Goodpasture's name has been used in a more specific clinical condition known as Goodpasture disease, which is the pulmonary renal syndrome specifically associated with anti-glomerular basement membrane (anti-GBM) antibodies. (medscape.com)
  • [ 1 ] These anti-GBM antibodies produce a characteristic linear deposition along the GBM, one way in which Goodpasture syndrome is differentiated from Wegener granulomatosis. (medscape.com)
  • To avoid confusion between Goodpasture syndrome and Goodpasture disease, the term anti-GBM disease is used. (medscape.com)
  • Go to Goodpasture Syndrome for complete information on this topic. (medscape.com)
  • On the basis of this clinical report, Goodpasture's name is often linked to the pulmonary renal syndrome of alveolar hemorrhage and necrotizing and proliferative glomerulonephritis, although vasculitis and not anti-GBM disease is believed to be the cause of the pulmonary renal syndrome in Goodpasture's original patient. (medscape.com)
  • Goodpasture syndrome (GPS), also known as anti-glomerular basement membrane disease, is a rare autoimmune disease in which antibodies attack the basement membrane in lungs and kidneys, leading to bleeding from the lungs, glomerulonephritis, and kidney failure. (wikipedia.org)
  • Goodpasture syndrome may quickly result in permanent lung and kidney damage, often leading to death. (wikipedia.org)
  • Some other signs and symptoms that could be used to identify Goodpasture syndrome during a physical exam include an increased respiratory rate, cyanosis, crackles, hepatosplenomegaly, and hypertension. (wikipedia.org)
  • Occasionally Goodpasture syndrome affects only the kidneys or only the lungs. (msdmanuals.com)
  • Goodpasture syndrome affects people who appear to be genetically susceptible. (msdmanuals.com)
  • Normal serum complement levels suggest a visceral abscess, polyarteritis nodosa, Goodpasture syndrome, or Henoch-Schönlein purpura. (medscape.com)
  • With the qualitative estimation of proteinuria, determination of high-molecular-weight (HMW) protein (eg, fractional excretion of IgG [FEIgG]) and low-molecular-weight (LMW) protein (eg, alpha-1-microglobulin), may help predict the clinical outcome and may help in guiding steroid and immunosuppressive therapy, especially in patients with primary glomerular diseases with nephrotic syndrome. (medscape.com)
  • In this study, the cases of a patient with Goodpasture syndrome (also referred to as anti-glomerular basement membrane disease) and a patient with the morphological features of Goodpasture syndrome or Goodpasture-like syndrome found in a histopathological examination are described. (edu.pl)
  • Finally, the importance of histopathological examination in the diagnosis of Goodpasture syndrome and the Goodpasture-like syndrome with atypical course is emphasized. (edu.pl)
  • Outcomes of patients with Goodpasture syndrome: A nationwide cohort-based study from the French Society of Hemapheresis. (edu.pl)
  • Cellular and molecular aspects of Goodpasture syndrome. (edu.pl)
  • Goodpasture-like syndrome induced by D-penicillamine in a patient with systemic sclerosis: report and review of the literature. (edu.pl)
  • Goodpasture-like syndrome associated with anti-myeloperoxidase antibodies following penicillamine treatment. (edu.pl)
  • A Case of Pulmonary-Renal Syndrome Leading to the Diagnosis of Legionnaires' Disease. (edu.pl)
  • There is no specific laboratory test or clinical scan that can definitively recognize fibromyalgia, so doctors must rule out other possible disorders such as lupus, chronic fatigue syndrome, restless leg syndrome, thyroid disease or chronic headaches. (lawyernc.com)
  • Using the PIXE method, we measured the iron content of alveolar macrophages in healthy subjects, with and without occupational exposure to iron dust, and in patients with pulmonary diseases (chronic obstructive pulmonary disease (COPD), lung cancer, Goodpasture's syndrome). (ersjournals.com)
  • Goodpasture syndrome is a rare, autoimmune disease that can affect the lungs and kidneys. (artemishospitals.com)
  • Goodpasture's syndrome: This is a rare autoimmune disease where the body's immune system mistakenly attacks the lungs and kidneys. (nkfs.org)
  • Examples of autoimmune conditions include the following: Rheumatoid arthritis (RA) Type 1 diabetes Crohn's Disease Hashimoto's thyroiditis Neurological diseases Multiple Sclerosis (MS) Glomerulanephritis Pernicious Anaemia Goodpasture's syndrome Scleroderma Raynaud's Phenome non Lupus (e.g., systemic lupus erythematosus [SLE]) Inflammatory bowel disease (IBD). (ecopolitan.com)
  • Goodpasture syndrome is an autoimmune disorder characterized by pulmonary hemorrhage and rapidly progressive glomerulonephritis in association with antibodies to alveolar and glomerular basement membrane (GBM). (rheumaknowledgy.com)
  • The cause of Goodpasture syndrome is unknown. (rheumaknowledgy.com)
  • Immunofluorescent staining of biopsy specimens from the lungs and kidneys of patients with Goodpasture syndrome reveals a characteristic linear pattern of anti-GBM antibody deposition. (rheumaknowledgy.com)
  • This provides an explanation for why end-organ involvement of Goodpasture syndrome is typically limited to the lungs and kidneys. (rheumaknowledgy.com)
  • Goodpasture syndrome is rare and mostly affects white men in their third decade, although all races and ages may be affected. (rheumaknowledgy.com)
  • 95% of patients with Goodpasture syndrome (see Antiglomerular Basement Membrane (GBM) Antibody ). (rheumaknowledgy.com)
  • The diagnosis of Goodpasture syndrome may be secured by demonstrating linear antibody staining of the basement membrane of renal or pulmonary biopsy specimens. (rheumaknowledgy.com)
  • Tests for serum anti-GBM antibodies are most commonly used to diagnose Goodpasture syndrome because of their widespread availability and high sensitivity and specificity. (rheumaknowledgy.com)
  • Goodpasture syndrome used to be associated with a poor prognosis and high associated mortality. (rheumaknowledgy.com)
  • Graft-versus-host disease ( GvHD ) is a syndrome , characterized by inflammation in different organs. (wikipedia.org)
Ernest Goodpasture3
  • In 1919, Ernest Goodpasture described an 18-year-old man with a fever and cough, followed by hemoptysis and renal failure. (medscape.com)
  • The disease was first described by an American pathologist Ernest Goodpasture of Vanderbilt University in 1919 and was later named in his honor. (wikipedia.org)
  • Abstract Personal papers of pathologist Ernest Goodpasture, best known for his method of growing uncontaminated viruses in chick embryos. (vanderbilt.edu)
Glomerulonephritis4
Antibodies1
  • On top of the anti-GBM antibodies implicated in the disease, about one in three of those affected also has cytoplasmic antineutrophilic antibodies in their bloodstream, which often predates the anti-GBM antibodies by about a few months or even years. (wikipedia.org)
Centers for Diseas4
  • Centers for Disease Control and Prevention. (cdc.gov)
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
  • Approximately 6.5 million children have been diagnosed with asthma according to the Centers for Disease Control and Prevention (CDC). (artemishospitals.com)
  • Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. (cdc.gov)
Renal12
  • Despite this triad of clinical findings, patients with anti-GBM disease may present with a spectrum of conditions ranging from pulmonary hemorrhage with minimal or no renal involvement to full-blown renal failure with limited or no pulmonary involvement. (medscape.com)
  • Anti-GBM autoantibodies that are present in the circulation of patients with anti-GBM disease cross the fenestrated endothelium in the glomerulus and bind with the underlying GBM, inducing renal injury. (medscape.com)
  • When renal disease is present, it can then be isolated or accompanied by pulmonary hemorrhage. (medscape.com)
  • When significant renal disease is present, it usually progresses rapidly. (medscape.com)
  • 2008 Annual data report: atlas of chronic kidney disease and end-stage renal disease in the United States. (medscape.com)
  • Miklovicova D, Cornelissen M, Cransberg K, Groothoff JW, Dedik L, Schroder CH. Etiology and epidemiology of end-stage renal disease in Dutch children 1987-2001. (medscape.com)
  • Alchi B, Griffiths M, Sivalingam M, Jayne D, Farrington K. Predictors of renal and patient outcomes in anti-GBM disease: clinicopathologic analysis of a two-centre cohort. (medscape.com)
  • She educates patients on how to keep their condition from progressing and prepares them for dialysis should they develop end-stage renal disease. (ucsfhealth.org)
  • This section deals with clinical conditions associated with renal disease which are covered by the Immunology department. (mft.nhs.uk)
  • Immunological processes are implicated in many renal diseases. (mft.nhs.uk)
  • The same tests are also useful for the diagnosis of chronic renal disease. (mft.nhs.uk)
  • Some of these tests are also used to monitor renal disease (ANCA, C4). (mft.nhs.uk)
Lungs3
  • Cystic fibrosis (CF) is an inherited chronic disease that affects the lungs and digestive system. (artemishospitals.com)
  • Interstitial lung diseases are named after the tissue between the air sacs of the lungs called the interstitium, the tissue affected by fibrosis (scarring). (artemishospitals.com)
  • Newer research indicates that other graft-versus-host disease target organs include the immune system (the hematopoietic system , e.g., the bone marrow and the thymus ) itself, and the lungs in the form of immune-mediated pneumonitis . (wikipedia.org)
Infectious diseases2
  • The length of hospitalization of patients with acute infectious diseases, including Spanish influenza, is associated with disease severity. (cdc.gov)
  • Principles and Practice of Pediatric Infectious Diseases , 5th edition. (cdc.gov)
Goodpasture's Disease3
  • Goodpasture's disease which may affect the basement membrane in both the lung and the kidney). (medicalxpress.com)
  • Hellmark T, Segelmark M. Diagnosis and classification of Goodpasture's disease (anti-GBM). (edu.pl)
  • Dammacco F, Battaglia S, Gesualdo L, Racanelli V. Goodpasture's disease: a report of ten cases and a review of the literature. (edu.pl)
Anti-glomerular6
Lupus7
  • Low serum complement levels suggest the following systemic diseases: cryoglobulinemia, systemic lupus erythematosus (SLE), bacterial endocarditis, and shunt nephritis. (medscape.com)
  • Lupus erythematosus is an autoimmune disease that develops when the immune system starts attacking the body as it confuses it for being foreign and harmful to the body. (epainassist.com)
  • Lupus is like an umbrella term that is used to refer to a number of immune diseases that have similar laboratory characteristics and symptoms. (epainassist.com)
  • Systemic lupus erythematosus is a chronic (long-term) disease that has some phases of aggravated symptoms followed by a period of mild symptoms or complete remission of the symptoms. (epainassist.com)
  • Other symptoms of lupus vary depending on the part of the body that the disease attacks, such as the heart, skin, or digestive tract. (epainassist.com)
  • Many physical therapists often use foam rollers as part of their physical therapy routine for patients with muscular and joint diseases, including lupus. (epainassist.com)
  • Polymyositis or Dermatomyositis (Conditions in which the muscles or skin get inflamed), Rheumatoid Arthritis (Disease in which the joints become painful or deformed), Systemic Lupus Erythematosus (A Chronic Inflammatory Condition). (askdrshah.com)
19192
  • We aimed to identify physical features, including respiratory sounds, that might be associated with disease severity among patients in Japan who were affected by Spanish influenza during 1919 and 1920. (cdc.gov)
  • Recently, additional records of patients affected by the second wave of disease during 1919-1920 were discovered, and these patients were the subjects of this study. (cdc.gov)
Basement membrane1
Multiple Sclerosis1
  • In the upcoming 5-hour 'Electromagnetic Pollution - Solid Solutions' Seminar for both doctors (5 CEUs awarded to applicable Minnesota doctors) and the public, we will explore the underlying mechanism that is a common thread in the evolution of numerous disease conditions, from headaches to joint pain, from multiple sclerosis (MS) to diabetes, and from asthma to cancer. (ecopolitan.com)
Diagnosis2
  • The diagnosis of GPS is often difficult, as numerous other diseases can cause the various manifestations of the condition and the condition itself is rare. (wikipedia.org)
  • September 2001, Prague, Czech Republic tional respiratory disease diagnosis. (cdc.gov)
Symptoms2
  • There is no various other neurological manifestations, zero symptoms to suggest connective tissues family members or disease background of seizure. (nanoker-society.org)
  • The symptoms of this autoimmune disease are also symptoms of several other diseases, which is why the process of diagnosing is challenging. (epainassist.com)
Lung disease3
  • Tuberculosis is an infectious lung disease caused by bacteria. (healthline.com)
  • This pattern of lung disease has not been previously described in ABMA-GS. (elsevierpure.com)
  • A raredisease which can involve lung disease and a quickly worsening kidney. (askdrshah.com)
Respiratory3
  • Dr. Macbruce has experience treating conditions like Respiratory Failure, Pleural Effusion and COPD (Chronic Obstructive Pulmonary Disease) among other conditions at varying frequencies. (sharecare.com)
  • In both cases the course of the disease was atypical, with a massive respiratory tract hemorrhage being the most significant symptom. (edu.pl)
  • The purpose of this study was to investigate the clinical usefulness of the PIXE technique in occupational respiratory medicine and in various pulmonary diseases. (ersjournals.com)
COPD2
  • COPD is a group of lung diseases that include chronic bronchitis and emphysema . (healthline.com)
  • COPD is a term that refers to a group of lung diseases that can interfere with normal breathing. (artemishospitals.com)
Associated with disease severity1
  • Autoantibodies specific for the Sm antigen are strongly associated with disease severity in SLE. (lupusresearch.org)
Cryoglobulinemia1
  • Essential mixed cryoglobulinemia should also be considered when evaluating a patient with suspected anti-GBM disease. (medscape.com)
Immune8
  • Hello 1-GSM Visitors, autoimmune diseases refer to a condition in which the immune system mistakenly attacks the body's healthy cells, tissues, or organs. (1-gsm.com)
  • Autoimmune diseases are a group of diseases caused by abnormal immune attacks on healthy cells, tissues or organs. (medicalxpress.com)
  • Autoimmune diseases arise from an inappropriate immune response of the body against substances and tissues normally present in the body. (medicalxpress.com)
  • The treatment of autoimmune diseases is typically with immunosuppression-medication which decreases the immune response. (medicalxpress.com)
  • American Auto Immune Related Diseases Association (AARDA) puts the estimate much higher at 50 million . (rarest.org)
  • Auto-immune-related diseases affect women at a much higher rate than their male counterparts. (rarest.org)
  • During many of my lectures here and abroad about the detriment of society's obsessive consumption of dairy products, I noticed that my audiences seemed amenable enough to digesting the scientifically proven facts regarding the close association between milk products and many kinds of cancer, asthma, infections, allergies, auto-immune disease, inflammation, arthritis, weight gain, many. (ecopolitan.com)
  • Auto-immune diseases are those where our body's own cells of immunity attack tissues and organs of it's own. (askdrshah.com)
Inflammation2
  • New research has revealed a potentially important role ginger supplements can play in controlling inflammation for people living with autoimmune diseases. (medicalxpress.com)
  • Sarcoidosis is a rare disease that results from inflammation. (artemishospitals.com)
Connective2
  • Ankylosis Spondylitis is defined as a chronic and generally progressive inflammatory arthritic disease affecting the spinal joints and adjacent connective tissues. (ecopolitan.com)
  • [6] Chronic graft-versus-host disease also attacks the above organs, but over its long-term course can also cause damage to the connective tissue and exocrine glands . (wikipedia.org)
Rheumatoid arthritis1
  • People who are treated with TNF-α inhibitors for their autoimmune disease such as Crohn's disease or rheumatoid arthritis lose their vaccination protection significantly earlier than average. (medicalxpress.com)
Patients3
  • Although available clinical techniques and treatment options for Spanish influenza patients were limited in this era, charts showing detailed records of lung sounds and fever exist and can be used to infer disease severity in affected persons. (cdc.gov)
  • Using these molecules, we will solve the crystal structure to elucidate the molecular conformation that drives the anti-Sm T cell response, and generate HLA-DR15 tetramers to determine the frequency, phenotype of anti-Sm specific T cells as well as obtain clonally expanded paired Valpha and Vbeta T cell receptor (TCR) sequences from SLE patients with active disease. (lupusresearch.org)
  • However, patients are often quite ill during the initial course of the disease, making biopsy more difficult. (rheumaknowledgy.com)
Pulmonary disease3
  • Isolated pulmonary disease is rare. (rheumaknowledgy.com)
  • Finally, the majority of (1) allergic and irritant dermatitis, and (2) asthma and type IV reactions are characterized by allergic contact chronic obstructive pulmonary disease. (cdc.gov)
  • Allergic and irritant dermatitis together account for type IV pulmonary disease. (cdc.gov)
Inflammatory Bowel D1
  • Millions of Americans have inflammatory bowel disease (IBD), which occurs in one of two forms: Crohn's disease or ulcerative colitis. (medicalxpress.com)